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Herpes Simplex virus – Wikipedia, The Free EncyclopediaHerpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as Human herpes virus 1 and 2 (HHV-1 and -2), are two members of the herpes virus family, Studies of vulnerable patient populations have indicated that daily use of antivirals such as acyclovir and valacyclovir can reduce reactivation rates. EBV HepatitisGanciclovir and the treatment of Epstein–Barr virus hepatitis (Adams LA, et al. Epstein Barr Virus (EBV)Epstein Barr Virus (EBV) Virology: Herpesviridae Enveloped, icosahedral nucleocapsid Aplastic anemia This disorder is usually fully expressed in males only. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. The lupus rash is a skin condition associated with the presence of the autoimmune disease called Systemic Lupus Erythematosus (SLE).
Lupus is an autoimmune inflammatory disease which means that a patient with the illness has antibodies that are faulty and attack the patient’s own tissue because they mistakenly identify these as foreign and unfamiliar. The lupus rashes are primarily treated through the topical application of skin creams such as corticosteroids and antimalarial drugs like hydroxychloroquine and chloroquine. SLE patients with rashes should always put on sunscreen with high SPF values before getting exposed to sunlight. All three antibodies in this combination recognize distinct epitopes in the hydrophilic carboxyl region of the latent membrane protein (LMP) protein encoded by the Epstein Barr Virus antibody (EBV). IVD is NOT for Sale in the United States but may be available in certain countries outside of the United States, please contact your local distributor for more information. A rash is the abnormal change in the skin and this change affects the texture, color and appearance of the skin. Itching is an unpleasant feeling in the human body that causes the reflex or desire to scratch.  Research has proved that itching has a number of similarities to pain but their behavioral response patterns are different. Rashes can be of two types, they could either induce an itching sensation or they might be non itchy rashes. Infants often suffer from itchy rash due to infection, dry skin or as a result of overactive glands in the infant.  Itchy rashes in infants can be petechial rash which are serious and require immediate medical attention or they can be erythematous rash which are usually not as serious as the petechial rashes. Certain childhood diseases cause red itchy spots in children and this condition is known as Exanthem. Itchy rashes are a common cause of worry during the last five weeks of pregnancy when the stretching of the skin is the greatest; however this condition clears with delivery. Many a times itchy rashes also appears s itchy red bumps and this could be due to various causes such as insect bites, acne, razor bumps, presence of a foreign object in the skin, side effects of various drugs, infection, immune deficiency or as a reaction to external stimuli. Itchy nevuses is another type of itchy rash that is a chronic condition where in the delimited rash appears on the mole or macule of the affected individual.
Itchy rashes also appear as itchy scaling patches in case of fungal infections and genetic disorder. In severe cases itchy rashes are characterized by itchy red patches that have blisters, crusts or are scaling.  Some of these conditions are severe sunburn, photosensitivity, sever cellulitis, shingles, cold sore, eczema, impetigo, paronychia, scabies, paget disease, pompholys and more.
Other than the above mentioned conditions, itchy rashes could also be an indicator of other internal diseases.


Patients with EBV-associated FRG Epstein–Barr virus (EBV) polymerase chain reactions on marrow aspirate samples were positive.
Journal of Gastroenterology and Hepatology 21(2006) 1758-1760) ? Adams LA, et in those suffering from severe overwhelming life-threatening infection (eg, liver failure) or other severe complications such as aplastic anemia. It reflects either more severe hepatitis or Epste in– Barr virus infection-associated hemolytic anemia. This testing, including antibody testing for the Epstein Barr virus, may then reveal the past infection.
As an autoimmune disease, SLE does not usually present itself with a predictable set of symptoms in each of the patients suffering from it, but its distinctive rash remains as a consistent sign in most SLE patients. The reactions that the antibodies make start up an inflammatory response, causing swelling and tissue damage to organs as well as to the skin.
EBV has been implicated with Hodgkin’s disease, and may be involved in the pathogenesis of Hodgkin’s occurring in children. While conditions such as goose bumps, roseola, skin tags and warts are non itchy, conditions such as bumpy hives, folliculitis and acne are itchy in nature.
Petechial itchy rashes may be caused by meningococcal infection, enterovirus infection, or due to tight clothing or even due to forceful coughing or vomiting. Exanthem is often coupled with headaches, high fever and malaise and is caused by bacteria or virus infection or as reaction to the toxin of these viruses or bacteria or as an immune reaction.
Irritation caused due to alkaline saliva is one of the most common causes for itchy rashes around the mouth.
During the last three months of pregnancy, pregnant women will notice itchy bumpy reddish rashes on the stretch marks on the abdomen and this condition is known as Polymorphic eruption or Polymorphous Eruption of Pregnancy. These itchy red bumps may or may not be painful depending on the conditions and each condition has to be treated separately depending on the cause of the itchy rashes. Some of these conditions are Nodular prurigo where in a number of itchy red nodules that has a warty surface appears on the limbs, Erythema nodosum which affects the lower legs, forearms or thighs and is characterized by raised red patches on the skin caused due to Tuberculosis or as a side effect to certain drugs. Some of these conditions are mild sunburn, hives, Angioedema, Scombroid fish poisoning, Pityriasis rosea, Amyloidosis, Granuloma annulare and Dermatomyositis. Fungal infections are associated with scaly areas and they can infect the feet, groin, body or scalp and are mostly caused due to ringworm infection. At times contact with certain plants such as chrysanthemum or even nettle can sure itchy rashes with blisters. In the case of skin cancers which could be squamous or basal cell carcinoma and melanoma tend to appear as ulcers on the skin. These conditions are mostly caused due to fungal infections, sexually transmitted diseases, clogging of sweat glands, cyst, lice and more. This condition is called as Onychomycosis which causes the ends of the nail to turn white or yellow and causes the nail to become fragile. Some of the diseases that have itchy rashes as one of their symptoms are liver diseases, Chron’s disease, kidney disease, Celicac disease, Chemochromatosis, Schistosomiasis, Lymphomatoid granulomatosis, drug induced jaundice and more.


The lupus rash appears on areas of the skin which receives the most exposure to sunlight, such as on the face. The rash in SLE patients is a result of the inflammatory process in combination with an abnormally increased sensitivity to the heat of the sun. Other studies have shown a low incidence of EBV in B-cell type lymphomas unless patients were immunologically impaired, such as post-organ transplantation or autoimmune type diseases. Some of the diseases that cause red itchy spots are chicken pox, which causes rashes over the face and the trunk, Measles, which casus itchy rashes on the trunk, face, limbs and mouth accompanied with cough. Scalp ringworm infection is also responsible for itchy rashes coupled with scaly skin and hair loss. This condition is also known as PUPPP (Pruritic Urticarial Papules and Plaques of Pregnancy) and is often noticed during the first pregnancy as the abdomen is the tightest at this stage. Some of these itchy red bumps are even gender specific such as Perioral dermatitis, which causes scaly rashes around the eyes and mouth in women and Grover’s disease which almost always appears only in men who are unwell and over 50 and is characterized by the pimple like red bumps appearing on the back and chest. Psoriasis causes itchy rashes due to genetic disorder and it affects the knees, elbows, genital area, scalp and other parts of the body. Gravitational eczema often appears on the lower legs of a person suffering from thrombosis or venous diseases. While dandruff and scalp ringworm are the main culprits for itchy rashes on the scalp, ringworm infection of the beard and fungal infection of the groin and inner thighs causes itchy rashes on beard and groin. In such cases, itchy rashes often disappear, when the treatment for the internal diseases are successful.
It is also known as a “butterfly rash” for the shape it assumes as it is spread horizontally across the patient’s cheeks and nose. Studies have shown that this antibody does stain EBV + Burkitt’s lymphomas but has shown some cross reactivity with smooth muscle and blood vessels. For example, a person suffering from severe psoriasis will suffer from itchy rash condition where as an individual suffering from mild psoriasis may not feel the urge to itch. Erythematous itchy rashes could be caused due to eczema, viral skin rash, diaper rash, thrush, measles and  heat rash.
Some of the other diseases that cause this red itchy spots condition are Fifth disease, hand foot and mouth disease, Hepatitis B, Roseola infantum, scarlet fever and more.
While most of these conditions are associated with certain infections, allergic reaction or other internal diseases, the casues of some of these conditions remains unknown. Fox-Fordyce disease is another disease that causes itchy rashes in the armpits or groins due to the clogging of sweat glands in young women between the age of 13 to 35 years.



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