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Initial, positive results have been reported for a therapeutic vaccine candidate for treating patients with genital herpes. T cells, a type of white blood cells, generate immune responses to pathogens and are important in controlling infections. Wald and her team presented the initial findings of the first-in-human clinical trial of the novel GEN-003 T cell vaccine Sept. Genocea plans to move into Phase 2 of this trial in 2014 to further evaluate GEN 003’s safety and effectiveness in a larger group of patients. At unpredictable times in those carrying the infection, the herpes virus will come out of hiding and  surface on the genitals, sometimes producing blisters and discomfort, and sometimes arising without any noticeable symptoms.  This surfacing is called viral shedding. The results also demonstrated that immunization with GEN-003 is associated with activation of T cell immunity. The first-in-human clinical trial was not designed to test whether GEN-003 lessens symptoms or lowers how often a breakout occurs. Genocea developed the proprietary platform ATLAS, which can identify protective T cell antigens in people exposed to a pathogen.
The vaccine contains, among other components, a proprietary adjuvant, trademarked Matrix-M. According to a new study published in the Advance Online Publication of Nature, Yale researchers are presently busy developing a new vaccine that could potentially keep people from becoming infected with HSV (herpes simplex virus, i.e.
The main drive behind their endeavor is represented by the fact that, although cases of genital herpes translate into noteworthy health problems and even death on quite a regular basis, proper treatment and effective means of immunization are still lacking.
Thanks to funding provided by the US National Institutes of Health, this team of specialists was able to perform laboratory experiments on mice. The official website for the Yale University informs us that it was these experiments which lead them to the conclusion that activated T cells (i.e. Apparently, once they are set in place, these T cells provide protection against HSV and keep it from spreading as it normally would.
Up until now, T cells have not been harnessed in organs such as intestines, central nervous system, lung airways and the vagina, seeing how they all restricted their access. The researchers speculate that this vaccination model could also be efficient went it comes to providing some levels of protection against other sexually transmitted infections such as HIV-1.


Visually explore Herpes Simplex Virus 1 pictures, or more commonly known as Oral Herpes (cold sores) Pictures. In its latest April 2014 survey, polyDNA found that 54% of respondents wanted to know about the best herpes treatment methods on the market.
About Drugs: WebMD notes that, “Treatment with antiviral drugs can help people who are bothered by genital herpes outbreaks stay symptom-free longer. About topical remedies: Some topical antiviral remedies claim on their websites to reduce itching and inflammation associated with blisters and itchy skin eruptions. About oral remedies: As far as we know, there are only two remedies with more than one scientific clinical study that tested and confirmed their safety and effectiveness. All orders of these products are completely confidential, and no information is shared or sold to any third party. Reach out to the author: contact and available social following information is listed in the top-right of all news releases.
This first-in-class, investigational, protein subunit vaccine, GEN-003, is under development by Genocea Biosciences Inc. Anna Wald, University of Washington professor of medicine and laboratory medicine in the School of Medicine and professor of epidemiology in the School of Public Health, is among those leading clinical studies of GEN-003.
David Koelle’s lab in the Division of Allergy and Infectious Diseases, Department of Medicine.
T cell vaccine research is trying to find safe, effective ways to spur this protective reaction. 12 at a session of the Interscience Conference on Antimicrobials Agents and Chemotherapy in Denver.
The infection can provoke recurring episodes of painful genital sores.  An estimated 50 million to 60 million Americans are affected. In those receiving the vaccine candidate, T cell immune responses increased more than 20 times to one vaccine antigen and more than 10 times to another antigen.  The vaccine candidate also increased neutralizing antibodies to the herpes simplex 2 by five times greater than baseline amounts. However, an exploratory analysis suggested that the interval between the first immunization with GEN-003 and the next recurrence of genital herpes might be longer in those receiving the actual candidate vaccine, rather than the placebo injection. Wald is enrolling women infected with herpes simplex virus 2 in a study to see whether the drug tenofovir, given orally or as a vaginal gel, reduces genital shedding of the virus.


These websites also claim that these topical herpes remedies also relieve burning, stinging pain and swelling, and help heal cracking and bleeding. The difference between the two is that Novirin has higher quality, more expensive ingredients. Scientists scanned thousands of scientific and medical papers published in various medical and scientific journals around the world to identify the highest quality, safest, most effective natural ingredients that target latent viruses. Polansky published the highly acclaimed scientific discovery, called Microcompetition with Foreign DNA. Genocea, located near Boston, is a clinical-stage biopharmaceutical company for the discovery and development of T cell vaccines to prevent and treat infectious diseases.
Viral shedding is a marker both of the risk of recurrence and the transmission of infection.
The adjuvant has a product that, in previous clinical studies, has been shown to stimulate B and T cell immune responses. Reducing the frequency of viral shedding is the first step to showing that a drug can reduce outbreaks or, potentially, sexual transmission to partners. The discovery explains how foreign DNA fragments, and specifically, DNA of latent viruses, cause most major diseases.
Tenofovir has been shown in some studies to reduce the risk of acquiring HIV, and in some studies there was also a reduction in the frequency of HSV-2 acquisition, but this is the first time that it is being tested as a drug specifically for HSV-2. There are three major (oral) drugs commonly used to treat genital herpes symptoms: acyclovir (Zovirax), famciclovir (Famvir), and valacyclovir (Valtrex). Severe cases may be treated with the intravenous (IV) drug acyclovir.” (See WebMD, last reviewed on August 6, 2012) (1). For instance, a meta-analysis of five placebo-controlled and two dose comparison studies evaluated the effect of aciclovir, famciclovir or valaciclovir on symptoms.



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