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admin | Get Rid Of Bv | 26.05.2015
Crohn’s disease is an inflammatory bowel disease (IBD,) which affects the intestines by causing inflammation.
Crohn’s disease is also an autoimmune disease, which means the body’s own immune system believes the digestive tract is harmful and attacks it. A recent study published in Cell Host and Microbe had researchers analyze the gut microbes of children receiving treatment for Crohn’s disease.
Early Crohn’s disease in children can cause developmental issues, such as stunted growth, delayed puberty and weakened bones. The study was conducted on 90 children with Crohn’s disease who were being treated with a formula-based diet and anti-inflammatory therapy.
Although there is no cure for Crohn’s disease, there are lifestyle and home remedies you can try to experience relief from symptoms and better manage the disease. Diet – Although a set diet has not been proven to help Crohn’s, some foods have been known to aggravate the disease. Traveling can be a lot of fun; it allows us to meet new and interesting people, experience different cultures, and in some cases enjoy delicious new cuisines. On any matter relating to your health or well-being, please check with an appropriate health professional. MNT – Hourly Medical News Since 2003 Sign in Your MNT Email address Password Remember me ?
Post-traumatic stress disorder occurs after a person is exposed to a traumatic event, though not everyone that experiences or witnesses such an event is affected by the condition.
Researchers from the University of California in Los Angeles (UCLA) have identified two gene variants that could influence the risk of post-traumatic stress disorder (PTSD). According to the National Institute of Mental Health (NIMH), 6.8% of the adult population of the US experience PTSD at some point in their lifetime. Symptoms can vary in intensity over time and can be triggered by reminders of the traumatic event that caused the disorder to occur in the first place. Previous research in 2012 involving these samples led to the discovery that survivors carrying two gene variants associated withdepression were more likely to have PTSD than those that did not carry the variants.
For the study, published in the Journal of Affective Disorders, the team assessed the roles of two genes in the DNA samples, taken from 200 individuals. Anyone can be exposed to a traumatic event and be affected by PTSD, regardless of age and gender.
Recently, Medical News Today reported on a study finding that women experiencing large numbers of PTSD symptoms could have almost two times the risk of developing type 2 diabetes compared with women who have not been exposed to trauma. The most frequent complications are irreversible changes (narrowing of the intestinal segments, fistulas).
The prevalence of Crohn’s disease in different countries ranges from 50-150 cases per 100 000 population. The first manifestations of the disease usually appear at a young age (15-35 years), and it can be both intestinal and extraintestinal manifestations. The second hypothesis is related to the assumption that some dietary antigen or nebraskaterry microbial agent can cause an abnormal immune response. The third hypothesis States that the role of provocateur in the development of the disease play autoantigens (i.e. The presence of Crohn’s disease can be suspected in continuous or nocturnal diarrhea, abdominal pain, intestinal obstruction, weight loss, fever, night sweats.
May be affected not only fat, but also the small intestine and the stomach, esophagus and even oral mucosa.
Often develop narrowing of the intestine with subsequent intestinal obstruction, pseudopolyps. Crohn’s disease is a relapsing or nepreryvnolitoy disease in 30% of cases gives spontaneous remission without treatment.
Sometimes, patients complain of pain in various parts of the abdomen, bloating, often vomiting. This variant of the disease with predominant development of the syndrome of intestinal failure, which occurs with lesions of the small intestine. Diagnosis of Crohn’s disease based on data from x-ray and endoscopic examination with biopsy that detect inflammatory lesions in one or more areas of the gastrointestinal tract, usually covering all layers of the intestinal wall. In the diagnosis of Crohn’s disease is an important role for x-ray studies with contrast (barium enema double-contrast study of the passage of barium, endotracheal enterography is a study of the small bowel with barium, which is administered through a nasogastric tube into the duodenum).
Scintigraphy with labeled leukocytes to differentiate inflammatory lesions from non-inflammatory; it is used in cases where the clinical picture is not consistent with the data of x-ray.
Endoscopy of the upper or lower gastrointestinal tract (if necessary, a biopsy) allows to confirm the diagnosis and to specify the localization of the lesion. At colonoscopy in patients undergoing surgery, it is possible to assess the condition of the anastomoses, the likelihood of recurrence and the effect of treatment given after surgery. A biopsy can confirm the diagnosis of Crohn’s disease, in particular to distinguish it from ulcerative colitis, to exclude acute colitis, identify dysplasia or cancer. Smoking significantly worsens the prognosis, therefore, such patients advised to quit Smoking. The choice of treatment for Crohn’s disease depends primarily on the severity of the disease. Surgical treatment of Crohn’s disease shows a narrowing of the intestine, purulent complications and failure of medical treatment. If the drug is ineffective, just adjust it from above or pass on one of the circuits shown in moderate form of the disease. If corticosteroids are ineffective or contraindicated, often helps infliximab in the form of infusions; it can be used as an adjunct to corticosteroid therapy. If, despite taking prednisone and infusion of infliximab, status in Crohn’s disease is not improving or has a high fever, frequent vomiting, intestinal obstruction, symptoms of peritoneal irritation, exhaustion, signs of an abscess, then hospitalization is shown. If the abscess is expelled or the patient has already taken corticosteroids, administered intravenously (by injection or long-term infusion) at a dose equivalent to 40-60 mg of prednisone.
Gavage feeding elemental mixtures or parenteral nutrition administered, if the patient cannot eat 5-7 days after the start of treatment.
Surgical treatment of Crohn’s disease is shown with the development of complications (stricture formation, abscesses) and the failure of medical treatment.
On our website describes the most common disease of adults and children, causes and symptoms of these diseases, as well as the most effective treatments for these diseases. The information on this health site are for informational purposes only, professional diagnosis and treatment of the disease should be done by the doctor in the clinic.
A new study by an international team of researchers shows for the first time that people may inherit some of the intestinal bacteria that cause Crohn’s disease and ulcerative colitis, collectively know as inflammatory bowel disease (IBD). About 1.6 million Americans suffer from Crohn’s disease or ulcerative colitis, according to the Crohn’s and Colitis Foundation of America. Knights and his colleagues at the University of Minnesota worked with collaborators at Harvard, MIT, University of Toronto and University Medical Center Groningen in one of the largest international studies of its kind. The results, which were replicated across two or more cohorts, showed that the human subjects’ DNA was linked to the bacteria in their intestines.
The intestinal community of bacteria is a complex system that is not only affected by genetics, but also by age, gender, medication and other factors.
The research was funded in part by the National Institutes of Health (NIH), the National Science Foundation, the Crohn’s and Colitis Foundation of America, and the Crohn’s and Colitis Foundation of Canada. In addition to the University of Minnesota, authors of the study were from the Broad Institute of Harvard and MIT, Massachusetts General Hospital and Harvard Medical School, Mount Sinai Hospital in Toronto, University Medical Center Groningen in the Netherlands, University of Toronto, and the Harvard School of Public Health.

To read the full research study entitled, “Complex host genetics influence the microbiome in inflammatory bowel disease,” visit the Genome Medicine website. Mutations in the human genome may cause shifts in the gut bacteria of patients with inflammatory bowel disease. Crohn’s and a related disease, ulcerative colitis, are the two main disease categories that belong to a larger group of illnesses called inflammatory bowel disease (IBD).
Because the symptoms of these two illnesses are so similar, it is sometimes difficult to establish the diagnosis definitively. Symptoms of Crohn’s disease include persistent diarrhea (loose, watery, or frequent bowel movements), crampy abdominal pain, fever, fatigue, and, at times, rectal bleeding. Aminosalicylates (5-ASA): These medications typically are used to treat mild to moderate symptoms. Corticosteroids: These drugs have significant short- and long-term side effects and should not be used as a maintenance medication. Immune modifiers: Azathioprine (Imuran®), 6-MP (Purinethol®), and methotrexate are used to help decrease corticosteroid dosage and also to help heal fistulas. Infliximab (Remicade®), adalimumab (Humira®), certolizumab pegol (Cimzia®), natalizumab (Tysabri®). Two-thirds to three-quarters of patients with Crohn’s disease will require surgery at some point during their lives. There is no evidence that any particular foods cause or contribute to Crohn’s disease.
When Crohn’s disease is active, soft, bland foods may cause less discomfort than spicy or high-fiber foods.
There is no evidence to show that stress, anxiety, or tension is responsible for Crohn’s disease.
Crohn’s disease, a chronic condition that causes inflammation of the digestive system, is a form of inflammatory bowel disease, or IBD.
Crohns disease is not curable, but while the condition is chronic, it is also usually intermittent. Turmeric (Curcuma longa), a spice and food coloring related to the ginger family and a common ingredient of curry is also a staple of traditional medicine in both India and China. This is because turmeric, an anti-inflammatory, decreases congestion and inflammation in the mucus membranes.
Because Crohns is not curable, but only manageable, treatment depends largely on the location and severity of the disease, as well as the body’s reaction to various treatments. With a complete medical history and physical examination, the physician seeks other causes of the symptoms of Crohn disease, particularly the presence of colon or rectal cancer. What they found was that although diet-based and anti-inflammatory therapies alter gut bacteria, they do not restore a normal balance. The use of antibiotics as associated with highly disturbed communities and an increase in fungi in the gut.
We observed that upon initiation of a therapeutic formula-based diet, the gut microbiota look even less similar to that of a healthy child, suggesting that one does not have to necessarily give back the healthy microbiota to have a therapeutic effect. Lewis concluded, “We hope to use this information to develop diets that are less restrictive but equally effective, or medications that mimic the mechanisms of the formula-based diets. As an autoimmune disease the immune system plays an evident role in its cause, but the specifics are still unclear.
Dairy products, high-fat foods, high-fiber, spicy foods, caffeine, and alcohol should be limited or avoided.
Symptoms vary widely in patients with Irritable Bowel Syndrome; however some of the most common symptoms include abdominal pain and discomfort, bloating, gas, constipation, diarrhea and nausea. No statement herein is to be construed as a diagnosis, treatment, preventative, or cure for any disease, disorder or abnormal physical state. New genetic research may now explain why some people develop the condition while others do not. This discovery could lead to improvements in the diagnosis and treatment of PTSD in the future. Goenjian traveled to Armenia in 1988 after a 6.8 magnitude earthquake hit the country, destroying many cities and killing more than 25,000 Armenians. The genes were COMT, an enzyme that degrades the mood regulator dopamine, and TPH-2, a controller of the production of serotonin. Goenjian says the team hopes that the study’s findings will lead to molecular methods for screening people at risk for PTSD and identify new forms of drug therapy to prevent and treat the disorder.
It is assumed provoking role of viruses, bacteria (for example, measles virus, Mycobacterium paratuberculosis). With diarrhea (in the beginning of the disease or during relapse) cal research on the causative agents of intestinal infections, protozoan, helminth eggs and clostridia.
It is very difficult to ensure that he became less stress, but we should remember that stress can play a significant role in the development of recurrence of Crohn’s disease. Measured by any single indicator is not possible, it is necessary to consider the nature of the lesion of the gastrointestinal tract, systemic manifestations, the presence of exhaustion and General condition.
Preparations are selected individually, assessing their efficacy and tolerability in the dynamics.
If the drug is effective, the treatment is continued until remission is achieved or the maximum possible improvement, then move on to maintenance treatment. Surgical consultation is required for intestinal obstruction and the presence of a painful mass in the abdominal cavity. The study, recently published in Genome Medicine, also confirmed that antibiotics could worsen the imbalance in the gut microbes.
Understanding the causes of these diseases is another step toward prevention and treatment. The researchers examined three independent cohorts of a total of 474 adults with IBD who live in Boston, Mass. For example, this study confirmed that use of antibiotics is associated with a greater imbalance in the bacterial community in the intestines. Studies indicate that the inflammation in Crohn’s disease involves a complex interaction of factors: the genes the person has inherited, the immune system, and something in the environment. Studies have shown that about 20 to 25 percent of patients may have a close relative with either Crohn’s or ulcerative colitis. American Jews of European descent are four to five times more likely to develop IBD than the general population.
Because Crohn’s is a chronic disease, patients may go through periods in which the disease flares up, when the disease is active. Doctors rely on a combination of the patient’s history and physical exam, results of laboratory tests, X-rays (small bowel series), colonoscopy and recently, small bowel capsule endoscopy. Surgery becomes necessary in Crohn’s disease when medications can no longer control the symptoms. Paying special attention to diet may help reduce symptoms, replace lost nutrients, and promote healing. Except for restricting milk in lactose-intolerant patients, most gastroenterologists try to be flexible in planning the diets of their Crohn’s patients. Also called ileitis or enteritis, common symptoms include abdominal pain and diarrhea, as well as weight loss, joint pain, fever, and rectal bleeding. Mistaking this harmless gut flora for harmful bacteria or infectious disease, the body produces an excess of white blood cells, which attack the lining of the intestine and cause painful inflammation in the GI tract.

Suffers experience both flare-ups and periods of dormancy in which they are largely symptom free. The mucus membranes, which coat the stomach and intestines as well as the throat and lungs, are vulnerable to swelling and irritation in the face of conditions such as Crohn’s. Doctors treating Crohn’s disease attempt to relieve symptoms and alleviate pain, and thus focus largely on controlling the inflammation and correcting any nutritional deficiencies that may result from the disease. Complete blood count, blood chemistries, other blood tests for markers of inflammation, along with imaging studies, are the basic tests used to diagnose Crohn disease. Inflammation can occur anywhere in the digestive tract and affects individuals differently. Like many autoimmune diseases the cause is unknown, and there is currently no cure for Crohn’s disease. As of yet no special, specific diet has been proven to help alleviate Crohn’s disease symptoms. The diet-based treatment reduced inflammation and decreased fungi but altered the gut bacteria even further away from being normal. Another possible theorized cause is that the condition is heredity; researchers have found that those with close family members who had the disease are more inclined to develop it.
Many people with intestinal disorders avoid trains, planes, buses, and car travel out of fear they will have an awful experience. The statements herein have not been evaluated by the Foods and Drugs Administration or Health Canada. During this time, many families agreed to have blood samples sent to UCLA so that the team could analyze their DNA for information pertaining to psychiatric vulnerability. He recommends that research into this area continues in a bid to uncover more of the genes involved.
This is an important step in developing drug treatments that target certain genes or certain products derived from the intestinal bacteria. Previous studies have shown links between human gut bacteria and increased risk of a wide variety of diseases including diabetes, autism, heart disease, and even some forms of cancer. Foreign substances (antigens) in the environment may be the direct cause of the inflammation, or they may stimulate the body’s defenses to produce an inflammation that continues without control. Crohn’s disease may occur in people of all ages, but it is primarily a disease of adolescents and young adults, affecting mainly those between the age of 15 and 35. If a person has a relative with the disease, his or her risk is about 10 times greater than that of the general population.
These episodes are often followed by times of remission, when the symptoms disappear or decrease.
Emotional distress that patients sometimes feel may be a reaction to the symptoms of the disease itself. Crohn’s can affect any part of the GI tract, from the mouth to the anus, but is most commonly found in lower part of the small intestine, in an area called the ileum. What causes such fluctuations in the severity of the disease is not known, but certain factors may play a role in minimizing symptoms, foremost of which are diet and nutrition. Turmeric not only reduces this irritation, it also has antibacterial properties, thus preventing infection.
Treatment generally includes a combination of prescribed drugs, nutritional supplements and dietary adjustments. Endoscopy (insertion of a tube to visualize the intestine) is often used, with biopsies (tissue samples) of involved tissues sent for laboratory examination.
There are, however, treatments to ease pain and discomfort associated with Crohn’s disease and treatments to aid in problematic symptoms. The researchers found that the diet and the medication had different effects on gut bacteria.
Doctors and nurses in those locations collected samples of DNA from each human subject and the DNA of their intestinal bacteria over about a two-year period. However, there has been a steady increase in reported cases of both Crohn’s disease and ulcerative colitis among African Americans.
Of note is that the disease is not always limited to the GI tract; it can also affect the joints, eyes, skin, and liver. Another indication for surgery is the presence of an intestinal obstruction or other complication, such as an intestinal abscess. Although formal psychotherapy is generally not necessary, some patients are helped considerably by speaking with a therapist who is knowledgeable about IBD or about chronic illness in general. One longstanding remedy used to alleviate the discomfort caused by Crohn’s is turmeric. Crohn disease may involve the entire gastrointestinal (GI) tract but most often occurs in the ileum (the last part of the small intestine). Most persons with Crohn disease see a gastroenterologist, a doctor with specialized training in the treatment of gastrointestinal diseases. Researchers believe that the immune system mistakes microbes, such as bacteria that is normally found in the intestines, for foreign or invading substances, and launches an attack. One of the major goals of medical therapy is to help patients regulate their immune system better. There is no way to predict which, if any, family members will develop Crohn’s disease. The prevalence rates among Hispanics and Asians are lower than those for Caucasians and African Americans. Some patients may develop tears (fissures) in the lining of the anus, which may cause pain and bleeding, especially during bowel movements. Surgery is not considered a cure for Crohn’s disease, because the disease frequently recurs at or near the site where the intestine has been reattached (anastomosis).
Genes and inherited traits may play a role determining an individual’s risk of developing PTSD. In the process, the body sends white blood cells into the lining of the intestines, where they produce chronic inflammation.
The overall goal of surgery in Crohn’s disease is to conserve bowel and return the individual to the best possible quality of life.
The inflammation seen in Crohn disease has similarities to the disease process of other immune diseases such as rheumatoid arthritis: the body's immune system reacts to antigens (proteins from the environment such as bacteria or food components that the body senses as invaders) and this causes the inflammatory process. Researchers from the University of California in Los Angeles (UCLA) have identified two gene variants that could influence the risk of post-traumatic stress disorder (PTSD). These cells then generate harmful products that ultimately lead to ulcerations and bowel injury.
A fistula is a tunnel that leads from one part of the intestine to another, or that connects the intestine to the bladder, vagina, or skin. If this complication arises, you may notice drainage of mucus, pus, or stool from this opening. This site complies with the HONcode standard for trustworthy health information: verify here.

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