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admin | Bv Homeopathic Treatment | 29.03.2016
Symptoms of pneumonia: Cough associated with sputum production, acute chest pain while inspiring. Enter your email address to subscribe to this blog and receive notifications of new posts by email.
If stomach acid is inhaled after it’s regurgitated, GERD can worsen asthma or pneumonia. The material in this site is intended to be of general informational use and is not intended to constitute medical advice, probable diagnosis, or recommended treatments. The exact dose of erythromycin a person is prescribed will depend on many different factors, which this eMedTV page lists. Erythromycin Dosage - Antibiotics Home PageErythromycin is an antibiotic used to treat bacterial infections.
In the 1920s and 1930s common bacterial infections ran rampant in Europe and the United States. Born the son of a teacher in Lagow, Germany, Domagk decided early in life to become a physician. Domagk was hired to establish a special pharmacology laboratory and to collaborate with two chemists, Fritz Mietzsch and Josef Klarer.
Domagk’s discovery of the antibacterial properties of Prontosil won him the 1939 Nobel Prize in physiology or medicine.
In their day sulfa drugs developed in Germany and elsewhere were used to good effect to treat, among other conditions, meningitis, childbed fever, pneumonia, blood poisoning, gonorrhea, burns from gas warfare, and other serious burns. The Center for Oral History captures and preserves the stories of notable figures in chemistry and related fields, with over 425 oral histories that deal with various aspects of science, of scientists, and of scientific practices. See the Terms of Service and Privacy Policy (Your California Privacy Rights) for more information. Includes erythromycin side effects, interactions and indications.Erythromycin is an antibiotic used to treat many kinds of infections, including acute pelvic inflammatory disease, chlamydia, gonorrhea, intestinal parasitic. Includes dosages for Bronchitis, Upper Respiratory Tract Infection, Pneumonia and more; plus renal.


Sulfa drugs, all of which are related to the compound sulfanilamide, provided the first successful therapies for many bacterial diseases. Staphylococcal and streptococcal infections loomed large as killers along with pneumococcal and tubercular infections.
His medical studies at the University of Kiel were interrupted by his service as a grenadier and medical corpsman in World War I.
They worked together on a research program to test compounds related to synthetic dyes for their effectiveness against disease.
He therefore placed great stock in testing drugs in living systems and was prepared to continue working with a compound even after it failed testing on bacteria cultured in laboratory glassware (in vitro). However, the Nobel committee had angered the German political authorities by awarding the 1935 Nobel Peace Prize to Carl von Ossietzky, an outspoken German pacifist.
But the advent of penicillin during World War II, followed by a host of other antibiotics that were more effective against bacteria, shifted the focus away from Prontosil and the sulfa drugs. Asian countries,[18] United States (including Hawaii), Canada ,[19] and Scotland)[20] due to bacterial resistance. In this environment minor scratches and scrapes could prove deadly, and pneumonia and tuberculosis killed even young adults. He completed his medical degree in 1921 and then began an academic career, pursuing research in pathology.
Mietzsch had already accomplished his synthesis of Atabrine, a successful substitute for quinine, the natural antimalarial extracted from the bark of cinchona trees. Among the hundreds of chemical compounds prepared by Mietzsch and Klarer for Domagk to test were some related to the azo dyes. In the intervening three years Prontosil had been successfully used to treat several diseases in humans, of both streptococcal and staphylococcal origins.
Under the grip of Hitler and the Nazi Party, German citizens were forbidden to accept the Nobel Prize.
Still, bacteria could become resistant to antibiotics, and in the latter part of his career Domagk turned his attention to the search for an antitubercular drug to replace the already increasingly ineffective streptomycin (see Selman Waksman).


Introduced in 1935 by Gerhard Domagk (1895–1964), sulfa drugs, or sulfonamides, all of which are related to the compound sulfanilamide, provided the first successful therapies for many bacterial diseases. He adopted a dynamic approach to pathology, incorporating physiology and chemistry into his work. Finding effective substitutes for natural treatments for bacterial diseases was very much on the new team’s agenda due to monopolistic pricing and wartime shortages of natural substances. They had the characteristic -N=N- coupling of azo dyes, but one of the hydrogens attached to nitrogen had been replaced by a sulfonamide group.
Among the early patients was Domagk’s own six-year-old daughter, Hildegard, who had contracted a severe streptococcal infection from an unsterilized needle. After Domagk accepted the prize, he was arrested by the Gestapo and forced to send a letter rejecting it. Although Domagk and his research team were unsuccessful in finding that replacement, their work contributed to the later discovery of isoniazid—one of the strongest and most reliable antitubercular drugs.
As such, they proved to be the forerunners of antibiotics, showing that bacterial diseases are vulnerable to substances not natural to the human body. In 1927 Domagk was recruited from the University of Münster by the pharmaceuticals division of IG Farbenindustrie, a recently organized industrial conglomerate made up of German companies, including the former Bayer Company, that specialized in dyes (Farben) and other fine chemicals. In 1931 the two chemists presented a compound (KL 695) that, although it proved inactive in vitro, was weakly active in laboratory mice infected with streptococcus. Although Domagk was able to receive his prize medal in 1947, the prize money had long since been redistributed. In this industrial setting Domagk felt at greater liberty to pursue his research and had far better resources at his command. The chemists made substitutions in the structure of this molecule and, several months and 35 compounds later, produced KL 730, which showed incredible antibacterial effects on diseased laboratory mice.



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