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A case of myeloid neoplasm with FIP1L1-PDGFRA rearrangement without marked peripheral blood eosinophilia.
Department of Hematology, Drum Tower Hospital, Medical School of Nanjing University, 321# Zhongshan Road, Nanjing 210008, PR China. We report a 29-year-old man with double hip pain and lower limb weakness for 6 months with myeloid neoplasm with FIP1L1-PDGFRA rearrangement without marked peripheral blood eosinophilia.
Fish oil supplementation improves pregnancy outcomes and size of the newborn: a meta-analysis of 21 randomized controlled trials. Department of Environmental Science and Analytical Chemistry (ACES) and the Bolin Centre for Climate Research, Stockholm University, SE-10691 Stockholm, Sweden.
The radiative absorption enhancement of ambient black carbon (BC), by light-refractive coatings of atmospheric aerosols, constitutes a large uncertainty in estimates of climate forcing. Disturbance characteristics of half-selected cells in a cross-point resistive switching memory array. Institute of Microelectronics, Peking University, Beijing 100871, People's Republic of China. Disturbance characteristics of cross-point resistive random access memory (RRAM) arrays are comprehensively studied in this paper.
The characteristics of cross-point RRAM arrays such as energy consumption, reliable operating cycles and total error bits are evaluated by the methodology.
Sodium Sulfide, a Hydrogen Sulfide-Releasing Molecule, Attenuates Acute Cerebral Ischemia in Rats. Department of Pharmacy, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Acute cerebral ischemia may lead to ischemic stroke, which is a major cause of death and disability worldwide. Acute cerebral focal ischemia was produced by middle cerebral artery occlusion (MCAO) in Sprague-Dawley (SD) rats.
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Institute of Modern Separation Science, Key Laboratory of Modern Separation Science in Shaanxi Province, Northwest University, Xi'an, 710069, China. STAT5 gene polymorphisms are associated with the response of acute myeloid leukemia patients to Ara-C-based chemotherapy. The constitutive activation of signal transducer and activator of transcription 5 (STAT5) occurs during the transformation of fusion genes in leukemia. Peripheral blood samples were analyzed through matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Increased Expression of Transient Receptor Potential Vanilloid 4 in Cortical Lesions of Patients with Focal Cortical Dysplasia. Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing, China. Focal cortical dysplasia (FCD) represents a well-known cause of medically intractable epilepsy. Thirty-nine surgical specimens from FCD patients and 10 age-matched control samples from autopsies were included in this study. Host Protein Moloney Leukemia Virus 10 (MOV10) Acts as a Restriction Factor of Influenza A Virus by Inhibiting the Nuclear Import of the Viral Nucleoprotein.
The viral ribonucleoprotein (vRNP) complex of influenza A viruses (IAVs) contains an RNA-dependent RNA polymerase complex (RdRp) and nucleoprotein (NP) and is the functional unit for viral RNA transcription and replication. MOV10 inhibited the polymerase activity in a minigenome system through RNA-mediated interaction with the NP subunit of vRNP complex.


Expression and cellular distribution of transient receptor potential vanilloid 4 in cortical tubers of the tuberous sclerosis complex. Cortical tubers in patients with tuberous sclerosis complex (TSC) are highly associated with intractable epilepsy. The aims of this article are: 1) to re-evaluate the accuracy of multiple planar reconstruction computed tomography (MPR-CT) imaging on stapes-prosthesis parameters, and 2) to clarify possible relationships between prosthesis intravestibular depth and postoperative hearing outcomes.
Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs.
Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. Nested reverse transcription polymerase chain reaction demonstrated that bone marrow was positive for FIP1L1-PDGFRA rearrangement. A systematic search of the Medline, EMBASE and Cochrane's library databases was conducted for the randomized controlled trials published till February 2015 that compared the effects of fish oil supplementation with a control diet in women during pregnancy.
The direct measurements of radiative absorption enhancement require the experimentally-removing the coating materials in ambient BC-containing aerosols, which remains a challenge.
An analytical model is developed to quantify the number of pulses (#Pulse) the cell can bear before disturbance occurs under various sub-switching voltage stresses based on physical understanding.
Bilateral vertebral arteries and common carotid arteries were blocked to establish cerebral global ischemia in SD rats. The size, morphology, magnetic properties and surface modification of magnetic silica nanospheres were characterized by various modern analytical instruments. We aimed to investigate whether or not the genetic polymorphisms in the STAT5 gene are associated with the treatment outcomes of Ara-C-based chemotherapy regimens in patients with acute myeloid leukemia (AML).
Studies found that transient receptor potential vanilloid receptor 4 (TRPV4) may participate in the occurrence of seizures. Protein expression and distribution were detected by Western blot, immunohistochemistry, and immunofluorescence staining. The vRNP complex is an important determinant of virus pathogenicity and host adaptation, implying that its function can be affected by host factors. Importantly, we found that the interaction between MOV10 and NP prevented the binding of NP to importin-?, resulting in the retention of NP in the cytoplasm. Recent evidence has shown that transient receptor potential vanilloid 4 (TRPV4) has direct effects on both neurons and glial cells. Immunostaining indicated that TRPV4 was specially distributed in abnormal cells, including dysplastic neurons (DNs) and giant cells (GCs).
Seventy patients (46 women and 24 men; 32 right and 38 left sides) with the mean age of 40 years (range, 19-62 yr) with clinical otosclerosis. The length and intravestibular depth of the stapes prosthesis (including absolute and relative depth) were calculated from the MPR-CT imaging. FIP1L1-PDGFRA fusion by reverse transcription polymerase chain reaction was still positive at 3 months. No benefit from fish oil supplementation was found with regard to risk of intrauterine growth restriction or stillbirth.
Both the binding of MOV10 to NP and its inhibitory effect on polymerase activity were independent of its helicase activity.
In addition, double immunofluorescent staining revealed that TRPV4 was localized on neurofilament proteins (NF200) positive neurons and glial fibrillary acidic portein (GFAP) positive reactive astrocytes. Relationships between the intravestibular depth of the prosthesis and hearing outcomes (pre- and postoperative audiograms) were analyzed using Spearman correlation analyses.


His 9-month post-treatment complete blood cell count, peripheral blood and bone marrow biopsy were all normal.
Dietary fish oil during pregnancy was associated with reduced risk of preterm delivery and improved size of the newborn. These results suggest that MOV10 acts as an anti-influenza virus factor through specifically inhibiting the nuclear transportation of NP and subsequently inhibiting the function of the vRNP complex. The result indicated that the magnetic microspheres showed unique characteristics of high selective separation behavior of protein mixture, low nonspecific adsorption, and easy handling.
The interaction between the influenza virus vRNP complex and host factors is a major determinant of viral tropism and pathogenicity. Furthermore, protein levels of protein kinase C (PKC), but not protein kinase A (PKA), the important upstream factors of the TRPV4, were significantly increased in cortical tubers. Axial and coronal measurements were significantly correlated (p? MPR-CT can provide an accurate estimation of stapes prosthesis parameters. The patient continues to be treated with imatinib 100 mg daily for more than 2 years with no recurrence. Sodium sulfide improved cerebral energy metabolism after cerebral global ischemia and prolonged survival time of animals with acute cerebral anoxia.
This demonstrates that the magnetic silica microspheres can be used efficiently in protein separation or purification and show great potential in the pretreatment of the biological sample. Our study identified MOV10 as a novel host restriction factor for the influenza virus life cycle since it inhibited the viral growth rate. Taken together, the overexpression and distribution patterns of TRPV4 may be linked with the intractable epilepsy caused by TSC.
However, the prosthesis intravestibular depth did not seem to affect postoperative hearing outcomes. The presence of PDGFRA rearrangement in this case conferred a high sensitivity to imatinib treatment and a favorable clinical outcome.
In addition, increased cerebral blood flow and decreased cerebrovascular resistance, blood viscosity, and thrombogenesis were observed in animals treated with sodium sulfide.
The overexpression and altered cellular distribution of TRPV4 in FCD suggest that TRPV4 may potentially contribute to the epileptogenesis of FCD. Conversely, importin-? has been shown as a determinant for influenza tropism and a positive regulator for viral polymerase activity in mammalian cells but not in avian cells. In cultured neurons, sodium sulfide increased cell viability and decreased cell apoptosis induced by oxygen-glucose deprivation. MOV10 disrupted the interaction between NP and importin-?, suggesting that MOV10 could also be an important host factor for influenza virus transmission and pathogenicity. Sodium sulfide, a H2 S donor, presents protective effect on acute cerebral ischemia, and might be a promising therapeutic drug. Importantly, as an interferon (IFN)-inducible protein, MOV10 exerted a novel mechanism for IFNs to inhibit the replication of influenza viruses. Furthermore, our study potentially provides a new drug design strategy, the use of molecules that mimic the antiviral mechanism of MOV10.



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