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Delysid has also enabled the doctor to gain an insight into the world of ideas of the mentally ill by experiencing schizophrenia-like symptoms himself.
The release of inhibitions produced by Delysid has a therapeutic effect; it brings about the re-living of repressed emotional experiences and, by abreaction, facilitates psychotherapy.
The effect of Delysid on artistic production has also been studied under medical supervision. It would be wrong to conclude from this that certain modern trends in art are manifestations of mental disorders. In April 1943 a research chemist at the Swiss Headquarters of the Sandoz drug company had made an extraordinary discovery. Hoffman's discovery of LSD soon began to interest psychiatrists who wondered whether a drug which appeared to open the doors of perception might be valuable in treating mental illness. On its back page, Macleans prints obituaries that pay tribute to Canadians from all walks of life. Delysid elicits a release of inhibitions and activates the subconscious without rendering the subject unconscious. As little as 10 micrograms (ten millionths of a gram or .01 milligram) produces some mild euphoria, loosening of inhibitions, and empathetic feeling. The results of their experiments were soon known to the chemical warfare scientists in all three members of the Tripartite Agreement, who began to evaluate the drug as a potential weapon. The Canadian Psychiatric Association Journal reported good results with LSD in reversing frigidity and sexual aberrations.


Under the influence of Delysid a realistic mode of portrayal may undergo progressive distortion and result in a production reminiscent of abstract art. The important feature is the release of inhibitions consequent on the removal of control by reason which normally thrusts emotional experiences out of the consciousness into the subconscious, preventing them becoming active. The lowest psychedelic dose is 50 to 100 micrograms, and the intensity and profundity of the effects increase up to about 400- 500 micrograms, with individual variations; higher doses may prolong but do not further alter the experience.
Most of the symptoms of sympathomimetic; they indicate activation of the sympathetic nervous system, which prepares the body physically for emergencies. Albert Hoffman was attempting to synthesize a drug from ergot, a fungus which attacks cereals. American mental hospitals reported that treatment of schizophrenic children which LSD met with some success when all other known methods had failed," reported an American assessment. Logical, rational thought is not alien to primitive peoples and to children even though these concentrate on intuition, pictorial thought and symbolism; their subconscious is not so repressed, can be more readily thrust into consciousness and can also be more easily traumatized, as is evidenced by running amok and falling into trances, reactions in which consciousness is temporarily absent and of which modern, rationally thinking man is not capable.
While working with the substance he experienced a strange, transient state of intoxication associated with changes in perception and personality. LSD probably produces a broader spectrum of physical symptoms than any other drug, almost all of them secondary effects of the complex psychological changes.
In order to ascertain the cause of this disorder he made a personal trial and ingested 250 millionths of a gram of Delysid. One person is said to have taken 40 mg and survived; in the only reported case of death possibly caused by overdose, the quantity of LSD in the blood suggested that 320 mg had been injected intravenously.


Most physiological measurements- liver function, serum cholesterol, urine, and so on- are unaffected.
Even this small amount exerted dramatic effects: disturbances in the perception of space and time, depersonalisation and colored hallucinations. Tolerance (resistance to the drug effect) develops quickly- within two or three days - and disappears just as fast. LSD is almost completely metabolized in the body; very little is excreted unchanged in the urine. As a succession of colours and patterns drifted across his consciousness, he took the first LSD 'trip'. 30 to 80 millionths of a gram, elicited mental changes reminiscent of symptoms of schizophrenia.
An extraordinarily potent substance exerting specific effects on mental functions was thus discovered.



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