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Your use of this website constitutes acknowledgement and acceptance of our Terms & Conditions. A chemical in smokeless tobacco products has been found to cause cancer, according to a new study in animals. While use of smokeless tobacco products has been strongly linked to the development of cancer, no specific chemical in the products had been identified as a strong oral-cancer causing agent until now, the researchers say. Previous studies have suggested that a group of chemicals called nitrosamines, of which (S)-NNN is a member, cause various types of cancer in animals, but no study has looked at the carcinogenicity of (S)-NNNspecifically, the researchers say. In future studies, Balbo said she and her colleagues hope to identify other carcinogens in smokeless tobacco, and to understand what levels of these chemicals are present in smokeless tobacco products.

In an era of rapidly proliferating, precisely targeted treatments, every cancer case has to be played by ear. Smokeless tabacco products are already required to carry warning labels saying the products can cause mouth cancer or are not a safe alternative to cigarettes, the Food and Drug Administration says.
The study will be presented this week at the American Association for Cancer Research (AACR) meeting in Chicago.
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The total dose was approximately equivalent to the amount of (S)-NNN to which a smokeless tobacco user would be exposed from chronic use of these products.

All 24 rats given (S)-NNN had esophageal tumors and oral tumors, and died within 17 months.

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