Each capsule for oral use, with opaque red cap and body, contains triamterene, 50 or 100 mg, and is imprinted with the product name DYRENIUM, strength (50 or 100) and WPC 002 (for the 50 mg strength) and WPC 003 (for the 100 mg strength). Triamterene has a unique mode of action; it inhibits the reabsorption of sodium ions in exchange for potassium and hydrogen ions at that segment of the distal tubule under the control of adrenal mineralocorticoids (especially aldosterone). The fraction of filtered sodium reaching this distal tubular exchange site is relatively small, and the amount which is exchanged depends on the level of mineralocorticoid activity.
Triamterene occasionally causes increases in serum potassium which can result in hyperkalemia. Triamterene has been shown to cross the placental barrier and appear in the cord blood of animals. Dyrenium (triamterene) is indicated in the treatment of edema associated with congestive heart failure, cirrhosis of the liver and the nephrotic syndrome; also in steroid-induced edema, idiopathic edema and edema due to secondary hyperaldosteronism. The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard. Edema during pregnancy may arise from pathological causes or from the physiologic and mechanical consequences of pregnancy.
Dyrenium (triamterene) should not be used in patients with pre-existing elevated serum potassium, as is sometimes seen in patients with impaired renal function or azotemia, or in patients who develop hyperkalemia while on the drug.
There have been isolated reports of hypersensitivity reactions; therefore, patients should be observed regularly for the possible occurrence of blood dyscrasias, liver damage or other idiosyncratic reactions. Periodic BUN and serum potassium determinations should be made to check kidney function, especially in patients with suspected or confirmed renal insufficiency. The presence of a widened QRS complex or arrhythmia in association with hyperkalemia requires prompt additional therapy. For tachyarrhythmia, infuse 44 mEq of sodium bicarbonate or 10 mL of 10% calcium gluconate or calcium chloride over several minutes.
The effect of calcium and sodium bicarbonate is transient and repeated administration may be required. Dyrenium (triamterene) tends to conserve potassium rather than to promote the excretion as do many diuretics and, occasionally, can cause increases in serum potassium which, in some instances, can result in hyperkalemia. Triamterene can cause mild nitrogen retention which is reversible upon withdrawal of the drug and is seldom observed with intermittent (every-other-day) therapy.
Triamterene may cause a decreasing alkali reserve with the possibility of metabolic acidosis.
By the very nature of their illness, cirrhotics with splenomegaly sometimes have marked variations in their blood pictures.
Triamterene has been reported in renal stones in association with other calculus components.
If a single daily dose is prescribed, it may be preferable to take it in the morning to minimize the effect of increased frequency of urination on nighttime sleep. If a dose is missed, the patient should not take more than the prescribed dose at the next dosing interval. Hyperkalemia will rarely occur in patients with adequate urinary output, but it is a possibility if large doses are used for considerable periods of time.
Caution should be used when lithium and diuretics are used concomitantly because diuretic-induced sodium loss may reduce the renal clearance of lithium and increase serum lithium levels with risk of lithium toxicity.
A possible interaction resulting in acute renal failure has been reported in a few subjects when indomethacin, a nonsteroidal anti-inflammatory agent, was given with triamterene. The effects of the following drugs may be potentiated when given together with triamterene: antihypertensive medication, other diuretics, preanesthetic and anesthetic agents, skeletal muscle relaxants (nondepolarizing). Potassium-sparing agents should be used with caution in conjunction with angiotensin-converting enzyme (ACE) inhibitors due to an increased risk of hyperkalemia. Triamterene and quinidine have similar fluorescence spectra; thus, triamterene will interfere with the fluorescent measurement of quinidine. There was an increased incidence of hepatocellular neoplasia (primarily adenomas) in male and female mice at the highest dosage level. Although hepatocellular neoplasia (exclusively adenomas) in the rat study was limited to triamterene-exposed males, incidence was not dose-dependent and there was no statistically significant difference from control incidence at any dose level.
Adverse effects are listed in decreasing order of frequency, however, the most serious adverse effects are listed first regardless of frequency. In the event of overdosage it can be theorized that electrolyte imbalance would be the major concern, with particular attention to possible hyperkalemia. Reversible acute renal failure following ingestion of 50 tablets of a product containing a combination of 50 mg triamterene and 25 mg hydrochlorothiazide has been reported. Although triamterene is 67% protein-bound, there may be some benefit to dialysis in cases of overdosage. Founded in the year 2002, Lancer Health Care is a well known Exporter, Distributor, Supplier & Trader of a wide array of premium quality tablets and injections.
We export our products to many countries, where we have found a huge demand of our products.
In-fact and most shocking the bulk of veterinary prescribed dry dog and cat foods are a perfect example of foods that cause UTIs – you can see why here. UTIs are often caused when bacteria, fungi or parasites find their way into the bladder or uretha. Left untreated UTI can be a very serious condition which can cause serious and life threatening problems. As well, the more times a dog and cat is on antibiotic the greater chance of the dog’s, cat’s system acquiring an immunity to antibiotics – a potentially life-threatening situation. Bath your dog using the following rinse – this will help to flush out bacteria that might otherwise invade your dog’s urinary tract.
Lemon can be used in combination with greet tea and organic apple cider vinegar as a highly effective cleansing and disinfecting rinse. If your dog will not eat the mixture as is, you can mix-in a piece of fatty fish, chicken or meat. University of Georgia researchers found that GSE is an effective antiviral, antifungal and anti-parasitic agent for fighting many viral and bacterial infections, including E.
Vitamin C, Citric Acid, sterols and multiple additional antioxidants that aid the immune system’s ability to battle infections. Juniper berries are harvested from the coniferous juniper which grows as a bush or medium height tree – a member of the pine family. We doesn't provide spironolactone side effects products or service, please contact them directly and verify their companies info carefully.
This activity is not directly related to aldosterone secretion or antagonism; it is a result of a direct effect on the renal tubule. Thus, the degree of natriuresis and diuresis produced by inhibition of the exchange mechanism is necessarily limited.
It does not produce alkalosis because it does not cause excessive excretion of titratable acid and ammonium. It also promotes increased diuresis when patients prove resistant or only partially responsive to thiazides or other diuretics because of secondary hyperaldosteronism.
Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developed toxemia. Diuretics are indicated in pregnancy when edema is due to pathologic causes, just as they are in the absence of pregnancy (however, see PRECAUTIONS below). Severe or progressive kidney disease or dysfunction with the possible exception of nephrosis.
Although dosage recommendations were exceeded in one case and in the other serum electrolytes were not properly monitored, these two drugs should not be given concomitantly. It is particularly important to make serum potassium determinations in elderly or diabetic patients receiving the drug; these patients should be observed carefully for possible serum potassium increases. If the ECG shows no widening of the QRS or arrhythmia in the presence of hyperkalemia, it is usually sufficient to discontinue Dyrenium (triamterene) and any potassium supplementation and substitute a thiazide alone.
The use of full doses of a diuretic when salt intake is restricted can result in a low-salt syndrome.
Since triamterene is a weak folic acid antagonist, it may contribute to the appearance of megaloblastosis in cases where folic acid stores have been depleted. A rise in plasma pH may cause a decrease in plasma potassium concentration and an increase in the intracellular potassium concentration. Patients receiving such combined therapy should have serum lithium levels monitored closely and the lithium dosage adjusted if necessary. Caution is advised in administering nonsteroidal anti-inflammatory agents with triamterene.
Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. The use of triamterene in pregnant women requires that the anticipated benefits be weighed against possible hazards to the fetus. Other symptoms that might be seen would be nausea and vomiting, other GI disturbances and weakness. The amount of drug in a single dose ordinarily associated with symptoms of overdose or likely to be life-threatening is not known. Based in Delhi (India), our company offers range of medicines to cure several minor and major ailments. Unprocessed real meat makes urine slightly acidic thus creating an environment that is not friendly for overgrowth of bacteria. As female dogs and cats have shorter urethras they are more vulnerable to infection via surface contaminates. An excellent alternative to commercially made pet shampoos which can be full of toxins and carcinogens. If the infection does not clear-up in the space of a day or two get your dog to a veterinarian. If the infection does not clear-up in the space of a day or two get your dog, cat to a veterinarian.
Juniper berries are safe for most dogs and cats when used in moderation as directed below. My German shepherd x Siberian Husky ‘Sarah’ likes juniper berries so much that she picks them herself – I keep an eye on her to ensure she does not consume too many! Increasing the amount of available sodium and the level of mineralocorticoid activity by the use of more proximally acting diuretics will increase the degree of diuresis and potassium conservation. Dependent edema in pregnancy, resulting from restriction of venous return by the expanded uterus, is properly treated through elevation of the lower extremities and use of support hose; use of diuretics to lower intravascular volume in this case is illogical and unnecessary. Sodium polystyrene sulfonate (Kayexalate®, Winthrop) may be administered to enhance the excretion of excess potassium. When combined with another diuretic or antihypertensive agent, the total daily dosage of each agent should usually be lowered initially and then adjusted to the patient's needs. Our product range combines Pharma medicines, Anti Alcohol, Anti Asthmatic, Anti Asthmatic Inhalers, Blood Pressure Diuretic Medicine, Cancer Medicines, Herbal Medicines, Herclon, HIV Aids Medicines, Kidney Medicines and many others. 6, Gelatin NF, Lactose NF, Magnesium Stearate NF, Sodium Lauryl Sulfate NF, Titanium Dioxide USP and Silicon Dioxide NF. There is hypervolemia during normal pregnancy which is harmful to neither the fetus nor the mother (in the absence of cardiovascular disease), but which is associated with edema, including generalized edema, in the majority of pregnant women.
Potassium levels persistently above 6 mEq per liter require careful observation and treatment. As with an overdosage of any drug, immediate evacuation of the stomach should be induced through emesis and gastric lavage.
We offer all our medicinal range in compliance with FDA set norms to assure maximum quality. We have garnered a huge clientele around the world, with his experience and in-depth knowledge of the industry.
The products are also packed in the standardized packaging to give the seal of trust to our clients. Our products are exported to countries like France, Thailand, Germany, Bhutan, Nepal, Vietnam, UK, USA, and others. Triamterene is rapidly absorbed, with somewhat less than 50% of the oral dose reaching the urine. Owing to our sizable team of members, we can supply healthcare products to fulfill the requirements of our esteemed client base. We offer all the products that give quick results, zero side effects, non pungent odor, long shelf life, accurate composition of chemical compounds. Duration of diuresis depends on several factors, especially renal function, but it generally tapers off 7 to 9 hours after administration.
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