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14.03.2015 admin
If any Copyright Owner objects to the use of any music or Images appearing in these videos, please contact us and I will remove the content immediately. Johnson & Johnson recently launched Stelara for the treatment of adult patients with moderate to severe plaque psoriasis.
There is no cure for psoriasis, which affects upwards of 7.7 million Americans, according to the National Institute of Health. The actual size of the psoriasis market is deceptive in terms of market size and sales potential. Overlapping pathogenic pathways in autoimmune diseases have not been lost on the makers of the three major TNF-alpha blockers. Stelara, like all existing autoimmune-modifying biologics on the market, can increase the risk of opportunistic infections in those patients hosting latent viruses or bacterium. Decision Resources, in a Treatment Algorithms in Psoriasis report opines that Stelara will change the prescribing habits of dermatologists and help to grow the entire market for systemic biologic agents.
Stelara has a clear field to build a loyal doctor-patient base; most of the biologic compounds in late-stage development are perceived as "me-too" TNF-alpha inhibitors and Abbott Lab's IL- blocker briakinumab is unlikely to hit the market before 2011.

David Phillips has more than 25 years' experience on Wall Street, first as a financial consultant and then as an equity analyst for several investment banking firms.
Powered and implemented by Interactive Data Managed Solutions News provided by The Associated Press. Although Stelara is entering a crowded treatment room for psoriasis, this first-in-class interleukin (IL) inhibitor could put the "no more tears" back in J&J's future -- if successfully marketed to specialists, in particular dermatologists, as it is a novel and less cumbersome injectable than established biologics for psoriasis, the tumor necrosis factor-alpha inhibitors.
Epidemiological studies have shown that as patients age their risk of developing co-morbid autoimmune diseases, such as the GI disease Crohn's, rheumatoid arthritis, and psoriatic arthritis, increases, too. Nonetheless, given J&J's experience in working with opinion leaders in the field of systemic biologics, expectations run high for Stelara. As intimated, with a still incomplete understanding of the numerous (and still to be identified) inflammatory cascades involved in the progression of psoriasis and co-morbid autoimmune diseases, there is an unmet need for effective long-term therapies that also do not grind down patient compliance.Enbrel and Humira are currently opinion leaders' drugs of choice for patients in need of systemic therapies because they believe those two TNF blockers offer a superior balance of efficacy and safety, according to pharmaceutical think tank Decision Resources. This pricing is competitive with the average annual budgets expended on each of the three popular injectable TNF-alpha inhibitors. Humira has the most to lose among the dermatologists polled in the survey, as most of them indicated that more of their Stelara prescriptions would replace Humira as their preferred second-line systemic biologic agent (after Enbrel).

And, in comparison to a possible 100 (plus) injections with Enbrel, the superior efficacy and better patient compliance associated with Stelara could quickly flip-flop skin doctors' preference in time.The new report also suggested that dermatologists are more readily moving patients from first-line topical corticosteroids to second-line conventional systemic agents and foregoing additional lines of topical treatment in the process.
Ergo, specialists have more than two years to gain clinical experience -- and improve their comfort level with the drug. Wenn du dich kostenlos registrierst, kannst du neue Themen und Beitrage unter deinem Namen verfassen, die Suchfunktion benutzen, den Board-Style andern, mit anderen Mitgliedern private Nachrichten austauschen, an Umfragen teilnehmen und weitere spezielle Funktionen nutzen. Die Registrierung ist einfach, schnell und vor allem kostenlos, also registriere dich jetzt!Jetzt kostenlos registrieren und alle Funktionen nutzen. Stelara (ustekinumab) is a novel monoclonal antibody that binds to IL-12 and IL-23, thereby slowing the overproduction of skin cells and the resultant inflammation (see image to left; click for a larger version).

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Rubric: Small Garden Sheds


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