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Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Varicella-zoster virusThe varicella-zoster virus (VZV), also known as human herpesvirus 3 (HHV-3), is one of the eight herpesvirus known to affect humans (and other vertebrates).
Varicella-zoster virus causes chickenpox as a primary infection and rarely VZV encephalitis. The Varicella-zoster virus can remain dormant in the host and later reactivates to induce shingles disease (herpes zoster, zoster multiplex, myelitis, herpes ophthalmicus, or zoster sine herpete) and post-herpetic neuralgia. Within the body it is combatted by a number of drugs including vidarabine, zoster immune globulin (ZIG), and acyclovir.

Keratitis is responsible for causing corneal ulcer, an open sore or erosion in the outer layer of cornea. It's lipid envelope encloses the nucleocapsid of 162 capsomeres arranged in a hexagonal form. It was developed by Merck, Sharp and Dohme in the 1970s from a virus isolated by Mishiaki Takahashi and identified as Oka.
Herpes simplex keratitis infects the superficial layer of the cornea with diffuse branching or punctuates lesions on the epithelium which excludes the stroma. It had a series of tests in the 1980s and was offered to the FDA for approval in 1990 and was finally passed in 1995.

The application of topical glucocoticoid to the infected eye can worsen the infection and lead to the inclusion of the stromal structure.

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