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08.10.2013
Stem cell biologist Amy Wagers and cardiologist Richard Lee, both of the Harvard Stem Cell Institute, wondered if any circulating factors, in young blood, such as hormones, might affect aging hearts. But the team spent years trying to figure out why; it was often the topic of Lee and Wagers' weekly bike rides.
One of the suspects, growth differentiation factor 11, or GDF-11, appeared to explain the miraculous heart rejuvenation. Additionally, the researchers report online today in Cell, old mice injected with this protein for 30 days developed younger, stronger heart tissue.
Srivastava adds that GDF-11 appears to be effective only against heart disease due to age, but he hopes that the protein may someday help diseased hearts, stiffened by heart attacks, to relax.
This study is a modern validation of 18th-century parabiosis science using 21st century molecular biology, says cardiologist Gerald Dorn of Washington University in St. If you don't know your way around a weight room, heading to the gym can be intimidating -- and even dangerous.
We spent an afternoon at Equinox with trainer and manager Rebecca Woll, learning the ins and outs of some of the most popular strength-training machines.
In the coming weeks, we'll be sharing Woll's thoughts on the biggest mistakes we all make while building muscle, plus her tips and tricks for better form. The Faux Pas: One of the most dangerous mistakes made in this position is taking the arms past 90 degrees, says Woll. The Fix: Luckily, most people aren't naturally flexible enough to extend the arms too far in this position, but be aware of how far back you push yours, says Woll. Tell us how it goes in the comments below, and be sure to check back over the following weeks to fix your form on the row machine, the shoulder press and more.
Feel free to take a look around, meet the Waverunners, and see how the foundation is being set in place, by building a softball powerhouse in Indiana!


Green Bay Packers' Clay Matthews is introduced before the first half of an NFL football game against the Minnesota Vikings Sunday, Nov. Drawing on an odd experimental technique invented more than a century ago but rarely done now, researchers have found that a blood-borne protein makes old mouse hearts appear young and healthy again. The thickened heart can still pump blood out normally, but it can't relax enough to refill between pumps.
One approach has been to apply a 150-year-old technique to infuse young blood into old mice.
Wagers, Lee, and their colleagues used parabiosis to yoke together five 2-year-old mice (downright ancient in mouse years) with 2-month-old counterparts. GDF-11, which regulates the growth of spinal and olfactory (smell) receptors, is produced abundantly in young mice, but production drops off with age.
Next, the team will investigate how GDF-11 affects other age-susceptible organs, such as spinal tissue.
But paying attention to a few simple rules of proper technique can make you slimmer, stronger and healthier all over.
This week, we're perfecting the reverse fly, a move performed on the same machine used in last week's seated fly. Also, too often there's an arch in the lower back or a curve to the shoulders that will decrease the effectiveness of the move and can lead to injury.
Make sure the toes and heels are firmly on the ground, she advises, and push through the whole foot as you lean your chest against the bench.
It's not clear yet whether humans would react the same way, but scientists are hopeful that this discovery may help treat one of the heart's most frustrating ailments.
The condition is called diastolic heart failure, named after the heart's resting, or diastolic, phase.


Called heterochronic parabiosis the method involves surgically linking the circulatory systems of two mice of different ages by opening a flap of skin on each mouse's side and stitching the two together so that the same blood pumps through both creatures.
The team also joined together 12 pairs of old mice and 10 pairs of young mice, as controls. With the help of SomaLogic, a protein-analysis company in Boulder, Colorado, the team made a breakthrough, narrowing down the likely suspects to only 13 factors. The team's further experiments on cultured heart cells confirmed that GDF-11 stops the thickening growth seen with age. We pride ourselves on hard work, dedication, and improvement; while enjoying the game of fastpitch softball. Louis' last game two weeks ago -- a blowout win over Indianapolis -- Austin scored a 65-yard TD on the third play from scrimmage on a fake reverse. There is currently no treatment to reverse the thickening of the heart and restore normal function.
The first result was "obviously positive," says Lee, who also practices at Brigham and Women's Hospital in Boston. Our goal as a team is to develop as softball players and build character within ourselves as well as represent our communities as responsible and classy individuals. After 4 weeks of connection to young mice, the five old mice's heart tissue had thinned and softened, looking just as spry and supple as the 2-month-olds'. We have been established in the area for several years and have helped to teach young ladies the skills needed to become champions on and off the field.



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