Magnesium is present in all cells of the body and is involved in over 300 enzymatic processes, including energy production. Magnesium is one of the most common world-wide deficiencies and it plays a role in most of the common health struggles people face every day. We developed Brain Calm Magnesium in order to provide the best form of magnesium to improve brain function and neuronal health. Brain Calm Magnesium features key Albion forms of Magnesium (malate, lysinate & glycinate chelate) as well as magnesium L-threonate the only form of magnesium proven in animal studies to cross the blood-brain barrier.
Because many forms of magnesium have low bioavailability, we carefully selected magnesium compounds backed by research and studies to formulate Brain Calm Magnesium. One animal study showed that when the bioavailability of several magnesium compounds was compared to controls, only Magtein significantly enhanced magnesium bioavailability and produced a significant increase (7% to 15%) in rat cerebrospinal fluid.[2] These small but significant increases in brain magnesium levels produced profound effects on neurological function. Delving deeper into the mechanisms involved, later animal research showed that magnesium increased receptor signaling; specifically, the signaling of the NR2B-containing N-methyl-D-aspartate (NMDA) receptor. The benefits of Magtein were observed in several pre-clinical animal studies that used assessments, such as the NORT (novel object recognition test), T-maze, Morris water maze, conditioned fear memory, and conditioned taste aversion.
For instance, NORT tests performed by Slutsky et al revealed ?135% improvement in short-term memory and ?85% improvement in long-term memory of aged rats treated with Magtein as compared to control (untreated) rats. One study examined the effects of Magtein in test mice (genetically altered mice that model age-related cognitive changes).
Magnesium is known to benefit the body in ways that counter stress, promote restful sleep, and support a healthy mood. I use Brain Calm Magnesium on a daily basis myself during the daytime in order to improve my concentration and productivity. I use this product with clients that are struggling with memory, anxiety, sleep, mood issues and depression. Several studies indicate that synaptic connections in the brain hippocampus, a critical brain region for learning and memory, decline during the normal process of aging.

Warnings: If pregnant or nursing or taking medications, consult your healthcare practitioner before use. The DaSilva Institute is dedicated to discovering and implementing innovative approaches towards reversing the destructive processes of aging & chronic disease while restoring the body to its optimal health.
Take 2 capsules in the morning and 1 in the evening, with or without meals or as directed by your qualified health care consultant. If you have a medical condition, are pregnant, lactating, trying to conceive, under the age of 18, or taking medications, consult your health care practitioner before using this product. Magnesium is essential for maintaining normal bone density, normal cardiac rhythmicity, normal pulmonary function, and normal blood glucose regulation. Boosting the brain’s magnesium level is vital to healthy cognition, which includes long- and short-term memory, learning, stress management and sleep. This product features a unique combination of highly absorbable, organic Albion minerals—di-magnesium malate and magnesium lysinate glycinate chelate—and Magtein. The results, publication forthcoming, support the in vitro and animal findings that Magtein positively affects memory, cognition, and synapse density. I also take some at night and have noticed much deeper and more restorative sleeping patterns. I also use it for individuals with neurodegenerative issues such as dementia, Alzheimer’s and Parkinson’s. Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer’s disease mouse model. Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala. Enhancement of synaptic plasticity through chronically reduced Ca2+ flux during uncorrelated activity. Targeting the NMDA receptor subunit NR2B for treating or preventing age-related memory decline.

Chronic dietary magnesium-Lthreonate speeds extinction and reduces spontaneous recovery of a conditioned taste aversion. Antidepressant-like activity of magnesium in the chronic mild stress model in rats: alterations in the NMDA receptor subunits. Magnesium supplement enhances spatial-context pattern separation and prevents fear overgeneralization.
Oral Mg(2+) supplementation reverses agerelated neuroendocrine and sleep EEG changes in humans. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. Memory Boost Plus, which uses the unique, patented, chelated mineral Magtein™, contains magnesium which is chelated to threonic acid (magnesium L-threonate). Unlike other brain products on the market that work via brain stimulation (often overstimulation), Magtein works via a completely different mechanism. It is superior to other forms of magnesium at getting through the blood brain barrier because it is able to transport magnesium ions across lipid membranes, including those of brain cells. Magnesium is to the body like oil is to a car’s engine and if we are deficient problems will arise. Researchers at MIT concluded that elevating brain magnesium content via supplementation with Magtein™ may be a useful strategy to support cognitive abilities and decrease common age-related memory decline. Usual nutrient intakes from food and water compared to 1997 dietary reference intakes for vitamin D, calcium, phosphorus, and magnesium.

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