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A 24-month, multicenter, double-blind, randomized study (ESPS2) was conducted to compare the efficacy and safety of Aggrenox capsules with placebo, extended-release dipyridamole alone and aspirin alone. Table shown below presents the incidence of adverse events that occurred in 1% or more of patients treated with Aggrenox capsules where the incidence was also greater than in those patients treated with placebo. The following is a list of additional adverse reactions that have been reported either in the literature or are from postmarketing spontaneous reports for either dipyridamole or aspirin. Patients who consume three or more alcoholic drinks every day should be counseled about the bleeding risks involved with chronic, heavy alcohol use while taking aspirin. Even low doses of aspirin can inhibit platelet function leading to an increase in bleeding time.
Patients with a history of active peptic ulcer disease should avoid using aspirin, which can cause gastric mucosal irritation, and bleeding.
If Aggrenox capsules is used during pregnancy, or if the patient becomes pregnant while taking Aggrenox capsules, the patient should be apprised of the potential hazard to the fetus. Concussion is a common type of traumatic brain injury which occurs due to an impact or trauma to the head. The cause of concussion can be a forceful blunt trauma resulting from a fall, sports activities, car accidents, being hit on the head with a blunt object.
Patient, however, will have a normal balance and does not lose consciousness in mild concussion. Persistent retrograde amnesia where the patient has memory loss of the events before the concussion. Neurological exam to look for changes in pupil size, coordination, thinking ability, coordination and reflexes. If patient suffers from repeated concussions, then this may be an indication of retirement from contact sports altogether.

Self care treatment involves ice application for 20-30 minutes and should be repeated every 2-3 hours. If there are any cuts present, they are numbed with lidocaine, either via injection or topical application.
The athlete should make a gradual return to training and sports activities under the supervision of a sports injury specialist. After this, the athlete can start sports specific activities which do not involve contact such as running. In the next stage, athlete can start on-field practice, but again it should not involve any contact.
After the consent of the sports specialist, the athlete can start on-field practice with contact. Items displaying this symbol are blind accessible.These items can be used without sighted assistance. The study was conducted in a total of 6602 male and female patients who had experienced a previous ischemic stroke or transient ischemia of the brain within three months prior to randomization. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate reliably their frequency or establish a causal relationship to drug exposure. This can adversely affect patients with inherited or acquired (liver disease or vitamin K deficiency) bleeding disorders. Although minor upper GI symptoms, such as dyspepsia, are common and can occur anytime during therapy, physicians should remain alert for signs of ulceration and bleeding, even in the absence of previous GI symptoms.
Maternal aspirin use during later stages of pregnancy may cause low birth weight, increased incidence for intracranial hemorrhage in premature infants, stillbirths and neonatal death. The doctor then cleans the cut with a saline solution or an iodine solution and looks for any foreign bodies and hidden injuries.

These follow-ups are important to diagnose more subtle problems of concussion such as memory deficits, changes in personality and cognition, as these may not be evident at the time of actual injury. In case of returning symptoms, the athlete should discontinue or stop the sports activities. The severity of the concussion is the deciding factor for the amount of time taken to get to this stage. Physicians should inform patients about the signs and symptoms of GI side effects and what steps to take if they occur. Because of the above and because of the known effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on the fetal cardiovascular system (closure of the ductus arteriosus), Aggrenox capsules should be avoided in the third trimester of pregnancy. A concussion is caused due to a closed-head type of injury and does not involve injuries where there is bleeding under the skull or into the brain. The wound is then closed with stitches (sutures), skin staples or sometimes using skin glue known as cyanoacrylate (Dermabond).
Concussion can temporarily affect the brain function causing headache, change in or loss of consciousness, tinnitus, dizziness etc. Many patients suffering from concussion don't lose consciousness, but may see complete see black or white color or stars.

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09.05.2015 admin

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