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There was once a little Kid whose growing horns made him think he was a grown-up Billy Goat and able to take care of himself.
The Wolf liked the idea of a little music before eating, so he struck up a merry tune and the Kid leaped and frisked gaily. But as he opened his mouth to say these foolish words he lost his hold on the stick, and down he fell to the ground, where he was dashed to pieces on a rock. A Dog and a Cock, who were the best of friends, wished very much to see something of the world.
At nightfall the Cock, looking for a place to roost, as was his custom, spied nearby a hollow tree that he thought would do very nicely for a night's lodging. The hungry but unsuspecting Fox, went around the tree as he was told, and in a twinkling the Dog had seized him.
The Mice once called a meeting to decide on a plan to free themselves of their enemy, the Cat. An Eagle, swooping down on powerful wings, seized a lamb in her talons and made off with it to her nest. The farmer climbed down from his seat and stood beside the wagon looking at it but without making the least effort to get it out of the rut.
And when the farmer put his shoulder to the wheel and urged on the horses, the wagon moved very readily, and soon the Farmer was riding along in great content and with a good lesson learned. A frisky young Kid had been left by the herdsman on the thatched roof of a sheep shelter to keep him out of harm's way.
After the meal the friends had a long talk, or rather the Town Mouse talked about her life in the city while the Country Mouse listened.
When they reached the mansion in which the Town Mouse lived, they found on the table in the dining room the leavings of a very fine banquet. The Country Mouse stopped in the Town Mouse's den only long enough to pick up her carpet bag and umbrella.
A Fox one day spied a beautiful bunch of ripe grapes hanging from a vine trained along the branches of a tree.
One day when the quarreling had been much more violent than usual and each of the Sons was moping in a surly manner, he asked one of them to bring him a bundle of sticks. Insulin is one of the most important hormones in the human body, and yet most people don’t really understand why our bodies make it or how what we eat affects the levels of insulin we produce. All cells, from bacteria and fungi to us, take glucose and use it to generate ATP by a process called Oxidative Phosphorylation. It’s particularly important for our bodies to maintain glucose levels every time we eat. It turns out insulin in the brain has a lot of functions, very few of which we understand well. While insulin levels are mostly regulated by the amount of glucose in our blood, other things can stimulate its release.
Once we start to eat, our bodies ramp up insulin secretion, in what is often called first phase insulin release. When your body stops producing insulin, injections are all that is left - credit, i5a, flickrDiabetes occurs when the body does not have the insulin signaling it should. Everyone should think about insulin and blood glucose levels, not just people with diabetes or metabolic syndrome. Research into the glycemic index have found strong support of the idea that low GI foods are better for us.
The GI or GL of a food isn’t the only thing you should consider when it comes to insulin and your diet. Thinking about how our diet affects insulin is especially key when trying to lose weight or maintain a healthy weight. Understanding how our bodies regulate insulin release also explains why certain foods are worse for us than we’d expect. High spikes in insulin lead to dramatic drops in blood glucose, which can cause your body to feel hungry sooner. My work on this whole project has slowed significantly over the summer as I pursued an interesting opportunity of sorts with the Rodale Institute up in Pennsylvania and as I work towards a masters in nutritional biochemistry.  Both opportunities have opened a whole new series of doors that will only serve to strengthen this site going forward. It solidified Lindsay Lohan as a huge star and introduced us to Rachel McAdams, Amanda Seyfried and Lizzy Caplan.
So one evening when the flock started home from the pasture and his mother called, the Kid paid no heed and kept right on nibbling the tender grass.
When he saw how gaily the birds flew about and how the Hare and the Chipmunk and all the other animals ran nimbly by, always eager to see everything there was to be seen, the Tortoise felt very sad and discontented. He seized the stick firmly with his teeth, the two Ducks took hold of it one at each end, and away they sailed up toward the clouds. But the little Frogs all declared that the monster was much, much bigger and the old Frog kept puffing herself out more and more until, all at once, she burst. So they decided to leave the farmyard and to set out into the world along the road that led to the woods. At least they wished to find some way of knowing when she was coming, so they might have time to run away.
A Jackdaw saw the deed, and his silly head was filled with the idea that he was big and strong enough to do as the Eagle had done. The horses could hardly drag the load through the deep mud, and at last came to a standstill when one of the wheels sank to the hub in a rut. The Kid was browsing near the edge of the roof, when he spied a Wolf and began to jeer at him, making faces and abusing him to his heart's content.
For lunch the Country Mouse served wheat stalks, roots, and acorns, with a dash of cold water for drink.
They then went to bed in a cozy nest in the hedgerow and slept in quiet and comfort until morning. There were sweetmeats and jellies, pastries, delicious cheeses, indeed, the most tempting foods that a Mouse can imagine. The grapes seemed ready to burst with juice, and the Fox's mouth watered as he gazed longingly at them. No words he could say did the least good, so he cast about in his mind for some very striking example that should make them see that discord would lead them to misfortune. He was sure that she, with her long neck and bill, would easily be able to reach the bone and pull it out. You probably know that people with type 1 diabetes need to inject themselves with insulin to survive, and must constantly monitor the amount of sugar they eat. More so than any other hormone, our diet is key in regulating insulin levels, and thus a number of biological processes. In cells, energy is stored and shuttled around using a molecule called Adenosine Tri-Phosphate, or ATP. First, glucose is converted to an intermediate molecule called pyruvate via a process called glycolosis.
Whenever we ingest food, our bodies have to quickly adjust to the sudden flood of glucose entering our systems as our meals are digested. Our bodies release insulin right before and during eating, and that insulin tells our bodies to start taking glucose out of the blood, thus lowering our blood glucose levels.
It’s main job is to signal the liver, muscle and fat tissues to take up glucose from the blood and store it as glycogen.
Mice that lack insulin and leptin receptors in their brains, however, exhibit insulin resistance that is characteristic of diabetes. Other molecules from digestion, like certain amino acids, proteins and lipids, can similarly stimulate insulin release.
Insulin that was kept in storage while our blood glucose levels were normal is released all at once, leading to a dramatic increase in insulin levels. If the first pulse was enough, then they slowly take up the insulin they released, and store it for the next meal.
As I just explained, insulin in the brain is particularly key, and can lead to neurological disorders. Prevalence rates of type 2 diabetes doubled between 1990 and 2005, causing the CDC to declare it an epidemic. Metabolic syndrome, often called prediabetes, is poorly characterized, and even more poorly understood. What we eat, how much of it, and when can impact our insulin release, which in turn can have a big impact on our bodies and how we feel. The glycemic index rates foods based on how much of an immediate impact they have on blood glucose per 50 grams of carbohydrate. People who eat less high GI foods have lower risks of developing both type 2 diabetes and heart disease.
Glycemic indices aren’t the whole story since they are based on a per-carbohydrate basis.

When different foods were tested for their GI values at different times of the day, for example, researchers found that the same food eaten for lunch instead of breakfast induced a lower glucose response.
For example, foods that contain fiber, protein, or fat will generally reduce the GI of the meal as a whole. This is important in keeping healthy and reducing the risk of metabolic syndrome and type 2 diabetes. Insulin actually triggers the storage of fats in adipose tissues, so sustained high levels of insulin promote weight gain! Sugary drinks are particularly bad for us, for example, even when we take into account their calorie and sugar content. Effect of alcoholic beverages on postprandial glycemia and insulinemia in lean, young, healthy adults. Consuming eggs for breakfast influences plasma glucose and ghrelin, while reducing energy intake during the next 24 hours in adult men. However, even I can see that the information in this website is better than anything those institutions have ever attempted at diagnosing, treating or curing any disease. I can attest from personal experience that intermittent fasting and very low carbohydrate consumption (below a total of 50-grams per day) has produced much better health and high energy levels. But most importantly, it gave us endlessly quotable moments -- stuff we're still laughing about nine years later.
They say that Jupiter punished him so, because he was such a lazy stay-at-home that he would not go to Jupiter's wedding, even when especially invited.
He wanted to see the world too, and there he was with a house on his back and little short legs that could hardly drag him along.
The old Frog soon missed the little one and asked his brothers and sisters what had become of him. The two comrades traveled along in the very best of spirits and without meeting any adventure to speak of. He thought he was still in the farmyard where it had been his duty to arouse the household at daybreak.
Indeed, something had to be done, for they lived in such constant fear of her claws that they hardly dared stir from their dens by night or day. So with much rustling of feathers and a fierce air, he came down swiftly on the back of a large Ram. There he stood, unwilling to give up a single filbert and yet unable to get them all out at once. The Town Mouse ate very sparingly, nibbling a little of this and a little of that, and by her manner making it very plain that she ate the simple food only to be polite.
In her sleep the Country Mouse dreamed she was a Town Mouse with all the luxuries and delights of city life that her friend had described for her.
But just as the Country Mouse was about to nibble a dainty bit of pastry, she heard a Cat mew loudly and scratch at the door. So he walked off a short distance and took a running leap at it, only to fall short once more.
Whenever the cell then has an energy-requiring reaction, enzymes can use the energy stored in ATP’s phosphate bonds to fuel it. As long as there is oxygen around, this pyruvate is further converted to Acetyl CoA, which enters a cycle of reactions called the Citric Acid Cycle. Unlike plants, though, we cannot create our own glucose, so we rely on our diets to provide it for us.
The amino acids that make up proteins can be converted to glucose via an enzymatic process called gluconeogenesis. It does this by both promoting uptake of glucose by cells and the storage of glucose within our cells. This creates an effective rise in tryptophan concentration in the blood, allowing it to pass through the blood brain barrier.
Strangely, though, they have a lot of reproductive deficiencies, too – the females have poor fertility, high testosterone levels and deformed ovaries, for example.
But most incredibly, our bodies begin releasing insulin before we even take a single bite of food. The amount of insulin secreted in the first phase response to a meal is determined by the amount of glucose encountered in the previous meal – the more you needed last time, the more is released in this first phase.
If the blood glucose levels stay high, though, the ?-cells begin producing and releasing insulin in pulses every ten to twenty minutes.
People with type 1 diabetes tend to realize their condition early in life, and must deal with it throughout their lifetime, while those with type 2 tend to develop symptoms later on. Insulin is meant to be a fast acting hormone – you release it when glucose levels are high, so that they drop. Symptoms include elevated blood pressure, high blood cholesterol, and increased waist circumference. There are enzymes in our saliva that begin carbohydrate breakdown before the foods even reach our stomachs!
If you picture the rise in blood glucose levels in response to a food on a graph over time, the glycemic index is a number that is related directly the area under a two-hour curve. Two foods that have the same GI can have dramatically different effects on blood glucose per serving if one has significantly higher carbohydrate content than the other. This is why it may be particularly important to eat a protein-rich breakfast, like eggs, instead of high glycemic foods like white bread toast. But insulin affects so many other things in our bodies, from amino acid uptake to fat storage. Furthermore, recall that our bodies don’t break down fat while insulin is circulating. Low GI foods don’t cause dramatic drops in glucose levels, thus you tend eat less throughout the day.
Very well written, comprehensible even by a person not from the medical background (like myself). Unlike doctors who don’t explain bullshit to you and just tell you to do something because and expect you to pay huge amounts of money for just ordering you to do something without telling you the reason. Everything is detailed with references to original sources and is not simplified to the point where it becomes a fallacy (simplifications when wrongly used can, and most of the time, become fallacies). I bet the writer is a person of great experience or of sound practical intelligence coupled with a strong sense of empathy for the reader. And contrary to feeling like crap, I feel better than ever before with much more clarity of thought and high energy levels. To celebrate this anniversary, we've collected GIFs of our favorite and funniest moments. They recognized the song the Wolf sings before a feast, and in a moment they were racing back to the pasture. But when he tried to rise again he found that he could not get away, for his claws were tangled in the wool.
So the next day when the Town Mouse asked the Country Mouse to go home with her to the city, she gladly said yes. In great fear the Mice scurried to a hiding place, where they lay quite still for a long time, hardly daring to breathe. This takes the carbon to carbon bonds and uses them to create high energy electrons, which are then passed down a chain of enzymes which use the electron’s energy to create a proton gradient, the force of which fuels ATP synthase, the enzyme which creates ATP from ADP.
Fats, too, are converted to glucose or its derivatives; glycerol, for example, can be converted to glucose via gluconeogenesis, and fatty acids can be converted to Acetyl CoA via beta oxidation.
You would think that since it’s so important, we would want a ton of glucose in our blood, but too much causes our blood to thicken, slowing it down and drawing fluid from our tissues to try and make it thin again. Without insulin, we would all go into hyperglycemic shock and die from something as common as a hamburger.
If it drops too low, an antagonistic hormone, called glucagon, is released which does the opposite of insulin, stimulating cells to break down glycogen and release glucose. Instead, they respond to insulin by taking the fats that enter the blood stream and turning them into fatty acids, which they store in large vacuoles. In the brain, tryptophan is converted to serotonin, a neurotransmitter whose primary purpose, in this case, is to reduce appetite. Why insulin has these effects on reproduction is unknown, but it just goes to show that insulin does a lot more than regulate blood sugar levels, and is far more important in our bodies than we once thought. When we think about, smell, or slightly taste foods, our brains trigger what is called Cephalic Phase Insulin Release. In a healthy person, this first phase response peaks a few minutes after you’ve started your a meal.
There is a special name for the series of diseases caused by impaired insulin signaling in the body. The main cause appears to be decreased response to insulin in certain tissues, specifically muscle and fat.

But more importantly, carbohydrates lead to immediate rises in blood glucose because they contain glucose. The higher the spike in blood glucose levels, the larger the area under the curve is, and thus the higher the glycemic index, which is somewhere on a scale of 1 (low) to 100 (high).
The affect a serving of food has on blood glucose is referred instead to its Glycemic Load. Morning is a special time for your body because you’ve just spent a while in a comatose state. Time of day has been found to have a larger effect on insulin responses in women than in men, though no one understands why. Furthermore, many cultures eat high GI foods like potatoes or rices but have low occurrences of diabetes and obesity. This means that if we eat foods with high GIs that produce sustained insulin levels, we’re shooting ourselves in the foot, even if we eat less calories overall. Thousands of years of evolution led our brains to believe that drinks, overall, were low-cal things that mostly contain water.
It’s thought that this effect, on top of the high-sensitivity of our bodies to high GI foods in the AM, is why eating eggs, a low GI food, instead of cereal or toast in the morning has been found to reduce overall food intake for the day by as much as 18%. For example, dieters often experience depression around 2 weeks after they begin cutting high-glycemic foods like carbohydrates out of their diet. Also, too many analogies (which when wrongly used too may become falasies) overloads the reader’s perception with useless information which leads the reader to a wrong understanding of concepts.
The Wolf's song ended suddenly, and as he ran, with the Dogs at his heels, he called himself a fool for turning piper to please a Kid, when he should have stuck to his butcher's trade. When at last they ventured back to the feast, the door opened suddenly and in came the servants to clear the table, followed by the House Dog. No matter where it comes from, the glucose from our meals then ends up in our blood to travel around our bodies to the tissues that need it. Too high of a blood glucose level, called hyperglycemia, can result in blurred vision, fatigue, dry mouth and heart problems that can sometimes be fatal. But serotonin has a lot of other effects, as those of you who have read the previous Understanding Our Bodies on Serotonin know well. A food’s color, appearance, flavor, aroma, and texture can all impact how our brains respond to the idea of eating it. The blood sugar rise caused by the meal peaks about half an hour after eating, and this, in turn, leads to a decrease in insulin production and release.
If we see a tiger, for example, our stress hormones spike so we can be prepared to fight if it attacks or run like hell to get away. Meanwhile, reduced levels of insulin and its related proteins are linked to Alzheimer’s disease and other degenerative disorders. While both conditions involve problems with the insulin pathway, type 1 diabetes is caused by a lack of insulin, while type 2 is caused by chronically high levels.
If you constantly eat too much or have a very sugary diet, you can end up with high insulin levels all the time.
Other molecules must first be converted to glucose, but carbohydrates, which include sugars, just need to be hacked into pieces by our digestive enzymes. Mainly, the faster it’s churning, the more likely the machinery is to leak reactive oxygen species (ROS). Glycemic load is calculated by multiplying the weight (in grams) of carboydrate in a serving by the food’s overall GI and divided by 100.
The changes your body undergoes while you sleep can have a dramatic impact on how it responds to food. Furthermore, studies have shown that the quality of sleep you get affects how strongly your body reacts to food. The truth is we have yet to tease out all the factors that lead to these conditions, and the GI level of our diets is likely only one of many related factors. You can create lower spikes in insulin not only by avoiding sugary drinks and eating lower GL foods but also by eating smaller meals. This means that if all the sugar from a single roll of those delicious candies were to enter my bloodstream at once and remain unchecked, it would raise by blood sugar by 8 mM! In general, increased serotonin leads to a feeling of happiness and calm, which is why we get such satisfaction when we eat. The goal is to prepare the body for what the brain thinks will be a sudden flood of glucose. Either way, we’ll need extra energy on hand to deal with the stressful situation, so stress hormones stop insulin from being released to ensure that a little extra glucose is in the bloodstream and able to reach whatever body parts need it most.
Often, people with metabolic syndrome are overweight, and at higher risk for other, even more life threatening conditions like heart disease.
Different carbohydrates contain different amounts of the monosaccharides, like glucose or fructose. There is another index, called the Insulin Index, that looks directly at rises in insulin levels. These oxygen radicals are highly reactive and tend to transform whatever they come in contact with, which can cause damage to proteins, membranes, or even our DNA. Insulin levels tend to be low in the early morning, for example, because your body releases stress hormones just before you wake up.
A restless night can lead to higher glucose responses and larger spikes in insulin in response to food in the morning. Thus when we look at a soda or even begin to sip one, we don’t have the same level of cephalic phase insulin release or first phase insulin release that we would for a solid treat. This is because the amount of first phase insulin release is dependent on the amount of insulin needed for the previous meal. She befriends outsiders (Lizzy Caplan and Daniel Franzese), whom she teams up with to bring down a clique known as the Plastics, a trio played by Lacey Chabert, Amanda Seyfried, and Rachel McAdams as their horrifying leader. This is about enough glucose to provide energy to the body for 20-30 minutes, so as we use up the glucose in our blood, our bodies constantly release more (hopefully) without overdoing it.
Thus insulin is important not just when it comes to dealing with fats and sugars but in regulating our emotions, too! The sweeter and sugarier the brain thinks the meal will be, the more insulin it stimulates the pancreas to release before the food even enters the mouth. Without the ability to produce enough of this vital hormone, they usually have consistently high blood glucose levels. While some drugs can be prescribed to treat the symptoms like high blood pressure, the only long-term solution is to lower chronic blood glucose levels and restore insulin sensitivity, if, indeed, it can be restored at that point. While the glucose and insulin scores of most foods are related, high-protein foods and baked goods that are rich in fat and refined carbohydrates usually elicit much higher insulin responses than their glycemic index values would suggest. By eating foods that increase glucose levels more slowly, we limit ROS bursts that can damage our cells. Once you’re awake, though, your body ramps up insulin secretion to metabolize the high glucose levels and give your cells a little fuel to start the day with.
So getting a good night’s sleep is also important in preventing the kinds of spikes which may be a major factor in type 2 diabetes. The end result of this is that our bodies are unprepared for the sudden sugar rush, and have to instead release a massive amount of insulin all at once to deal with what it considers an inexplicable rise in blood glucose.
The bigger meals are, the larger the spike at the beginning of every meal, and the bigger the drop in glucose afterward. Decreased insulin means decreased amino acid uptake, and because the level of other amino acids affects how well tryptophan crosses the blood brain barrier, decreased insulin means less serotonin which leads to, in layman’s terms, feeling like crap. If you only get a little static every once in a while, you can hear the song fine, and understand what the artist is saying. While you should monitor the GI of your meals to reduce insulin spikes, you shouldn’t go for rock bottom either.
By carefully controlling their sugar intake and taking insulin when they need it, people with type 1 diabetes can regulate their blood glucose levels to being almost normal. But start having high static all the time and you can’t tell what song is playing anymore. But there’s a lot less carbohydrates per serving in the whole gain loaf, and thus its GL is only 9 while the GL of the french baguette is 27! Type 2 diabetes is that much more dangerous because the body will rarely respond to insulin treatment, meaning that drastic diet changes and exercise are the only ways to fight back.
We've collected GIFs of the best and funniest moments that still make us laugh almost a decade later.

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