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The researchers found that genome amplifications for hepatitis B and C viruses, cytomegalovirus herpes simplex virus, and Epstein-Barr virus were negative.
New research funded by the World Health Organization (WHO) estimates that 20.1 million individuals were infected with hepatitis E virus (HEV) genotypes 1 and 2 across 9 world regions in 2005.
The first systematic analysis of hepatitis E virus (HEV) transmission by blood components indicates that about 1 in 3000 donors in England have HEV in their plasma. Infection by virus cytomegalovirus (CMV) is a common and major complication following kidney transplantation.


Twenty-eight days after kidney transplantation, acute humoral rejection was diagnosed and treated with a three-day course of methylprednisolone, plasma exchange, and intravenous immunoglobulins. Previous studies have related CMV infection with increased kidney transplant failure and reduced patient survival. Based on sequencing using open reading frame 1, HEV RNA genotype 3f was detected in the patient's blood 19 months after transplantation.
The patient tested positive for anti-HEV immunoglobulin (Ig)G and negative for anti-HEV IgM.


Analysis of a frozen plasma sample drawn five months after transplantation confirmed that the patient had been infected for more than one year.
A strain of HEV identical to that in the patient was identified in plasma used during a plasma exchange.



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