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07.11.2014, admin
Inflammatory bowel disease (IBD) comprises ulcerative colitis and Crohn’s disease, which are inflammatory disorders that have a chronic, relapsing and remitting course, usually extending over years. Ulcerative colitis is more common in non-smokers and ex-smokers than in those actively smoking. There is abdominal pain, often associated with diarrhea which is watery and does not contain blood or mucus. Some of the complications of IBD are intestinal ones like toxic megacolon, perforation of small intestine or colon, life-threatening acute haemorrhage, perianal disease like fistulas, and increased risk of colon cancer after 8 years of the disease. In those relapsing frequently after courses of steroids can be given immunosuppressants like azathioprine, but they start having effect only after 6 to 12 weeks, so steroids should be given in the meantime.
The symptoms and signs of ovarian cancer might start early and women need to keep a watch on these symptoms to diagnose the disease and seek aid quickly. The ovarian cancer that occurs from the epithelial cells, which are the outermost layer of cells, is the most common type of cancer. According to the statements issued by the American Cancer Society, the Society of Gynecologic Oncologists and Gynecologic Cancer Foundation, the following are some of the key symptoms that are noticed in females with ovarian cancer.
Occasionally symptoms such as low back pain, involuntary weight loss, lack of energy and extreme fatigue, rectal bleeding, abdominal distension, abnormal vaginal bleeding are also noticed in a woman with ovarian cancer. Persistent (they do not go away with normal interventions such as laxatives, exercise, rest or diet change), frequent (occur several times in a month) and new (they might have started sometime back and they are not common). In case, there is a family history of breast cancer or ovarian cancer the risk of developing this type of cancer is quite high.

Due to its silent and vague symptoms only 19% of the ovarian cancer are detected in the initial stages. Ulcerative colitis involves mainly the colon, and Crohn’s disease can involve any part of the gastrointestinal tract but usually small intestine. This should not be construed as implying that smoking would necessarily lead to an improvement of the symptoms. Weight loss is present in most patients, either due to avoidance of food, as eating can provoke pain, or due to malabsorption. Extraintestinal complications of IBD are many, for example, mouth ulcers, joint pains, stones in gall bladder, fatty liver, liver abscess, ankylosing spondylitis, erythema nodosum, pyoderma gangrenosum, and metabolic bone disease. Other drugs that have a place in treatment are immunomodulators like infliximab, natalizumab, adalimumab and certilozumab.
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This is the 9th most common kind of cancer in women and is the 5th leading reason of cancer deaths. Ovarian cancer represents a cluster of diverse types of tumors that occur from different kinds of tissue which are present within in the ovary.
The cancer that develops from the supporting tissue or egg forming germ cells is some of the rarest types of the ovarian cancer. Usually, the symptoms are not specific to the ovarian cancer and they generally mimic common ailments like bladder or digestive problems.

Testing for gene mutations will help in the diagnosis, as it gives information about the risk involved. Infection, emotional stress, gastroenteritis, antibiotics or a type of analgesic therapy (NSAIDs) may provoke a relapse. Endoscopy (sigmoidoscopy and colonoscopy) can show areas of inflammation with characteristic lesions. Maintenance of remission is with aminosalicylates like 5-aminosalicylic acid (5-ASA) and its derivatives sulfasalazine, mesalamine, balsalazide and olsalazine. Therapy with methotrexate, cyclosporine, nicotine patch, butyrate enema, heparin and thalidomide is in the experimental stages. The genes implicated are IBD1, CARD15, and other susceptibility genes located on chromosomes 12, 6 and 14.
Sometimes steroids can also be given intravenously or in the form of suppositories and enemas.

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