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We offer family and pediatric naturopathic medical care for those natural-minded individuals seeking alternative treatments. Naturopathic doctors (NDs) are medical professionals who receive training in the same subjects as medical doctors (MDs).
In our society today we are inundated with the newest and latest trends concerning our health. Conventional medical professionals, concentrated on acute distress and are focused on immediate health concerns, have little time to answer many of the questions that we may have regarding our overall health and wellbeing.
In contrast, Naturopathic Doctors can help navigate us through the sea of information and educate us on what information is relative to our personal health regime and provide us with alternative, preventative solutions. A Naturopathic Doctor is a healthcare professional that has been trained in holistic, non-invasive forms of treating and determining the cause of disease.
A Naturopathic Doctor focuses on understanding the whole wellness of an individual and not just assessing symptoms.
Naturopathic Doctors strive not only to build a personal relationship with you through their comprehensive understanding of your whole heath (body, mind and spirit) but they enable you to build a relationship to your own health and wellness. Asking questions about your overall wellbeing and having answers to these questions can empower you to have control over your health and allow you to better take care of yourself, now and in the future. Naturopathic Doctors are focused on the cause of the disease, getting to the root of your ailment and not just treating your symptoms. Conventional medicine focuses on ‘what it is not’ and that can lead to prolonged discomfort and lengthy trial and error testing that may not provide any answers or ease. Naturopathic Doctors can educate you on your options and choices for taking better care of your overall heath, preventing illness before it happens. Naturopathic Doctors are trained in many diverse modalities to assess and treat overall health and wellness issues. This variety in education allows them to customize specific long lasting treatment plans for you that can include nutrition coaching, counseling, homeopathy and acupuncture to name a few.
Naturopathic Doctors can prescribe the right remedies that are specific to you and your overall health.
Naturopathic Medicine uses the least invasive and most natural treatments to help restore balance and health to the body.
Like medical doctors, Naturopathic Doctors undergo extensive training: 4 years of premedical school, 4 years of medical school, and rigorous board certification. Medical doctors tend to use pharmaceutical medicine and invasive surgery as their primary treatments. Naturopathic Doctors look at the whole person, the whole picture, and address the physical, mental, emotional, and spiritual aspects of disease. Yes, NDs are trained and certified to prescribe pharmaceutical medications, although, we usually choose not to do so because we have much more effective and efficient treatments with little to no side effects. Depending on the complexity of your health concerns, follow up appointments typically range from 1-10 visits.
I already have a Primary Care Physician, does it make sense for me to have a Naturopathic Doctor, as well?
Absolutely, Naturopathic Doctors are considered Primary Care Practitioners in the state of California.
This program is funded through Health Resources and Services Administration, US Department of Health and Human Services. Discuss best treatment options for HIV-infected patients with acyclovir-resistant herpes simplex virus infections.
Figure 1Figure 1 - Persistent Facial LesionLarge, gradually expanding superficial ulcerated lesion on face that did not respond to high-dose oral acyclovir. Which one of the following would be the most effective therapy at this point for presumptive acyclovir-resistant herpes simplex virus infection?
Famciclovir (Famvir) 500 mg PO tid.IncorrectMost acyclovir-resistant herpes simplex virus infections result from decreased viral production of thymidine kinase, the enzyme responsible for the first phosphorylation step in converting acyclovir to its active triphosphorylated form acyclovir triphosphate. Valacyclovir (Valtrex) 1000 mg PO tid.IncorrectValacyclovir (Valtrex) is an acyclovir prodrug (it is the L-valine ester of acyclovir).
Figure 1Figure 1 - Mechanism of Action of AcyclovirIn this HSV-infected human cell, the acyclovir molecules enter the cell and are converted to acyclovir monophosphate by the HSV enzyme thymidine kinase (TK).
Figure 2Figure 2 - Common Mechanism of Acyclovir Resistance in Herpes Simplex Virus InfectionThe most common types of acyclovir-resistant HSV infection involve either absent production of viral thymidine kinase (TK-negative mutants), or partially reduced production of viral thymidine kinase (TK-partial mutants). Figure 6Figure 6 - Therapy for Acyclovir-Resistant Mucocutaneous HSVSource: This table is based on recommendations from Panel on Opportunistic Infections in HIV-Infected Adults and Adolescents. The drug acyclovir (Zovirax) does not have activity against viral pathogens until it is converted to the active form acyclovir triphosphate. All of the drugs that require initial activation by HSV thymidine kinase (acyclovir, famciclovir, and valacyclovir) generally produce ineffective results against HSV strains that have absent or decreased thymidine kinase production.

Cidofovir (Vistide), formerly HPMPC, is an antiviral compound that reaches the cell in a monophosphorylated form whereby it is activated by cellular kinases.
They learn about the same diagnostic tests and examination technologies that MDs do, although they do not attend major surgeries as part of their training. Having access to this information regarding preventive care, alternative treatments and warnings of underlying health issues can be empowering but it can also be overwhelming, causing more questions than providing answers. As a form of primary care, Naturopathic medicine is the science, practice and art of diagnosing, treating and preventing diseases of the human body and mind. Just like medical doctors, Naturopathic Doctors learn a lot of the same advanced sciences, physical and lab diagnostic techniques, imaging, and pharmaceutical medicine.
They often don’t spend much time with their patients, and they use generalized protocols to treat symptoms of disease.
Although our treatments help relieve the symptoms, our goal is to identify and treat the underlying cause of disease in order to create lasting change. We recommend calling your insurance carrier and asking specifically if they cover Naturopathic Medicine. There are people who train in Naturopathy to become Naturopaths, but have not undergone 4 years of accredited, graduate level medical school or board certification, so they are not doctors, and they cannot practice medicine.
The Naturopathic Doctor will ask questions to understand the details of your current state of health, past medical history, family history, and other lifestyle factors to get a sense of your complete health picture. At the end of the initial visit, your doctor can give you a better idea of what your plan will look like.
Some of our patients choose to utilize their Naturopathic Doctors for their primary care since we can do physical exams, order labs, diagnose and treat and prescribe medications. We are trained and licensed to use pharmaceutical medicine, however, we often choose not to use pharmacology. He has a history of recurrent herpes simplex infection and has received multiple courses of oral acyclovir (Zovirax).
Famciclovir (Famvir) is a prodrug of penciclovir and because activation of penciclovir also depends on viral thymidine kinase, acyclovir resistance generally also causes famciclovir resistance.
Foscarnet does not require activation by viral thymidine kinase and thus retains activity against herpes simplex virus strains with absent or altered production of viral thymidine kinase. Following absorption of valacyclovir, it is almost completely converted to acyclovir during first-pass hydrolysis in the liver and intestines. Enzymes in the human cell add two more phosphates to eventually form the active drug acyclovir triphosphate. In this illustration, the notation TK- refers to deficient production of viral thymidine kinase, either through TK-negative mutants or TK-partial mutants. Guidelines for the prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from the Centers for Disease Control and Prevention, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. If acyclovir resistance is suspected, testing for HSV should include a viral culture of the sample, since resistance testing will require isolation of virus. Drugs that require activation via a similar viral kinase, such as ganciclovir (Cytovene) and valganciclovir (Valcyte), are also ineffective.
Because cidofovir does not require activation by a viral kinase, it should theoretically have activity against acyclovir-resistant HSV infections. Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management.
Resistance of herpes simplex virus infections to nucleoside analogues in HIV-infected patients.
Genotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals. Resistance to antiviral drugs of herpes simplex virus isolated from a patient treated with acyclovir. Acyclovir-resistant genital herpes among persons attending sexually transmitted disease and human immunodeficiency virus clinics.
Acyclovir-resistant herpes simplex virus infections in patients with the acquired immunodeficiency syndrome. Herpes simplex virus type 2 meningoencephalitis resistant to acyclovir in a patient with AIDS.
Mucocutaneous dissemination of acyclovir-resistant herpes simplex virus in a patient with AIDS. Foscarnet therapy for acyclovir-resistant mucocutaneous herpes simplex virus infection in 26 AIDS patients: preliminary data. A controlled trial comparing foscarnet with vidarabine for acyclovir-resistant mucocutaneous herpes simplex in the acquired immunodeficiency syndrome.
Foscarnet therapy for severe acyclovir-resistant herpes simplex virus type-2 infections in patients with the acquired immunodeficiency syndrome (AIDS).

A randomized, double-blind, placebo-controlled trial of cidofovir gel for the treatment of acyclovir-unresponsive mucocutaneous herpes simplex virus infection in patients with AIDS.
Treatment with intravenous (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]-cytosine of acyclovir-resistant mucocutaneous infection with herpes simplex virus in a patient with AIDS. Pilot study of topical trifluridine for the treatment of acyclovir-resistant mucocutaneous herpes simplex disease in patients with AIDS (ACTG 172).
In addition to this, NDs also receive training in botanical medicine, homeopathy, nutrition, IV and injection therapy, hydrotherapy, lifestyle coaching, counseling, and physical medicine. Someone who is deemed a Naturopath, may not be a doctor, but sometimes Naturopathic Doctors refer to themselves as Naturopaths (for short). At this visit, we will perform any necessary physical exams, discuss ordering labs, and initiate an individualized treatment plan that is tailored to your needs and preferences. As primary care doctors, we can perform routine wellness exams, women’s gyn exams, and check-ups.
Bear in mind that a visit to a naturopathic doctor is much like scheduling maintenance for your car. In fact, we can assist patients in discontinuing certain medications safely and effectively. He increased his acyclovir dose from 400 mg PO three times daily to 800 mg PO three times daily, but the lesion expanded further (Figure 1).
Although oral valacyclovir has a relative bioavailability 3 to 5 times greater than acyclovir (and oral doses can generate relatively high serum levels of acyclovir), it would not likely override the acyclovir resistance. The acyclovir triphosphate competes with 2-deoxyguanosine triphosphate (dGTP) as a substrate for viral DNA polymerase, as well as acting as a chain terminator. As a result of the deficient production of TK, the HSV strains fail to effectively generate acyclovir triphosphate and thus acyclovir does not effectively inhibit viral DNA polymerase. Acyclovir triphosphate has a two-pronged mechanism of action: (1) it competes with 2-deoxyguanosine triphosphate (dGTP) as a substrate for viral DNA polymerase and (2) once it becomes incorporated into the replicating viral DNA, it acts as a chain terminator because it does not have a terminal 3' hydroxyl group. Rarely, acyclovir-resistant HSV infections result from altered viral thymidine kinase and these strains of HSV could theoretically respond to famciclovir. NDs spend a lot of time listening to their patients, forming relationships, and tailoring their natural treatment plans to each individual. At Thrive Natural Medicine, all the Naturopaths are all Naturopathic Doctors- licensed to practice medicine. Two hours may seem like a long time, but it often passes quite quickly, and typically, we use the entire amount of time. Once your health and vitality is restored, regular check-ups can be limited to once or twice a year.
Just as frequent tune-ups help to keep the tow truck away, regular visits to your naturopathic doctor can keep you healthy and out of your medical doctor’s office.
This lesion is now painful and culture of the lesion has grown herpes simplex virus type 1. In actual infection, the HSV releases its naked capsid that delivers DNA to the human nucleus; the active drug acyclovir triphosphate exerts its action on the viral DNA located in the nucleus. In contrast, penciclovir, the active component of the prodrug famciclovir (Famvir), does not act as a chain terminator because it has a terminal 3' hydroxyl group that permits viral primer-template extension. Because foscarnet does not require activation by viral thymidine kinase, it retains activity against HSV strains with absent, partially reduced, or altered production of thymidine kinase. We educate our patients to make informed decisions about their health, and help restore vibrance and vitality to each person we treat. Naturopathic Doctors focus on disease prevention and wellness optimization, while the education of medical doctors tends to focus on emergency care and crisis resolution.
Foscarnet (Foscavir) is a pyrophosphate analog that directly inhibits viral DNA polymerase by reversibly blocking the pyrophosphate binding site of the viral polymerase (in addition to inhibiting the cleavage of pyrophosphate from deoxynucleotide triphosphates).
We are “Out of Network” and you will want to ask your insurance provider what the coverage is for these types of visit. Your Naturopathic Doctor and your medical doctor can play different, yet complementary roles on your healthcare team by using different methods to keep you healthy. Naturopathic Doctors often work in unison with medical doctors to create optimal adjunctive care.
Click here for more information about how to most successfully seek reimbursement from your insurance carrier.

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