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Herpes simplex virus 1 and 2 (HSV-1 and HSV-2) are two strains of the Herpes virus family, Herpesviridae, which cause infections in humans.
After an initial, or primary, infection, HSV establishes latency, during which the virus is present in the cell bodies of nerves which innervate the area of original outbreak. Herpes infections are marked by painful, watery blisters in the skin or mucous membranes (such as the mouth or lips) or on the genitals.
HSV is generally transmitted by direct contact of lips or genitals when the sores are present, or just before they appear (known as shedding). Entry and replication of the HSV involves interactions of several viral glycoproteins with cell surface receptors or particles. Once bound to the HVEM, glycoprotein D changes its conformation and interacts with glycoproteins H and L, which form a complex. The packaging of the viral particles, which include the genome, core and the capsid, occur in the nucleus. About Me“The master in the art of living makes little distinction between his work and his play, his labor and his leisure, his mind and his body, his information and his recreation, his love and his religion. La muestra se lleva al laboratorio y es analizada por especialistas para determinar la presencia y cantidad de anticuerpos, que el organismo genera en defensa de este virus. Asimismo, el resultado puede ser falso negativo si la infeccion ocurrio desde hace unas cuantas semanas hasta tres meses y, por tanto, el organismo aun no genera anticuerpos suficientes para ser detectadas mediante esta prueba. During reactivation, virus is produced in the cell and transported outwardly via the nerve cell’s axon to the skin.
The blisters resemble those seen in Chickenpox — an infection caused by a third member of the alpha-Herpesviridae subfamily, Varicella Zoster Virus (VZV), also known as Human Herpes Virus 3 (HHV-3).
In addition, herpes may be transmitted during childbirth, which can be fatal to the infant. The virus particle contains an envelope which, when bound to specific receptors on the cell surface, will fuse with the cell membrane. Glycoprotein B interaction with the glycoprotein H and L complex allows the virus to enter into the cell.

In the nucleus, cleavage of genome concatemers occurs and these are placed into pre-formed capsids. Causa del herpes genital; alrededor de 20% de los adultos presenta anticuerpos contra este virus. Entonces, se recomienda confirmar el resultado posteriormente, a criterio del medico tratante y factores de riesgo y condicion del paciente. The ability of Herpes virus to establish latency leads to the chronic nature of Herpes infection; after the initial infection subsides, Herpes symptoms may periodically recur in the form of outbreaks of herpetic sores near the site of original infection.
The immature immune system of the child is unable to defend against the virus and even if treated, infection can result in brain damage.
The viral particle migrates to the nucleus, where the genome is replicated using enzymes from the host cell. The viral envelope is acquired from the nuclear envelope, more specifically the inner lamellae of the membrane. He simply pursues his vision of excellence at whatever he does, leaving others to decide whether he is working or playing. Es muy comun, aproximadamente 70% de los adultos han estado infectados y tienen anticuerpos contra esta clase. Transmission occurs while passing through the birth canal and the risk of infection is minimal if there are no symptoms or exposed blisters during delivery. Initially, glycoprotein C, on the surface of the viral envelope, targets and binds to a cell surface particle, heparan sulfate. Upon entering the cell, an ?-TIF protein also joins the viral particle and aids in immediate early Transcription.
Las personas pueden contagiarse con este virus en cualquier etapa o fase de sus vidas y cualquiera puede contagiarse una vez entran en contacto con el virus.Por lo general se piensa que el herpes genital es extremadamente doloroso y peligroso tambien. This is particularly likely during an outbreak, although individuals may shed virus between outbreaks. The first outbreak after exposure to HSV is commonly more severe than future outbreaks, as the body has not had a chance to produce antibodies; this first outbreak also carries the risk of developing meningitis.

En algunos casos esto es cierto, pero eso depende del sistema inmunologico de la persona contagiada.Un sistema inmunologico fuerte puede ayudar al cuerpo a controlar la duracion y severidad de los brotes.
Although no cure is yet available, treatments exist which reduce the likelihood of viral shedding.
Two major glycoproteins, glycoprotein B and glycoprotein D, also associate with the cell membrane. This enzyme shuts off protein synthesis in the host, degrades host mRNA, helps in viral replication, and regulates gene expression of viral proteins.
Los bebes y aquellas personas con condiciones medicas como el SIDA o el Cancer, sufren mas las consecuencias del herpes ya que su sistema inmunologico no se encuentra bien desarrollado o no funciona al maximo.Los estudios han demostrado que cuando la persona ha tenido el herpes por bastante tiempo los brotes se hacen menos frecuentes, aun se desconoce el por que. Glycoprotein D binds specifically to the herpesvirus entry mediator receptor (HVEM), thus providing a strong, fixed attachment to the host cell. While the viral genome immediately travels to the nucleus, the VHF protein remains in the cytoplasm.
Otro factor que influye en el numero de brotes es el lugar donde el virus se establece cuando no se encuentra activo.Normalmente, el virus del herpes simple 1, causante del herpes labial, se aloja en el area facial. El virus del herpes simple 2 se aloja en la parte sacra de la columna vertebral, sin embargo, un reves en la locacion de estos virus tiende a disminuir la cantidad de brotes y produce brotes mas ligeros en el futuro.Es importante saber que el herpes se puede contagiar sea con el virus del herpes simple 1, o el virus del herpes simple 2. Como pasa con cualquier enfermedad de transmision sexual, si la padeces, debes aprender todo lo relacionado con ella para protegerte a ti y a los demas.Al aprender sobre el herpes, puedes ayudar a otros a tomar consciencia sobre esta enfermedad.
De esta manera, las personas pueden aprender a vivir una vida feliz, saludable y bien informada.

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