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Magnesium is present in all cells of the body and is involved in over 300 enzymatic processes, including energy production.
Research has shown that 68% of individuals in the US do not consume the daily recommended amount of dietary magnesium and 19% do not even consume half of the RDA levels (310-420mg daily) (3).
This elevated calcium to magnesium ratio is a major player in conditions such as mitral valve prolapse, migraines, attention deficit disorder, autism, fibromyalgia, anxiety, asthma and allergies.  Wherever there is elevated calcium and insufficient magnesium inside of cells the effects are muscle contractions, spasms, twitches and even convulsions (6). Specifically, the hippocampus region of the brain is the primary location for retaining long term memories. Associated with decision making, the prefrontal cortex area of the brain aids in the retrieval of short-term memories. As a result of increased long-term potentiation, resulting from the repetitive stimulation of a nerve, as well as the ability for nerves to transmit signals more effectively, magnesium better enables an individual to improve their ability to learn.
Researchers looked to test rats using Magnesium threonate (MgT) supplementation and look at their ability to swim and find a submerged platform on which to rest. Amazingly, the supplemented group was able to retain their memory of where the submerged platform was hidden after 24 hours. This meant that older MgT supplemented rats showed significantly better memory and recall than young rats who didn’t get MgT. With the deteriorating health habits of our modern culture, it is not a surprise that Alzheimer’s disease is associated with decreased levels of magnesium.  Toxic plaque buildup is evident in patients with declining cognitive abilities symptomatic of the pathogenesis of Alzheimer’s disease. Restoring adequate levels of brain magnesium has been found to prevent the further decline of cognitive function. Case studies show that treating magnesium deficiency has helped patients struggling with anxiety, irritability, confusion, hyperexcitability, postpartum depression, drug and alcohol abuse, as well as traumatic brain injuries. Known as an anti-stress mineral, cellular magnesium levels stimulate serotonin production which improves mood.
Have you ever experienced instances when you were highly reactive towards situations or people for minimal or no apparent reason? Magnesium therapy can treat symptoms of anxiety by relaxing nerves, assisting in digestion, relieving muscle tension, and conducting healthy nerve responses (5). A healthy sleep cycle is important to promoting overall health and the production of hormones which are synthesized during sleep.
Primarily reliant on the same factors which regulate mood and manage stress, a healthy night’s sleep is dependent on cellular magnesium concentrations. Magnesium is a critical component involved in the regulation and maintenance of regulating blood glucose levels. Many studies conducted show that supplementing diet with magnesium via food or oral supplementation improves insulin secretion and response in type-2 diabetic patients (6). However, clinical testing has yet to determine if the magnesium alone is solely responsible for improved glucose control. Regardless of the lack of scientists to directly correlate magnesium to the healthy balance of blood sugar, a decreased risk factor for developing diabetes is not to be overlooked following dietary magnesium supplementation. Up to 60% of magnesium is concentrated in bones and the remaining is found in soft tissue and blood. Limited clinical trials have found that when magnesium citrate is taken daily over long periods may prevent and possibly reverse osteoporosis (7). Magnesium assists in detoxifying the body’s tissue of acids, toxins, gasses, poisons and other impurities. Magnesium improves the motility of the gastrointestinal tract and colon and thereby stimulating the removal of contaminants by promoting a laxative effect.
Individuals at greatest risk of magnesium deficiency should pay special attention to health problems they are experiencing. Crohn’s disease, Celiac disease and patients with other gastrointestinal diseases– These individuals are less able to absorb nutrients from dietary intake. Type-2 diabetics- A high concentration of blood glucose leads to increased urination and a higher risk of kidney damage. Alcoholics- Chronic alcohol abuse is likely to cause gastrointestinal problems which further promote the removal of magnesium in urine. Elderly- As the body ages, the gastrointestinal tract becomes less efficient at absorbing minerals. Most magnesium supplements are most efficiently absorbed by the gastrointestinal tract and limited quantities are able to cross the blood brain barrier where it can penetrate into cells.
Magnesium mineral sprays can temporarily reduce pain by becoming directly absorbed through the skin and alleviate pain entirely when used over long term periods.
Commonly used forms of magnesium supplements include magnesium oxide, magnesium citrate and magnesium chloride.
Researchers suggest that magnesium citrate, lactate and chloride are most readily available forms of magnesium for the body to use (7). The latest research indicates that magnesium L-threonate is the best form of magnesium which you could take. A transport process makes the absorption of magnesium into cells extremely difficult and can often lead to inaccurate blood tests results suggesting healthy levels of magnesium.
Brain calm magnesium contains magnesium L-threonate along with other magnesium compounds designed to promote optimal magnesium support.
Before taking on a magnesium supplementation regimen, you should first consult your doctor to see if any medications may interact with magnesium. Magnesium is a naturally present mineral found in many of the foods we should be eating which are farmed from the Earth. The following lists of foods are excellent sources of achieving the recommended dietary dose of magnesium (1, 8). November is National Alzheimer’s Awareness Month and the serious issues of cognitive health will be in the spotlight in the coming weeks. The solution is still unclear, however the good news is that the human brain has a greater degree of plasticity than scientists previously believed, and new studies, specifically those made in nutritional research, show that magnesium deficiency in adults may play a more important role in CI, and more seriously, Alzheimer’s Disease (AD), than previously thought. Furthermore, he states, “There is no question that cognitive impairment is a major fear and health issue for the nation.
According to the Centers for Disease Control and Prevention, estimates show that approximately 20% of people ages 55 and older will experience some form of cognitive impairment.
Disclaimer: None of the above statements have been evaluated or approved by the Food and Drug Administration or the American Medical Association. I am absolutely shocked at what I recently discovered about the importance of magnesium when it comes to our health. Your doctor can order a very simple blood test. A magnesium test checks the level of magnesium in the blood.
Tests for other electrolytes, such as calcium, potassium, sodium, and phosphorus, may be done along with a test for magnesium. Find a cause for nerve and muscle problems, such as muscle twitches, irritability, and muscle weakness. Find the cause of symptoms such as low blood pressure, nausea, vomiting, diarrhea, dizziness, muscle weakness, and slurred speech. Find the cause of heart problems or trouble breathing, especially in people who have kidney disease. Talk to your doctor about any concerns you have regarding the need for the test, its risks, how it will be done, or what the results will mean. A test for magnesium may be done along with testing for otherelectrolytes, such as calcium, chloride, potassium, and phosphorus. Enter your email address to subscribe to this blog and receive notifications of new posts by email.
Many individuals are consuming a whole-food based diet that is rich in magnesium but they are still dealing with magnesium deficiency syndrome.

When we consume a large amount of carbohydrate our body must produce and secrete large amounts of insulin into the blood stream. Magnesium oil is a transdermal magnesium supplement, designed to deliver magnesium through the skin, bypassing the gastrointestinal tract for convenient, rapid absorption into the cells. Magnesium oil, liquid magnesium, and magnesium spray — all names which refer to a concentrated solution of magnesium chloride applied to the skin — are the new darlings of many holistic health professionals. It helps to greatly increase the amount of magnesium in body tissues and overcomes the problems that some people have with loose stools when they try to take enough magnesium to meet their needs. As to the success of magnesium chloride for health via oral supplementation, the benefits are admirable. Some people simply do not produce enough hydrochloric acid (HCl), which can result in a number of health issues related to metabolism and nutrient absorption. Magnesium chloride’s use as a magnesium supplement has the added benefit of helping to reduce many potential problems that could arise from steadily declining secretions of gastric acid in the stomach. These advantages come from the extra chloride found in magnesium chloride, enough to increase production of gastric acid, thereby enhancing absorption and assimilation of magnesium itself, and improving overall digestive efficiency — creating an ideal environment for the assimilation of critical micronutrients important to health, especially as we age. Magnesium Chloride is recognized by many medical professionals as the “Master Magnesium Compound” for both dietary and topical uses, due to its high potency and efficient action.’ Your magnesium oil should be applied topically with a fine mist spray bottle.
Ancient Minerals takes its name from its ancient and pristine source, the ancient Zechstein Sea, a geological formation in Northern Europe from the Late Permian Era.
While it is possible to extract magnesium chloride from various ocean water and inland brine sources, it’s important to question the purity of any product derived from sea water that has been exposed to industrial pollutants — similar to concerns regarding the mercury content of fish. Our magnesium oil utilizes only Genuine Zechstein™ magnesium chloride, the purest and most pristine source of natural magnesium chloride in the world, extracted in a preserved state from an ancient time millions of years prior to our modern age. For those who struggle with sleeping, whether it is falling asleep or staying asleep, I recommend the Magnesium Goodnight which has melatonin in it for deeper and more fulfilling sleep cycles. The results of the study suggest that elevation of brain magnesium through dietary intake of magnesium exerts substantial positive effects on brain, actually restoring aging brains to their youthful conditions. Over 300 enzymes require magnesium to perform biological reactions essential to tissue and organ function (2).
Studies show that low levels of brain magnesium directly correlate to poor memory function (4). Magnesium is known to strengthen the function of synapses in the hippocampus thus improving long-term potentiation.
One study found that the supplemental treatment of magnesium over a 17 month period reduced amyloid plaque accumulation in the hipocampus region of the brain by 35.8% and by 36% in the prefrontal cortex. Damage to the nervous system has been implicated as the cause of numerous health concerns including dementia and depression (5). Magnesium has also been reported by the American Academy of Neurology and the American Headache Society as a “probably effective” treatment for preventing migraines and headaches which can be associated with stress (7). Clinical studies have found that 125-300 mg of supplemental magnesium is effective at treating symptoms of depression after just one week (5). Unhealthy nerve impulses in the hippocampus can cause factors conducive to stimulating fear and anxiety (3). A healthy magnesium balance is needed to regulate hormones such as melatonin which in turn helps to induce sleep and decreases cortisol.
Deficiencies in magnesium impair insulin secretion and the ability of glucose to be transported into cells (7). It is this increased concentration of glucose in the kidneys that leads to frequent urination and further promotes magnesium deficiency (7). Physicians speculate whether the improved health benefits are a result of another vitamin or mineral commonly found in food sources high in magnesium. When magnesium supply is deficient in cells, the body has to search for magnesium which can affect overall health.
Magnesium has to be in a proper balance with calcium in order to maintain healthy bone density and is essential to bone health as we age. Women who supplemented their diets with enriched magnesium food sources over a 2 year period reportedly had fewer fractures and a decreased rate of bone loss (1). In combination with these other minerals, magnesium is responsible for the function of muscle contraction and heart rhythm.
Aside from alleviating symptoms of anxiety, relieving the restriction around blood vessels and regulating a healthy contraction of the heart may lower blood pressure (2, 7).
Lower doses of magnesium supplementation was found to reduce the risk of stroke by 8% requiring further studies to analyze the link between dose dependency and results. Environmental contaminants in our food expose our bodies to a higher amount of toxins and impurities than in the past. For this reason, magnesium is a primary ingredient in most laxatives used to relieve constipation. Only 32% of Americans are believed to meet the recommended daily requirements for magnesium (2).
Older adults are more likely to be taking medications which can interfere with the absorption of magnesium. The body filters out up to 90% of magnesium before it reaches the cells of the body where it is needed most (7). People experiencing symptoms of osteoarthritis can benefit from these mineral oil sprays by improving the balance of magnesium to the affected area. Anecdotal evidence suggests that spraying magnesium oil over extended time duration can alleviate cramping during menstruation. Be sure to buy a pure magnesium supplement product free of other elemental compounds which may adversely affect the body. Unlike other magnesium compounds, magnesium threonate is capable of passing the blood brain barrier and becoming absorbed into cells (2, 3, 4).
The dietary supplementation of magnesium threonate is the most highly bioavailable magnesium compound effective at increasing the concentration of magnesium inside cells.
Only magnesium L-threonate has the highest absorption rate of magnesium available for cells and may be the best form of a magnesium supplement that you could buy.
For instance, some antibiotics have compounds in which magnesium can bind with and become insoluble (7). Without a constant replenishment of this mineral, the brain and nervous system loses ability to function properly.
Be sure to purchase organic and non-GMO farmed foods to receive the maximum benefit from these sources. Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women.
Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala. Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer’s disease mouse model. The medical community agrees that cognitive impairment (CI), ranging from mild to severe, is almost epidemic in the U.S. Liu said, “The body of our peer-reviewed and published work underscores that magnesium threonate can help maintain healthy brain activity. People are living longer and they want to take steps to maintain the quality of their physical and mental health. Peter Osborne, a Board Certified doctor of clinical nutrition, said, “Healthy cognitive function begins with a solid nutritional foundation. The information provided on this site is intended for your general knowledge only and is not a substitute for professional medical advice or treatment for specific medical conditions. I recently went through a scare where my doctor thought my symptoms were due to a benign brain tumor.

Magnesium is an important electrolyte needed for proper muscle, nerve, and enzyme function.
Be sure to tell your doctor about all the nonprescription and prescription medicines you take. These ranges vary from lab to lab, and your lab may have a different range for what’s normal. Your doctor will talk with you about any abnormal results that may be related to your symptoms and past health. Symptoms of a magnesium deficiency include weakness, dizziness, irregular heartbeat, shaking, twitching, and seizures. Magnesium is essential for maintaining normal bone density, normal cardiac rhythmicity, normal pulmonary function, and normal blood glucose regulation. Magnesium deficiency is often misdiagnosed because it does not show up in blood tests as only 1% of the body's magnesium is stored in the blood (1). Most researchers believe this RDA level is far too low and if it was raised to where it should be we would see that roughly 80% of Americans are consuming insufficient quantities (4). This is due to a diet that contains too many carbohydrates which leads to blood sugar instability. Magnesium is a key part of the insulin pathways and insulin is what helps funnel magnesium into the cells of the body. Many use capsulated products but research has indicated that the transdermal approach is the best.
With regard to forms of magnesium supplements, the closer the stability constant is to zero, the more bioavailable the supplement. Many researchers advocate magnesium chloride as the most effective form of dietary supplementation, in part due to the vital role that chloride has in the production of hydrochloric acid in the stomach. These deficiencies can be due to various disorders that affect the stomach, or simply due to individual differences or reasons unknown. For 250 million years Genuine Zechstein™ magnesium salt has been protected deep within the Zechstein Seabed at a depth of 1600-2000 meters beneath the earth’s crust, isolated from the impurities of the modern world. There are no added ingredients except those found naturally occurring in the deep underground deposits of this pristine source.
The nutritional research concluded that magnesium deficiency in adults may play a more important role in cognitive impairment (CI), and more seriously, Alzheimer’s Disease (AD), than previously thought. The study is the first to show a mechanism for reversing cognitive decline in advanced stage AD mice, and is also the first to show an effective long-term treatment in AD mice.
Magnesium supports optimal cognitive health by maximizing the various intricate functions of the brain. In other words, magnesium better equips the brain with the ability to retain memories over long term periods.
Magnesium also strengthens the synaptic nerve endings responsible for transmitting a response (2, 3). Some researchers even propose that the development of the disease may even be reversed following magnesium therapy. Remember, magnesium is used by our cells as a type of fuel source for biological processes to function.
Magnesium therapy is not only found to strengthen the ability of nerves in the brain to function properly, but magnesium treatment also increases the selectivity of nerves to fire which reduces one’s risk of excitability and agitation (2).
Magnesium is also needed for a restful night’s sleep because it promotes muscle relaxation ensuring less of your night is spent counting sheep.
Other reports found that there was a 15%-23% reduction in the risk of developing diabetes following different doses of magnesium supplements. Low levels of blood magnesium affects heart rate, nervous function, and can lead to chronic headaches.
When magnesium is pulled from the bones resulting from cellular magnesium deficiency, the concentration of calcium to magnesium becomes too imbalanced leading to the calcification of bones and joints. As previously mentioned, magnesium assists in regulating nerve impulses and is perhaps most important in maintaining cardiovascular health. There is no doubt that magnesium threonate has dramatic effects in preventing synapse loss and reversing memory decline in mice with Alzheimer’s disease. Cognitive impairment can affect a person’s memory, language, perception, ability to plan and carry out tasks, and judgment. It also helps the body use energy and is needed to move other electrolytes (potassium and sodium) into and out of cells.
Low magnesium levels are usually caused by not eating enough of the foods that contain magnesium or from problems that block the way food is absorbed from the intestines. Magnesium is one of the most common world-wide deficiencies and it plays a role in most of the common health struggles people face every day. Magnesium is to the body like oil is to a car’s engine and if we are deficient problems will arise.
Magnesium is absorbed through the skin, giving transdermal magnesium therapy many of the same benefits as some of the much more expensive transdermal patches available today.
The most common supplemental form is magnesium oxide, which has been shown to have as low as a 4% absorption rate (10). These metal-ligand compounds may each be assigned a “stability constant”, which defines their relative ability to dissociate into ionic form. Lower stability constants represent soluble complexes, more easily broken down into ionic form for bioavailability.
As we age, production of HCl in the stomach declines, often dramatically, and is nearly always left undiagnosed. More exciting, though, are the implications of this study for the potential for treating AD in humans. According to the Centers for Disease Control and Prevention, estimates show that approximately 20% of people ages 55 and older will experience some form of cognitive impairment. The higher amount of both physical and mental demands in our lives, the higher the rate our bodies deplete magnesium sources. As a result of their magnesium hunt, cells are forced to pull what limited magnesium concentration is found in a delicate balance out of bone formations. We know 50 million Americans are magnesium [deficient] because people do not eat enough foods that contain magnesium.
This includes antacids that contain magnesium, laxatives (such as milk of magnesia or Epsom salts), magnesium supplements, and some diuretics.
Magnesium oxide is great for improving bowel tone but not addressing magnesium deficiencies. This is important, as we assimilate magnesium not as the magnesium chloride compound, but rather as free magnesium and chloride ions.
Shealy compared intracellular magnesium levels of participants before and after a period of daily application of topical magnesium, via magnesium baths and spray application of magnesium chloride oil. Researchers feel confident that magnesium threonate can help maintain healthy brain activity and has dramatic effects in preventing synapse loss and reversing memory decline. So I started doing some research to see what else could cause the symptoms I have been having.
This means that a value that falls outside the normal values listed here may still be normal for you or your lab. Elevation of Brain Magnesium Prevents and Reverses Cognitive Deficits and Synaptic Loss in Alzheimer’s Disease Mouse Model.

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