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The pathogenetic mechanisms of acute cochleo-vestibular lesions are still unknown, but viral infections and vascular phenomena with impairment of microvascular perfusion are thought to play a major role.
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Between 1 July, 1986 and 28 February 1998, 1501 patients were treated with an infusion protocol using cortisone, dextrane 40 and pentoxifylline.
In Gruppe 1 zeigte das Gehor eine Vollremission in 44,8%, eine teilweise Erholung in 40,4%, keine Anderung in 12,1% und eine Verschlechterung in 2,6%. Group 1 contained 1001 patients with sudden hearing loss, group 2a 107 patients with isolated tinnitus and group 2b 393 patients with labyrinthine disorders (among which were 81 patients with cochleovestibular dysfunction).


In Gruppe 2a mit isoliertem Tinnitus wurde in 17,9% Patienten ein komplettes Sistieren, in 43,9% eine Besserung, in 35,5% ein Persistieren und in 2,8% eine Verschlechterung gesehen. In Gruppe 2b wurde in 56,8% eine Besserung des Schwindels, in 21,0% eine teilweise Besserung und in 7,4% ein Sistieren erreicht.
Schwerwiegende Nebenwirkungen, die zum Abbruch der Therapie gefuhrt hatten, wurden nicht beobachtet. Als multimodale Behandlungsstrategie bei kochleovestibularen Storungen hat sich das Stennert-Schema als effektiv und gut vertraglich erwiesen. In the 1501 patients treated, no significant side-effects were found to the medical interventions used.


From these results we conclude that the infusion protocol is safe and effective in the treatment of cochleo-vestibular disorders.



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