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Researchers have found that an experimental vaccine to protect against Herpes Simplex virus has shown good results against one of the two types of these viruses but has not fulfilled the required objectives.
This research has been published online in January 5 issue of The New England Journal of Medicine. Researchers worked on 8323 women in the age range of 18-30 and found that the vaccine, containing the component called as glycoprotein D (gD, which is present in the envelope surrounding herpes simplex virus 2), worked effectively against herpes simplex virus type 1, known as HSV1, but not type 2, known as HSV2, and the reasons are not clear. HSV1 results in sores in the mouth and the lips while HSV2 causes blisters and lesions in the genital area. This research study has been funded by the National Institute of Allergy and Infectious Diseases in Bethesda, Maryland, and GlaxoSmithKline.
Cold sores -- also called fever blisters -- are a painful infection caused by the herpes simplex virus (HSV). Although cold sores generally are not serious, the infection may be life-threatening for anyone who has AIDS or whose immune system is depressed by other disorders or medications.


The infection from a cold sore may cause blindness if it spreads to the eye, and meningitis or encephalitis if it spreads to the brain.
Cold sores are usually caused by the herpes simplex virus (HSV) type 1, which is transmitted by such forms of contact as kissing an infected person or sharing eating utensils, towels, or razors. Many of the viruses have complex life cycles and may remain dormant in the body for prolonged periods of time. These blisters are usually caused by HSV type 1, but can less commonly be due to HSV type 2. Leone, an infectious disease specialist at the University of North Carolina, Chapel Hill, said in a statement. According to the reports of Centers for Disease Control and Prevention (CDC) one in six people in U.S. They may show up anywhere on your body, but are most likely to appear on the outside of your mouth and lips, your nose, cheeks, or fingers.


A person with a cold sore who performs oral sex on another person can give that person genital lesions with HSV-1.
Blisters form, then break and ooze; a yellow crust or a scab develops and eventually sloughs off, revealing new skin underneath. After the first infection, many people develop antibodies and never have another cold sore.
Similarly, a person who performs oral sex on another person with genital HSV-2 lesions can develop oral lesions. The virus may be triggered by certain foods, stress, fever, colds, allergies, sunburn, and menstruation.



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