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Enter the email associated with your account and we will send you an email with a link to reset it. It was nearly 3 years ago when Michael Douglas announced that he had been diagnosed with Stage 4 throat cancer. Without wanting to get too specific, this particular cancer is caused by HPV [human papilloma virus], which actually comes about from cunnilingus. Low-risk HPVs, which do not cause cancer but can cause skin warts (condylomata acuminata) on or around the genitals or anus. HPVs establish productive infections only in keratinocytes of the skin or mucous membranes, including the skin, the throat, the genital tract, and the anus. Researchers believe that it can take between 10 and 30 years from the time of an initial HPV infection until a tumor forms. Virtually all cervical cancers are caused by HPV infections, with just two HPV types, 16 and 18, responsible for about 70% of all cases. Most recently, HPV infections have been found to cause cancer of the oropharynx, which is the middle part of the throat including the soft palate, the base of the tongue, and the tonsils.
The incidence of HPV-associated oropharyngeal cancer has increased during the past 20 years, especially among men.
Other factors may increase the risk of developing cancer following a high-risk HPV infection.
The most reliable way to prevent infection with either a high-risk or a low-risk HPV is to avoid any skin-to-skin oral, anal or genital contact with another person.
Research has shown that correct and consistent use of condoms can reduce the transmission of HPVs between sexual partners.


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Physicians and other healthcare professionals may also receive Continuing Medical Education (CME) and Continuing Education (CE) credits at no cost for participating in MedPage Today-hosted educational activities. Since 1990, helping busy clinicians master the science and art of caring for people with HIV disease. Most of these series of images were created with molecular graphics software Qutemol, VMD or Chimera. Most of these images are 1200 x 784 pixels and saved qith Quality 12 (Maximum) from Photoshop.
Permission is granted for the non-profit educational use of the PS10 images in classrooms and seminars. More than 40 of these viruses can be easily spread through direct skin-to-skin contact during vaginal, anal and oral sex. In fact, more than half of sexually active people are infected with one or more HPV types at some point in their lives.
However, most high-risk HPV infections occur without any symptoms, go away within 1 to 2 years, and do not cause cancer.
Persistent infections with high-risk HPV types can lead to more serious cytologic abnormalities or lesions that, if untreated, may progress to cancer. Two of the proteins made by high-risk HPVs, E6 and E7 oncoproteins, interfere with normal functions in the cell, enabling the cell to grow in an uncontrolled manner and to avoid cell death. Sometimes, however, these infected cells are not destroyed, and a persistent infection results.


It has been estimated that, by 2020, HPV will cause more oropharyngeal cancers than cervical cancers in the United States. For those who are sexually active, a long-term, mutually monogamous relationship with an uninfected partner is the strategy most likely to prevent HPV infection. Areas not covered by a condom can be infected with the virus, though, so condoms are unlikely to provide complete protection against virus spread.
Recent research indicates that, at any point in time, 42.5% of women have genital HPV infections, whereas less than 7% of adults have oral HPV infections. As the persistently infected cells continue to grow, they may develop mutations that promote even more cell growth, leading to the formation of a high-grade lesion and, ultimately, a tumor. The percentage of high-grade cervical lesions that progress to invasive cervical cancer has been estimated to be 50% or less.
HPV types 16 and 18 have also been found to cause close to half of vaginal, vulvar, and penile cancers. However, because of the lack of symptoms it is hard to know whether a partner who has been sexually active in the past is currently infected with HPV. The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider.



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