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For many physicians, corticosteroids, of which glucocorticoids are one kind, are a first-line treatment for a number of diseases, including multiple sclerosis, sarcoidosis, lupus, and rheumatoid arthritis.
Research shows that any kind of short-term symptomatic improvement from corticosteroid use does not last, and that over the longer term, use of the drugs can have adverse consequences, including a litany of side effects. Ther term corticosteroids refers to a family of drugs that includes synthetic drugs, such as prednisolone, and natural ones such as cortisol, ­an adrenal hormone which is found naturally in the body. Corticosteroids include mineralocorticoids, which affect salt and water retention, and glucocorticoids, which affect protein, fat, and carbohydrate metabolism. Corticosteroids can be administered by injection, topically, nasally, orally, or via eye drops. Because they suppress the innate immune response and do significant long-term damage, all corticosteroids and hormonal steroids are contraindicated and must be discontinued before beginning the Marshall Protocol (MP). Patients with chronic disease may find that while taking corticosteroids, both symptoms and markers of the disease, including X-rays, liver enzymes, etc., may temporarily decrease.
Even if the dose of corticosteroids is continually increased over time, the sheer amount of toxins that the bacteria generate will, at some point, become uncontrollable.
Corticosteroids act on a host of nuclear receptors, activating some and inactivating others. Whether nuclear receptors are active or inactive is important because they control, and, when modulated, can upset everything from immune response to energy metabolism.
The function of the glucocorticoid receptor (GCR) is not fully known, as mice who are bred without it do not survive gestation. The body exquisitely balances the endogenous production of its steroid hormones in a manner which cannot be mimicked with endogenous drugs. Fibrosis, which is not stopped by steroids, encases bacterial pathogens in collagen, from which they will eventually begin to break free.
The long-term use of steroids promotes parasitization of the more dense organs, rather than just soft-tissue in the lungs. There are no studies which show that steroids improve long-term prognosis in the treatment of illness.
The 2003 NIH ACCESS study2), the largest and most ambitious to date, validates that these drugs are ineffective for sarcoidosis patients, even for a time period as short as two years. Table 3 in the paper shows how, for the majority of patients, markers of the disease process remained unchanged. Oral steroids improved the chest X-ray and a global score of CXR, symptoms and spirometry over 3-24 months. Relapse… rarely occurred in patients who had not been treated with corticosteroids in the past. Whether taking injectable or inhaled corticosteroids, children are particularly susceptible to the negative long-term effects of the drugs. Am I suffering treatment-induced diseases or damage as a result of taking high-dose steroids?
Am I familiar with reports indicating that corticosteroids do not halt the advancement of sarcoidosis? Do I realize that withdrawal from corticosteroids causes relapse of disease symptoms that may be worse than the original symptoms? While on the MP, limited use of sniffed, inhaled or topical steroids is allowed for intolerable symptoms of nasal congestion, shortness of breath or itching if management of MP medications fails to dampen immunopathology symptoms. MP patients should consult with their health care practitioners to devise a plan to substitute other medication for symptom relief, if possible, or to discontinue the use of the steroid product as soon as the acute inflammation is under control. DMSO, or dimethyl sulfoxide, is a super-cheap by-product of wood-chipping in the paper industry.
In 1962 another key property of DMSO was discovered: it's ability to penetrate skin and human tissue membranes without damage.
Besides its industrial uses, DMSO has been found to help a range of medical conditions in both animals and humans. There's a long list of conditions that DMSO is said to help, including infections, injuries, and inflammatory conditions such as arthritis, bursitis, tendonitis, neuritis, sciatica, etc., also progressive degenerative conditions such as scleroderma.
Although DMSO is used extensively for veterinary treatment, it is not approved by the FDA for any use in humans except for one: interstitial cystitis, which is an inflammatory bladder condition that has no other recognised effective treatment. In spite of medical and popular enthusiasm, the FDA has to date rejected all but one of the new drug applications submitted by pharmaceutical companies.
The FDA did relent somewhat and approved clinical trials in 1966 for serious conditions such as scleroderma, herpes zoster (shingles) and severe rheumatoid arthritis, and in 1968 they further relaxed their stance and allowed short term trials for some less serious conditions such as sprains, tendonitis and bursitis. A further sticking point for the FDA has been the inadequate design of the clinical trials. There is also the ongoing issue that pharmaceutical companies have with all natural treatments – that they are going to incur huge costs to get it approved, but won't be able to patent it and recoup their money. At this point, the FDA has approved DMSO only for treatment of interstitial cystitis (in 1978) – and in 1970 for veterinary use, to treat musculo-skeletal disorders in dogs and horses. It may be that the sheer variety of the conditions that DMSO is reputed to help might make the FDA stalwarts sceptical. But once you start to take a look at how DMSO works, you can see how it might truly be able to help all those different medical conditions. We've talked a bit about the first two, but so far not about the anti-inflammatory properties.
Pain is almost always connected with some sort of inflammation, so this may be part of the mechanism by which DMSO relieves pain.
However, it appears to still be the case that any registered medical practitioner who uses or prescribes or recommends DMSO for a patient, while not breaking the law, is at risk of losing their licence. The point here to take away is that DMSO is being used in very large doses without causing any problems. I'm going to stress here that I'm not giving medical advice, or indeed any sort of advice, except to explain the cautions as I understand them, for using DMSO topically. It's recommended to test out a small patch on your elbow first, and at about 50% dilution, to check for any allergy or reaction.

The purest DMSO you can get - 99.9% - may be diluted with either distilled water, or with aloe vera.
The idea is to apply the DMSO either with your fingers, or a cotton ball, or a cotton bud (depending on how big an area you want to treat) and let it dry (for about 20 minutes). Because DMSO gets carried into the tissues, you don't have to worry too much about precise application. The best thing is, if possible, apply the DMSO to an area wider than the place you want to target. Depending on the condition you are targeting, you may want to make several applications per day. DMSO is helpful for wound healing and pain relief, and some people find that DMSO, used as described above, helps their herpes lesions in this way. DMSO on its own has been used for shingles (Herpes zoster) with good results, particularly in treating the painful lesions.
In laboratory studies, it's been found that DMSO is able to penetrate the protein coating of the herpes virus, and interfere with its replication – in clinical terms, blocking the outbreak. To use DMSO in this way for herpes, apply your chosen form and strength of DMSO several times per day for 3 days at the first sign of an outbreak, and then on a regular monthly basis thereafter. Another promising report is the use of Vitamin C crystals dissolved in DMSO, which has been used effectively for both herpes simplex and herpes zoster. To get the complete herpes protocol, which includes a number of cutting edge herpes treatments combined for maximum effectiveness, click here. The biggest medical caution is for those taking blood thinners such as warfarin or even aspirin, and even more so for hemophiliacs (who lack blood coagulant). Note: for most people, the anti-coagulant properties of DMSO will be generally beneficial, helping prevent coronary thrombosis, strokes, etc. There are some scare warnings online about DMSO carrying all sorts of toxic stuff like bacteria and toxic chemicals into your body.
DMSO's capacity as a carrier depends on the size, shape and electrochemistry of the target molecule.
It's freely available for industrial or veterinary use, and it's easy to find good quality pharmaceutical grade DMSO to buy online. The gel and the creams are easier to apply topically than the liquid form, but it's not always easy to tell just what's in the jar, or how much DMSO is in it. Highly recommended for anyone who wants a complete holistic protocol to reduce or stop outbreaks completely.
DISCLAIMER: The information contained in this Website is provided for general informational purposes only. Where names have been used on this website, these should be considered as pen names of real people which have been changed to protect privacy unless otherwise stated.
Corticosteroids suppress the innate immune response, which provides some patients with temporary symptom palliation but also allows chronic pathogens to proliferate. Though synthetic and natural corticosteroids are both potent anti-inflammatory compounds, the synthetics exert a stronger effect. MP patients are strongly discouraged from using any of these corticosteroid forms because they are absorbed systemically and are, to some degree, immunosuppressive. As damaging as they are, the abrupt discontinuation of corticosteroids can cause serious harm.
This is due to the short-lived decrease in inflammation as well as the fact that pathogens are not being killed. For example, cortisol has an affinity for the glucocorticoid receptor, and aldoesterone has an affinity for the mineralocorticoid receptor. The problem with viewing cortisol or any other hormone as a supplement is that it acts as a steroid rather than a replacement. By way of example, hydrocortisone alters operation of the VDR, thyroid-alpha, thyroid-beta, glucocorticoid, mineralcorticoid and too many other alterations for me to detail. There is every reason to believe that a longer-term study as well as one looking at dose would further demonstrate how corticosteroids are worse than ineffective – they're dangerous. The striking difference in relapse rate between treated and untreated patients suggests that patients with disease that would later be severe and protracted were almost unerringly identified early in their course.
Also, being a health care worker at the time of SARS infection more than tripled the risk of psychiatric morbidities at follow-up.
What is DMSO used for?The DMSO controversy How DMSO works How to use DMSO How to use DMSO for herpesShould I be worried about DMSO side-effects? It's a clear, odourless liquid with some extremely interesting properties that have led to its many uses, initially as an industrial solvent. Not only that, DMSO is also able to carry other substances with it, so that they can be absorbed directly.
DMSO seems to be able to replace some of the water in human tissues, and this ability to keep burned areas dry proved to be hugely useful in helping prevent infection. It's been used a lot as a topical analgesic for cuts and sprains as well as burns, and has been reported to be effective for relieving chronic pain as well. There are reports that DMSO may be useful in the treatment of cancer, stroke, and Alzheimer's disease. Between 1964 and 1983, over 1500 medical studies had been submitted, with results from 120,000+ patients with a range of medical conditions.
By this time, toxicology studies of DMSO use in humans showed no evidence of any negative effects on the eye – though the myths persist.
One of the problems has been that, because DMSO gives a distinctive odour to the patient's breath, it's not possible to disguise which patients are being given the DMSO and which are being given a placebo.
These properties are central to DMSO's reputation as a wonder drug, so let's go there right now.
Combined with its ability to penetrate the skin, this means it's able to get to the site of the inflammation and mop up the free radicals floating around causing problems. When something irritates a tissue – it could be anything at all, a bit of pollen in your nose, or a bee sting, or an injury to your wrist – then a chemical called histamine is released.

There do appear to be some brave medical practitioners who carry out IV treatment with DMSO – this tends to be for patients with severe conditions such as rheumatoid arthritis, and in clinics dedicated to this purpose, and able to withstand the displeasure of the authorities. If you are planning to apply it to broken skin or mucous membrane (eg mouth or genital area) you might want to keep to the 50% dilution until you know how your own body handles the DMSO – some people are more sensitive than others. For example, DMSO can be mixed with arnica tincture or gel for sore joints or muscles, or sports' injuries.
Be careful If you are going to cover the area with clothing – remember that DMSO is a solvent, and can interact with synthetic fabrics. For example, in one study of scleroderma patients, they were asked to dip one hand into a solution of DMSO, and then later the two hands were compared. For example, with an injured knee, apply DMSO down to the calf area and up to the lower thigh as well. For acute pain, eg a burn or sprain, you can apply DMSO every couple of hours, for 3 or 4 applications.
One combination that is reported to work is a mixture of DMSO and an anti-viral drug (idoxuridine). DMSO is broken down in the body to dimethyl sulphide – which is perfectly harmless, and excreted within 24 hours, but can be unpleasant to be around.
In this case you really do need to talk to your doctor before trying DMSO treatments, since DMSO can potentiate the anti-coagulant effect (which could be dangerous). So here's the thing: DMSO is certainly a solvent and a carrier, so make sure your skin is clean before you apply DMSO.
It's been found to be more effective at transporting some molecules than others, eg morphine sulphate, penicillin, steroids and cortisone are able to be transported easily, whereas insulin is not. But you can also just buy the purest DMSO liquid (99.9% pure) and then dilute it with distilled water or with aloe vera juice to the strength you want. You can buy a scented version, but I wouldn't recommend it - most fragrances are chemicals that you don't want in your body! All images displayed on this website should be considered as stock photos used for illustration purposes and to protect privacy unless stated otherwise.
For their own safety, patients on the Marshall Protocol (MP) must wean off of them as opposed to discontinuing them outright. MP patients currently taking corticosteroids should consult with their physicians to slowly wean off the drugs.
The bacteria multiply in the tissues without any hindrance once the corticosteroids have shut down the body's immune reaction. Corticosteroids also bind to other key receptors including the Vitamin D Receptor, PPAR-alpha, PPAR-gamma, and others. A more comprehensive paper would also have examined the range of negative side effects associated with coriticosteroid use.
There are limited data beyond two years to indicate whether oral steroids have any modifying effect on long-term disease progression. But there's one treatment that has been known about for years, yet has been mothballed by the FDA and the pharmaceutical companies because of its reputed almost miraculous super-powers. Then researchers discovered something that caused huge public excitement and a massive explosion of interest in DMSO: DMSO not only helped prevent infection, but significantly relieved burn pain. It's also showing promise in the treatment of head injuries – and the FDA have recently approved clinical trials for this, one of the very few that has been given the green light for further study. Histamine causes blood vessels to dilate, and fluid escapes into the nearby tissues, causing swelling.
And it will probably sting a bit too, especially if you are applying it to a lesion or wound.
Keep in mind that DMSO will help transport other agents into your body, so be careful what you mix it with! In most cases both hands showed some improvement, because the DMSO gets carried through the bloodstream to any part of the body that might need it. For chronic pain and other chronic conditions, the usual procedure is to apply once daily, but you will need to continue for 4-6 weeks before noticing any result. It's always a good strategy to start cautiously and at a lower concentration, and test a small area first. The information may not apply to you and before you use any of the information provided in the site, you should contact a qualified medical or other appropriate professional. This combination of properties has taken DMSO way past it's humble roots as a paint thinner, and given it a key role in preserving stem cells, embryos and organs for transplant at below-freezing temperatures. And make sure you thoroughly clean your hands and the area before applying DMSO, so you don't unwittingly zap yourself with some toxic substance.
Likewise with arthritis, applying DMSO to one part of the body tends to have a beneficial effect everywhere – and sometimes on unexpected complaints that were not being targeted.
But DMSO can't carry anything across your skin that would not be absorbed anyway – it just does it a lot faster. You should assume unless specifically stated otherwise that the owners of this website may be compensated for purchases of products or services mentioned on this website. Members of the MP study site are advised not to begin steroid withdrawal without first discontinuing antibiotics and consulting with our support community. But often the inflammation itself becomes the problem, and that's when an anti-inflammatory like DMSO can help.
What's more, bacteria can't survive in the DMSO solution at the levels we are talking about.

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