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Current Concepts for Genital Herpes Simplex Virus Infection: Diagnostics and Pathogenesis of Genital Tract Shedding.
SUMMARYHerpes simplex virus 2 (HSV-2) is a DNA virus that is efficiently transmitted through intimate genital tract contact and causes persistent infection that cannot be eliminated. Efficient Gene Suppression in Dorsal Root Ganglia and Spinal Cord Using Adeno-Associated Virus Vectors Encoding Short-Hairpin RNA. RNA interference is a powerful tool used to induce loss-of-function phenotypes through post-transcriptional gene silencing.
Identification of molecular determinants for the nuclear import of pseudorabies virus UL31. Li M1, Jiang S1, Mo C2, Zeng Z2, Li X2, Chen C2, Yang Y2, Wang J2, Huang J3, Chen D1, Peng T4, Cai M5. Herpes simplex virus 1 (HSV-1) UL31 is a multifunctional protein and important for HSV-1 infection.


Genital herpes is a disease caused by the herpes simplex virus (HSV), of which there are two types.
HSV-2 cannot survive long on a non-living surface, so there is no real risk of getting it from a toilet seat or hot tub, for example. Afecta a los ganglios sensoriales y a sus areas de inervacion y se caracteriza por dolor neuralgico intenso a lo largo del area de distribucion del nervio afectado y brotes de vesiculas arracimadas por todo el area. HSV-2 may cause frequent, symptomatic self-limited genital ulcers, but in most persons infection is subclinical. When it's active, it travels to the surface of the infected area (skin or mucous membrane) and makes copies of itself.
One reason may be that the virus can infect a woman's genitals more easily than it can a man's.
HSV-1 can also spread from the mouth to the genitals during oral sex (fellatio, cunnilingus, analingus).


But just as HSV-1 can infect the genitals and cause genital herpes, HSV-2 can pass from one person's genitals to another person's mouth, resulting in oral herpes. This is called "shedding" because these new viruses can, at this time, rub off on another person. Genital herpes is more common among blacks than it is among whites, and it becomes more common as people age. In the past, HSV-1 was not known to cause genital herpes, but that is changing, especially among people who begin having sex at a young age. Then the virus travels back down the nerve to a ganglion (mass of nerve tissue), usually at the base of the spine, where it lies dormant for a while.



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