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The first vaccine against human papillomavirus, or HPV, which causes cervical cancer, came out five years ago.
But as much as he believes in the vaccine, Bocchini doesn't think the government should require kids to get it yet. HotCopper is the largest stock market forum in Australia with over 250,000 registered members and more than 8,000 posts per day.
2016 is looking to be an important year for Admedus as our immunotherapy programs continue to progress well.
Admedus is currently using DNA vaccine technology to develop therapeutic vaccines targeting human papilloma virus (HPV) and herpes simplex virus 2 (HSV-2), although the technology developed by Admedus in conjunction with Professor Ian Frazer can potentially be applied to a range of viruses, bacterial infections and cancers. According to the Centers for Disease Control and Prevention, HPV is the most common sexually transmitted infection (STI).
HPV is associated with a number of cancers including cervical cancer and cancer of the vulva, vagina, penis, and rectal cancer.
HPV can remain asymptomatic and sometimes there is no way to know which people who have HPV will develop cancer or other health problems. Using the principles of DNA vaccine technology, we optimise the HPV gene that makes the antigen and transfer it into agency approved DNA plasmids in order to manufacture large amounts of clean, safe and high quality DNA vaccine.
Once the vaccine enters into the cells, the cells themselves begin to make a small amount of the foreign antigen which in turn alerts the body’s immune cells to its presence.
It’s important to note that not everyone who becomes infected with HPV will have it progress to cancer. In the US about 79 million people are currently infected with HPV and each year another 14 million people are infected. To date we have completed a number of successful pre-clinical studies with very exciting responses. Admedus is on track to initiate the first clinical study with the HPV vaccine after the successfully completed pre-clinical studies. Therapeutic vaccines, like those being developed by Admedus, typically have shorter clinical studies with fewer participants. If you are interested in learning more about our work in HPV, please contact us via the website. GARDASIL is a human papillomavirus (HPV) vaccine that helps protect against 4 types of HPV. GARDASIL may not fully protect everyone, nor will it protect against diseases caused by other HPV types or against diseases not caused by HPV.
Anyone who is allergic to the ingredients of GARDASIL, including those severely allergic to yeast, should not receive the vaccine.


The side effects include pain, swelling, itching, bruising, and redness at the injection site, headache, fever, nausea, dizziness, vomiting, and fainting.
Please read the Patient Information for GARDASILA® [Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) Vaccine, Recombinant] and discuss it with your childa€™s doctor.
This site is intended only for residents of the United States, its territories, and Puerto Rico.
But now it has become a hot political topic, thanks to a Republican presidential debate in which candidate Michele Bachmann inveighed against "innocent little 12-year-old girls" being "forced to have a government injection." Behind the political fireworks is a quieter backlash against a public health strategy that has won powerful advocates in the medical and public health community. It seemed very odd to be mandating something for which 95 percent of infections never amount to anything.
All comments must follow the NPR.org Community rules and terms of use, and will be moderated prior to posting. Working with Professor Ian Frazer and his team, we are developing therapeutic vaccines to target human papilloma virus (HPV) and herpes simplex virus 2 (HSV-2). This is done by delivering engineered DNA into the body so that a person’s own cells directly express an antigen. HPV is so common that nearly all sexually active men and women get it at some point in their lives. It can also cause cancer in the back of the throat, including the base of the tongue and tonsils (called oropharyngeal cancer), which is also associated with some head and neck cancers. The types of HPV that can cause genital warts are not the same as the types of HPV that can cause cancers. This purified DNA vaccine is injected as a solution just under the skin surface (an area which has a high population of migrating immune cells). The Admedus technology adds ubiquitin to the antigen and this helps to flag to the immune system that there is a foreign antigen present.
Even though our technology and Gardasil are both created by Professor Ian Frazer, they are very different vaccines.
Whilst Gardasil is a very effective vaccine, the current uptake is quite low, around 40%, and therefore the level of protection from HPV in the community is suboptimal. In a model that replicates the HPV related cancer disease state, treatment with the Admedus HPV vaccine achieved 100% survival after 50 days, and over 85% had no detectable tumours after 50 days.
As part of this study we will look at safety of the vaccine as well as and efficacy data in the study participants. This is due to the fact we are looking at a more immediate response in the study participants.
In girls and young women ages 9 to 26, GARDASIL helps protect against 2 types of HPV that cause 70% of cervical cancer cases, 70% of vaginal cancer cases, and up to 50% of vulvar cancer cases.


GARDASIL does not prevent all types of cervical cancer, so ita€™s important for women to continue routine cervical cancer screenings.
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These vaccines address significant diseases with a huge unmet medical need and if successful, will positively impact patient lives. The immune system will then target this antigen, thus resulting in a protective immunological response and activated immunity.
The activated immune system is now on the lookout for anything resembling the foreign antigen, targeting the antigen and anything attached to it and clears it from the body.
However, for those people where the HPV infection progresses to the early stages of cancer, Admedus is looking to replicate the process by using its DNA vaccines to produce safe (non-cancer causing) versions of the cancer related proteins in greater numbers and this will train the body into thinking there is a higher level of infected cells, effectively amplifying the immune system and assisting them to mount a better defence. Gardasil creates a prophylactic (antibody) response to protect you from HPV infection in the future.
We feel there is an opportunity to work on a therapeutic vaccine to treat people infected with HPV and with HPV related cancers. Prophylactic vaccines, on the other hand, can take longer as they need to look at differences in large populations of people over a longer period of time. In males and females ages 9 to 26, GARDASIL helps protect against about 80% of anal cancer cases and 90% of genital warts cases. With this in mind, we wanted to shed some light on how our therapeutic vaccine works to target HPV related tumours and explain the science behind DNA vaccines. Admedus, on the other hand, is working on a DNA vaccine designed to target and clear HPV-positive tumour cells in people already infected, although the preclinical data indicates it may also work in boosting the immune system in uninfected people. For this reason, your childa€™s health care professional may ask your child to sit or lie down for 15 minutes after he or she gets GARDASIL. We want to educate the public about the infection and its consequences." So for now, the CDC's lead adviser thinks the decision should be left to parents.
For more information on our work to date in targeting HSV-2, please read our previous blog ‘World Health Organisation: You probably have herpes’. That's why Julie Stewart was shocked when the pediatrician said her 11-year-old Sophie should get it.




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