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Diagnosis of hepatitis C can be done with the help of blood tests that determines HCV antibodies in the blood. A diagnosis of hepatitis C does not really mean that a patient needs hepatitis C treatment. Interferon is given by injection and has certain side effects which include flu-like symptoms such as headaches, fatigue, loss of appetite, nausea, depression, vomiting, fever and thinning of hair. This blog will help the Hepatitis C to cope with most clinical situations related to the abdominal and alimentary tract in patients with FMF.
April 23 (Reuters) - AbbVie Inc's experimental hepatitis C treatment cured up to 96 percent of patients in just 12 weeks, according to data released on Tuesday, shoring up its position in the race to deliver a potent oral therapy for the serious liver disease.
AbbVie's treatment, a combination of five oral medications, is expected to be a close contender to a treatment in development by Gilead Sciences Inc. AbbVie said on Tuesday that about 88 percent of new patients with hepatitis C were deemed cured after only eight weeks of treatment, while 96 percent of those treated for 12 weeks eliminated the liver virus, as verified by blood tests 24 weeks after completion of treatment. If the virus is undetectable 24 weeks after completing treatment - known as sustained virologic response, or SVR 24 - a patient is considered cured.
The latest findings from an ongoing trial sponsored by AbbVie, called Aviator, were unveiled at a meeting of the European Association for the Study of the Liver (EASL) in Amsterdam.
Hepatitis C affects an estimated 170 million people worldwide, and if left untreated can lead to cirrhosis, liver cancer or the need for a new liver. Existing treatments must be taken by patients for either 24 or 48 weeks and the most effective have a cure rate as high as 80 percent. The latest results from AbbVie confirmed interim data presented in October, which showed a 99 percent SVR rate for patients evaluated 12 weeks after completing a 12-week regimen of the treatment. Gilead has been given an edge by many analysts because its experimental regimen involves fewer drugs and may be closer to reaching the market. Bristol-Myers Squibb unveiled data on Tuesday at the meeting from a smaller mid-stage study of its three-drug combination that does not include ribavirin.
Patients in the AbbVie Aviator study had the most common, but hardest to treat, genotype 1 variation of the infectious virus.
The AbbVie regimen included three experimental direct acting antiviral drugs that each attack a different target necessary for virus replication.

Kowdley, director of the Liver Center of Excellence at Virginia Mason Medical Center in Seattle, said the trial also showed impressive results among patients who had failed to benefit from earlier therapy.
The cure rate after 12 weeks of treatment was 93 percent for those patients, called null responders, assessed both 12 weeks and 24 weeks after completion of their drug regimens.
AbbVie said the safety of the tested drugs was similar to that seen in results presented last year. Less-serious side effects seen in more than 10 percent of patients included headache, fatigue, nausea, insomnia and diarrhea. This journal is a member of and subscribes to the principles of the Committee on Publication Ethics. A new treatment for hepatitis C "cured" 90% of patients with the infection in 12 weeks, scientists said. It is passed on by the blood, or bodily fluids of an infected person, and can be transferred through tattoo needles, or people taking drugs and sharing needles. The study worked for patients with genotype 1 infections, which account for 45% of infections in the UK.
The UK is set to send a Royal Navy warship to the Mediterranean to help tackle arms smuggling in Libya, Prime Minister David Cameron announces. It should be kept in mind regarding diagnosis of hepatitis C that this test is not a part of routine physical examination and people should ask the doctor for hepatitis C test, if better hepatitis C treatment is required. Analysts see the Gilead drug winning regulatory approval as early as 2014, with AbbVie close behind. Several companies are working to eliminate infusions of difficult-to-tolerate interferon from the regimen, while raising cure rates and shortening the length of treatment. AbbVie said it is testing regimens with fewer drugs and ones that do not include the older oral drug ribavirin, which can also be difficult for some patients to tolerate.
Its program is behind those of Gilead and AbbVie, but cure rates in excess of 90 percent and a relatively clean safety profile are expected to make it a formidable player in the field. The drugs were the protease inhibitor ABT-450, whose effect was boosted by a widely used antiviral called ritonavir; the polymerase inhibitor ABT-333, and ABT-267 from a class known as NS5A inhibitors. In addition, data showed a cure rate of 95 percent for patients treated for 24 weeks, and then assessed 24 weeks after treatment stopped.

Of the 247 patients evaluated, serious side effects were seen in four patients (1.6 percent), while seven patients had elevated levels of liver enzymes that can be considered a potential sign of toxicity. Researchers at the University of Texas Health Science Centre tested the new oral drug in 380 patients at 78 centres in Spain, Germany, England and the US in 2013. In case if the initial test is found to be positive, a second test is referred to confirm the diagnosis of hepatitis C and liver enzymes.
A liver biopsy is done to identify the degree and type of liver damage and for less complication in the hepatitis C treatment. The side affects were fatigue, headaches and nausea.Political will neededCurrent treatment for hepatitis C can include a year's worth of injections and involve side-effects such as depression, tiredness and feeling sick. There is a new treatment for hepatitis C which includes a longer acting form of interferon which cures more patients having fewer side effects. Gkikas Magiorkinis, consultant physician in medical virology at the University of Oxford, said treating the patients with cirrhosis was a "major breakthrough". Concerns over the high toxicity and low efficiency of current treatment had meant it was not widely been applied. Efficacy data and FDA labeling for this population is based solely on mathematical modeling. Whether or not the treatment prevented further transmission in the public was also yet to be seen, he added.
We suddenly have the opportunity to eliminate the virus in the UK - even without a vaccine."Mr Gore said whether or not the disease could be eliminated would be down to political will, which he said was lacking in the UK. He said although the study involved genotype 1, treatments for genotypes 2 and 3 were "close behind", he said.

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