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admin | Herbal Remedies For Bv | 02.04.2015
While flipping through umpteen choices, she found her true love in writing and since then, it’s happily-ever-after! A recent groundbreaking study of clinical, histological and immunological data of 22 cases of  Pemphigus foliaceus, or PF, shows evidence that it can occur as an adverse drug reaction to the canine flea and tick preventive ProMeris. PF is the most common spontaneously occurring autoimmune skin disease of dogs and typically displays as lesions on the face, nasal planum and ears.
Ultimately, ProMeris Duo (Metaflumizone–amitraz ), which is also used for treating demodicosis, will be discontinued.
Olivry says this examination of all parameters studied suggests that this ADR might represent the first instance of contact drug-triggered PF to be published in Veterinary Dermatology. Spontaneously occurring PF, thought to develop through genetic and environmental triggers, has a higher prevalence in chow chows and Akita Inus, whereas ProMeris-triggered PF has a higher occurrence in Labrador retrievers and other large-breed dogs, Olivry says. The study found that ProMeris Duo-associated PF not only had a reaction to the same drug, but also shared many of the same phenotypes.
Skin biopsies from said PD-associated lesions had to reveal microscopic characteristics similar to those of PF, which means the presence of superficial keratinocyte acantholysis.


Olivry’s goal in revealing his study findings is to provide veterinarians with information on the prognosis and management of this disease. Metaflumizone-amitraz (Promeris)-associated pustular acantholytic dermatitis in 22 dogs: evidence suggests contact drug-triggered pemphigus foliaceus. Olivry recommends that veterinarians use alternatives to ProMeris in animals known to have autoimmune disease, Labradors and other large-breed dogs, as well as in dogs that previously developed lesions.
One of Olivry’s concerns with lesions occurring after ProMeris application is that primary care practitioners may not be able to identify or connect the product as a cause of the lesions and misdiagnose the patient, as in the case of the 7-year-old female Labrador.
Before ProMeris became available for veterinary purchase and distribution, studies evaluating its safety and efficacy reported the development of skin lesions at the site of drug application in some treated animals, Olivry says.
In another experimental study of dogs infested with either fleas or ticks, one dog treated with ProMeris developed dorsal skin lesions that required treatment with an anti-inflammatory drug for seven days. Kind, Cheerful and Lovable, this 22 year old writer is wiser beyond her age but when it comes to shopping, she readily goes back to her teens. The reaction is rare but serious, says the study’s lead author, Thierry Olivry, DrVet, PhD, Dipl.


The product, marketed by Pfizer Animal Health, will be available while supplies last or until mid-September. Promeris-triggered pemphigus foliaceus in two dogs: case reports and recommendations for diagnosis and treatment. In one clinical trial enrolling dogs with flea or tick infestation, six of 293 subjects (2 percent) exhibited skin hyperpigmentation, hair matting or scales at application sites. A traveler by heart, she wishes to leave no place unexplored on the earthly sphere (specially the shopping destinations).
In the case of a 7-year-old (spayed) female Labrador, a two-week history of skin lesions and lameness was presented.



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