Neo-Mercazole, an imidazole antithyroid agent, converts to methimazole after being absorbed by the body, which generates an antithyroid action that works against hyperthyroidism (excessive production of thyroid hormones) and thyrotoxicosis (inflammation of the thyroid gland).
Neo-Mercazole is available by various brand names, including Atirozidina, CG1, Neo-Theyreostat, Neo-Tireol, Neomercazole and Tyrazol.
Hyperthyroidism occurs when the thyroid gland produces an excess amount of T3 (triiosdothyronine) or T4 (thyroxine) hormones.
Patients with hyperthyroidism need to tell their healthcare professional if they are allergic to Neo-Mercazole or any of its ingredients. Known side effects include headaches, pruritus (itching), nausea, blood disorders, diarrhea, constipation, nausea, vomiting and stomach aches, myalgia (muscle pain), arthralgia (joint pain), jaundice (yellowing of the skin), hair loss, and a skin rash. A serious side effect involves a decrease in the bone marrow's production of blood cells, also known as bone marrow suppression. If other side effects that are not listed here develop, consult your healthcare professional immediately.


This medication is most often used for hyperthyroidism, when preparing a patient for thyroidectomy (surgical removal of all or part of the thyroid gland), and together with radio-iodine therapy for hyperthyroidism. Thyroid hormones regulate metabolism, so too many thyroid hormones in the body will speed up metabolism, including the digestion and cardiovascular functions. Neo-Mercazole works by preventing iodine from binding with other components to form thyroid hormones. If patients experience any allergic reactions, the medication should be stopped until they can consult their healthcare professional.
If this is accompanied by signs of an infection including a fever, a sore throat or mouth ulcers, the condition requires immediate medical attention. Symptoms include palpitations, intolerance for heat, insomnia, breathing difficulties, frequent bowel movement, fatigue, weight loss, warm moist skin, muscle weakness, hair loss, trembling hands, and light or absent menstrual periods. This decreases thyroid function by reducing the thyroid gland's production of thyroid hormones.


Patients who are pregnant should use Neo-Mercazole with extreme caution and only if the benefits of taking the medication outweigh the risks to their unborn child.
Healthcare professionals often prescribe a gradually reduced dosage, giving just enough medication to control the condition. The effects of this medication are usually noticed three to four weeks after treatment begins, because the body will need to use up the thyroid hormones already existing before the medication was started. Since Neo-Mercazole passes into breast milk, breastfeeding is not recommended while taking this medication as it might harm the nursing infant.




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