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admin 16.07.2014

Get actionable intelligence on medical innovation at MedCity CONVERGE July 12-13 in Philly. After decades of stagnancy in the herpes therapeutics space, a real neck-and-neck race is emerging among three biotechs in the immunotherapy space: Genocea and Agenus, both based in Massachusetts, San Diego’s Vical are speeding ahead in developing a herpes vaccine.
On top of that, Australian biotech Admedus just announced positive early clinical results for its own genital herpes vaccine. Now, standard vaccines usually corral the immune system’s B cells, siccing them on invaders and successfully drawing out antibody responses. Genocea may have a few toes ahead in the race, but the triumvirate’s all in the Phase II vicinity and eliciting positive results. Stay tuned for a closer look at what’s going on with the herpes vaccine, with insights from stakeholders and CEOs.
HIV may be the most dreaded for STD in US but genital herpes is the most common and more prevalent. This research made another startling discovery– these T-cells (CD8??+) are programmed to remain in the skin surrounding the genitals at all times, so they are the resident memory T-cells. Even though this vaccine may not cure those of HSV-2, it could ultimately help stop the spread of it. Our FDA-Approved HIV RNA test can be taken after 6 days of exposure and conclusively detect an HIV infection as early as 9-11 days after exposure. Initial, positive results have been reported for a therapeutic vaccine candidate for treating patients with genital herpes. T cells, a type of white blood cells, generate immune responses to pathogens and are important in controlling infections.
Wald and her team presented the initial findings of the first-in-human clinical trial of the novel GEN-003 T cell vaccine Sept. Genocea plans to move into Phase 2 of this trial in 2014 to further evaluate GEN 003’s safety and effectiveness in a larger group of patients. At unpredictable times in those carrying the infection, the herpes virus will come out of hiding and  surface on the genitals, sometimes producing blisters and discomfort, and sometimes arising without any noticeable symptoms.  This surfacing is called viral shedding. The results also demonstrated that immunization with GEN-003 is associated with activation of T cell immunity.
The first-in-human clinical trial was not designed to test whether GEN-003 lessens symptoms or lowers how often a breakout occurs. Genocea developed the proprietary platform ATLAS, which can identify protective T cell antigens in people exposed to a pathogen.


The vaccine contains, among other components, a proprietary adjuvant, trademarked Matrix-M. And Oregon’s Tomegavax is using Gates-funded research to forge its own path in developing its own vaccine.
Big pharma dabbled in developing a genital herpes vaccine, but GlaxoSmithKline was particularly noteworthy for its epic flop – compared to controls, it actually caused even worse outbreaks in the women studied in a huge Phase III study. A subtype of immune cells, as researchers say, seem to have power to suppress this painful outbreaks. They promise more breakthroughs in near future though we don’t have much information about them at present. At the point of reactivation of this virus these cells are the first to act to contain this virus. These cells that are located in the DEJ are responsible for controlling HSV-2, so this implies that herpes reactivation is controlled in the skin, not the ganglions in spine. Corey says, “The real implication here is that the way herpes seems to act is that the virus is actually reactivating very frequently. If we can find a way to increase the number or function of these T-cells that would be one route we would want to take first. This first-in-class, investigational, protein subunit vaccine, GEN-003, is under development by Genocea Biosciences Inc. Anna Wald, University of Washington professor of medicine and laboratory medicine in the School of Medicine and professor of epidemiology in the School of Public Health, is among those leading clinical studies of GEN-003. David Koelle’s lab in the Division of Allergy and Infectious Diseases, Department of Medicine. T cell vaccine research is trying to find safe, effective ways to spur this protective reaction. 12 at a session of the Interscience Conference on Antimicrobials Agents and Chemotherapy in Denver.
The infection can provoke recurring episodes of painful genital sores.  An estimated 50 million to 60 million Americans are affected. In those receiving the vaccine candidate, T cell immune responses increased more than 20 times to one vaccine antigen and more than 10 times to another antigen.  The vaccine candidate also increased neutralizing antibodies to the herpes simplex 2 by five times greater than baseline amounts. However, an exploratory analysis suggested that the interval between the first immunization with GEN-003 and the next recurrence of genital herpes might be longer in those receiving the actual candidate vaccine, rather than the placebo injection. Wald is enrolling women infected with herpes simplex virus 2 in a study to see whether the drug tenofovir, given orally or as a vaginal gel, reduces genital shedding of the virus.


What the newer methods of vaccination are doing is mobilizing the T cell response to reduce the viral load.
Registration or use of this site constitutes acceptance of our Terms of Service and Privacy Policy. It’s main frustration comes from frequent eruptions around genitals, mouth, or rectum. Genocea, located near Boston, is a clinical-stage biopharmaceutical company for the discovery and development of T cell vaccines to prevent and treat infectious diseases. Viral shedding is a marker both of the risk of recurrence and the transmission of infection. The adjuvant has a product that, in previous clinical studies, has been shown to stimulate B and T cell immune responses. Reducing the frequency of viral shedding is the first step to showing that a drug can reduce outbreaks or, potentially, sexual transmission to partners. You can manage it for some time, shorten the outbreaks, and minimize the painful condition for each outbreak, but there’s no permanent relief from this as there are no cures to genital herpes so far.
An outbreak can confirm a reduced number of CD8??+ T-cells at that point of time, so the eruption could not be contained. This vaccine can help people to almost go without outbreaks, even when the stage of genital herpes is most contagious.
Tenofovir has been shown in some studies to reduce the risk of acquiring HIV, and in some studies there was also a reduction in the frequency of HSV-2 acquisition, but this is the first time that it is being tested as a drug specifically for HSV-2. Under the HoodBehavior, Neuroscience & Your Brain What Brain Hacks Can Psychologists Teach Us?
Larry Corey who is an internationally renowned virologist and president and director of the Fred Hutchinson Cancer Research Center in Seattle, claims that this can be a possible breakthrough we are looking for.
This refocuses our attention form the “ganglion level of the spinal canal area” to the new T-cells. These CD8??+ T-cells are located in the DEJ – the layer of tissue just below the skin’s surface.



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