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December 14, 2013 By Belinda Medical researchers have been searching for years for an effective HSV-2 vaccine, but up until now every trial has failed to live up to the early hopes. However, a new HSV-2 vaccine is now in the early stages of human clinical trials, and researchers are once again hopeful they may have a winner. However, the success of vaccines for chickenpox and shingles, which are caused by a related herpes virus known as varicella-zoster virus, suggests that a vaccine for HSV-2 should be possible. According to the Centers for Disease Control and Prevention (CDC), at least 45 million people ages 12 and older in the United States, or one in six adolescents and adults, have genital herpes.
Herpes is unpleasant enough by itself a€“ but even worse, public health officials have discovered that those infected with HSV-2 are more likely to become infected with HIV too a€“ and become carriers of both diseases. The vaccine against chickenpox uses a live, weakened version of the virus which is injected into a persona€™s body to stimulate an immune response, but this may not be the most appropriate way to develop an effective HSV-2 vaccine. One vaccine was promising enough to proceed to full clinical tests.A But in a randomized, double-blind clinical trial involving 8,323 women, the vaccine did not prevent infection by HSV-2 a€” although it did offer some protection against a closely related virus, HSV-1. The National Institute of Health (NIH) is about to begin an investigative clinical trial of a newly developed HSV-2 vaccine. An effective HSV-2 vaccine would be great news from a public health point of view, and for those who are most at risk of getting infected (those who are most sexually active, with multiple partners).
But it does nothing to help those who have already been infecteda€¦ or for those who might be monogamous, but with a partner who isn't. Highly recommended for anyone who wants a complete holistic protocolA to reduce orA stop outbreaks completely. DISCLAIMER: The information contained in this Website is provided for general informational purposes only. Where names have been used on this website, these should be considered as pen names of real people which have been changed to protect privacy unless otherwise stated. Researchers have identified a subtype of immune cells that suppress outbreaks of genital herpes caused by the herpes simplex virus type 2 (HSV-2).
The discovery could lead to a vaccine capable of preventing herpes lesions on people who have already contracted the STI – or in other words, a vaccine that could “clinically cure” an individual of herpes symptoms. Researchers had originally estimated that herpes reactivated once a month, but the discovery of these ever-present T-cells led Corey and his team to believe the virus actually reactivates once a week or every few days. According to the Centers for Disease Control and Prevention, 776,000 people in the United States are infected with herpes each year, and one out of six people between the ages of 14 and 49 have genital HSV-2 infection. I am sure one day the amount of over-the-counter drugs available will put the condom industry out of business.


Initial, positive results have been reported for a therapeutic vaccine candidate for treating patients with genital herpes.
T cells, a type of white blood cells, generate immune responses to pathogens and are important in controlling infections.
Wald and her team presented the initial findings of the first-in-human clinical trial of the novel GEN-003 T cell vaccine Sept. Genocea plans to move into Phase 2 of this trial in 2014 to further evaluate GEN 003’s safety and effectiveness in a larger group of patients. At unpredictable times in those carrying the infection, the herpes virus will come out of hiding and  surface on the genitals, sometimes producing blisters and discomfort, and sometimes arising without any noticeable symptoms.  This surfacing is called viral shedding. The results also demonstrated that immunization with GEN-003 is associated with activation of T cell immunity.
The first-in-human clinical trial was not designed to test whether GEN-003 lessens symptoms or lowers how often a breakout occurs. Genocea developed the proprietary platform ATLAS, which can identify protective T cell antigens in people exposed to a pathogen.
The vaccine contains, among other components, a proprietary adjuvant, trademarked Matrix-M.
The herpes virus has the ability to go dormant a€“ which happens when it is attacked by antibodies a€“ and while dormant it is effectively in stealth mode, and doesn't produce the proteins that signal its presence. They estimate that annually, 776,000 people in the United States get new herpes infections. This early trial is only to investigate the vaccine's safety, and so it is being tested at this stage only on those already infected by herpes simplex 1 or herpes simplex 2.
All images displayed on this website should be considered as stock photos used for illustration purposes and to protect privacy unless stated otherwise.
While this vaccine would not cure those of HSV-2, it could ultimately help stop the spread of this very prevalent STI. This first-in-class, investigational, protein subunit vaccine, GEN-003, is under development by Genocea Biosciences Inc. Anna Wald, University of Washington professor of medicine and laboratory medicine in the School of Medicine and professor of epidemiology in the School of Public Health, is among those leading clinical studies of GEN-003. David Koelle’s lab in the Division of Allergy and Infectious Diseases, Department of Medicine.
T cell vaccine research is trying to find safe, effective ways to spur this protective reaction.


12 at a session of the Interscience Conference on Antimicrobials Agents and Chemotherapy in Denver. The infection can provoke recurring episodes of painful genital sores.  An estimated 50 million to 60 million Americans are affected. In those receiving the vaccine candidate, T cell immune responses increased more than 20 times to one vaccine antigen and more than 10 times to another antigen.  The vaccine candidate also increased neutralizing antibodies to the herpes simplex 2 by five times greater than baseline amounts.
However, an exploratory analysis suggested that the interval between the first immunization with GEN-003 and the next recurrence of genital herpes might be longer in those receiving the actual candidate vaccine, rather than the placebo injection. Wald is enrolling women infected with herpes simplex virus 2 in a study to see whether the drug tenofovir, given orally or as a vaginal gel, reduces genital shedding of the virus. Not only that, but it hides out in your nervous system a€“ where antibodies can't get at the virus.
The virus is transmitted almost exclusively through sexual contact, though pregnant women with herpes outbreaks can also infect their babies during delivery. The information may not apply to you and before you use any of the information provided in the site, you should contact a qualified medical or other appropriate professional. Genocea, located near Boston, is a clinical-stage biopharmaceutical company for the discovery and development of T cell vaccines to prevent and treat infectious diseases.
Viral shedding is a marker both of the risk of recurrence and the transmission of infection. The adjuvant has a product that, in previous clinical studies, has been shown to stimulate B and T cell immune responses. Reducing the frequency of viral shedding is the first step to showing that a drug can reduce outbreaks or, potentially, sexual transmission to partners. To add to this, HSV-2 interferes with the activity of antibodies, T cells, and other major components of the immune system. You should assume unless specifically stated otherwise that the owners of this website may be compensated for purchases of products or services mentioned on this website. Tenofovir has been shown in some studies to reduce the risk of acquiring HIV, and in some studies there was also a reduction in the frequency of HSV-2 acquisition, but this is the first time that it is being tested as a drug specifically for HSV-2. Under the HoodBehavior, Neuroscience & Your Brain What Brain Hacks Can Psychologists Teach Us?



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