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Research conducted at Weill Cornell Medical College and the Gladstone Institutes shows that using a precursor to vitamin B3 to elevate the activity of a certain protein could help prevent noise-induced hearing loss. Kevin Brown, MD, PhD, associate professor of otolaryngology at University of North Carolina School of Medicine.
The researchers chose NR for their study because it is a precursor to the chemical compound nicotinamide adenine dinucleotide (NAD+), which had previously been shown by Dr Brown and co-senior author Samie Jaffrey, MD, PhD, to protect cochlea nerve cells from injury.
Beyond just preventing hearing loss, the researchers believe the results may have broader applications because of the underlying way NR protects nerve cells. Supplementation with vitamin B3 could help to protect against noise-induced hearing loss by increasing the activity of a protein that has been linked to hearing loss, say researchers.
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A chemical precursor to vitamin B3 may help prevent the hearing loss caused by exposure to loud noises, according to a study conducted by researchers from Weill Cornell Medical College and the Gladstone Institutes and published in the journal Cell Metabolism.
The vitamin B3 precursor, known as nicotinamide riboside (NR), increases the activity of a protein that not only protects against hearing loss but may also help prevent a wide variety of age-related disorders. The study was funded by Weill Cornell, the Gladstone Institutes, the New York State Department of Health Spinal Cord Injury Fund and the National Institutes of Health. The body turns NR not just into vitamin B3 but also into another related compound, nicotinamide adenine dinucleotide (NAD+). NAD+ is a highly unstable compound, however, causing the researchers to worry that it would be ineffective in living animals.
The researchers exposed mice to NR either before or after exposing them to noises loud enough to cause cochlear damage. 3 New Incredible Marc Faber Warnings: Global Economy Is Imploding, Bankrupt Greece & China!
A supplement that scientists describe as the precursor to vitamin B3 may help prevent and treat noise-induced hearing loss, researchers at Weill Cornell Medical College and the Gladstone Institutes have found. In new research published Tuesday in the journal Cell Metabolism, a chemical called nicotinamide riboside (NR) successfully prevented short- and long-term hearing loss in mice when administered before and after noise exposure. The researchers pointed out that their findings may lead to better treatments in the future, as current antidotes for inner-ear disorders— including hearing loss— are limited.
During the animal trial, researchers used NR to protect the nerves that innervate the cochlea. According to the news release, the study authors chose NR because it is a precursor to the chemical compound nicotinamide adenine dinucleotide (NAD+), which Dr. Study authors tested the power of SIRT3 by eliminating the gene in mice, which in turn abolished any of the protective properties of NR.
SIRT3 decreases naturally as the body ages, and some individuals carry different versions of the SIRT3 genes that may make them more susceptible to noise-induced hearing loss.
The gradual deterioration of hearing is primarily a result of the environmental, lifestyle, and dietary choices we make during our youth.
Combined with a poor diet, including increasing amounts of chemical and artificial ingredients in our food, our bodies begin to fail as a result of toxic buildup. Chinese medicine recognizes a link between hearing loss and the underlying essence of the person. I’ve worked with a number of ear, nose, and throat specialists on hearing-related problems in patients ranging from three to ninety-three years old. A balanced diet of smaller and more frequent meals with ample amounts of complex carbohydrates and organic animal proteins is a good start. Adding more warming foods, such as organic chicken and lamb, can help strengthen the kidney yang energy.
Scallions, sesame seeds, fish, baked tofu, soybeans, walnuts, eggs, lentils, black beans, lotus seeds, ginger, and cinnamon bark are also helpful.
Avoid cold and raw foods and icy beverages, as the coldness may constrict the eustachian tubes, causing poor drainage from the inner ears.
Avoid processed meats and dairy products, as they have a tendency to increase mucus production.

Make a spice-ginger tea by boiling together 1 heaping tablespoon each of dried oregano, cilantro, rosemary, sage, and cinnamon, plus 3 slices of fresh ginger in 4 cups of water for 15 minutes.
Ear, nose, and throat specialists will sometimes recommend up to 300 milligrams of niacin (vitamin B3) to increase blood flow to the microcapillaries of the inner ear, which feed the auditory nerve.
N-acetylcysteine (NAC; 500 milligrams) may help prevent hearing loss-this is especially useful for people who are constantly exposed to loud noise. Carotenoids (1,000 milligrams) and vitamins A (200 IU), C (1,000 milligrams), and E (800 IU) can reduce the risk of noise-induced hearing loss.
Herbs can be found in health food or vitamin stores, online, and at the offices of Chinese medicine practitioners.
Traditional Chinese herbs used to support healthy hearing include rehmannia, wild yam, schizandra, Asian cornelian, and magnetite. Exercise is important for stimulating blood circulation, maintaining healthy immunity, and preventing colds and flu. Cover both ears with your palms, with the fingers of each hand pointing toward each other at the back of the head. Inhaling, place your index fingers on top of your middle fingers and then snap them off, striking the back of the head on the depressions located behind the ears at the base of the skull, where the Wind Pond (GB-20) acupoints are located.
Continue breathing and striking for 20 to 30 seconds, until you’ve struck the points 36 times.
Find the acupoint Forceful Torrent (KID-3), in the depression between the inner anklebone and the Achilles tendon of the right foot. Locate the acupoint Listening Palace (SI-19), directly in front of the right ear canal, in the depression formed when the mouth is slightly open. Antibiotics such as aminoglycosides, gentamicin, and tobramicin, which have been shown to cause hearing loss, usually temporary, but occasionally permanent.
Some diuretics, such as furosemide (Lasix), in high doses and some anti-hypertensive drugs, such as a combination of bisoprolol and hydro-chlorothiazide (Ziac), which can cause hearing loss.
This website is meant to educate, but it should not be used as a substitute for personal medical advice.
According to a study paper published in the December 2, 2014 edition of Cell Metabolism, researchers conducted mouse experiments using a simple chemical compound called nicotinamide riboside (NR), a precursor to vitamin B3. Their findings have important implications not only for preventing hearing loss that is linked to this protein, but also potentially for treating some aging-related conditions that are linked to the same protein. NR was reportedly successful at preventing damage to the synaptic connections, avoiding both short-term and long-term hearing loss. However, NAD+ is an unstable compound, calling into question whether it could be used in a live animal. The scientists showed that NR and NAD+ prevent hearing loss by increasing the activity of the protein sirtuin 3 (SIRT3), which is critically involved in the function of mitochondria, the powerhouses of the cell.
The use of NR prevented damage to the nerves, which can be caused by exposure to loud noises.The team set about trying to prevent this nerve damage by giving mice NR (a vitamin B3 precursor) before or after exposing them to loud noises.
Indeed, the team showed that NR and NAD+ prevent hearing loss by increasing the activity of the protein sirtuin 3 (SIRT3), which is critically involved in the function of mitochondria. In laboratory studies, Brown and co-senior author Samie Jaffrey found that NAD+ could prevent injury in the nerve cells of a part of the ear known as the cochlea. They found that regardless of whether it was administered before or after the noise, NR reduced synaptic damage in mice. The cochlea transmits sound information through these nerves to the spiral ganglion, which sends those messages to the brain. Brown and co-senior author Samie Jaffrey, pharmacology professor at Weill Cornell, previously observed could protect cochlea nerve cells from injury.
They saw that NR and NAD+ work together to increase the activity of the protein sirtuin 3 (SIRT3), which plays a crucial role in the function of mitochondria, the powerhouses of the cell. A new strain of mice engineered to express high levels of SIRT3 also was resistant to noise-induced hearing loss— even without the administration of NR. The popularity of digital audio players is certainly adding to the problem of sensorineural hearing loss. For example, there is a link between high blood cholesterol and loss of hearing.[3] Genetic, physical, and other disease factors may also be involved. Prolonged overindulgence and being overworked during youth deplete the body’s vital essence, causing deficiencies-especially of the kidney-bladder network. My treatments focus on fortifying the underlying essence, strengthening the vital energy of the kidneys, and opening blocked sensory orifices.

Herbs should be used according to individual needs; consult with a licensed practitioner for a customized formulation. I recommend a daily regimen of qi gong and tai chi combined with moderate cardiovascular exercise. On an exhale, continue striking the Wind Pond points with your index fingers while bending forward at the waist. This is a great exercise for maintaining the health of the mouth, teeth, and auditory canal.
The website user should consult his or her physician or clinician for specific information concerning specific medical conditions. Further, the study showed that NR was equally effective regardless of whether it was given before or after the noise exposure. They suggested that it was this enhancement of SIRT3 that was behind the protective properties of NR.
The cochlea is the part of the ear that transmits sound into the spiral ganglion, which then sends the information on to the brain.
This was made possible by a recent advance by co-author Anthony Sauve, PhD, who developed a new method allowing NR to be synthesized in quantities high enough for animal studies. In addition, mice treated with NR suffered less hearing loss in both the short and the long term. Exposure to loud noises damages the synapses connecting the nerves and the hair cells in the cochlea, causing noise-induced hearing loss.
Even when they need to use the highest volume on the television, some people don’t recognize or admit that they have a hearing problem. Continued exposure to loud environments, inadequate sleep and rest, overindulgence, and being overworked place an enormous amount of strain on the body. Some childhood illnesses, such as measles, mumps, and chronic adenoid inflammations (inflammation of the tonsils), can lead directly to hearing loss. I often use acupuncture with electrostimulation to increase neurological function and circulation within the ears, while using herbal therapy to reduce inflammation and swelling and to promote healing.
You may also want to visit your ear, nose, and throat specialist if the problem becomes severe. I often use Dao In Qi Gong exercises to help support healthy hearing function in my patients.[4] Immortal Beating the Heavenly Drum and Immortal Sounding the Heavenly Bell exercises work best-do these exercises daily for optimum results. Hypertension, hyperlipoproteinemia, chronic noise exposure: Is there synergism in cochlear pathology? While all reasonable efforts have been made to ensure that all information presented is accurate, as research and development in the medical field is ongoing, it is possible that new findings may supersede some data presented.
However, they noted that NAD+ is an unstable compound, calling into question whether it could be used out of the petri-dish and in a live animal. To test this, Brown and his colleagues manipulated SIRT3 levels independently of NR to see if they could still prevent noise-induced hearing loss by administering NR.
Conductive hearing loss occurs when there is a problem conducting sound waves anywhere along the route through the outer ear, eardrum, or middle ear. Strong emotions such as anger and frustration can aggravate the liver energy, which rises to the head and ears, producing hearing impairment and tinnitus (ringing in the ears).
A retrospective case-controlled study of 1490 consecutive patients presenting to a neuro-otology clinic to examine the relationship between blood lipid levels and sensorineural hearing loss. The names of organizations, products and alternative therapies appearing in the content are again given for informational purposes only and not necessarily as an endorsement. In these experiments, deleting the SIRT3 gene in mice abolished any of the protective properties of NR. Fluid in the middle ear or Otitis media with effusion sometimes causes conductive hearing impairment.
Acute loss of hearing is often associated with external pathogens such as the viruses that cause colds, flu, ear infections, and shingles.

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