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There are other common causes of fatigue that are often not investigated in the medical setting such as adrenal fatigue and cell energy production deficits. Sleep maintenance difficulty is a pattern where it is usually easy to fall asleep but then the individual wakes up 2-5 hours later and has difficulty going back to sleep. Cortisol also is a stress hormone intensifying brain alertness in response to danger or stress. Adrenal fatigue is diagnosed by a combination of questionnaires regarding symptom patterns, 16-hour cortisol analysis and Biomeridian Testing. The report below shows the normal values are much higher first thing in the morning, moderate mid-day and much lower at bedtime. Occasionally, an added specimen is used if the patient wakes up during the night and has difficulty getting back to sleep to differentiate spiking of cortisol or excessive low cortisol response both of which disrupt sleep. This pattern often requires early morning treatment with activating herbs and evening treatment with calming herbs. Resolving adrenal fatigue involves identifying the causative factors (stress, blood sugar imbalances, food sensitivities) and adrenal restoration with the appropriate nutrients and reparative herbs. Because both cortisol and thyroid hormones activate cell energy, cells are carefully regulated to protect cells from too much activation from intense cortisol and thyroid hormone activation at the same time. When cortisol levels are high, cells protect themselves from overstimulating by both cortisol and thyroid hormone. The type II deiodinase enzyme knocks an iodine off the wrong corner making an inactive molecule rT3. Standard testing for thyroid related fatigue typically only looks at “how much” and not “why”. The generation of ATP is done taking potential energy molecules that the cell has processed such as sugar and fats and transitioning them through several enzymes that result in the final production of ATP. There are hundreds of different enzymes in humans, and the unique ones that are underactive in each person is unique. While each individual may have a unique group of factors producing their cell energy deficits, identification of these factors, correction of modifiable factors (inflammation, oxidative stress, etc) and an individualized nutritional program will often produce pronounced symptomatic relief.
Currently, relatively cost effective genetic testing is available for some of the common gene variations that cause imbalances in energy metabolism and ultimately, fatigue. Amongst the many health benefits of honey, what is most impressive to me a€“ it can be a powerful immune system booster. Honey does not cure cancer but what many people don't think enough of or have overlooked is - honey possesses carcinogen-preventing and anti-tumour properties! Hangovers: When you get a hangover from drinking too much alcohol, combat its effects by applying honey remedy.
Sore Throats: One of the better known health benefits of honey is that it is able to help treat sore throats. Cortisol is a multi-tasking hormone involved in energy production, inflammatory control, stress activation of the brain and blood sugar regulation. This can cause difficulty getting to sleep at night, some anxiety and an abundance of energy. In adrenal fatigue we produce inadequate levels magnifying symptoms such as muscle and joint pains, allergies and other inflammatory responses. Inadequate cortisol while awake will often dull perception with individuals typically referring to it as brain fog or poor concentration. This pattern will often correspond with a symptom pattern of strong fatigue throughout the day with improved energy in the later evening.

In this pattern cortisol is very low in the morning and often mid-day but gets high in the evening and night. As with all other fatiguing patterns, the triggering cause of the adrenal fatigue must be found and resolved. The fatigue may, however, be caused by reverse T3 (rT3) thyroid syndrome which is different from simple hypothyroidism, or under functioning of the thyroid.
The high cortisol causes the cell to produce another enzyme called a reverse deiodinase, or type II deiodinase. Nutrient deficiencies, inflammation, oxidative stress, and genetic mediated enzyme variations can all slow these enzymes making it difficult to produce adequate ATP to keep up with energy demand.
However, when it is produced, it is inactive and has to be combined with “cofactor” to be fully active. Testing is now available looking at the gene polymorphism in the common enzymes in the energy production process. This testing looks at intermediates called organic acids in the enzyme pathways in the urine. A great natural source of carbohydrates which provide strength and energy to our bodies, honey is known for its effectiveness in instantly boosting the performance, endurance and reduce muscle fatigue of athletes.
Next time before you go for a workout, take a spoon of honey to enable you to go for the extra mile.
If you are feeling low and lethargic in the morning, instead of reaching out for a can of carbonated energy drink , try honey. If your kids are finding hard to cope with the physical strain from the buzzing activities at school, prepare them some sandwiches with honey, butter and ham to make sure they have enough energy to sustain through the day. Honeya€™s antioxidant and anti-bacterial properties can help improve digestive system and help you stay healthy and fight disease. Its antiseptic properties inhibits the growth of certain bacteria and helps keep external wounds clean and free from infection. Honey is gentle on the stomach and contains a mix of natural sugars such fructose which is known to speed up the oxidation of alcohol by the liver, acting as a 'sobering' agent. Thanks to its antimicrobial properties, honey not only soothes throats but can also kill certain bacteria that causes the infection. Most who have fatigue and present to medical care have lab tests done to investigate causes such as thyroid disease and anemia.
However, it will eventually transition to the development of fatigue as the adrenal glands begin to fail to keep up with the demand for cortisol. It is important to correlate the time of the low cortisol readings with the timing of fatigue to improve diagnostic accuracy. This pattern seen below is often associated with daytime fatigue and high energy in the evening making it difficult to get to sleep. The presence of high amounts of rT3 will suppress cell thyroid signal even in the presence of normal amounts of thyroid hormone. If both thyroid hormone and cortisol were very active at the same time, it would be too stimulating. As shown above this is a molecule with an iodine on each of four corners hence the name T4.
Some thyroid dysfunction results from autoimmune attack on the thyroid triggered by things such as food sensitivities. Cofactors are typically micronutrients such as vitamins and minerals with each enzyme requiring a different combination.

One of the interesting findings has been that in these genetically underactive enzymes, their activity can often be raised to normal with much higher amounts of the nutrients that are co-factor for that enzyme normalizing energy production.
Spread it on hot toast or replace the sugar in your tea with it for a refreshing surge of energy. Start every brand new day with this cleansing tonic if you want to see this health benefit of honey: before breakfast, mix a spoonful of honey and lemon juice from half a lemon into a cup of warm water and drink it. Honey has been used as a natural cure in first aid treatment for wounds, burns and cuts as it is able to absorb moisture from the air and promote healing. Follow this recipe: 15ml of liquid honey with 80ml of orange juice and 70ml of natural yogurt. Other signs of adrenal fatigue include sleep maintenance difficulty, poor inflammatory control and brain fog or lack of mental clarity. The TSH which is used to determine thyroid hormone function will often be normal in the presence of rT3 syndrome as the production of TSH only indicates the presence of adequate normal thyroid hormone. This is prevented when cortisol is too high by its inactivation of thyroid hormone by the conversion of much of it to rT3.
This circulating form has lower cell activating properties, and most T4 once it enters a cell will have an iodine removed from one corner by an enzyme called a deiodinase making it a more active hormone, T3. The answer in this case is often isolating the cause and removing it allowing the thyroid to normalize its own function. The mitochondria are small “engines” within the cell that generate the molecule responsible for energy, ATP. The glucose in honey is absorbed by the body quickly and gives an immediate energy boost, while the fructose is absorbed more slowly providing sustained energy. They couldn't care a bit about the health benefits of honey, but simply love the taste of it!
Its antibacterial properties prevent infection and functions as an anti-inflammatory agent, reducing both swelling and pain, and even scarring. The fatigue is caused by the lack of effect of the thyroid hormone at the cell level because too many of the cell thyroid hormone receptors are being taken up by the inactive rT3 present.
Many patients have had limited thyroid testing and been told that is not the problem when it may be. It is known that honey has also been found to keep levels of blood sugar fairly constant compared to other types of sugar. It is widely believed that UMF Manuka is the preferred honey for wound dressing due to its strong antibacterial property. Direction: Take a spoonful of honey to soothe the inflammation or gargle with a mixture of two tablespoons of honey, four tablespoons of lemon juice and a pinch of salt. Comprehensive testing should involve looking at the pituitary signal to the thyroid (TSH), thyroid antibodies, as well as free thyroid hormones. Personally, whenever I have a sore throat or cough, I especially like to take warm water mixed with Manuka UMF honey which is well-known for its anti-bacterial healing properties.

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