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admin 20.01.2016

At this year’s San Antonio Breast Cancer Symposium (SABCS), the humble pharmaceutical, Metformin, finally came into its own. Alternative practitioners (naturopaths, traditional Chinese medicine doctors, integrative oncologists, integrative nutritionists, etc.) postulated that this holistic approach reduces relapse risk because of reductions in blood glucose, insulin levels and another very important promoter of cancer, insulin growth factor-1 (IGF1).
Now many converging lines of research have demonstrated that reducing IGF-1 (and therefore insulin levels) with a cheap, non-toxic pharmaceutical called Metformin substantially reduces breast cancer growth, reduces relapse rates, and improves overall survival especially for those with triple-negative breast cancer (notorious for being particularly difficult to treat). It is an oral drug initially approved for treating diabetes in the UK in 1958; Canada and the US followed several years later. As an aside, Metformin had even more powerful anti-cancer effects in other cancers, particularly pancreatic and hepatocellular cancers.
So it’s clear that Meformin provides a hostile environment for TNBC initiation and progression in diabetics.

There have been so many recent media reports of single-agent nutriceutical trials or holistic approaches failing to prevent cancer or its relapse. This site complies with the HONcode standard for trustworthy health information: verify here. If you are seeing this, you have attempted to link to the UpToDate widget but are experiencing a problem. In recent years many, but not all, clinical studies have shown that such interventions, particularly the diet and exercise, can dramatically reduce breast cancer relapse rates, especially those of triple-negative breast cancer (TNBC).
Those with kidney problems or congestive heart failure need to be especially careful when taking Metformin as there is a risk of acid build-up in the blood (lactic acidosis). In order to post comments, please make sure JavaScript and Cookies are enabled, and reload the page.

Dodd talks about the advancements in cancer treatment and what he loves most about being an oncologist.
He is an active researcher and has been published in numerous well-respected journals such as Cancer, Journal of Clinical Oncology and Journal of Urology.
If you like free and unbiased breast cancer information, please donate to keep this blog going! He has also written reviews and chapters for Urologic Clinics of North America and the American Cancer Society Textbook of Clinical Oncology.

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