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This section focuses on conventional HCV treatment with the current standard of care, which is a combination of pegylated interferon and ribavirin.
Lifestyle-related choices that help your liver are covered later in the section "Living with coinfection". Interferon is a man-made version of a chemical made by the human body that works against HCV in two ways. Use of full or reduced dose pegylated interferon as a maintenance therapy in people who did not clear their hepatitis C with treatment, did not reduce the risk for liver disease progression.
SVR reduces the risk of liver cirrhosis, liver cancer and liver failure for HIV negative and HIV positive people.
For HIV-positive people, there may be an additional benefit from HCV treatment in reducing the risk of liver-related side effects from HIV drugs. SVR-12 is used in research, meaning that a person is still undetectable 12 weeks after finishing treatment. People with a history of depression are more likely to develop depression during HCV treatment.
Some people can manage HCV treatment while they are using drugs; others have found that stopping or cutting down on drug use has helped them to prepare for, and stay on HCV treatment.
If you are still injecting drugs, ask your doctor or local syringe exchange programme for information on safer injection to lower your risk of HCV reinfection (and other infections). If you did not respond to treatment with the older non-peglated formulations of interferon, which was much less effective, you should consider retreating with pegylated interferon. Some of the new oral hepatitis C drugs are being studied in people who were unsuccessfully treated for hepatitis C. The Body is a service of Remedy Health Media, LLC, 750 3rd Avenue, 6th Floor, New York, NY 10017. Over the past few years, enormous strides have been made in treatment options for people living with hepatitis C, a form of viral hepatitis that causes chronic liver disease. The hepatitis C virus (HCV) is usually transmitted through infected blood, but can also be spread by having unprotected sex. In the past, the go-to medication for physicians treating patients with HCV was pegylated interferon together with ribavirin, or combination antiviral therapy. Most often, treatment was reserved for severe cases involving the patients who were most likely to develop cirrhosis, met other laboratory criteria via blood tests, and were likely to adhere to treatment requirements. The past few years have introduced protease inhibitors, drugs designed to prevent the virus from multiplying.
The newest treatment developments include using drugs like simepravir and sofosbuvir to reach SVR, often without the need for interferon or ribavirin.
The New York State Department of Health (NYSDOH) offers numerous resources for individuals who would like to be screened for HCV either via a rapid test (similar to rapid HIV testing) or through more traditional laboratory techniques. As with any medical screening, be prepared for positive or negative results and be familiar with follow-up activities, which might include meeting with a physician, answering questions about alcohol use and drug history, and medical monitoring. This entry was posted in LGBT Health, Men's Health, Sexual Health, Women's Health and tagged hcv, hepatitis c, ledipasvir, pegylated interferon, ribavirin, simepravir, sofobuvir, svr. About UsPerspectives on health care and wellness from the experts of the Mount Sinai Health System.
Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. We offer Hepatitis C treatment which is based on herbal formulations which provide quick relief to a person suffering from Chronic Hepatitis C Virus and inhibits the spread of viruses. Clipping is a handy way to collect and organize the most important slides from a presentation.
ATLANTA – In what is being hailed as a “landmark shift in the treatment of Hepatitis C,” the Food and Drug Administration has approved two new drugs to treat—and cure—Hepatitis C (HCV) in most patients.


Globally there is roughly five times the number of people with Hepatitis C as HIV, with the World Health Organization estimating that 150 million people have the disease. Previous medicines treating the disease required pills as well as weekly injections, which are infamous for causing severe flu-like side-effects, as well as anemia and depression. Genotype 1, roughly 70% of Hepatitis C cases in the United States, will still require the interferon shots. For genotypes 2 and 3, 20-25% of American cases, use of Sovaldi will constitute the first all-oral treatment for HCV and will take 12 and 24 weeks, respectively, to cure.
Clinical trial results are expected to be released shortly, and, barring negative outcomes, Sovaldi could become available by the end of 2014. As many as 3.3 million Americans are infected with Hepatitis C, with “baby boomers” thought to have the highest rate of infection. Transmission of HCV is through blood contact, mostly by needles during intravenous drug use, blood transfusions, and more rarely through sexual contact and unsterile tattooing. Experts point out that innovations in HCV treatment do nothing if the drugs do not reach the people who need them. Roughly 80% of people with acute HCV are asymptomatic, but the disease can lead to severe liver disease in 10-20% of infected people. Experts fear that the high cost of the new drugs could be cripplingly high for those suffering in the developing world. Initiative for Medicines, Access & Knowledge (I-MAK), an American patient rights group, reports that it is pursuing action to block Sovaldi’s creator Gilead Sciences’ bid for a patent on the drug in India.
Andrew Hill, a pharmacologist at Liverpool University, published a study that shows that generic Sovaldi can be made for between $62 and $134 for the 12-week treatment. Some analysts predict that Sovaldi will become one of the top-selling drugs globally, with sales potentially reaching over $100 billion in the next 10 years.
Most people who have had an SVR stay free of HCV, although there are less long-term results in HIV-positive people. Therefore, maintenance therapy is no longer recommended for people with hepatitis C, regardless of their HIV status. If HCV viral load is undetectable, it is a good indication of continuing to have an SVR later. This could be from a self-help programme, counselling, drug treatment, or heroin substitution, methadone maintenance, naltrexone implants, or using buprenorphine. Based on the experience with HIV, it may be better to wait until there is more than one new HCV drug to add to a regimen that didn't work before. The Body and its logos are trademarks of Remedy Health Media, LLC, and its subsidiaries, which owns the copyright of The Body's homepage, topic pages, page designs and HTML code. Treatments in the past were difficult to tolerate, produced numerous side effects, and for a large percentage of patients, were often unsuccessful.
The World Health Organization estimates that 130-150 million people worldwide are living with HCV, and according to the Centers for Disease Control and Prevention, approximately 3.2 million Americans have chronic HCV infection. Even if someone is asymptomatic (showing no symptoms), he or she can still transmit the virus to others. This therapy was administered in the hopes of achieving a sustained virologic response (SVR), essentially pushing the amount of virus in a person’s body to undetectable levels, thereby limiting further damage to the liver and improving health outcomes.
Another consideration was the genetic type of the virus, or genotype, as some genotypes are more easily treated than others.
Telapravir and bocepravir were taken orally in combination with interferon and ribavirin, a treatment known as triple therapy. People who have a confirmed HCV infection and would like to learn about their treatment options and get connected to care can do so at the NYSDOH website. Getting screened and knowing your HCV status can also help you make lifestyle changes that could improve your health and prolong the time before you need to explore treatment.


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The newest drug, Sovaldi, is thought to have no side effects, work in a shorter amount of time, and be more effective than other Hepatitis C medicines.
Sovaldi allows some patients with HCV to treat their illness with just pills, eliminating side effects completely. The cure rates associated with Sovaldi are much better at roughly 80%, depending on the genotype of the disease. However, treatment time will be 12 weeks rather than the previous 24-48 weeks, and the cure rate is 90% for the newly treated.
This is due to previous drug use and exposure in medical settings before testing for the virus was common practice. More than 10% of the population has chronic HCV due to early and widespread use of improperly sterilized needles from Egyptian Public Health efforts. John Ward, the director of the Division of Viral Hepatitis at the Centers for Disease Control, asserts, “The potential of these and other treatment advances hinges entirely on our ability to get more people screened and into care. The wholesale cost of Sovaldi would be $1,000 per daily pill, putting the full treatment at a cost of $84,000 for most patients and $168,000 for those needing 24 weeks of treatment.
The country is known as the “pharmacy of the world” for their strict patent laws and a strong industry of generic medicines.
David Thomas, liver specialist at Johns Hopkins University, citing the importance of the interferon-free drug says, “[It’s] about as hot as I’ve ever seen…it’s the kind of thing where we did something that didn’t work that much and hurt people a lot. Although some recent research has found very low levels of hepatitis C in the blood and liver tissue of some people with a sustained virological response, this may not have any significant effect on liver health. However, RVR is not good at predicting who is unlikely to respond, so treatment should not be stopped if there is no RVR. Visit HIV i-Base's website to find out more about their activities, publications and services. General Disclaimer: The Body is designed for educational purposes only and is not engaged in rendering medical advice or professional services. Promising new drugs, however, will likely reduce the burden of treatment (the work patients do to care for themselves, such as visiting the doctor or going for medical tests), produce quicker results, and cause fewer and less profound side effects. The interferon-based therapy had numerous and sometimes intense side effects, was administered from 6 months to one year, and sometimes did not even work for certain patients after treatment had ended. While these drugs resulted in improved success rates, they also, according to many sources, were underutilized by providers and still required the use of pegylated interferon and ribavirin.
Speaking with your current doctor is also a good way to obtain a referral to a provider specializing in HCV treatments.
These growing options for HCV treatment have made it easier for providers and patients to collaborate and achieve the healthiest and most promising results. The information provided through The Body should not be used for diagnosing or treating a health problem or a disease. These liver problems, in turn, can significantly affect other aspects of a person’s health. The hope is that this combination pill will allow patients to reach SVR sooner and with fewer side effects along the way. This means you only need to inject once a week, and makes it more effective at treating HCV. There is much enthusiasm behind this new drug treatment, accompanied by strong worries about its access and affordability, as one complete treatment to achieve SVR could reach nearly $100,000 per patient.



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