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A study in guinea pigs finds that polySia is a functional biomarker which controls the development of inner ear stem cells. AsianScientist (Jul 23, 2014) - Researchers have identified a polysialylated glycoprotein that regulates neurodevelopment exists on the surface of cells in the adult inner ear.
Having a biomarker for immature stem cells could make it possible to isolate neural stem cells from the adult inner ear in a person with hearing loss, induce their replication and maturation in the laboratory, and then re-introduce them back into the inner ear as functioning neurons.
During development, certain glycoproteins (carbohydrate-protein linked molecules) that are expressed on cell surfaces serve critical functions essential to the normal growth and organization of the brain. The predominant carriers of polySia in the brain are neural cell adhesion molecules (NCAMs), which are glycoproteins expressed on neuronal cell surfaces.
Neural stem cells with these polySia-NCAMs on their surfaces are important in embryonic development because they are able to travel throughout the body where they can differentiate into specialized cells. Although it was already well known that cells expressing polySia-NCAM exist in the central nervous system, this study is the first to document that they are also in the peripheral nervous system, specifically in the spiral ganglia, groups of nerve cells located in the inner ear that are essential to hearing.
Working with adult cells isolated from the inner ear spiral ganglia of guinea pigs, the research team was able to show that they expressed both polySia and NCAM. Lead author Park Kyoung Ho, a professor at Catholic University College of Medicine in Seoul, Korea, initiated the research for this article while on sabbatical leave in Troy’s laboratory at UC Davis. Disclaimer: This article does not necessarily reflect the views of AsianScientist or its staff. One of the essential parts of ear that play role in hearing is the group of nerve cells called spiral ganglion cells present in the inner ear. Most of the hearing loss is attributed to the irreversible degeneration of these nerve cells. The discovery is a milestone as spiral ganglion stem cells make a promising source of replacement cells for therapies. Enter your email address to subscribe to this blog and receive notifications of new posts by email.
A Harvard University scientist has found that a compound, LY-411575, can restore 20% of hearing in deaf mice, or ten decibels.
For the last 17 years, I've traveled to over 40 countries, and every continent, as an audiologist conducting presentations and training on audiology and hearing instruments for a major manufacturer. The causes of hearing impairment are numerous, but if there were a pill that would slow the aging process of the inner ear and make it less susceptible to hearing loss from noise exposure, hearing losses could be reduced in well over 60% of the worldwide hearing impaired population.
While many of the homeopathic agents have not been proven successful, there is mounting scientific evidence that certain vitamins, magnesium and antioxidants can reduce the effects of aging and other issues that create hearing loss. Evidence suggests that The Hearing Loss Pill improves the nerve performance in the ears and the brain, stops the harmful molecules that continuously worsen inner ear nerve damage, and provides the body with many of the compounds necessary for proper hearing function. In addition to the studies presented in the Morning After Pill article, there a numerous others that support the use of The Hearing Loss Pill in many cases of hearing impairment.
My daughter has was born with hearing loss and now they want to do a cochlea implant in 3to 4 months she is 8 yrs old 85 pds and i wonder if its safe to give her this pill.
Deafness is a major public health issue worldwide, with more than three million people in the UK alone enduring a moderate to profound hearing loss. Current developments in stem cell technology led by Dr Marcelo Rivolta, from the University of Sheffielda€™s Department of Biomedical Science, could offer new hope for the treatment of auditory neuropathy, a common form of deafness in which the damage occurs at the level of the cochlear nerve. Dr Rivolta has spent 10 years researching how to differentiate human embryonic stem cells into the two cell types that are essential for hearing: auditory neurons and the inner-ear hair cells that translate sound into electrical signals. His research team converted human embryonic stem cells into cells similar to spiral ganglion neurons a€“ the nerve cells which pass sounds into the brain.


The research was funded by the Medical Research Council (MRC) and the UK hearing research charities, Deafness Research UK and Action on Hearing Loss. This biomarker of early cells allows researchers to identify immature cells so that they can be used for further research and possible treatment.
It is postulated that they may recolonize and establish themselves, thereby improving hearing. One member of the class of cell-surface glycoproteins is an unusual molecule called polysialic acid (polySia). As their name suggests, NCAMs by themselves are important in helping cells stick together and stay in one place. During adulthood, neural stem cells with polySia-NCAMs may migrate to injured areas and promote healing.
The polySia component was abundantly present on neural stem cells but markedly reduced on mature cells, implicating the polySia-NCAM complex as being present on immature cells and able to serve as a biomarker to identify these cells. With his colleague and co-author, Yeo Sang Won, he is now planning clinical trials, based on the findings, in Korea with individuals who suffer from hearing disorders.
These regenerative cells can rejuvenate neural structures of the inner ear, and hence restore hearing loss. I ask my eye doctors why can’t they fix scarred macula in my right eye and a hole in retina but says not much going on stem cells and eyes. Since electroacoustic hearing aids, at best, improve hearing by five decibels, there is a “good chance” the work will lead to help for deafened patients, according to Harvard stem cell researcher Albert Edge.The drug caused stem-like cells in the cochlea to generate new hair cells, which capture sound vibrations. I've learned that audiologists the world over, while a diverse group, share the same goals and objectives for our patients. These results provide further evidence of the intrinsic role of free radical generation in aminoglycoside ototoxicity, and highlight a potential clinical therapeutic use of alpha-lipoic acid in the management of patients undergoing aminoglycoside treatment. This may provide significant and potentially clinically important information about the effective therapeutic window for acute acoustic trauma treatment.
Ohinata et al  in Hearing Research, Volume 146, Issues 1–2, August 2000, Pages 28–34. report results indicating that Glutathione is a significant factor in limiting noise-induced cochlear damage.
He is also a member of the Universitya€™s Centre for Stem Cell Biology, which was the first laboratory to undertake research on human embryonic stem cells in the UK and has played a major role in training scientists in this dynamic field. The discovery, published in the journal Biochemical and Biophysical Research Communications, opens the door to developing stem cell replacement treatments in the inner ear to treat certain hearing disorders. Its large size fills up spaces between cells and its strong electric charge repels other molecules, qualities that help to prevent cells from adhering or attaching to one another, thereby promoting cell movement to other areas. But when an NCAM becomes modified with polysialic acid (becomes “polysialylated”), the cells gain the ability to migrate to new areas. However, a new evidence shows that hearing loss due to the above cause can be restored using the spiral ganglion stem cells in inner ear which are capable of self renewal, and can be grown and induced to differentiate into mature spiral ganglion cells as well as neurons and glial cells. Whatever the reason, we should be grateful to science that we probably won’t go deaf.
I invite guest articles on topics ranging from differences in training, expertise, and scope of practice from one country to another to interesting, debonair, or disgusting practices. If you’ve tried to restore or improve your hearing and failed, it makes sense consider this combination of hard-working ingredients.
Alpha-Lipoid acid exerts a protective effect against hearing loss in acoustic trauma through its antioxidant effects.


This is compatible with the notion that reactive oxygen specie generation plays a role in noise-induced hearing loss and that antioxidant treatment may be an effective prophylactic intervention. For example, re-expression of the “anti-adhesive” polySia glycan on the surface of many adult human cancer cells facilitates their detachment, thus enhancing their metastatic spread. It was the first time anyone had regenerated mammalian cochlear hair cells.A company Edge formed to commercialize this work scored big pharma funding this year. Stories of travel, clinical practice, research, training diversity and other topics are of particular interest. Based upon the research, chances seem good that patients may see an improvement when the Hearing Pill is taken daily according to directions. The improvement was evident about four weeks after administering the cells and observed for 10 weeks.
Recently, Edge scored another coup, restoring hearing in mice by transplanting sensorineural cells he created from embryonic stem (ES) cells, he told an International Society for Stem Cell Research (ISSCR) presser in June.
This is the first time that transplanted cells have successfully restored hearing in animals.
The equivalent improvement in humans would be a shift from being unable to hear traffic to hearing a conversation. It was thought that regenerating those hair cells in mammals was impossible.But last year, Edge’s team, by blocking a pathway called Notch in certain supporting cells, not only caused new cochlea hair cell generation in adult mice, but also improved their hearing. In the journal Neuron, his team reported that since Notch signaling represses cochlea hair growth in the developing embryo, they decided to apply a drug that might block Notch in the cochlea of adult deaf mice: LY-41157. His group had earlier found that drug could grow hair cells from the above supporting cells, which have stem cell properties, in vitro.In the cochlea, in vivo, the drug acted by inhibiting an enzyme called gamma-secretase, which activates many cellular pathways, Edge found. Using newborn mice, he found the Notch inhibition sparked by the compound turns on expression of the stem cell gene Lgr5 in those supporting cells when new hair cells form.LY-411575 is toxic when administered systemically. But Edge’s results were compelling enough, said a recent Science review, that they “will likely motivate the search for compounds or delivery methods that can selectively inhibit the Notch signaling pathway in cochlear supporting cells.” Indeed, the company Edge co-founded for the work (Audion Therapeutics) attracted Eli Lilly funding this February. Together, the companies are working on many small molecules they believe can regenerate hair cells.Sarah Crunkhorn wrote in Nature Reviews Drug Discovery that Edge’s work has revealed “modulation of Notch signaling may represent a potential therapeutic approach for the treatment of deafness.
Given that hair cell loss also underlies vestibular system disorders that affect the sense of balance, these findings may have implications for the treatment of several conditions.”“We are also replacing neurons,” Edge said at the ISSCR presser. Those mice, too, have partial restoration of their hearing…So, by replacing hair cells, and by replacing neurons, we have been able to, for the first time, partially restore hearing in deafened animals.
Just focusing on these two cell types we have made a lot of progress in the last couple of years actually starting to replace them. But we do partially restore hearing,” he said.Last month, Edge published a paper characterizing yet another hearing-related stem cell, the spiral ganglion stem cell. He coaxed spiral ganglion stem cells, which he found in postnatal mice, into forming both neurons and glial cells.



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