The boom in ebook publishing means that the days of sending your manuscript to a literary agent and waiting weeks to hear whether it has made it through the slush pile are long gone.
Today, more and more writers are opting to go down the self-publishing route, giving them greater control over their work and immediate access to millions of potential readers via platforms such as Amazon’s CreateSpace. Whether you are aiming for your novel, novella or non-fiction book to be a bestseller, promote your business, or are self-publishing to provide a lasting memento for friends and family, it is important to send your paperback, hardback or ebook into the world in the best possible shape.
Attempting to edit your book yourself, running it through a computer spell check, or giving it to a friend or family member to read through is no substitute for the assistance of a professional freelance editor. We also work with a talented team of tried and tested industry professionals who can assist you with all the other essential aspects of self-publishing a book. Danielle Wrate, the creative mind behind Wrate’s Editing Services, has a background in national journalism and works as a freelance editor and writer. News digest – Rising womb cancer rates, gene editing immune cells, missed waiting time targets and… ‘good’ bacteria? A cancer patient in Cambridge became the first in Europe to be scanned with a new bit of tech that could help show whether cancer drugs are working or not. Our scientists in London showed how gene editing technology could be used to engineer better cancer-targeting immune cells. As our graphic below shows, new monthly figures revealed that the 62 day cancer waiting time target in England has been missed again, continuing a worrying trend that now spans over two years. The way that plants make certain molecules came under the spotlight, with some making a bit of a leap in connecting this to developing new cancer drugs. The latest monthly percentage of people in England who started their cancer treatment within 62 days of being diagnosed – the target is 85 per cent. A new US report raised the issue of taking aspirin regularly to prevent bowel cancer, among other conditions. Cancer cells can corrupt nearby healthy neighbours in order to grow and spread, according to a new study we part-funded.
A new report highlighted that smoking is the biggest contributing factor to why people with mental health issues have an average lifespan between 10 and 20 years shorter than the general population. The first ever live stream of cancer surgery hit virtual reality headsets this week from a London hospital.
The tech billionaire behind Napster, Sean Parker, gave $250 million to research into cancer immunotherapy. The world’s largest medical imaging study launched this week, with plans to scan 100,000 Britons in a drive to better understand many different health conditions including cancer.
This article in The Conversation looks at the challenges of long term side effects among children treated for cancer.
US research showed that different types of bacteria in the gut slowed the development of cancer in mice predisposed to certain tumours. Text from Cancer Research UK Science blog by Cancer Research UK, is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike License. Cancer Research UK is a registered charity in England and Wales (1089464), Scotland (SC041666) and the Isle of Man (1103). The ability to precisely and accurately change almost any part of any genome, even in complex species such as humans, may soon become a reality through genome editing. Although genetic engineering techniques have been around for some time, genome editing can achieve this with lower error rates, more simply and cheaply than ever a€“ although the technology is certainly not yet perfect.


Genome editing offers a greater degree of control and precision in how specific DNA sequences are changed.
CRISPR has prompted recent calls for a genome editing moratorium from a group of concerned US academics. Ethical concerns over genetic modification are not new, particularly when it comes to humans. First, there is no clear consensus as to whether genome editing is just an incremental step forward, or whether it represents a disruptive technology capable of overthrowing the current orthodoxy. Second, there are significant ethical concerns over the potential scope and scale of genome editing modifications.
Should we reach this tipping point, we will have to revisit the conclusions of the first few decades of the genetic modification debate. While this may mean weighing up potential benefits, risks and harms, as the potential applications of genome editing are so broad even this sort of assessment isn't straightforward. Genome editing techniques have so far been used to change genomes in individual cells and in entire (non-human) organisms. Genome editing potentially changes this, presenting us with the very real possibility that any aspect of the human genome could be manipulated as we desire. The concern prompting the US academics' call for a moratorium is the potential for altering the human germ-line, making gene alterations inheritable by our children. Nevertheless, even if changes to the germ-line turn out to be safe, the underlying ethical concerns of scope and scale that genome editing brings will remain. No longer viewed as a vanity exercise, indie publishing is now an accepted, and often lucrative, arm of the book industry. You may well have a great story to tell, but if your book is littered with typos, grammatical errors, poorly constructed sentences and inconsistencies, your story will fall flat and your readers will lose interest. See our prices page for an outline of the different services we offer, and decide which one will suit you best. We understand that authors’ requirements differ as much as their writing styles and subject matters, but no matter what type of extra help you require, we can oversee the project, saving you the headache of having to deal with multiple organisations and people.
Her years spent working to tight deadlines and word counts means that she has an excellent eye for detail and knows how to make every sentence matter. A team of our scientists, also funded by the Wellcome Trust, helped develop the approach, which was picked up by the BBC. And with virtual reality and precision diagnosis in the mix, they make for exciting reading. STAT News has the story, but it’s important to remember that aspirin has risks as well as benefits – so speak to your GP if you’re thinking of taking it regularly. Wired and the Washington Post have the details, and STAT News posed some important questions. But it’s still very early days, so it doesn’t mean you should neck loads of yoghurt drinks, despite what certain news outlets reported by linking ‘good’ bacteria to preventing cancer.
But with great power comes great responsibility a€“ and few subjects elicit such heated debates about moral rights and wrongs. Because it is the easiest technique to set up and so could be quickly and widely adopted, the fear is that it may be put into use far too soon a€“ outstripping our understanding of its safety implications and preventing any opportunity to think about how such powerful tools should be controlled.
While we don't think genome editing gives rise to any completely new ethical concerns, there is more to gene editing than just genetic modification.


If this is the case a€“ and it's a very real prospect a€“ then we will need to carefully consider genome editing's ethical implications, including whether current regulation is adequate. Currently modifying plants, some animals, and non-inheritable cells in humans is allowed under strict controls. Benefits have included better targeted gene therapy in animal models of some diseases, such as Duchenne Muscular Dystrophy. While this has been the basis for many works of fiction, in real life our capacity to provide the sort of genetic engineering seen in films and books such as Gattaca and Brave New World has been substantially limited. This could mean eliminating harmful genetic conditions, or enhancing traits deemed advantageous, such as resistance to diseases. Gene therapies that produce non-inheritable changes in a person's genome are ethically accepted, in part because there is no risk for the next generation if things go wrong.
If a technique can be used widely and efficiently, without careful oversight governing its use, it can readily become a new norm or an expectation. Although this gives authors immense creative freedom, one obvious pitfall is that they don’t benefit from the editing support of those with the backing of a publishing house. She also has contacts with major national newspapers and magazines and is happy to share her knowledge of the media industry (with no extra charge) to help you publicise your book and attract more readers.
We also highlight other relevant material, debunk myths and media scares, and provide links to other helpful resources.
There are a variety of techniques but clustered regularly inter-spaced short palindromic repeats, or CRISPR, is perhaps the foremost.
Our consideration of a technology that is rarely used and then only in specific cases will differ from one that is widely used and put to all sorts of uses. But modifications that alter the human germ-line are not allowed, with the exception of the recent decision in the UK to allow mitochondrial replacement.
It's also hoped that it will lead to a better understanding of the structure, function and regulation of genes. But this ability may also open the door to eugenics, where those with access to the technology could select for future generations based on traits considered merely desirable: eye, skin or hair colour, or height. However to date only one disease a€“ severe combined immunodeficiency a€“ has been cured by this therapy.
Of course the flip-side is that, if carried out safely and as intended, germ-line alterations could also provide potentially permanent solutions to genetic diseases. Those unable to access the desired genetic alterations, be they humans with diseases, humans without enhanced genetic characteristics, or farmers without genetically modified animals or crops, may all find themselves gravely and unfairly disadvantaged.
This is where we come in, offering a range of low cost, professional editing services tailored to meet individual needs.
The BBC and Guardian were among those who covered the story, and we had this guest blog post from Kath, who had womb cancer, on how she’s made changes to live a healthier life. Genetic modification through genome editing of plants has already created herbicide- and infection-resistant crops.



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