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Author: admin | 11.03.2016 | Category: Ear Drops For Tinnitus

The Heart of the Matter: What Does America Really Know about Coronary Artery Disease Treatments? Just click the button below to get started, it takes less than 5 minutes to register and be online.
We provide you with a full web hosting account and the latest versions of PHP, MySQL, and cPanel. Sign up for free from our main website, no strings attached, no billing information needed. How does a three-pound mass of wet gray tissue (the brain) succeed in representing the external world so beautifully? Yes, and in order to predict you have to have, at the very least, a simple image inside that tells you something about the purpose of the outside world. This colored scanning electron micrograph shows the synapses, or connections, between two nerve fibers (in purple) and a nerve cell (yellow).
Our experience of a bird is made up of many different sensory inputs, including color, sound, smell, and touch. The other thing that can happen is that deep in the brain there is a structure called the thalamus. So externally they'll look like the same problem, or for the person they will feel like the same problem? The cortex, also known as "gray matter," is a thickly folded band of tissue responsible for higher mental functions. If the thalamus and the cortex weren't able to "bind" all these different sensory inputs, what would the world look like? If the thalamus is so important in maintaining consciousness, can you trace specific psychiatric or neurological disorders to problems in the thalamus? This is a beautiful story that is just beginning to be understood now because it is such a different point of view. Do you think that someday you might be able to insert electrodes in the appropriate part of the brain to solve all these different problems? Well, hopefully it is only a temporary solution while we think of better ways to solve the rhythm problem. Most people, it seems, don't view the brain as electric—they view it as a big gland secreting neurotransmitters. Dopamine and serotonin work by modifying directly and indirectly the electrical activity of neurons. What other diseases might involve this timing problem, or lack of rhythm, between the thalamus and the cortex? We think that this thalamo-cortical dysrhythmia is responsible for some types of epilepsy, Parkinson's, depression, obsessive-compulsive disorder, some aspects of schizophrenia, central pain, and tinnitus. You can either put the patients in an instrument, like an EEG [electroencephalogram], or better an MEG [magnetoencephalograph], or else you can put electrodes in the thalamus during surgery and see abnormal activity. During an EEG, electrodes are placed on the scalp to detect electrical impulses within the brain.
Supporters of biofeedback therapy have cited your work as support for their theories of why biofeedback could work in treating epilepsy. Not at the moment, but rational drug development in neuropharmacology will result in some, at some point in the near future. So what is coming out of this research is not necessarily pacemakers for the brain but more targeted drugs? What do you think about this work that has come out recently that suggests that the brain is always generating new neurons? Do you find, spending so much time thinking about how the brain thinks, that it's hard, even when you're not at work, to stop thinking about how how your brain thinks? Even so-called "mild" head injuries can lead to serious concussions with long-term consequences. National corporate funding for NOVA is provided by Google and Cancer Treatment Centers of America.
In this interview with noted neuroscientist Rodolfo LliníA?s of the New York University School of Medicine, find out how the rhythm of electrical oscillations in the brain gives rise to consciousness, and how failures in this rhythm can lead to a variety of brain disorders. The nervous system is about 550 million years old, and it first came about when cells decided to make animals. So if you happen to be a plant you have to worry only about the very small space you grow into. I think consciousness is the sum of perceptions, which you must put together as a single event. It is a long and very distinguished group of cells—about 550 million years or so old. They respond to one another's messages, so they basically chat all day, like people do in society.


Imagine many cells making an activity circle, with electrical activity going around and around like a windmill. One of the ways we can attempt to understand how it happens is by studying people who have mental or neurological problems.
Even a neurologist cannot tell the difference, so he or she will have to do an MRI to see where the lesion is, either cortical or thalamic. It is connected to the thalamus, shown here in green, an older structure in the center of the brain. It would be a hodgepodge of things, like when people drink too much and get into problems of timing and cannot move properly or think properly and see things that might not be the way things actually are.
They move, they oscillate, like the waves in the ocean at a certain speed, a certain velocity, a certain frequency. That's how cells control consciousness—by voltage, by becoming electrically inactive or active. Because of these rhythms, which are known to be related to the sleep-waking cycle and which we have been studying since the beginning of the last century, we ask certain questions. And if that is the case then if you wake up the appropriate part of the thalamus this problem should disappear.
You can see how when the person is stimulated the results are immediate and the person begins to function. So what happens if something like this happens in a part of the brain that feels pain—the cingular cortex?
So that if you have an imbalance of serotonin you might have depression, or if you don't have enough dopamine, you have another problem—Parkinson's. Forty hertz [number of cycles per second], or beta gamma band activity, as it's known, is not as well organized with age. Each animal has a different universe—the universe it sees, the universe it feels, the universe it tastes. I seriously believe that consciousness does not belong only to humans; it belongs to probably all forms of life that have a nervous system.
Imagine that out of this circle come a few cells into the center and perform a particular dance that the other cells see but are not necessarily part of. As the nervous system gets more complex in higher animals there's another totally astounding property, which is the ability of the nervous system to invent things inside the head, which it can then make into reality.
Someone with a lesion on his or her visual cortex would be able to hear and feel and move but would not be able to see, so you know that he or she injured the conscious component that sees but not the other conscious components. If the part of the thalamus that connects to the visual cortex is damaged then you don't see. Rhythm tells you when to move and at what speed to move, whether you are dancing a waltz or doing the cha-cha. If you take a drug, if you fall asleep, if you get hit in the head, the brain does not generate the functional state that is you.
I ask, for example, isn't it incredible that we fall asleep as a single entity and then wake up as a single entity?
If you put an electrode in the part of the thalamus that polarizes it, this problem should immediately disappear.
You are bringing the circuit back into the correct timing by either returning the cells to their correct rhythm or by taking them out of the loop.
These are molecular problems, and we are attacking them with spoon- or toothpick-sized tools. A paralyzed leg is a big problem, but worse than a paralyzed leg is one that moves in the wrong direction or at the wrong time. Esthetically the brain has been beautifully assembled by evolution, and it's also, fundamentally, about the nature of our own existence. They don't need a nervous system because they don't move actively, they don't pull up their roots and run in a forest fire! And you're following the sun anyhow, so there is no planned movement, and therefore there is no necessity to predict what is going to happen if, which is what the nervous system seems to be about. Earth probably looks very different not only for all of us as individual humans, but also for different animals.
Our brain is about one-and-a-half liters, or three pounds, but it has 1010 cells, which is a huge number of cells. And the dialogue is not between one cell and another cell, but rather between many cells and many other cells.
They generate this electrical dance at a given frequency because they have similar rhythms—they hum in unison. Now these cells that do this particular dance may be cells that have learned something from the outside that they want to put in the context of whatever else is happening in the nervous system.
If you are asleep but dreaming then the brain makes another dance during which you exist but you don't care about the external world.


Consciousness can be damaged at the cortex, at the thalamus, or at the connections between the thalamus and the cortex. For instance, some dyslexic children have binding problems and so their timing is slightly off, they think a little slower. So if we put a local anaesthetic in someone's visual cortex, although we are not damaging the brain or changing the synapses or the neurons, the neurons are now not capable of having electrical activity. Like when you lose an arm but the hand that should be there hurts, you have a phantom limb. What happens then is that the thalamus becomes hyperpolarized and starts firing continuously. The best way to correct these things is with specialized designer drugs that would go to specific cells and change the properties. So people don't hear so well, they have a little ringing in the ears, and they don't see so well. Anything that moves actively requires a nervous system; otherwise it would come to a quick death. It's like having a huge number of people holding hands, dancing together, making ever-changing circles and organized together in such a way that every cell belongs, at some time, to some circle.
But as in the case of choirs and dancing, you can have two groups doing different things at the same time.
You can exist on your own with dreams, hallucinations, or deep thoughts, or you can relate to the outside world. These two levels are organized as a feedback system in which the thalamus speaks to the cortex and vice versa in a dialogue. When they did a brain scan they found that she had a bilateral lesion on the temporal lobe.
To them everyday events happen a bit too fast for them, a bit like action movies, so they have problems following fast events or reading or even hearing the sounds of words properly. In order to bind things many parts of the brain must fire and be active together, and they must have a rhythmicity. In the case of Parkinson's, dopamine goes down, and then the thalamus begins to oscillate, and you get tremors and paralysis. Most of the nerve cells are as old as we are, and they have known one another for as long, so they have established their connectivity—they have a common history. Now imagine that each group doing something represents an aspect of an external event, like a color.
When new information from the outside comes in it has to be put into context with whatever else was happening just before. The problem was that she couldn't see things that were in motion, so things were continually appearing and disappearing. Cells are negatively charged; they are negative with respect to the outside world, by about 60 to 70 millivolts. What you would expect to happen happens—the edge effect now produces a sound, rather than a tremor. A 25-year-old is agile, intelligent, sees things better, and can memorize and remember better. This is basically what consciousness is about—putting all this relevant stuff there is outside one's head inside, making an image with it, and deciding what to do.
The visual cortex has one function, the frontal lobes have another function, the auditory system has yet another function. If she had to cross the street she would be terrified because she wouldn't see cars coming.
If the membrane potential, the voltage across the membrane of the cells, is modified so it becomes a little less negative, the rhythm of the cells changes. There is friction between neighboring areas, one of which is asleep and one of which is awake. There are bad side effects to neurosurgery too and to having cables coming out of your head. He has the disadvantage of not having experience, hence the saying, "if only the young knew or the old could." The young don't know but they can and the old know but they can't. And yet when we look at the external world we see things as having properties that are inseparable from the object itself. So there are a whole lot of psychiatric and neurological problems that might be related to a thalamo-cortical dysrhythmia. We came to the conclusion that in Parkinson's the inability to move in a coordinated manner was created by the fact that the frequency of oscillations did not allow for generation of proper movement orders to the muscles.



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