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The study will be published online on November 3 in the journal Pediatric Blood & Cancer. In both the general pediatric population and among children with non-brain related tumors, even mild hearing loss has been associated with declines in academic performance and language acquisition. For purposes of this study, the presence of sensorineural hearing loss was determined as a level consistent with a patient’s need for a hearing aid after treatment. Among brain tumor survivors treated with platinum-based therapies, 55 percent sustained sensorineural hearing loss. The study indicates that children who received radiation therapy and developed hearing loss are at particularly high-risk for neurocognitive decline. Children's Hospital Los Angeles has been named the best children’s hospital in California and among the top 10 in the nation for clinical excellence with its selection to the prestigious U.S.
Investigators at Children’s Hospital Los Angeles now report that this type of chemotherapy may not only impact hearing, but that the hearing loss may then contribute to long-term neurocognitive deficits.


However, recent studies did not specify the exact parameters of such declines, and included only a brief follow-up period. Care at the two participating institutions included comprehensive screening for late-effects – health problems that develop as a result of cancer therapy – inclusive of neurocognitive and audiological changes. Developmentally appropriate neuropsychological testing included evaluation of intelligence, executive function, memory, visual-motor integration and achievement. Independent of radiation therapy effects, patients who experienced hearing loss were found to have significant deficits in intelligence, executive function, and verbal reasoning skills.
The CHLA researchers suspected that a longer follow-up period might reveal greater information about the true neurocognitive impact, as well as specific areas affected. Time from diagnosis to audiology testing was two to three years, and the interval for neurocognitive testing was four to five years from start of treatment.
Children’s Hospital is home to The Saban Research Institute, one of the largest and most productive pediatric research facilities in the United States.


Patients who received radiation therapy were balanced between the two groups – individuals with and without hearing loss. Children’s Hospital is also one of America's premier teaching hospitals through its affiliation since 1932 with the Keck School of Medicine of the University of Southern California. Funding was provided in part by the National Institutes of Health through the Southern California Clinical and Translational Science Institute (UL1TR000130) and by The Saban Research Institute.




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27.12.2015 admin



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