Neurotoxin producing gut bacteria cause autism,how to get rid of sugar spots on tongue images,home remedies to cure sinusitis xray - PDF Books

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Another Clostrida metobolite is P-Cresol.  Massive quantities of metabolites, P-Cresol and HPHPA (propionic acid) are produced by the overgown clostridia in the disturbed gut of autistic children. Tylenol (acetaminophen) is a drug known to deplete glutathione, and has been implicated in etiology of autism. The herbicide Roundup which contains glyphosate manufactured by Monsanto has received attention because animal studies show dysbiosis and disruption of gut flora in animals treated with glyphosate. Holland has just taken steps to ban Glyphosate sale to private individuals.  Canada, Brazil, Sri Lanka and the Netherlands have or will soon impose restrictions or bans on glyphosate, the main ingredient in Monsanto’s Roundup weed killer.
The author, a parent of a child with autism, describes an n=1 case in which his child’s autism symptoms dramatically and rapidly improved following administration of a common antibiotic. Thanksgiving Day in the United States is usually a quiet time with family, unless both of your young children contract strep throat while visiting family as ours did in 2012.
Earlier that year our son had been diagnosed with moderate-to-severe autism by a team of clinicians and practitioners at Children’s Medical Center in Dallas, Texas.
The microbiota modulates gut physiology and behavioral abnormalities associated with autism .  Elaine Y. Although autism spectrum disorder (ASD) is defined by core behavioral impairments, gastrointestinal (GI) symptoms are commonly reported. Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children.  Parracho HM1, Bingham MO, Gibson GR, McCartney AL. Children with autistic spectrum disorders (ASDs) tend to suffer from severe gastrointestinal problems. New approaches are needed to examine the diverse symptoms and comorbidities of the growing family of neurodevelopmental disorders known as autism spectrum disorder (ASD). Propionic acid has bioactive effects on (1) neurotransmitter systems, (2) intracellular acidification and calcium release, (3) fatty acid metabolism, (4) gap junction gating, (5) immune function, and (6) alteration of gene expression that warrant further exploration.
A method for diagnosing the likelihood of autism in patients is provided which comprises first obtaining from the patient a sample of body fluid such as urine and analyzing the sample to determine the quantity therein of at least one marker compound selected from the group consisting of citramalic acid, 5-hydroxy-methyl-2-furoic acid, 3-oxo-glutaric acid, furan-2,5-dicarboxylic acid, tartaric acid, furancarbonylglycine, arabinose, dihydroxyphenylpropionic acid, carboxycitric acid and phenylcarboxylic acid; if the quantities of one or more of the compounds are abnormally high, as compared with the urine of non-autistic individuals, an ultimate diagnosis of autism is likely.
A compound identified as 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA) was found in higher concentrations in urine samples of children with autism compared to age and sex appropriate controls and in an adult with recurrent diarrhea due to Clostridium difficile infections.
A comprehensive review of intestinal health issues in Autism Spectrum Disorders and the options available for treating them. The presented results evidence that the highly pathogenic bacteria as Salmonella Entritidis, Salmonella Gallinarum, Salmonella Typhimurium, Clostridium perfringens and Clostridium botulinum are highly resistant to glyphosate. There is now a strong probability that glyphosate residues in animal feeds result in botulism in the cattle and also in related ailments in poultry. From 41 dairy farms in Schleswig Holstein, Germany, 196 fecal specimens of diseased cows, 77 fecal specimens of farmers and family members from 26 of these farms, 35 animal feed specimens and 7 house dust specimens were investigated for Clostridium botulinum and its antigens, respectively.
The Effect of Glyphosate on Potential Pathogens and Beneficial Members of Poultry Microbiota In Vitro by Awad A. 24) Glyphosate suppresses the antagonistic effect of Enterococcus on Clostridia Kruger 2013 by Monika Kruger, Awad Ali Shehata, Wieland Schrodl, Arne Rodloff.
During the last 15 years, an increase of Clostridium botulinum associated diseases in cattle has been observed in Germany. Urinary p-cresol is elevated in young French children with autism spectrum disorder: a replication study.
The aromatic compound p-cresol (4-methylphenol) has been found elevated in the urines of Italian autistic children up to 8 years of age. In order to ascertain whether autistic children display characteristic metabolic signatures that are of diagnostic value, plasma amino acid analyses were carried out on a cohort of 138 autistic children and 138 normal controls using reverse-phase HPLC. Altered Genes, Twisted Truth gives a graphic account of how this elaborate fraud was crafted and how it not only deceived the general public, but Bill Clinton, Bill Gates, Barack Obama and a host of other astute and influential individuals as well.
By the time this gripping story comes to a close, it will be clear that the degradation of science it documents has not only been unsavory but unprecedented—and that in no other instance have so many scientists so seriously subverted the standards they were trained to uphold, misled so many people, and imposed such magnitude of risk on both human health and the health of the environment.
29) Glyphosate Roundup Human Placental Cells Aromatase Seralini Richard 2005 Env Health Persp   Richard, Sophie, et al. Macfabe D1.    1The Kilee Patchell-Evans Autism Research Group, Departments of Psychology (Neuroscience) and Psychiatry, Division of Developmental Disabilities, Lawson Research Institute, University of Western Ontario, London, Ontario, Canada. Published on Jun 24, 2009  During a recent Metametrix sponsored breakfast at the IFM Symposium in Hollywood,  Florida, Dr. 39) Glyphosate pathways to modern diseases Celiac Gluten Two Seneff 2013 Samsel, Anthony, and Stephanie Seneff. There is increasing interest in the gut-brain axis and the role intestinal microbiota may play in communication between these two systems. METHODS:  We investigated basal behavior of adult germ-free (GF), Swiss Webster female mice in the elevated plus maze (EPM) and compared this to conventionally reared specific pathogen free (SPF) mice. Naushad SM, Jain JM, Prasad CK, Naik U, Akella RR.In order to ascertain whether autistic children display characteristic metabolic signatures that are of diagnostic value, plasma amino acid analyses were carried out on a cohort of 138 autistic children and 138 normal controls using reverse-phase HPLC.
Massive quantities of metabolites, P-cresol and HPHPA (propionic acid) are produced by the overgown clostridia in the disturbed gut of autistic children.
The author, a parent of a child with autism, describes an n=1 case in which his child’s autism symptoms dramatically and rapidly improved following administration of a common antibiotic. Many parents of children with “regressive”-onset autism have noted antecedent antibiotic exposure followed by chronic diarrhea.
19) Severe Neurological and Psychiatric Disorders Caused by Gastrointestinal Overgrowth of Clostridia Bacteria.
23) Effect Glyphosate Pathogens Poultry Microbiota In Vitro Krueger Shehata Curr Microbiol 2012 The Effect of Glyphosate on Potential Pathogens and Beneficial Members of Poultry Microbiota In Vitro by Awad A. 24) Glyphosate suppresses the antagonistic effect of Enterococcus on Clostridia Kruger 2013 by Monika Kruger, Awad Ali Shehata, Wieland Schrodl, Arne Rodloff.
There is increasing interest in the gut-brain axis and the role intestinal microbiota may play in communication between these two systems.
No period at all (no ovulation) The period comes infrequently (every few months) Heavy and frequent periods (large clots, due to buildup in the uterus) Spotting a few days before the period. Although progesterone is an FDA approved drug, mainstream medicine has yet to accept bioidentical natural human progesterone as a treatment for PMS and irregular menstrual cycles.
Conservative management of endometrial hyperplasia Childs OBG MANAGEMENT 2003  Childs, A. Oral micronized progesterone de Lignieres Clinical therapeutics 1999  de Lignieres, Bruno. Objective: To integrate and evaluate the pharmacokinetic, endocrine, and clinical effects of micronized progesterone formulations.
Design: Published articles concerning the pharmacokinetics of orally administered progesterone and the potential clinical uses of oral micronized progesterone were reviewed.
Result(s): Because of the enhanced bioavailability of oral micronized progesterone, the compound may be useful for a variety of therapeutic indications. Conclusion(s): Oral micronized progesterone has widespread clinical potential, particularly for the treatment of secondary amenorrhea and dysfunctional premenopausal bleeding, and as a component of postmenopausal hormone replacement therapy. In summary, oral micronized progesterone has the potential for widespread clinical utility.
Managing acute heavy menstrual bleeding Recommendations for hormonal regimens to halt blood loss in the outpatient January 01, 2014  By Anita L. Treatment of Premenstrual Syndrome Premenstrual Syndrome is a condition of estrogen dominance-progesterone deficiency.


Hsiao et al, in a 2013 report in Cell stated that many autistic children “display dysbiosis of the gut microbiota, and some exhibit increased intestinal permeability. This produces gut dysbiosis similar to that found in autistic children.  Which pathogenic bacteria are we left with? The author asserts that this finding is not unusual in the autism population and that, when combined with prior recent medical research, suggests that a link between autism and the microbiome in some children is not just plausible, but in fact likely for some meaningful percentage of cases. Because it was a holiday, my wife and I took them to an extended-hours clinic, where a physician confirmed strep via a rapid strep test and prescribed a 10-day course of amoxicillin, one of the most commonly prescribed antibiotics in the United States. Sandler RH1, Finegold SM, Bolte ER, Buchanan CP, Maxwell AP, Vaisanen ML, Nelson MN, Wexler HM. We speculated that, in a subgroup of children, disruption of indigenous gut flora might promote colonization by one or more neurotoxin-producing bacteria, contributing, at least in part, to their autistic symptomatology.
Subsets of ASD individuals display dysbiosis of the gut microbiota, and some exhibit increased intestinal permeability.
Such symptoms may be due to a disruption of the indigenous gut flora promoting the overgrowth of potentially pathogenic micro-organisms.
ASD originally was thought to be a static, inheritable neurodevelopmental disorder, and our understanding of it is undergoing a major shift. Traditional scientific experimentation is needed to verify the hypothesis that enteric short-chain fatty acids may be a potential environmental trigger in some forms of ASD. The invention also pertains to a method of treating autistic patients by administration of antifungal drugs, in order to ameliorate the clinical symptoms of autism. Manuel Casanova made his residency training in neurology and then spent 3 years doing a fellowship in neuropathology at The Johns Hopkins Hospital.
The aim of the present study was to determine the real impact of glyphosate on potential pathogens and beneficial members of poultry microbiota in vitro.
However, most of beneficial bacteria as Enterococcus faecalis, Enterococcus faecium, Bacillus badius, Bifidobacterium adolescentis and Lactobacillus spp.
Gabriele S1, Sacco R, Cerullo S, Neri C, Urbani A, Tripi G, Malvy J, Barthelemy C, Bonnet-Brihault F, Persico AM. The present study aims at replicating these initial findings in an ethnically distinct sample and at extending them by measuring also the three components of urinary p-cresol, namely p-cresylsulfate, p-cresylglucuronate and free p-cresol. Pre-column derivatization of amino acids with phenyl isothiocyanate forms phenyl thio-carbamate derivates that have a lamba(max) of 254 nm, enabling their detection using photodiode array. It tells the fascinating and frequently astounding story of how the massive enterprise to restructure the genetic core of the world’s food supply came into being, how it advanced by consistently violating the protocols of science, and how for more than three decades, hundreds of eminent biologists and esteemed institutions have systematically contorted the truth in order to conceal the unique risks of its products—and get them onto our dinner plates. Todd LePine gave a compelling presentation entitled The Gut-Brain Connection: An Inside Look at Depression.
Acquisition of intestinal microbiota in the immediate postnatal period has a defining impact on the development and function of the gastrointestinal, immune, neuroendocrine and metabolic systems.
Additionally, we measured brain mRNA  expression of genes implicated in anxiety and stress-reactivity. Hsiao et al, in a 2013 report in Cell stated that many autistic children “display dysbiosis of the gut microbiota, and some exhibit increased intestinal permeability.
This produces gut dysbiosis similar to that found in autistic children.  Which pathogenic bacteria are we left with? Mechanism and Treatment; A lecture by William Shaw PhD at ICIM Nashville March 14 16, 2014 Although dysbiosis or abnormal microbial overgrowth of the gastrointestinal tract has long been suspected of causing psychiatric disorders, the exact mechanism was unknown. Acquisition of intestinal microbiota in the immediate postnatal period has a defining impact on the development and function of the gastrointestinal, immune, neuroendocrine and metabolic systems.
Write a letter to your elected officials using our online advocacy tool.Act now to defend your right to bio-identical hormones! Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician -- patient relationship.
Estrogen is produced throughout most of the month, from days 5-26 with a peak just before ovulation (day 11) and another peak around day 19.
Results concerning their use for secondary amenorrhea, premenopausal bleeding disorders, luteal phase dysfunction, termination of premature labor, hormone replacement therapy, and premenopausal syndrome are summarized.
Oral micronized progesterone is available in France, and a formulation recently has been approved in the United States for the treatment of secondary amenorrhea and postmenopausal hormone replacement therapy. For indications in which oral delivery of the synthetic progestins currently are used, the theoretic benefits of oral delivery of the natural form of the hormone are obvious. The most common cause of these problems is irregular or inadequate production of progesterone. The author speculated that this small study indicated a possible gut flora-brain connection in autism.  Left image vancomycin courtesy of Hospira. To help test this hypothesis, 11 children with regressive-onset autism were recruited for an intervention trial using a minimally absorbed oral antibiotic. Here we demonstrate GI barrier defects and microbiota alterations in a mouse model displaying features of ASD, maternal immune activation (MIA). The faecal flora of patients with ASDs was studied and compared with those of two control groups (healthy siblings and unrelated healthy children). It is emerging as a dynamic system of metabolic and immune anomalies involving many organ systems, including the brain, and environmental exposure. Novel collaborative developments in systems biology, particularly examining the role of the microbiome and its effects on host metabolism, immune and mitochondrial function, and gene expression, hold great promise in ASD. The psychosis remitted after treatment with oral vancomycin with a concomitant marked decrease in HPHPA.
The normal intestinal microflora is a critical factor in preventing intestinal colonisation by C. Food and Drug Administration (FDA) was induced to become a key accomplice—and how it has broken the law and repeatedly lied in order to usher genetically engineered foods onto the market without the safety testing that’s required by federal statute. For  example, the presence of gut microbiota regulates the set point for hypothalamic-pituitary-adrenal (HPA) axis activity.
June 17, 1999 The New England Journal of Medicine GASTROINTESTINAL TOXICITY OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS M. Effects of hormone replacement on progression of coronary calcium as measured by electron beam tomography.Budoff MJ, et al. Although identities will remain confidential as much as possible, as I can not control the media, I can not take responsibility for any breaches of confidentiality that may occur. Vaginal progesterone suppositories are an accepted treatment for infertility attributed to luteal phase defects.
Critical issues to be resolved through ongoing preclinical and clinical research are highlighted. In addition to the decreased potential for adverse effects, there are clear advantages in convenience, cost, compliance, and quality of life. On day six he rode a tricycle around the room for the first time, alone and unprompted, which was remarkable because we had purchased the tricycle 6 months earlier and had worked with him continuously so he could learn to ride it, however until that point, he had never so much as been able to push the pedals enough to move forward. Entry criteria included antecedent broad-spectrum antimicrobial exposure followed by chronic persistent diarrhea, deterioration of previously acquired skills, and then autistic features. Oral treatment of MIA offspring with the human commensal Bacteroides fragilis corrects gut permeability, alters microbial composition and ameliorates ASD-related defects in communicative, stereotypic, anxiety-like and sensorimotor behaviors. Faecal bacterial populations were assessed through the use of a culture-independent technique, fluorescence in situ hybridization, using oligonucleotide probes targeting predominant components of the gut flora.


The initial detailed observation and inquiry of patients with ASD and related conditions and the histories of their caregivers and families have been invaluable.
The source of this compound appears to be multiple species of anaerobic bacteria of the Clostridium genus. As a result, for fifteen years America’s families have been regularly ingesting a group of novel products that the FDA’s own scientific staff had previously determined to be unduly hazardous to human health. The pill can cause headaches, bloating, nausea, irregular bleeding and spotting, breast tenderness, weight gain, or vision changes. Although oral micronized progesterone may be preferable to suppositories for many patients, there are no studies on its use for patients with luteal phase defects. There also are data indicating that oral micronized progesterone could be of potential use for the treatment of premenopausal bleeding disorders, luteal phase disorders, and premature labor. It is delivered to cells throughout the body within minutes of application.] Oral [pill] progesterone does not work for PMS. Symptoms may include headaches, migraines, menstrual cramps, depression, irritability, fatigue, emotional outbursts, low blood sugar, rage, out of control behavior, dizziness, decreased resistance to infection and epileptic seizures.
The faecal flora of ASD patients contained a higher incidence of the Clostridium histolyticum group (Clostridium clusters I and II) of bacteria than that of healthy children.
The significance of this compound is that it is a probable metabolite of m-tyrosine (3-hydroxyphenylalanine), a tyrosine analog which depletes brain catecholamines and causes symptoms of autism (stereotypical behavior, hyperactivity, and hyper-reactivity) in experimental animals. The effect of glyphosate on potential pathogens and beneficial members of poultry microbiota in vitro. Numerous bacteria in the gastro-intestinal tract (GIT) produce bacteriocines directed against C. Earlier that year our son had been diagnosed with moderate-to-severe autism by a team of clinicians and practitioners at Children’s Medical Center in Dallas, Texas. Furthermore, the excess dopamine leads to oxidative stress that can result in permanent damage to the brain, sympathetic nervous system,  and adrenal glands if not treated. Additionally, we measured brain mRNA  expression of genes implicated in anxiety and stress-reactivity. 2008.(33)(2) Another excellent article is The Safety of Bioidentical Hormones — the Data vs. Other more serious adverse effects that can occur from a few months to a few years after starting oral contraceptives include high blood pressure, gallbladder disease, liver tumors, depression, and metabolic disorders, such as diabetes. This article may be reproduced on the internet without permission, provided there is a link to this page and proper credit is given. Historically, oral progesterone has been regarded clinically ineffective because of its poor absorption and rapid clearance. This study evaluated the efficacy of oral micronized progesterone for the treatment of luteal phase defects.
A double blind, randomised, crossover trial of oral micronised progesterone (two months) and placebo (two months) was conducted to determine whether progesterone alleviated premenstrual complaints. These included coded, paired videotapes scored by a clinical psychologist blinded to treatment status; these noted improvement in 8 of 10 children studied. Nevertheless, many patients with ASD have a history of previous antibiotic exposure or hospitalization, GI symptoms, abnormal food cravings, and unique intestinal bacterial populations, which have been proposed to relate to variable symptom severity. A reduction of beneficial bacteria in the gastrointestinal tract microbiota by ingestion of glyphosate could disturb the normal gut bacterial community.
These results confirm the elevation of urinary p-cresol in a sizable set of small autistic children and spur interest into biomarker roles for p-cresol and p-cresylsulfate in autism. Temporary infertility has been associated with the period of time right after pill use is stopped. FAIR USE NOTICE: This site contains copyrighted material the use of which has not always been specifically authorized by the copyright owner. Recent evidence suggests that an oral micronized form of natural progesterone is readily absorbed, produces luteal phase serum concentrations, provokes an end-organ response, and has no detrimental effect on the lipoprotein profile.
Twenty three women were interviewed premenstrually before treatment and in each month of treatment. In addition to traditional scientific inquiry, detailed clinical observation and recording of exacerbations, remissions, and comorbidities are needed. A reduction of LAB in the GIT microbiota by ingestion of strong biocides like glyphosate could be an explanation for the observed increase in levels of C. But the two most dangerous risks associated with taking birth control pills are blood clots and cancer. We are making such material available in our efforts to advance understanding of issues of significance. They completed Moos’s menstrual distress questionnaire, Beck et al’s depression inventory, Spielberger et al’s state anxiety inventory, the mood adjective checklist, and a daily symptom record. Although the protocol used is not suggested as useful therapy, these results indicate that a possible gut flora-brain connection warrants further investigation, as it might lead to greater pathophysiologic insight and meaningful prevention or treatment in a subset of children with autism. This article reviews the role that enteric short-chain fatty acids, particularly propionic (also called propanoic) acid, produced from ASD-associated GI bacteria, may play in the etiology of some forms of ASD. We evaluated the effects of a single oral dose of micronized progesterone 300 mg in eight healthy postmenopausal women. Analyses of data found an overall beneficial effect of being treated for all variables except restlessness, positive moods, and interest in sex. Taken together, these findings support a gut-microbiome-brain connection in ASD and identify a potential probiotic therapy for GI and behavioral symptoms of autism.
Human populations that are partial metabolizers of propionic acid are more common than previously thought.
In the present paper, we report on the toxicity of glyphosate to the most prevalent Enterococcus spp. Strategies to reduce clostridial population levels harboured by ASD patients or to improve their gut microflora profile through dietary modulation may help to alleviate gut disorders common in such patients. The results from pre-clinical laboratory studies show that propionic acid-treated rats display ASD-like repetitive, perseverative, and antisocial behaviors and seizure. Section 107, the material on this site is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes. Despite complaints of drowsiness, the majority of patients preferred the oral formulation over the vaginal route of administration.
Nevertheless, an appreciably beneficial effect of progesterone over placebo for mood and some physical symptoms was identifiable after both one and two months of treatment. Ingestion of this herbicide could be a significant predisposing factor that is associated with the increase in C. To conclude, elevated levels of excitatory amino acids (glutamate and asparagine), decreased essential amino acids (phenylalanine, tryptophan and methionine) and decreased precursors of neurotransmitters (tyrosine and tryptophan) are the distinct characteristics of plasma amino acid profile of autistic children.




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