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Description: This podcast covers several new topics, including celebrities who are convinced the earth is flat, the growing threat that is Zika virus, and how HIV is eluding CRISPR treatments.
Keywords: glycans, glycobiology, podcast, Pascal Gagneux, sperm, evolution, biolegend, science, chimpanzees, non-human primates, Neanderthal, pathogen, Ajit Varki Having difficulty playing this episode? Description: In this episode, we discuss some a variety of current scientific news, including the discovery of woman who can smell Parkinson's disease, a correlation between bovine leukemia virus and breast cancer, using an individual's microbial cloud to identify them, and how we're using specialized antibodies to combat both HIV and cancer.
Keywords: immunology, comics, cancer, chimeric antigen receptor, T cells, gene therapy, hypoxia, immune checkpoints, goinvivo, tumors, podcast, pedromics, pedro velica Having difficulty playing this episode? Keywords: neuroscience, neurodegeneration, Parkinson's disease, microbes, microbial, gut microbiome, bacteria, asthma, allergy, leukemia, cancer, AML, antibody, virus, cow, bovine, breast cancer, HIV, AIDS Having difficulty playing this episode? Description: Special guest and global health scientist Jessica Taaffe joins us to discuss educating the public, funding research, and the passion needed in scientific role models.
Keywords: global health, Jessica Taaffe, HIV, ebola, education, Bill Nye, Neil degrasse Tyson, vaccines, anti-vaxxers, world bank, funding, research, NIH, primates, biolegend, podcast Having difficulty playing this episode? Description: The podcast team discusses the potential anti-venom shortage, a wasp-venom derived protein for cancer therapy, 30,000 year-old viruses, and a new hominid species discovered in South Africa.
Keywords: venom, anti-venom, snakebites, wasp venom, Fav-Afrique, MP1, Polybia-MP1, Polybia paulista, phosphatidylserine, annexin V, cancer cells, homo naledi, fossils, Mollivirus sibericum, viruses, Siberia, giant viruses Having difficulty playing this episode? Description: On this podcast, we discuss current events in science, including recent outbreaks of polio in the Ukraine and Legionnaire's disease in California and Illinois. Keywords: polio, Legionnaire's disease, outbreaks, virus, bacteria, saturated fats, obesity, microbiome, mice, inflammation, leptin, neurons, brain, exercise, neutrophils, T cells, infection, lungs, influenza, open-access, journal, the wall of polio, science, podcast, virology, immunology Having difficulty playing this episode? Description: Glioblastomas and medulloblastomas are two common forms of brain cancer that afflicts thousands of people a year. Description: We cover the latest science current events, including the new Ebola vaccine, limb regeneration, being hangry, and Kim K's flub with the FDA.
Keywords: Kim Kardashian, ebola, vaccines, anti-vaxxers, current events, limb regeneration, repair, hangry, science, podcast, food and drug administration, morning sickness, FDA Having difficulty playing this episode? Description: In our latest podcast, we talk about narcolepsy and the fight between local colleges for the rights to an Alzheimer's disease database. Keywords: UCSD, USC, University of Southern California, University of California San Diego, Alzheimer's disease, Pandemrix, narcolepsy, sleep, Paul Aisen, BioLegend, science, podcast Having difficulty playing this episode?
Description: Ed Chen and Rea Dabelic, two members of the BioLegend Technical Team, take over the podcast this week to discuss Selman Waksman (the Father of Antibiotics), tuberculosis, and giving credit where its due. Keywords: Selman Waksman, Albert Schatz, streptomycin, neomycin, antibiotics, Neosporin, tuberculosis, granulomas, macrophage, biolegend, immunology, mycobacterium tuberculosis, podcast, patents, inventions, royalties, tuberculin skin test, lab assistants, consumption, avastin, microbiology, birthday blog, controversy, Nobel prize Having difficulty playing this episode?
Description: We welcome Chris Gould to discuss neuroscience, protein misfolding, aggregation, and prion-like proteins in neurodegenerative diseases.
Keywords: neuroscience, tau, a-synuclein, alzheimer's disease, parkinson's disease, neuroinflammation, prions, Creutzfeldt-Jakob disease, mad cow disease, kuru, cannibalism, brain, aggregation, protein misfolding, blood brain barrier, lymphatic system, chris gould, biolegend, immunology, podcast, neurofibrillary tangles, lewy bodies, inclusion, Lou Gehrig's disease, ALS, amyotrophic lateral sclerosis, neurodegeneration, microglia Having difficulty playing this episode? Description: Neuroinflammation can be beneficial in some instances, but too much of it can cause any number of neurological diseases. Keywords: Kenya Cohane, neuroinflammation, neuroscience, alzheimer's disease, parkinson's disease, multiple sclerosis, tau protein, a-synuclein, aggregation, immunology, podcast, biolegend Having difficulty playing this episode?
Description: Antibody therapies have become incredibly popular for the treatment of diseases, including cancer.
Keywords: cancer, tumor, antibody therapy, therapeutics, immune checkpoints, PD1, PDL1, LAG3, TIM3, CD80, CD86, Galectin 9, MHC II, CTLA4, Pembrolizumab, Ipilimumab, Nivolumab, nanobody, melanoma, carcinoma, biolegend, science, podcast, merck, amgen Having difficulty playing this episode?
Description: CRISPR is an amazing technology originally discovered in bacteria as a defense mechanism against invading foreign genetic material.
Description: Despite our advances in science and technology, it seems like more and more people are outright denying scientific principles and concepts like evolution and climate change.
Keywords: podcast, biolegend, immunology, biology, climate change, ted cruz, NASA, jim inholfe, brain, neuroscience, music, ignorance, science, education, ivory tower, spock, star trek, leonard nimoy, evolution, fluorine, fluoridination, fanta, Tourette Syndrome, nerdy, nerds, nerd, fandom Having difficulty playing this episode? Description: In this podcast, we discuss bacterial hot spots in New York, a brand new antibiotic found in dirt, telomeres and aging, and an interesting article published in 17 scientific journals about Cocoa Puffs. Keywords: podcast, podcasts, New York, subways, bacteria, antibiotics, MRSA, antibiotic resistance, telomeres, cocoa puffs, teixobactin, beer, alzheimer’s disease, parkinson’s disease, aging, BioLegend, immunology, biology, science, grad school, scientific journals Having difficulty playing this episode?
Description: In this podcast, we take a look at how a lack of vaccinations has once again caused an outbreak of a once-controlled disease, the efficacy of the flu vaccine this year, and why people are clamoring to know if their food contains DNA. Keywords: podcast, science, measles, vaccinations, vaccines, anti-vaxxers, Jenny McCarthy, research, cures, Disney, Disneyland, outbreak, flu vaccine, influenza, flu, dna, food, GMO, genetically modified organism, antibiotics, virus, viruses Having difficulty playing this episode? Description: In this podcast, we examine why it’s so hard to transition from animal research into human cures and Obama’s latest visit to the NIH.
Keywords: podcast, president, Obama, Barack Obama, BioLegend, NIH, National Institutes of Health, science, Ebola, HIV, Human immunodeficiency virus, AIDS, acquired immune deficiency syndrome, translational models, animal models, translation, research, bench to bedside, cures, vaccines Having difficulty playing this episode? We want to let you know about companies that provide free movies, handouts, and teaching tools for childbirth educators, doulas, and lactation consultants. During the great ice storm of December 2013, 4-6 December, SML taught at the Fort Worth Police Academy.
SML Contracted To Appear As An Expert Witness-Early December saw SML appear as an expert witness in northern Ohio.
SML Attends IACP Convention-Mid-October saw SML attend the IACP convention in Philadelphia, PA. Of specific interest was laser guns that take such pictures and accompanying video that allows for a tracking history. Major Texas City To Use Adopt A School Zone Program-A major Texas city will be taking advantage of i??i??the Adopt A School Zone program. SML Cancels Appearance At Annual New Mexico Chiefs Of Police Convention-SML contacted authorities at the New Mexico Chiefs Of Police Convention scheduled for 10-12 December 2013 telling them that road conditions did not permit SML to travel to the Albuquerque event. SML Attends IACP Convention-Mid-October saw SML attend the IACP convention in Philadelphia, PA.A  SML attends the annual convention as it is an Associate Member of the International Association of Chiefs of Police. Of specific interest was laser guns that take such pictures and accompanying video that allows for a tracking history.A  This has been done for over a decade with radar guns tied to dash cam video systems. Major Texas City To Use Adopt A School Zone Program-A major Texas city will be taking advantage of the Adopt A School Zone program. We examine increasing cases of diabetes and how finding the "secret sauce" for beta cells might fight this trend.
BioLegend is working with Sean Parker and the Parker Institute’s collaboration in fighting back against cancer. Recent studies have reported a link between Herpes Simplex Virus 1 (HSV-1) and increased AD risk. This blog will cover the major apps provided by BioLegend relevant to research steps from conceptualization to discovery, as well as a few useful apps not from BioLegend. Look back at this year’s most popular posts and find out which blogs our writers enjoyed composing.
Our latest podcast invites guest Pascal Gagneux to discuss his thoughts on glycans, evolution, and sex cells! Learn what makes this virus dangerous and why some countries are advising women to avoid pregnancy. Although respiration is considered the more efficient pathway because it has more ATP output per molecule of pyruvate, rapidly-dividing cells sometimes choose fermentation instead. Almost 50 BioLegend employees took part is this fun race which supports awareness for local charities trying to bring about positive change in San Diego.
By controlling key molecules involved in regulating the immune response, researchers have obtained very promising results in the treatment of certain cancers. Read this blog to learn more about Mazumdar-Shaw’s humble beginnings and how she built her empire by literally starting in her garage. Scientists would like to reanimate this virus to learn more about its origins and the evolution of giant viruses.
We also cover recent research linking high-fat diets with a change in the gut microbiome and obesity-linked inflammation, as well as the role that leptin plays in the rewarding effects of exercise.


Immunotherapy is a groundbreaking option because it can hypothetically target cancer cells specifically while leaving healthy cells intact, which can decrease the number of adverse effects associated with current treatment options.
Some may notice a modest decline in their mental abilities, including memory function, while some may develop neurodegenerative diseases as they age. Tune in to hear our guest Mohar Chattopadhyay discuss its symptoms, treatments, and research.
Using bioinformatics methods, they reconstructed the evolutionary tree of AAV and made viruses that represent different branching points.
Resistance to anti-microbial drugs occurs naturally, however, the misuse of these drugs, among other factors, is helping the spread of multidrug resistant microbes.
However, communication between the CNS and the periphery occurs through unknown mechanisms. The cause of this disease is unknown, and although there is presently no cure, there are some treatment options such as medication and surgery to manage its symptoms. Learn more about neuroinflammation and the newly discovered central nervous system lymphatic system with our special guest, Kenya Cohane. They are highly similar to peripheral macrophages and respond to pathogens and injury by becoming activated. But, how does this peer review work and why have so many controversies sprung up recently about this system? The Neuroinflammation page shows how neuronal injury can lead to immune infiltration, and how differential activation of microglia can be either neuroprotective or neurotoxic.
This versatile system can accommodate your experimental needs, whether you are doing positive or negative selection. In cancer, it may be beneficial to prevent interaction of "immune checkpoints", which can inactivate T cells.
This time we contribute to science enrichment classes in elementary schools throughout San Diego. In this blog, we discuss the potential impact of sequencing or genotyping individuals and why the FDA temporarily shutdown one company for marketing their kit as a medical device. Quite often, they manage to subvert a highly evolved immune system and proliferate inside a host. It allows researchers to listen to important talks, collaborate, and see what companies have to offer. Researchers are now repurposing this for useful applications in like increasing crop size and treating diseases like HIV and cancer. With open source sharing of 3D models, anyone with access to a 3D printer can print tube racks, 96 well plates, gel combs, and many other things. We also take a look at some of the inner workings of the brain including synchronization, implanting false memories, and how it blocks distractions. In this blog, we discuss one of the biggest scientific scandals in recent memory: The publication of high-profile stem cell papers in one of the most reputable journals that was riddled with errors, and, in at least a couple of spots, obvious data manipulation. Depending on the requirements of your assays, as well as your equipment at hand, you may need to use a colorimetric assay.
This blog discusses the implications of red meat consumption in humans and the characterization Neu5Gc as a xeno-autoantigen capable of inducing low level inflammation leading to cancer. These are called plantibodies, and in fact, there are already companies developing therapeutic antibodies using them. There we showcased some of our newly released products, such as LEGENDplex and newly aquired NeoClone antibodies.
Our blog examines possible causes, treatments, and mechanisms of action for food allergens. Keywords: BioLegend, science, podcast, podcasts, immunology, neuroscience, memory, alcohol, beer, neurons, ion channels, NMDA receptor, redox, oxidation, reduction, calcium, potassium, sodium, hippocampus, GIRK receptor, addiction, Karthik Bodhinathan, Stuart Lipton Having difficulty playing this episode? Here is a post to show some of the cool costumes and pumpkin carving contest we had this year. The case involved the i??Ohio State Police and the court had not given judicial notice for the use of laser guns in that jurisdiction. SML has been asked to bid on a program that involves sponsorship of school zones by private businesses. Students i??were required to i??estimate the speed and distance of fifty estimations each at the local airport with help from the Emporia Police Department.
The case involved the Ohio State Police and the court had not given judicial notice for the use of laser guns in that jurisdiction. It sits on the ETATS committee that in part sets performance specifications for the operation of radar and laser systems.
The Kustom Signals, Inc LaserCam IIA® and the Laser Technology Incorporated, LTI, accomplish such tasks.
Students were required to estimate the speed and distance of fifty estimations each at the local airport with help from the Emporia Police Department.
And, we talk about Sean Parker's new $250 million grant to establish the Parker Institute for Cancer Immunotherapy. In this blog, we discuss a landmark case study, and human trial, in which gene editing was successfully used in the treatment of leukemia.
As hard as it is to secure funding, prioritizing how to stay within the lab’s budget is an equally daunting task.
The use of monoclonal antibodies against some of these molecules, called immune checkpoint receptors, have provided some answers and hope in the search for a cure. Tune in to hear our discussion on the release of an open-access journal that will publish ideas as well as data and results, and other exciting research on influenza infection. In this blog, read about adoptive cell transfer, the process of training and expanding a patient's own immune cells and placing it back into the patient to fight the cancer with their own cells. Scientists are increasingly interested to understand the factors and mechanisms that may impact brain health. These viruses were used to circumvent detection by the immune system to successfully deliver genes to various mammalian tissues. This is a serious public health issue at the moment, and if we don’t act with energy, there can be hard consequences.
In this blog, we discuss a recent paper published in Nature that discovered that the CNS does, in fact, have a lymphatic system that can be used to communicate with immune cells in the periphery. Read our blog to learn more about Selman Waksman, his work in antibiotics, and the controversy over streptomycin. Read our blog to learn more about the correlation between the flu vaccine and narcolepsy, and the evidence to support or refute the hypothesis. Read our blog to learn about the work being done to uncover how bacteria can influence the mental state. This blog discusses the blood-brain barrier, which can be compromised under certain conditions, leading to immune cell infiltration and chronic neuroinflammation. As part of their response, they secrete cytokines and chemokines, which help in the resolution of the inflammatory response.
The page also features IHC reagents for detection of neuroinflammation and a list of our neuroinflammation products. Learn more with our podcast about some of the more popular antibody and nanobody treatments. Read about BioLegend at IMMUNOLOGY 2015™ in this blog, and we’re excited for next year's AAI Annual Meeting!
Check out our blog to learn how Joseph Lister turned it all around and why he is now known as "the father of modern surgery". In this post, we comment on the number of mechanisms that HIV, a retrovirus, has to escape the immune system. Learn about BioLegend's involvement in scholarships, talks, and interesting facts about this year's host city, New Orleans.


There's a battle brewing over the CRISPR patents with millions in funds (and profit) at stake.
This allows for on-the-fly access to lab goods, and also nearly infinite customizability for lab supplies in your experiments. The fallout after the retraction of these papers just goes to show that scientific misconduct is not worth the risk. Luckily, our immune system has also “learned” how to deal with most of these pathogens, so we can eliminate most of these infections. Read through our blog to learn more about the logistics of picking out the right animal for you. The final day had to be postponed until 23 December when the attendees gave their ten i??minute presentation to the class.
The court recognized SML as an expert witness and gave judicial notice to the use of laser in the jurisdiction.
This has been done with Rest Areas being sponsored by forward thinking communities along interstates. The final day had to be postponed until 23 December when the attendees gave their ten minute presentation to the class. Unique to the new LTI TruSpeedA® Sx binocular system is the easy interface with a smart phone that is already equipped to take still and video images.
Read this blog to get an idea about how much it costs to run an academic research lab in the U.S. BioLegend develops and manufactures world-class, cutting-edge immunological reagents for biomedical research, offered at an outstanding value.
If you're able to score a perfect 100%, you'll win a goodie bag filled with BioLegend prizes. But these cells are also known for their harmful roles in neurodegenerative diseases and brain injuries, such as Alzheimer’s and Parkinson’s disease. In this post, we comment on a number of mechanisms that Salmonella has to escape the immune system.
In this post, we comment on a number of mechanisms that Listeria has to escape the immune system. During the trial, SML noticed the Ohio State Police were mounting their radar antennas externally by the light bar. Individual participating schools will construct a budget for signs, radar displays, personnel, and painting of school zone boundaries.
In Canada, this is done country-wide with lime green paint being affixed to curbs that delineate the begin and end points of school zones. A Kustom Pro Laser III was used to determine the speeds and distances of the target vehicles as the department had a model of the ProLaser III.
Of specific interest is to ascertain the sales of radar and laser speed enforcement systems.
It takes advantage of existing technology to accomplish the task of a€?evidence of speedinga€?. A Before and After study will be conducted at a selected elementary school, a middle school, and a high school in the district. An Emporia Police Department Charger was used in addition to a Lyon County Sheriffa€™s Department Ford Explorer for the field exercise. This year the emphasis was the use of laser guns that take pictures of infractions for court use for a€?evidence of speedinga€?.
A Before and After study will be conducted at a selected elementary school, a middle school, and a high school in the district.A  The Before study will look at the speed limit compliance with posted speed limits when the school zone is active. The classwork was consistent with NHTSA recommendations of 24 hours of classroom instruction for Master Radar Laser Instructor Certification. The field activity of estimations of speed and distance is essential in establishing a Valid Visual Tracking History substantiated by a radar or laser gun reading. An After study will look at the same school zones after posting a radar displays, increased signage, or improved painting in the school zone and the percentage of drivers adhering to the speed limit.A  Solicitations will be made to the community to fund those devices or strategies that are effective.
Each successful student was given both wall and billfold certificates entitling them to teach both Master Instructors and Operators of radar and laser based speed enforcement systems.
In the classroom setting, the importance of using the correct tuning fork that accompanied the radar gun model was demonstrated.
According to USDOTa€™s Traffic Safety Facts, Speeding is the second leading cause of death and injuries on Texas and national highways. Many departments find such teaching important as they must continually find officers who have attended the NHTSA compliant instruction. In response to this cancer possibility the Occupational Safety And Health Act (OSHA) and the National Highway Traffic Safety Administration (NHTSA) at the urging of the International Association of Chiefs of Police (IACP) found that, a€?In sum, the assessment found that even with continuous exposure, no measurements at the aperture of the antennas of all devices tested exceeded the acceptablei?? OSHA levels. Students were told to keep their completed speed and distance form for court use in the future. In response to this cancer possibility the Occupational Safety And Health Act (OSHA) and the National Highway Traffic Safety Administration (NHTSA) at the urging of the International Association of Chiefs of Police (IACP) found that, a€?In sum, the assessment found that even with continuous exposure, no measurements at the aperture of the antennas of all devices tested exceeded the acceptable OSHA levels. Further, tests were conducted by mounting radar units in patrol cars to see if microwave energy reflected off the windshield and thereby exposed the occupants of the vehicle. There were no measurable amounts of microwave energy anywhere in the drivera€™s seat or the front passengera€™s seat. Florida actually tests equipment to a more stringent standard than to the federal standard of DOT HS 809 812(radar) and DOT HS 809 811 (laser). Most radar antennas, save motorcycle units, are not designed to be externally mounted and must constantly be modified to meet the purpose of accurate readings consistent with the Operatora€™s Manual of the specific radar system.
The State of New Mexico issues compliance with their standards and has issued approval to SML curriculum and the approval number of NM12-53C. The Texas Commission of Law Officer Standards and Education, TCLOSE, issues its own approvals and has issued the number of #2054 for the SML course. Part of the instruction is having students estimate the speeds of fifty (50) vehicles and the distances of (50) vehicles.
This is done with various laser guns operated by students and is critical to establish a Valid Visual Tracking History.
Court cases abound demanding the prima facia evidence is the officera€™s estimation speed of a vehicle i.e. Hall the court admonished the officer in making the traffic stop with probable cause based solely on the laser gun readi??ing. Hall the court admonished the officer in making the traffic stop with probable cause based solely on the laser gun reading. Each officer is billed $350.00 for attending such training and SML regularly conducts such training at different parts of the United States annually. Students record 100 speeds of vehicles before any treatment and then record 100 after a large radar display is added to the same highway. In many cases, a laser gun tied to a computer is shown to students allowing for immediate results. The most prestigious award is the TOP GUN Award presented to the highest score in a particular class.
The TOP GUN Award during the Fort Worth Police Academy teaching was presented to Officer Deena Evans for her fine performance.



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