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Hea€™s been the head of the Council for Responsible Genetics for more than 30 years, and he is no fan of GMOs. Among his many critiques of the biotecha€™s poison crops, he states that one negative finding regarding risks of GMOsA weighs ten times more than any positive study since most of the studies a€?proving GMO safetya€™ are funded by the industry itself.
According to Cedars Sinai Medical Centre in the USA, arthritis is a term that actually encompasses around 100 conditions. Osteoarthritis is the most common form of arthritis in the UK, affecting around eight million people, and occurs when cartilage at the end of bones wears away, leading to joint pain and stiffness.
There are many myths regarding arthritis, including the suggestions that it only affects older adults, and that there is nothing you can do about it if it hits you. In a recent global study carried out as part of pharmaceutical company AbbVie’s ‘RA: Join the Fight’ initiative, it was revealed almost two thirds of rheumatoid arthritis (RA) patients in the UK don’t feel that their conditions are well managed.
Professor Anthony Woolf, Professor of Rheumatology at the Royal Cornwall Hospital Truro and University of Exeter Medical School wants to see greater availability of rehabilitation programmes for people living with arthritis. He told me, “If someone is not working, just reducing their benefits is not going to help them be more independent and return to work.
It’s a call that’s echoed by Disability Rights UK and a number of other disabled people’s organisations campaigning against benefit cuts.
Meanwhile, a large number of groundbreaking research projects are seeking to improve people’s lives, using advances in computing power to study genetics and identify which lines to follow.
Ian Bruce, Professor of Rheumatology at The University of Manchester and consultant at Central Manchester University Hospitals NHS Foundation Trust, has led research that looked into possible risk factors for the onset of RA.
Working alongside the Arthritis Research UK (ARUK) Epidemiology Unit, they followed over 25,000 people aged 40-79 and identified those who subsequently developed RA. They found that smoking, obesity and diabetes all increased the risk of developing the condition, while drinking a small amount of alcohol and belonging to a higher social class were associated with a reduced RA risk. Women with more than two children, but who breastfed for a shorter time, were also at greater risk – but you could live the healthiest life possible, and still have a chance of getting RA.
Barton is co-leading the ?10m ‘Maximising Therapeutic Utility for Rheumatoid Arthritis’ (MATURA) project, alongside Costantino Pitzalis – Professor of Experimental Medicine and Rheumatology at Queen Mary, University of London. The study is thought to be unique, in that it combines analysis of synovial tissue in joints (led by Pitzalis) and blood biomarkers (led by Barton).
In terms of other developments, Barton, notes that, “In the Netherlands there is a study looking at high risk patients with a family history who may carry antibodies.
Another piece of good news is that Arthritis Research UK – thought to be the largest medical research charity of its kind in the world, with a research spend of ?28m in 2011-12 – has announced a major new research centre in the quest to discover RA’s underlying causes. The researchers at the new Pathogenesis Centre will headed by Professor Iain McInness at the University of Glasgow.


RA is a serious, inflammatory, autoimmune condition that affects joints, tendon sheaths and the body’s internal organs, leading to chronic pain and fatigue. Researchers at Cedars Sinai Medical Center in the USA state that RA can be accompanied by a low grade fever.
According to the UK charity Arthritis Care, RA inflammation affects the thin synovial membrane that lines the joint capsule, tendon sheaths (the tubes in which the tendons move); and the bursae – sacs of fluid that allow the muscles and tendons to move smoothly over each other. People’s symptoms might include feeling generally unwell and tired, and often stiff – particularly first thing in the morning, or after sitting still for a prolonged period.
At 18, Dizzy (who prefers not to be further identified) had just started working for a media organisation when a lump appeared on her ankle. My father had curvature of the spine due to ankylosing spondylitis, and I knew arthritis could be inherited.
Wrist supports and an electric typewriter helped [at work], but I also had a very good boss who protected me, which I think you need, and also a very supportive mother. My older sister Jackie, who is now retired, finds she is only aware of her hands being affected. A three-year EULAR-funded project aimed at improving and harmonising standards of care for RA and other musculoskeletal conditions across EU member states. One of the world’s largest medical research charities, ARUK funds research into all types of arthritis and related conditions. A user-led charity and campaigning organisation providing support to people with all forms of arthritis. About accessWelcome to Access magazine, the leading product guide for the disability health care sector.
The professor of Tufts University states that he isna€™t FOR or AGAINST GMOs, but thinks that the agricultural industry has been negligent in telling the truth about the way they create our food. Along with back pain and other musculoskeletal disorders, it’s the biggest cause of physical disability in the UK, resulting in challenging lives and untold human distress – as well as costing individuals and the larger economy billions of pounds. Yet small children can get juvenile idiopathic arthritis; for many patients, their condition can be managed to improve their quality of life, whilst others experience pain so severe that they can lose consciousness, need help dressing and cannot work. Just over a quarter said they have a disease management plan in place, compared to 56% globally, prompting calls for increased collaboration between doctors and patients. ARUK’s Medical Director, Professor Alan Silman, advises taking appropriate exercise, avoiding obesity and not smoking. It is highlighting targets for biologic drugs to block a pathway involved in inflammation,” explains Anne Barton, Professor of Rheumatology and Research Lead for inflammatory arthritis in adults at the Manchester Musculoskeletal Biomedical Research Unit (BRU) – a National Institute for Health Research-funded unit that presently has 22 projects underway.
Barton and her colleagues have been awarded ?2.5m of funding from ARUK and the Medical Research Council to research the genetic and genomic markers that can predict which RA patients will respond best to which treatment – otherwise know as a ‘stratified’ or personalised approach to treating the condition.


In the UK, Switzerland and France there are investigations into predicting and preventing who can get it.
The ?2.5m Rheumatoid Arthritis Pathogenesis Centre of Excellence is a collaboration between the Universities of Glasgow, Newcastle and Birmingham, with all three committing to an additional ?4m of funding over five years. Small lumps may appear under the skin at pressure points, there can be inflammation of the tear and salivary glands, in the linings of the heart and lung, and in rare cases, the blood vessels. The affected joints and inflamed tissues will subsequently become stiff, painful and swollen. I had therapy to help overcome certain things, and rediscovered my femininity when I got into a relationship.
It meant that I could drive, do hobbies and be independent, without relying on other people. For example, I was on a photography course and reluctantly had to ask someone to switch a light meter on. You know you can’t physically defend yourself, and it’s said that I scrutinise people a lot – like [when] I’m on the underground, encountering drunk lads, or people not understanding why I need to ask for a seat.
She is, as Professor Anne Barton describes her patients, ‘stoical’, taking it in her stride without much complaint.
Advertisers will benefit from being informed about upcoming features and offered premium positions in both the print magazine and online. Each month, we aim to offer lifestyle guides, practical care advice, help with needs assessment and therapeutic ideas for improved quality of life from a range occupational health experts, leading charity advisors and government agencies. Some people – like my own older sister Jackie, who now has difficulties writing – live with both.
Following a Mediterranean diet might help prevent the onset of the condition, but is not thought to affect its progress.
There’s [also] a lot of interest in using ultrasound to look inside joints to better manage it.” Another step forward has been the development of some drugs that can be self-injected. Its onset is most common between the ages of 40 and 70 – but it can affect any adult from the age of 16 – and affects two to three times more women than men. I saw the way I was walking reflected in a shop window and I didn’t know what was going on. It will look at genetic and genomic approaches, using protein analysis to identify novel biomarkers.
I felt I didn’t know who I was – I felt isolated, unfeminine and frightened, so I put off seeing a doctor.



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