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An integral component of Jupiter Medical Center’s mission to improve the health and well-being of our community is access to clinical trials.
Jupiter Medical Center participates in clinical studies and affiliates with national research organizations to deliver clinical trials to our local community. Deciding whether or not to enroll in a clinical trial involves careful consideration between patient and physician.
Jupiter Medical Center has a local Institutional Review Board (IRB) designated to review and monitor biomedical research involving human subjects.
Jupiter Medical Center relies on your charitable gifts to ensure the quality of all that we do for our patients and their families. Originally published on April 9, 2014 8:59 am Most experimental drugs fail before they make it through all the tests required to figure out if they actually work and if they're safe. Not Intended As Specific Medical Advice.Material provided on this site is for background educational use only.
This site complies with the HONcode standard for trustworthy health information: verify here. Two studies released Monday found major flaws with a large number of research papers in the biomedical sciences, a problem that authors say wastes billions and slows the pace of life-saving research.
One of the studies in the journal PLOS Biology analyzed a random sample of 441 biomedical journal articles published in the last 15 years, and found that only one included a full protocol of the information necessary for evaluating and replicating the research. Scientific studies are considered valid only if they can be reproduced by outside teams of researchers who come to the same conclusions using independent methods.
Furthermore, most of the studies did not say where their funding came from, and did not establish whether there were any conflicts of interest. A separate study by researchers in Germany examined hundreds of published experiments on stroke and cancer research and found that most did not contain sufficient information about how many animals were used. In many papers, the number of animals used over the course of the "vanished," making any conclusions far less reliable. When human subjects are part of a clinical trial, information about how many took part is considered crucial to the findings, and would not be left out of the published study, the authors said.
An accompanying editorial in PLOS Biology noted that a "credibility crisis" is ravaging scientific research. For instance, a recent attempt to replicate 100 psychology studies found that only 39 percent could in fact be reproduced.
Other previous research has found that "85 percent of research investment in the biomedical sciencesa€”or US $200 billion of the worldwide investment in 2010a€”is wasted," it said. In a proof-of-concept study at Johns Hopkins, researchers have shown that results of common and routine blood tests are not affected by up to 40 minutes of travel via hobby-sized drones. For more than 100 years, exposing students to basic and clinical research has been an essential component of a medical school education in the United States.
The National Institutes of Health (NIH) is easily the world's largest funder of medical research, and outside scientists perform most of the research. Clinical trials are one of the most important weapons in the continuing fight against disease in addition to advancing all areas of medicine.
Patient-centered, individualized discussion includes a detailed informed consent, eligibility screening and education of the benefits and possible risks related to the clinical trial.
In accordance with FDA regulations, Jupiter Medical Center’s IRB has the authority to approve, require modifications in (to secure approval), or disapprove research.


But some drugs get fairly far down that road, at the cost of hundreds of millions of dollars, based on poorly conducted studies at the outset.
Learn directly from medical researchers published in major and specialty medical journals and health care meetings.
While you may freely discuss your troubles, you should not look to the Website for information or advice on such topics. Always seek the advice of your physician or other qualified health and ask your doctor any questions you may have regarding a medical condition. These studies may offer patients the opportunity to receive new or potentially more effective therapies, as well as state-of-the-art approaches to treatment. Study participants receive ongoing monitoring and follow-up by the research staff throughout their participation. The purpose of IRB review is to assure, both in advance and by periodic review, that appropriate steps are taken to protect the rights and welfare of those participating as subjects in research offered by Jupiter Medical Center and its medical staff. Medical researchers reviewing this sorry state of affairs say the drug-development process needs serious improvement.
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In the past decade or so, nine potential drugs have been tested in people who have this degenerative nerve disorder. So Steve Perrin, who runs the ALS Therapy Development Institute in Cambridge Mass., decided to take a close look at the mouse studies that had initially suggested these drugs were promising.
Scientists who did those early studies would have known that — if they had done the studies correctly, Perrin wrote in the journal Nature. Instead, it ended up wasting a huge amount of time and potentially hundreds of millions of dollars.
It's also a rough deal for the patients who have diseases like ALS, which can progress rapidly to paralysis and death, if they choose to try an experimental treatment. They might not qualify for the next trial that looks promising, or they may lose their battle with the disease." And this is not just a problem for ALS.
Glenn Begley worked at the drug company Amgen in Thousand Oaks, Calif., to develop cancer drugs. But when he actually sat down to review more than 50 studies that had come in over the transom, "I was frankly shocked to find that the number was more like 90 percent of papers that we were unable to reproduce." Because Amgen and other big pharmaceutical companies know that many animal studies are dubious, they always redo them before deciding whether to go ahead with human studies. So the company did not end up wasting hundreds of millions of dollars or years on a dead end. Begley says this problem doesn't apply to drugs that make it all the way through the approval process. We really want to discover something that's going to improve human health." So scientists are too eager to seize on hopeful results, and not skeptical enough about their own work.
Drug studies in human beings take that into account by making sure scientists running the tests don't know who's getting the drug and who's getting the comparison pill. Scientists doing this research need to be rewarded for getting it right, he says, not just for getting it published. It will cost more in the short run to do it right, but that will avoid wasting time and money in the long run, Perrin says. But researchers say many of those failures can be caught earlier in the testing process, saving precious money and time.


RICHARD HARRIS, BYLINE: To get a sense of this problem, consider drugs that are being developed to treat ALS, or Lou Gehrig's disease.
So Steve Perrin, who runs the ALS Therapy Development Institute in Cambridge Massachusetts, decided to take a close look at the mouse studies that had initially suggested these drugs were promising. STEVE PERRIN: We tried to replicate those findings precisely by talking to the authors and trying to repeat the experiments in an identical fashion. HARRIS: Perrin says that if scientists had been more careful with their initial mouse studies, they would have realized that these drugs were never good candidates, so it made no sense to try them in people. And he writes in Nature that scientists who did those early studies would have known that, if they had done those studies correctly. PERRIN: Once you start getting into clinical trials, you're talking hundreds of millions of dollars per drug. HARRIS: It's also a rough deal for the patients who have diseases like ALS, which can progress rapidly, if they choose to try an experimental treatment. He decided to review more than 50 animal studies that had come across the transom to see how many of them were valid. GLENN BEGLEY: And I was frankly, shocked to find that the number was more like 90 percent of papers that we were unable to reproduce. HARRIS: Because Amgen and other big pharmaceutical companies know that many animal studies are dubious, they always re-do them before deciding whether to go ahead with human studies. BEGLEY: For small companies that have got limited resources, they probably do go ahead with studies that ultimately will burn out.
HARRIS: Begley says this problem doesn't apply to drugs that make it all the way through the approval process. Begley, who is now at Tetralogic Pharmaceuticals in Pennsylvania, says it's not that scientists doing these tests are deliberately sloppy. HARRIS: So scientists are too eager to seize on hopeful results and not skeptical enough about their own work. Drug studies in human beings take that into account by making sure that scientists running the tests don't know who's getting the drug and who's getting the comparison pill. Perrin at the ALS Therapy Institute says, yes it will cost more in the short run to do it right, but it will avoid wasting time and money in the long run. We can't possibly keep living under the same system that we have been for the last decade or so. Scientists doing this research need to be rewarded for getting it right, Begley says, not just getting it published. If you're online, you can visit us at the MORNING EDITION Facebook page and also at our website, npr.org. Now you're listening this morning on your local radio station and your station has a great website as well, lots of great content about your community.



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