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Professor Ian Frazer says the herpes vaccine could be available to the public within six years. This service may include material from Agence France-Presse (AFP), APTN, Reuters, AAP, CNN and the BBC World Service which is copyright and cannot be reproduced. Initial, positive results have been reported for a therapeutic vaccine candidate for treating patients with genital herpes.
T cells, a type of white blood cells, generate immune responses to pathogens and are important in controlling infections. Wald and her team presented the initial findings of the first-in-human clinical trial of the novel GEN-003 T cell vaccine Sept.
Genocea plans to move into Phase 2 of this trial in 2014 to further evaluate GEN 003’s safety and effectiveness in a larger group of patients.
At unpredictable times in those carrying the infection, the herpes virus will come out of hiding and  surface on the genitals, sometimes producing blisters and discomfort, and sometimes arising without any noticeable symptoms.  This surfacing is called viral shedding. The results also demonstrated that immunization with GEN-003 is associated with activation of T cell immunity. The first-in-human clinical trial was not designed to test whether GEN-003 lessens symptoms or lowers how often a breakout occurs. Genocea developed the proprietary platform ATLAS, which can identify protective T cell antigens in people exposed to a pathogen. The vaccine contains, among other components, a proprietary adjuvant, trademarked Matrix-M. New York NYC Crime Bronx Brooklyn Manhattan Queens Education Obituaries Sports Yankees Mets Giants Jets Knicks Nets Rangers Islanders Football Basketball Baseball Hockey Soccer College High School The Score News Crime U.S. Follow Us Facebook Twitter Instagram Pinterest YouTube Subscribe Follow UsNewsletter App Subscriptions Subscribe Get Our Newsletter A daily blend of the most need-to-know Daily News stories, delivered right to your inbox. A clinical trial in Denmark to fight HIV is the latest attempt to find an elusive cure for the virus. Danish scientists claim theya€™re on the brink of a a€?promisinga€? breakthrough to cure HIV. Researchers at the Aarhus University Hospital in Denmark said they're now conducting clinical trials on humans using a a€?novel strategya€? that has worked in lab tests, Londona€™s The Telegraph reported. The Danish trial uses a treatment that forces the HIV virus from so-called reservoirs it forms in DNA cells, bringing the virus to the surface, according to The Telegraph. Once the virus is exposed, the bodya€™s natural immune system can destroy it with the help of a vaccine.
While the procedure appeared to work using human cells in a lab, whether it will prove successful in a human body remains to be seen, said Dr.
Fifteen people have been signed up for the trial, which was awarded a new round of funding from the Danish Research Council worth about $2.1 million.
Similar research is being conducted in Britain through a collaboration of five universities focusing on people who only recently were diagnosed with HIV.
Sogaard said that the research in Denmark would be a cure for those already infected, but wouldna€™t prevent HIV or AIDS. Finding a cure a€” one that is also widely accessible and affordable to the public a€” took a hit in the United States when experimental shots failed to reduce the amount of the AIDS virus in the blood, the National Institutes of Health said. Ita€™s a strategy known as a€?prime-boost.a€? A DNA-based vaccine made with genetically engineered HIV material is given to prime the immune system to attack the AIDS virus. The idea: Train immune cells known as T cells to spot and attack the very earliest HIV-infected cells in someonea€™s body.
A safety review last week found that slightly more study participants who had received the vaccine later became infected with HIV. When researchers examined only participants diagnosed after being in the study for at least 28 weeks a€” long enough for the shots to have done their job a€” there were 27 HIV infections among the vaccinated and 21 among the placebo recipients.
The NIH said Thursday that it is stopping vaccinations in the study, known as HVTN 505, but that researchers will continue to study the volunteersa€™ health. Both approaches need continued research funding, said Mitchell Warren of the international AIDS Vaccine Advocacy Coalition.
The ImmunoWash™ 1575 microplate washer is essential for performing accurate and reproducible immunoassays in a microplate format, such as ELISA. This site complies with the HONcode standard for trustworthy health information: verify here.
The MRF Scientific Advisory Panel The work of the Scientific Advisory Panel is integral to MRF’s success.
Professor Ray Borrow PhD MRCPath (Chair) Head of Vaccine Evaluation Department, Health Protection Agency, Manchester Prof Ray Borrow is Head of the Vaccine Evaluation Unit at the Health Protection Agency (HPA) North West, Manchester, UK, where he is responsible for the evaluation of serological responses to various bacterial and viral vaccines with a special interest in meningococcal and pneumococcal vaccines. Professor Ian Feavers BSc PhD (Vice-chair)Head of the Division of Bacteriology, NIBSC Ian Feavers  is Head of the Division of Bacteriology at the NIBSC, UK. Professor Adam Finn MA PhD FRCP FRCPCH Professor of Paediatrics, Head, Unit of Child Health Dept Clinical Sciences at South Bristol, University of Bristol Adam Finn is Head of the Academic Unit of Child Health at Bristol Medical School, School of Clinical Sciences and an honorary consultant in paediatric infectious diseases and immunology at Bristol Royal Hospital for Children.
Professor Nigel Klein BSc MB.BS PhD MRCP FRCPCH Head of Department of Infection Institute of Child Health, University College London Professor Nigel Klein is Professor and Consultant in Paediatric Infectious Diseases and Immunology at Great Ormond Street Children’s Hospital, London, and the Institute of Child Health, University College London. Dr Shamez Ladhani PhD MRCPCH(UK) MSc(distinction) MBBS(hons) BSc(hons) Paediatric Infectious Diseases Consultant, St.


Professor James Stuart MA, MB, FFPH Honorary professor at the London School of Hygiene and Tropical Medicine and at the University of Bristol.
Dr Caroline Trotter BA MSc PhD Senior Lecturer in EpidemiologyDepartment of Veterinary Medicine, University of Cambridge. This first-in-class, investigational, protein subunit vaccine, GEN-003, is under development by Genocea Biosciences Inc. Anna Wald, University of Washington professor of medicine and laboratory medicine in the School of Medicine and professor of epidemiology in the School of Public Health, is among those leading clinical studies of GEN-003.
David Koelle’s lab in the Division of Allergy and Infectious Diseases, Department of Medicine. T cell vaccine research is trying to find safe, effective ways to spur this protective reaction. 12 at a session of the Interscience Conference on Antimicrobials Agents and Chemotherapy in Denver. The infection can provoke recurring episodes of painful genital sores.  An estimated 50 million to 60 million Americans are affected.
In those receiving the vaccine candidate, T cell immune responses increased more than 20 times to one vaccine antigen and more than 10 times to another antigen.  The vaccine candidate also increased neutralizing antibodies to the herpes simplex 2 by five times greater than baseline amounts. However, an exploratory analysis suggested that the interval between the first immunization with GEN-003 and the next recurrence of genital herpes might be longer in those receiving the actual candidate vaccine, rather than the placebo injection. Wald is enrolling women infected with herpes simplex virus 2 in a study to see whether the drug tenofovir, given orally or as a vaginal gel, reduces genital shedding of the virus. This depends on the strength and sensitivity of individual immune systems,a€? Sogaard told The Telegraph. Half received dummy shots, and half received a two-part experimental vaccine developed by the NIH. Then a different vaccine, encasing the same material inside a shell made of a disabled cold virus, acts as a booster shot to strengthen that response. The hope was that the vaccine could either prevent HIV infection, or help those infected anyway to fight it. A 2009 study in Thailand is the only one ever to show a modest success, using a somewhat different prime-boost approach. CLICK HERE FOR VIDEO Send a Letter to the Editor Join the Conversation: facebook Tweet Get Daily News stories, delivered to your inbox.
It ensures that the Charity only funds research of high scientific merit, which is relevant to our research strategy, original and likely to succeed.
He studied for his PhD at the University of Newcastle upon Tyne, eventually moving to NIBSC after periods of postdoctoral research at the University of Sheffield and the Friedrich Miescher Institut in Basel. PhDResearch Scientist, Sir William Dunn School of Pathology at the University of Oxford Rachel Exley is a research scientist based at the Sir William Dunn School of Pathology at the University of Oxford. He is director of the South West Medicines for Children Research Network and heads the Bristol Children's Vaccine Centre. She directs a comprehensive childhood infection research program both in the UK and sub-saharan Africa and holds an MRC Program Grant. George’s Hospital, Consultant Epidemiologist, Public Health England Shamez Ladhani is a paediatric infectious diseases consultant at St. Professor of Tropical Medicine, Liverpool School of Tropical Medicine David Lalloo underwent initial training in Newcastle upon Tyne, then trained in General (Internal) Medicine, Infectious Diseases and Tropical Medicine, spending three years in Papua New Guinea. He trained in medicine in South Africa and in paediatrics in the UK before specialising in infectious diseases. Genocea, located near Boston, is a clinical-stage biopharmaceutical company for the discovery and development of T cell vaccines to prevent and treat infectious diseases.
Viral shedding is a marker both of the risk of recurrence and the transmission of infection. The adjuvant has a product that, in previous clinical studies, has been shown to stimulate B and T cell immune responses. Reducing the frequency of viral shedding is the first step to showing that a drug can reduce outbreaks or, potentially, sexual transmission to partners. Newer research suggests another approach a€” to try creating powerful antibodies that could work a step earlier than the T-cell attack, before HIV gets inside the first cell. During the late 1990s, when new conjugate vaccines were being introduced, he headed the laboratory responsible for the control and standardisation of meningococcal and pneumococcal vaccines. After obtaining a degree in Biochemistry from the University of Leeds, she completed a PhD in microbial genetics from the Universite Paris XI, France on bacterial physiology. He trained in Infectious Diseases at the Children's Hospital of Philadelphia and in Immunology at the Institute of Child Health in London where he obtained his PhD.He worked in Sheffield between 1992 and 2001 where he was involved in several trials of meningococcal group C and other vaccines.
In 2009 she was awarded an NIHR Senior Research Training Fellowship (the only awardee in that category in 2009) and has subsequently set up a research study and network for childhood tuberculosis involving 9 NHS Trusts in the UK. He undertook clinical and laboratory research in Oxford before moving as Senior Lecturer to the Liverpool School of Tropical Medicine in 1999. Tenofovir has been shown in some studies to reduce the risk of acquiring HIV, and in some studies there was also a reduction in the frequency of HSV-2 acquisition, but this is the first time that it is being tested as a drug specifically for HSV-2. Overall, there were 41 HIV infections in the vaccinated group and 30 among placebo recipients.


They bring great insight and dedication to the funding process. We are enormously grateful for their commitment, which can only serve to further research into meningitis and septicaemia. He serves as a member of the DoH Joint Committee on Vaccination and Immunisation (JCVI) and frequently advises WHO and companies on both meningococcal and pneumococcal vaccines. Ian continues to oversee an active research programme on the molecular genetics and immunology of meningococcal and pneumococcal antigens. She then moved to Imperial College London to work on an MRF funded project to understand the genetic basis of meningococcal carriage, and the development of novel vaccines. His current main research interest is the mucosal immune response to respiratory bacteria including pneumococcus and meningococcus. His training in paediatrics and infectious diseases was at the Royal Children’s Hospital, Melbourne, the John Radcliffe Hospital, Oxford and St George’s Hospital, London.
Recently, she has initiated a novel research program for maternal immunization at Imperial Healthcare NHS Trust, funded by Imperial BRC.Professor Kampmann has extensive practical and research experience in childhood infection for over 15 years and brings an established funding track record as PI and co-applicant from major international funders for the conduct of laboratory-based and programmatic research in TB and Vaccinology in both resource-poor and resource rich settings. Since then he has focused on clinical trials in the tropics, particularly in HIV related infections, malaria and envenoming.
He is the co-ordinator of a European Commission FP7 award studying the genetic basis of meningococcal and other life threatening bacterial infections of childhood, working with a consortium of colleagues from Europe, Africa and Singapore.
He has been involved in the investigation and control of outbreaks of meningococcal disease in the UK and international level, and has published extensively on the epidemiology of meningococcal disease and carriage. She is an infectious disease epidemiologist, with an MSc and PhD from the London School of Hygiene and Tropical Medicine and has had previous posts at the University of Bristol. Because of his broad experience of bacterial vaccines and molecular biology, he has been closely involved with a number of meningococcal vaccine developments. His particular research interests are in the epidemiology of vaccine preventable diseases, in clinical vaccine trials, particularly in at-risk groups, and in perinatal infections. At the MRC Unit in The Gambia, she oversees all research activity in infant immunology, tuberculosis and molecular diagnostics, which ranges from basic research into innate and acquired immune responses to infection and vaccination in healthy and sick infants to clinical trials of novel vaccines and adjuvants.
He is the clinical lead for a number of national vaccine preventable infections, including Haemophilus influenzae type b (Hib), Streptococcus pneumoniae and Neisseria meningitidis, which are all major causes of childhood bacterial meningitis. He currently has collaborations and studies in a number of countries including Uganda, Malawi, Sri Lanka and Vietnam. In recent years he has been involved in a major research project into meningococcal carriage during the introduction of MenAfriVac, a conjugate serogroup A vaccine rolled out across the meningitis belt of Africa. Her research focuses on assessing the population impact of vaccination against meningococcal and pneumococcal disease, using a range of research methods including mathematical modelling, costeffectiveness studies, analyses of large databases and seroprevalence studies. He regularly contributes to WHO and EU guidelines, serves as one of NIBSC’s representatives on the Vaccine Working Party of the EMA, and is a member of the JCVI subgroup on meningococcal vaccines.
She has spent more than ten years working to understand the biology of meningococcal and gonococcal infection.
He coordinates a national neonatal infection surveillance network (neonIN) and recently, a national study on neonatal meningitis.
She is passionate about the supervision and mentorship of her large group of PhD students in both UK and Africa with funding received from the Wellcome Trust, MRC, NIH, EDCTP, Thrasher Foundation and other sources. He holds an appointment as Honorary Consultant at the Royal Liverpool University Hospital and is Director of the Liverpool Wellcome Trust Tropical Centre. He has assisted the WHO to revise outbreak response guidelines in the African meningitis belt.
Ian teaches on a number of vaccine related courses in the University of London and is a Visiting Professor at Imperial College.
Rachle's major research interests are the development and evaluation of novel vaccine antigens, understanding complement resistance of meningococci, and structure:function studies of Type four pili which enable the bacterium to adhere to human cells.
He sits on national committees concerned with meningitis, Group B streptococcus prevention, Pneumococcal and Hib infections, neonatal infections and on immunisation policies in children. She remains clinically active as part of the paediatric infectious disease team at Imperial Healthcare NHS Trust and divides her time between Imperial College and West Africa, having set up an “Open Lab” approach where science and personnel are closely aligned between both locations. Additionally, Rachel helps to organise and teach the Microbiology Course for medical students at the University of Oxford and is a tutor for students at Somerville College.
He is a Fellow of the Royal Australasian College of Physicians, a Fellow of the Royal College of Paediatrics and Child Health, a member of the research committee of the European Society of Paediatric Infectious Diseases and a member of the steering committee of the international Brighton Collaboration on vaccine safety. Upon returning to London, he obtained his PhD in genetic epidemiology and vaccine failure in children and completed his specialist paediatric infectious diseases training at St.
He is currently responsible for the national evaluation of the meningococcal group B vaccine, Bexsero®, in the national infant immunisation programme and the meningococcal ACWY conjugate vaccination programme for teenagers. His main research interests include vaccine-preventable infectious diseases and he has published extensively in this fields.



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