The FDA approved another new weight loss medication, Contrave which is a combination of Bupropion and Naltrexone in extended release formulation for the treatment of obesity and weight management, including for weight loss and maintenance of weight loss, used in conjunction with lifestyle modification.
Obesity is a rapidly growing epidemic among adults, adolescents, and children in the United States.
Diet and exercise is the mainstay of weight management and generally precedes other measures.
Unfortunately, diet and exercise alone yield mostly limited and transient weight loss, with many individuals finding it difficult to adhere to such regimens. The strategy to implement pharmacotherapeutic or surgical approaches in addition to diet and exercise depends upon the patient’s BMI as well as the presence of obesity-related comorbidities. However, unlike the situation for other metabolic diseases such as hypertension and type 2 diabetes, there are very limited obesity pharmacotherapies available.
All four Phase 3 studies showed statistically significant improvement in each co-primary endpoint relative to placebo. Patients may experience elevated blood pressure or pulse during Contrave treatment; the risk may be greater during the initial 3 months of therapy. All four Phase 3 Contrave studies demonstrated statistically significant and clinically meaningful weight loss following up to 56 weeks of treatment with Contrave compared with placebo. The average percent weight loss from baseline observed with NB treatment across the four studies corresponded to between approximately 5 and 9 kg (11 to 22 pounds).
Patients with type 2 diabetes in Contrave Study showed the smallest degree of weight loss, although a significantly greater proportion of Contrave-treated patients benefitted with at least 5% weight loss at endpoint compared to placebo. Clinically meaningful weight loss was apparent early in treatment, and was greater than that observed with either naltrexone or bupropion alone.
Patients with type 2 diabetes benefitted from weight loss, improvements in waist circumference, HDL and triglycerides, and clinically significant improvements in glycemic control (particularly decreased HbA1c).
Greater proportions of NB-treated patients reported clinically meaningful improvements in weight-related quality of life compared with placebo, providing further evidence of the range of clinical benefits that can be derived from NB treatment. The use of NB was generally well-tolerated, with the frequency and distribution of safety findings being consistent with the established profiles for naltrexone and bupropion. Common AEs such as nausea and vomiting tended to occur early in treatment (during the dose-escalation phase), were mostly mild to moderate in severity, and were generally self-limiting. The incidence of treatment-emergent SAEs overall was low; the vast majority of SAEs in NB-treated patients were considered unrelated to study drug.
Initiation of treatment with NB was associated with transient increases from baseline of approximately 1 mm Hg in mean blood pressure, followed by small reductions below baseline. The incidence of major cardiovascular events (cardiovascular death, myocardial infarction and cerebrovascular accident) and revascularization procedures were low and comparable between NB- and placebo-treated patients, although the number of events is too low to draw firm conclusions. Seizures occurred infrequently at a rate that is consistent with that observed for the lowest approved dose of bupropion SR. Treatment with NB in the target patient population does not appear to be associated with an increased risk for depression or suicidality.
Clinical laboratory evaluations were generally unremarkable, and values outside of normal ranges tended to be sporadic and unrelated to dose. Neither bupropion nor naltrexone has historically been associated with prolongation of QTc intervals, and review of QT, QTc and the other ECG parameters in patients during long-term NB treatment revealed no noteworthy findings.
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In summary, the benefits of NB outweigh the risks given the clinically meaningful weight loss and improvement in multiple markers of cardiometabolic risk and patient-reported quality of life.
Overall, the NB safety profile is well-understood, with known risks that are predictable and manageable via appropriate risk mitigation approaches.
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It has been found to be effective for people who are already undergoing a weight loss program. There is no evidence of the clinical results, which the company claims the green coffee extract works like a miracle. There is no support for the claim by the company that the product boosts energy and mood while reducing hunger pangs.
Fat Go Slim Capsules are an Ayurvedic weight loss supplement introduced by Jolly Health Care.


The Ayurvedic product manufactured by Jolly Healthcare targets the impaired fat burning process called metabolism. The claimed weight loss benefit of this Ayurvedic capsule is that it works as a cure for impaired metabolism.
No clear information about the working mechanism of the Fat Go Slim capsule is really available.
Amla, Haritaki, Plumbago zeylanica, Ginger, Neem, Tylophora Asthamatica, Beorhavia Diffusa, etc are its most important ingredients. We’re certainly not happy about the fact that Jolly Health Care didn’t disclose the result of the clinical test to the public. If the ingredient formula used in Fat Go Slim capsules is really effective, it will be successful. The herbs used in the product improve the overall digestive system and balance the metabolism.
It will be a value for money product provided it addresses the obesity concern of the consumers effectively.
Although orlistat is approved for long-term use and provides efficacy beyond that usually achievable using diet and exercise alone, it is not tolerated well by some patients. The most commonly reported side effects (those that occurred at a ?5% incidence in the Total NB group and greater than the incidence in the placebo group) for patients treated with NB are displayed in the table below.
Weight loss was on average sustained, and those patients who continued treatment through 56 weeks experienced the most substantial weight loss. A lower proportion of NB-treated patients required adjustments to their antidiabetic medications due to poor glycemic control. These increases are consistent with the known hemodynamic effects of bupropion and were attenuated by weight loss in patients who responded to therapy, although mean blood pressure reductions with NB were always less than that observed with comparable placebo patients.
Bupropion has been extensively prescribed since its original approval more than 20 years ago, and has a long history of safe use even in populations considered at risk for CV disease. These benefits in aggregate are expected to be greater in general clinical practice, as proposed labeling would lead to discontinuation of treatment for patients not experiencing at least a 5% decrease from baseline in body weight. Orexigen is developing a plan for additional clinical studies to assess: 1) prescription utilization patterns, 2) physician and patient adherence to labeling, and 3) the impact of Contrave on cardiovascular outcomes. Tumpati, I can't thank you enough for helping transform my daughter Erin (lost 64 lbs*) into a much happier young lady and she looks amazing and also thanks for helping me lose 25 pounds I feel great - Lisa, Erin's mom. W8MD medical weight loss website or any of our affiliated weight loss blogs is not intended to diagnose, treat, cure, or prevent any disease.
Find out what sets this brand of garcinia cambogia apart from the others Discover The Pure Garcinia Cambogia - YouTube Due to recently being featured on T.V. This means if someone is putting on weight because of metabolic disorder, this Ayurvedic capsule will treat and stabilize the condition.
According to the manufacturer, if your body is not able to burn fat on its own, this supplement will offer an extended hand to repair the internal issues creating nuisance. The company says the product is clinically tested and was found to be effective for stimulating fat loss in human. Most of these herbs address some specific aspects directly or indirectly related to obesity. Judging the product result validation is just not possible without transparency of information. Or else, it will be like any other scam weight loss product currently available in the Indian market. Although it’s an herbal product, as we said earlier, this doesn’t eliminate all chances of triggering side effects. It’s not a too expensive product, but, the investment will be useless if the product makes no difference at all.
But, if this product launched by this company will be successful or not, that’s a question. If it has been able to launch such a remarkable product, it could clearly show us reliable evidences of product success, which we don’t see till now. Achieving 5% weight loss is not only an FDA guidance efficacy benchmark, but this degree of weight loss is known to confer significant cardiometabolic benefit.
As patients with hypertension or a history of hypertension may be at increased risk of blood pressure elevations, care should be exercised when initiating treatment with Contrave in such patients. The efficacy of NB was observed across all demographic and clinical subgroups evaluated, including patients with hypertension, dyslipidemia, history of cardiovascular disease, type 2 diabetes, impaired fasting glucose, or history of depression.
The small elevations in heart rate seen with NB treatment (compared with decreases with placebo) are also consistent with known bupropion effects.
Benefits are observed across a range of overweight and obese patient subgroups and in various treatment settings. So far I have lost 42 pounds with 18 to go before by youngest daughter's 21st birthday trip to Hawaii. I would highly recommend him to anyone that is serious about not only losing weight but improving their overall health , gaining knowledge about their bodies and nutrition and developing a healthier lifestyle. Metadolic disorder, which is also known as metabolic syndrome, can be a result of insulin resistance, fatty liver, Polycystic ovarian syndrome or sleep apnea.


The ingredients present in the weight loss supplement will stimulate the body’s fat burning ability.
If the company is so confident about its weight loss supplement, it should make all related evidences public, or at least show us confirmation from any reliable authorized body that the product is safe and effective for the purpose of weight loss.
Given the information on the company website and information gathered through our research, we can’t guarantee anything. The company didn’t make any precautionary announcement to warn people about the conditions when people shouldn’t take the drug, when people on specific prescription drugs should avoid the supplement, contacting a health supervisor if consumers experience certain product side effect symptoms, etc. In the face of such limited options, patients often resort to the use of off-label medications or dietary supplements that may be ineffective or unsafe. Of note, the population of patients receiving currently approved bupropion-containing therapies has important similarities to patients enrolled in the NB clinical program, as well as the population of patients who receive currently marketed obesity pharmacotherapy. The industry leading fat burning formula boosts your metabolism, while also breaking away stubborn fat cells – giving you the lean and healthy body you want and deserve.
The company says none of its products are launched in the market without conducting quality assurance test under the guidance of the supervisors. Improvement of the digestive functions is very important for getting rid of the extra body mass.
Any and all information included on this site is intended as general information, but should not be construed as medical advice, healthcare advice, legal advice, nor should it be used to diagnose, treat or address any medical or health problem.
In this context, agents such as Contrave, a combination of Naltrexone and Bupropion(NB), may offer viable alternatives for many obese patients.
In addition, clinical experience and investigation in relevant patient populations, including those with cardiovascular risk factors or established cardiovascular disease, have not identified specific safety signals for clinical cardiovascular events.
Amazing energy enhancers and appetite suppressents minimize food cravings, helping you achieve your goals MUCH faster. Having said that, conditions like Polycystic ovarian syndrome might need health expert’s attention. The only best solution to judge the product effectiveness is getting real reviews from the consumers. Some of them have been found to be effective for controlling blood sugar, insulin response and improving metabolism.
However, if the concentration used in the medicines is really good for the overall health of an obese person, that remains unanswered. Before using any of the products or services of company, you should consult with your physician or qualified medical practitioner.
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But that’s not enough to make a firm affirmation about the reliability of the weight loss supplement. If the problem cause is related to a genetic condition, this weight loss supplement will not solve the issue.
If you find impartial product reviews from anywhere like, YouTube, Facebook, friends, colleagues, any product review site like ours, try to develop a product understanding from there. So, if Fat Go Slim weight loss formula is perfect for stimulating the natural fat burning work mechanism of the body, that’s excellent.
If any research association in India could confirm the product effectiveness, that would have been best ideally.
This pill is an ALL NATURAL weight-loss aid and it naturally promotes appetite suppression and fat burning. If there is any flaw in the manufacturing process, the poisonous substances of the plant can trigger side effects in the consumers instantly or gradually.
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