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08.07.2014
Legal stuffNorth Texas Kids is dedicated to bringing you the best in parenting resources in the North Texas area. Among overweight and obese patients with type 2 diabetes, daily injection of the diabetes drug liraglutide with a modified insulin pen device, in addition to diet and exercise, resulted in greater weight loss over 56 weeks compared with placebo, according to a study in the August 18 issue of JAMA. The Food and Drug Administration has approved a Novo Nordisk diabetes drug as a treatment for obesity.
Obesity guidelines recommend an initial weight loss goal of 5 to 10% of start weight to improve health.
Liraglutide, an injectable diabetes drug that US regulators approved last year for weight loss, helped obese people lose an average of 18 pounds (eight kilograms), a yearlong study said Wednesday.
A new study from Newcastle University has shown that people who reverse their diabetes and then keep their weight down remain free of diabetes. In patients suffering from Type 1 diabetes, the immune system attacks the pancreas, eventually leaving patients without the ability to naturally control blood sugar. A new research study has revealed an important relationship between proteins secreted by the heart and obesity, glucose intolerance, and insulin resistance. The FDA approved a new weight loss drug that many doctors consider the most effective therapy in a new generation of anti-obesity pills designed to help patients safely shed pounds.
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COMMENTEMAILMOREWith the arrival of a diet drug to pharmacies today, there are now two new prescription medications to treat obesity — the first new ones available to heavy patients in more than a decade.
Cari is a registered dietitian and previously served as Wellspring New York’s nutrition instructor during the 2006-2008 summer seasons. The majority have type 2 diabetes, and for them insulin resistance - their body's inability to effectively process sugar - is a part of daily life.
Image: Associated Press The Food and Drug Administration approved a new weight loss drug from Vivus Inc. The drugs offer to boost weight loss a modest 5% to 10%, but become another "tool in the toolbox" for physicians trying to help America out of its obesity crisis.Beginning today, Belviq (pronounced bel-VEEK) sold by Eisai, will start arriving in pharmacies. She graduated with honors from Miami University with a BA in psychology and a minor in nutrition and completed her dietetic coursework at NYU’s Steinhardt Graduate School before heading to the University of Houston for her dietetic internship.


Moderate weight loss (5 percent-10 percent) can improve glycemic control and other cardiometabolic risk factors and disorders.
A 12-week "off-drug" follow-up period was included to assess treatment-cessation effects (total study length, 68 weeks). It works on brain chemistry to create a feeling of fullness and can help obese patients lose an average of about 5% or so of their starting weight when used in combination with a reduced-calorie diet and exercise.The wholesale cost of a month's supply of Belviq to pharmacies is just under $200, says Gary Palmer, chief medical officer for Eisai. She has since worked in both clinical and corporate health environments, but has happily returned to Wellspring to serve as the Wisconsin Camp’s director. Weight loss is especially challenging for individuals with type 2 diabetes, who often experience a reduced response to weight-management pharmacotherapies compared with individuals without diabetes. The agency cleared the pill Qsymia for adults who are obese or overweight and have at least one weight-related condition such as high blood pressure, diabetes or high cholesterol. The price that patients will pay depends on their insurance coverage and may vary between pharmacies, he says. During the rest of the year she resides in Katy, Texas with her husband Dave and yellow lab Gabe. Participants were also instructed to follow a reduced-calorie diet and increase physical activity for weight management. Weight loss has also been observed with liraglutide at these doses, according to background information in the article.
Despite its impressive performance in clinical trials, Qsymia is not exactly a scientific breakthrough, and its development underscores the slow pace of research for obesity treatments. The drug is actually a combination of two older drugs that have long been known to help with weight loss: phentermine and topirimate. Phentermine is a stimulant that suppresses the appetite, and has long been used for short-term weight loss. Topiramate is an anticonvulsant, sold by Johnson & Johnson as Topamax, which makes people feel more satiated after eating. Researchers say the innovation of Qsymia lies in targeting multiple brain signals that drive people to overeat.
Qsymia is the second weight loss drug approved by the FDA in less than a month, following Arena Pharmaceutical’s pill Belviq in late June.


But a long line of prescription diet pills have been associated with dangerous side effects, particularly heart problems.
The cocktail of phentermine and fenfluramine was a popular weight loss combination prescribed by doctors, though it was never approved by the FDA.
In 2010, Abbott Laboratories withdrew its drug Meridia after a study showed it increased heart attack and stroke. The FDA’s successive approval of Qsymia and Belviq suggests a new willingness to make weight loss medications available, even in the face of lingering safety issues. The FDA initially rejected Vivus’ drug in 2010 over concerns that it can cause birth defects if taken by pregnant women. The agency laid out a risk-management plan specifically designed to minimize the chance of the women becoming pregnant while using the drug.
It recommends that women of childbearing age test negative for pregnancy before starting the drug and take a monthly pregnancy test while taking it.
The agency also says patients with recent or unstable heart disease or stroke aren’t good candidates for the drug because its effect on heart rates in those patients is not known. Analysts estimate the new pill could garner more than $1 billion in sales by 2016, though Mountain View, Calif.-based Vivus Inc. The pill will launch in the last quarter of the year with a relatively small sales force of 150 representatives.
Company executives say their initial marketing efforts will focus on obesity specialists, not general doctors. However, FDA regulators ordered the company to change the name to avoid potential confusion with similar sounding drugs. A third California drugmaker, Orexigen Therapeutics Inc., is still running clinical trials of its product, Contrave, and is working toward an FDA approval date in 2014.



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