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Please confirm or modify the email address to which you will have subscription offers sent. The views expressed in the contents above are those of our users and do not necessarily reflect the views of MailOnline. Early research suggests the heart failure drug spironolactone hinders infection from the Epstein-Barr virus, a pathogen linked to mono and different types of cancer.
Spironolactone is a “potassium-sparing diuretic” that prevents potassium levels from dropping too low and ensures the body doesn’t absorb excess levels of salt. University of Utah scientists discovered that spironolactone blocks infection during a screening for potential antivirals that use a treatment mechanism different from current medications, according to the school’s official announcement. Anti-herpes therapies work by blocking the middle phase of a viral infection, which consists of the disease replicating its DNA.
Spironolactone performs the same blocking function, but the big difference is that the medication can target the SM protein, anintegral part in the late stage of the infection cycle.
Plus, spironolactone’s viral features are separate from its ability to treat heart failure, according to the university. Currently, the researchers are testing the drug’s ability to prevent herpes infection in mice and in vitro. Imlygic, a cancer drug developed by biotech company Amgen, uses a genetically modified herpes virus that's programmed to kill tumor cells in patients with melanoma that recurs after surgery.
Melanoma is the most dangerous formA ofA skin cancer, characterized by unusual moles or pigment areas. Oncolytic virus development has been in the works for more than 20 years, and the concept of using viruses to fight diseaseA hasA been around for more than 100 years.


According to the FDA, 16.3% of participants in a clinical study saw a decrease in their lesions that lasted for at least 6 months. An estimatedA 74,000 people are diagnosed with melanoma in the United States per year, and it's responsibleA for 1.7% of all cancer deaths in the US. More research needs to be done to refine the molecule to work as a side-effect free antiviral. That's much less than other new cancer treatments, which typically cost more than $100,000, with some new treatments costing more than $250,000 in the first full year of treatment. Forbes reports that analysts expect the drug will bring in about $200 million in sales per year, so it won't be like aA typical blockbuster drug that makes billions. It's offered by Kentucky One Health, The James Graham Brown Cancer Center and University of Louisville researcher Dr. Amgen said in a news release that it expects the drug to become available starting next week.
That means it won't infect the person with herpes, but instead attack the cancerous cells directly, and may stimulate an immune system response to tumors especially in combination with other chemotherapy drugs. It also hasn't been shown to be effective against melanoma that's spread to other organs in the body. It will be used to treat lesions, or the areas of skin that still have moles and other marks related to melanoma, if they pop up again after being surgically removed. IT's got some side effects, too: The FDA disclosed that the most common ones wereA fatigue, fever, nausea, flu-like symptoms and pain a€” and maybe herpes, since the drug is a modified herpes virus. IT STARTED IN FEBRUARY, TRINITY HIGH SCHOOL TEACHER STEVEN TOMPKINS SAYS HE FOUND A LUMP IN HIS GROIN AREA THAT STARTED OUT AS AN ITCH.


STEPHEN THOMPKINS: I THOUGHT IT WAS A HERNIA SO I WENT TO MY GENERAL DOCTOR, IN EXAMINING ME HE SAID THAT'S NOT A HERNIA , THAT'S A LIPOMA. JENNIFER: TOMPKINS SAYS HIS GENERAL SURGEON FOUND ANOTHER LUMP THAT TURNED OUT TO BE CANCER. JENNIFER: TOMPKINS AND HIS WIFE DECIDED THE BEST TREATMENT WAS A CLINICAL TRIAL CALLED TVEC USING A FORM OF THE HERPES VIRUS THAT CAUSES A COLD SORE. IT'S OFFERED AT THE JAMES GRAHAM BROWN CANCER CENTER BY UNIVERSITY OF LOUISVILLE RESEARCHER DOCTOR JASON CHESNEY. JENNIFER: THE TRIAL HAS LEAD TO SEVERAL DISCOVERIES INCLUDING AN IMPROVED IMMUNE SYSTEM IN PATIENTS.
CHESNEY: IMMUNE THERAPIES WILL ACTIVATE YOUR BODY'S OWN IMMUNE SYSTEM TO GO AFTER THE CANCER AND YOUR IMMUNE SYSTEM STAYS THERE AND IT CONTINUES TO FIGHT THE CANCER FOR YEARS TO COME. JENNIFER: THE SIDE EFFECTS ARE MINIMAL, SOME EXPERIENCE A FEVER AND CHILLS WHILE OTHERS REPORT NOTHING OTHER THAN SORENESS AT THE INJECTION SITE. TO GET THE RESULTS THIS MORNING TO SAY HEY THERE'S NOTHING, YOUR SCANS ARE GREAT, IT'S STILL IN ONE SPOT YOU KNOW THAT'S VERY EXCITING. I SUSPECT IN FIVE YEARS WE'RE GOING TO SEE AT LEAST A 33% REDUCTION IN DEATH RATES, I THINK IN 20 YEARS WE'RE GOING TO SEE PROBABLY AN 80% REDUCTION.



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