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09.10.2015
This chapter explains why you should read this book and how it can help you with any computer performance problem, now or in the future.
Some have hundreds of pages of very difficult math that most people cana€™t do and most problems dona€™t require. There are so many different technologies in your transaction path; to read all the necessary books would take longer than the average corporate lifetime. Almost all manuals about a specific version of a technology were written under tremendous time pressure at about the same time the engineering was being completed; thus the engineers had little time to talk to the writers.
What Ia€™m about to tell you will work for any collection of computers, running any software that has ever been built. Whether you are studying the slow response time of a computer, the root cause of a traffic jam, or why you are always in the slowest line, understanding those forces gives you a big insight into why this is happening. Many parts of this book help you solve the diversity and complexity problems mentioned earlier by helping you quickly determine that large chunks of your computing infrastructure are not the problem. Once focused, a large fraction of everyonea€™s effort is spent working in the right place and on the right problem. If you can replace S with the number 2 and U with the number 0.5 and calculate that R is equal to (spoiler alert) 4, then you have all the math you need for a long career in performance. In the future, money will still be important, humans will still want to avoid risk, office politics will still matter, and there will be many ways that you can be right, but still fail because you did not pay attention to the people involved. Having worked many performance problems from problem discovery, through solution presentation to senior management, and then on to problem resolution, Ia€™ve made a few mistakes and learned a few tricks.
If you are impressed with work experience, then read on as Ia€™ve spent the last 25 years teaching performance fundamentals, capacity planning, modeling, and performance testing of websites. If you are a person who is only impressed with academic qualifications then I have few to offer you. Your business depends on a collection of computers, software, networking equipment, and specialized devices. All companies have an internal language and shorthand terms they use when describing the subset of the entire computing universe that determines their customera€™s experience. In performance monitoring you need to know three things: the incoming workload, the resource consumption and what is normal. You need to know the incoming workload (what the users are asking your system to do) because all computers run just fine under no load. Expected problems are when the users are simply asking the application for more things per second than it can do.
Unexpected problems are when the incoming workload should be well within the capabilities of the application, but something is wrong and either the end-user performance is bad or some performance meter makes no sense. On any given day you, as the performance person, should be able to have a fairly good idea of how much work the users are asking the system to do and what the major performance meters are showing. With rare exception Ia€™ve found the lack of easily available workload information to be the single best predictor of how bad the situation is performance wise.
The data you collect can also be used to predict the future with the other three tools in your bag: Capacity Planning, Load Testing, and Modeling.
Capacity planning is the simple science of scaling the observed system so you can see if you have enough resources to handle the projected peak load, but it only works for resources you know about. Capacity planning is like a pre-party checklist where you check if there are enough: appetizers, drinks, glasses, places to sit, etc.
Capacity planning starts by gathering key performance meters at a peak time on a reasonably busy day. Now scale (multiply) the observed meters by the bossa€™s answer to get the projected peak utilization. In my experience, the application is rarely reengineered unless the inefficiency is egregious and the fix is easy and obvious. Capacity planning can be that simple, but there are a few more things you need to consider.
Even though you base your projections on one peak day, you should look at the data over a period of a few days to a few weeks.
Capacity planning can show you how busy key resources are at peak load, but it cana€™t tell you about response time changes as the load increases.
Load testing is the art of creating artificially generated work that mimics the real work generated by the real users.
Load tests depend on good performance monitoring to keep an eye on critical system resources as the load builds. For a load test to be really useful it must test the entire part of the transaction path that you care about. Load testing can also help you find where subsystems break, and isolate the effect of one transaction type. Load testing can tell you many interesting things, but it can only give you data on the computing infrastructure you have now. If you need to predict a future that is different from your present, then you need to model. When your boss asks you to predict future performance of some application, first see if you can do a simple capacity plan.
This model of Hurricane Irene is accurate enough for anyone with a house on the Gulf of Mexico and it looks hopeful for Floridaa€™s Atlantic coast as well.
In a computer context, imagine your model shows that at peak load this servera€™s CPU is 20% busy. Unfortunately, the above model of Hurricane Irene, at that moment, could not see far enough into the future to predict the devastating flooding Irene would cause in my home state of Vermont.
If you respect these limits, modeling is doable, useful and has its place when you are asking questions about the future. This chapter shows you how to gain confidence you will make it smoothly though a projected future peak load by scaling up your current observed load.
This chapter gives you practical advice on how to load test an existing application to see if can really handle the upcoming peak.
This chapter dispels the myth of modeling complexity and shows how modeling performance can save you a lot of time and money. This chapter teaches you how to present your results so that they are understood and are believable. This book is concise, useful, and occasionally funny.A  It gives you the tools needed to explore, and discover the hidden truths about your computing world. Unfortunately, the above model of Hurricane Irene, at that moment, could not see far enough into the future to predict the devastating flooding Irene would cause in my home state of Vermont.A  All models have limits. 3.The writer must avoid the two essential faults of creative writinga€”those that touch its essence and those that are accidental. 4.The plot should have a beginning, middle, and end, and thus resemble a living organism in all its unity. 5.The beginning and end of the story must be capable of being brought within a single view or theme. 6.Plot should be arranged on the complex plan, one in which change of fortune takes place through reversal of situation, recognition, or both and includes scenes of suffering. 8.Plot can consist of either a single thread or double thread in which an opposite ending occurs for the good and bad characters. 10.Plot should imitate actions that incite pity and feara€”pity as aroused by unmerited misfortune, and fear by witnessing the misfortune of a character like ourselves. 11.This character must be someone who brings misfortune on himself or herself, not through vice or depravity, but by some error or frailty.
13.The writer must focus on the action in the story and the part taken by the characters, and not drift off in several lines of action carried on at the same time. 14.The writer should put the scene before his or her eyes, as if he or she is an actual eyewitness to an event happening while writing. Hero or heroine faces jeopardy that incites in reader emotions of sympathetic fear and anxiety as to the outcome of the situation. Plant the idea or action early, then develop readera€™s understanding by returning to idea or action later in story. Description is the attempt to represent reality by using language to present as directly as possible the qualities of a person, place, object, or event. 1)The Eye of Insight sheds new light by examining inscape, viewing the interior, the shape within the shape of a thing. 2)The All-Accepting Eye examines things that we might rather not see, discards the labels, and searches for the beauty in a flaw, beginning discovery with the thing and not its label. 3)The Gliding Eye observes things in movement through time or space or both, picks up details of the passage, recording birth and decay of sensation at the center of a spinning mind. 4)The Childa€™s Eye observes a thing with the seriousness of a child at play, in a focused, highly concentrated way, without hurrya€”like watching an ant crawl across the ground or observing a dung beetle move a mass five times its size and weight. 5)The Dream Eye fragments reality and reshapes it, perhaps using symbols to penetrate below surface appearances.
The Naked Eye merges with the Imaginative Eye to create effective descriptiona€”The Big Picturea€”by making things from, not making things up. New idea built from comparison between two unlike things; tension between two actualities creates possibility, or new meaning. An Allusion measures a thing against a known cultural or memory tweak by referencing something the reader will know (Allegory, Conceit, direct or indirect reference to other texts (intertextuality), music, movies, etc.
Respond to each othera€™s work with respect, depth and thoughtfulness, in a manner that is civil and constructive.
Over the Top a€“ material is presented in such a way that reader has a hard time believing the story. Greenfield, Tennessee, a farm and factory town of twenty-two hundred in the statea€™s rural northwest corner, has never been more than a place between places, one in a long list of towns to be passed through along kudzu-choked U.S. It was in fact the railroad, and not the nearby Mississippi River, which was the prime mover in the delta land where I grew up. On September 2, 1979, two members of the Weakley County rescue squad found the raped and murdered body of eight year-old Cary Ann Medlin in one of the communitya€™s namesake green fields, not far from the Illinois Central tracks. I remember hearing news of her murder and running to find my first grade yearbook, hoping to fix her school days photo in my mind so I wouldna€™t lose it. It wasna€™t until twenty-one years later, long after Ia€™d left Tennessee, after Martin and Greenfield had became only places in my mind and that Lovera€™s Lane a Memory Lane that I began to consider the murdera€™s place in a childhood which I now see as violent in so many other ways. That first grade photo of Cary appeared over and over in the news in the months leading up to the Coe execution, along with another I found printed years before in the Nashville Tennessean and now reprinted as the newspaper re-capped the story: a shot of those rescue workers bent over the soybean plants, long-haired and t-shirted, hunting the girla€™s body.
Bob Cowser, Jr.'s first book, Dream Season, was a New York Times Book Review a€?Editor's Choicea€? and a€?Paperback Rowa€? selection and was listed among the Chronicle of Higher Education's best-ever college sports books.
Above our heads, a banner of the eartha€™s children: an African boy with corduroy hair, a fur-muffled Eskimo, a golden girl from Holland. Six years later my first stockings were seamed and I thought of Miss Ranney while I sat on the edge of the bathtub shaving the pale brown hairs. Rebecca McClanahan has published nine books, most recently Deep Light: New and Selected Poems 1987-2007 and The Riddle Song and Other Rememberings, which won the 2005 Glasgow prize in nonfiction. There was a woman who died while I was in Daffiama; she was young and eight months pregnant.
Jillian Schedneck taught Literature and Creative Writing at the American University in Dubai for the 2007-2008 academic year.
Sitting on the edge of her bed, with legs dangling and shoulders slumped, my six-year-old stares at the wall in a trance. She moves to the beat of her own drum, but once in the car, I settle into the morning routine. As the overburdened stretch of I-95 south of the Capitol extends before me, with cars packed in every lane as we creep toward our northbound destinations, I cannot stop the seething anger and indignation that boils within me.
Our passage onto the base is slowed at the gate by the forklift placing barriers in front of the gate shack.
I look at her, and though I answer a€?yes,a€? I realize that I was late because I forgot to leave.
Being a mother is not just something I do; it is who I am, who I should have been, and who I always want to be.
On the way to work, I listen to the news, but then I turn it off and just listen to the sound of my breathing. During my first sixth months of recruiting duty, workdays lasted from 0700 to 2300 Monday thru Friday, and from 0800 to 1800 on Sunday. Making all those a€?numbersa€? was occasionally impossible, especially the a€?three appointments for the next day.a€? The recruiter had to contact the staff non-commissioned officer in charge and report his numbers before securing. Create Scene, driving home, reflecting on the hours spent on the road as a recruiter and the nastiness of the bars carried on Na€™s clothing into the cara€”describe car: At the end of that night, I went home exhausted, sweaty, and smelling like the smoke from the bars, an odor I despise. Create Scene: Pulling into the driveway at 0200 all I could think of was getting a shower and going to sleep. Deodorant soap replaced the smell of sweat and cigarette smoke from my body, but the taste in my mouth was getting worse.
A recruiting SNCOIC doesna€™t want his recruiters getting caught with their integrity down but he is willing to risk it to make mission. This is a separate story inside this storya€”N is avoiding the real story by ending with this: Anyway, rumor had it the old man had assaulted a recruiter in Georgia and the Colonel just moved him to a new duty-station, in Daytona Beach, Florida. Like I said before, you have real talent, so dona€™t think badly of your writing when you see my comments. One of the most important things you can do, is to take this piece and determine what is summary and what is scene. When you create your timeline, start with placing the major events in this piece on the line first. Being assigned to recruiting from my usual job as a criminal investigator was both good and bad. Getting back to those tasks based on statistics, stay with me now as I get through how the numbers worked out. I talked to those people either on the telephone or in person, what we called daily activities. When I returned to my desk from the bathroom, the old sergeant was heading out the door with his Bible. This was the guy I had to call every night and get approval to secure, to leave work and go home at night. After almost five hours of talking to people on the phone and going out and talking to people at malls, stores and various other public places, I felt done for the day.
Dragging ass, I continued to approach people around 7-eleven stores and such, acting like I just happened to be stopping by on my way home from work.
After ironing out the details and writing down his contact information, I finally left the musty tavern and drove home, exhausted and sweaty. The glowing numbers on the clock said it was a short night before I had to get back up and start another recruiting day. Born and raised in a small town in the South, David Charles joined the US Marine Corps as a teenager during the Cold War period. I am pleased to report that, today, I joined NIEHS Director and SOT Past President Linda Birnbaum to sign a memorandum of understanding (MOU) between SOT and NIEHS. Because of these close connections, it seemed only natural for SOT and NIEHS to formalize our robust, working relationship.
Essentially, SOT and NIEHS will be proceeding as we always have: working together to improve environmental health.
As a feedback comment, one of the students stipulated that, although there are several webinars and online sources available about scientific writing, career development in toxicology, and other topics, hearing from one of the alumnus was remarkably provocative. After completion of all scheduled activities, students and faculty interacted with me asking simple yet important questions regarding career opportunities in the United States and research prospects. I sincerely appreciate SOT's support of the outreach programs for developing countries.
The National Institutes of Health (NIH) has announced a call for images of NIH funded research to be posted to the NIH Image Gallery on Flicker and in the Funded Research album.
The Society for Environmental Toxicology and Chemistry (SETAC) is initiating a Horizon Scanning effort to advance the science and application of the Adverse Outcome Pathway (AOP) framework.
Workshop results will be publically disseminated in the form of publications and international presentations at professional meetings. You also will find four Editor's Highlights, which were prepared by ToxSci Associate Editors Jeffrey M.
The mission of ToxSci, the official journal of the Society of Toxicology, is to publish the most influential research in the field of toxicology. Thirty-six outstanding undergraduates and five advisors were selected to attend this year’s program.
The success of this program is due in large part to over fifty dynamic volunteers who so generously gave their time to teach and inspire the next generation of young scientists during the SOT Annual Meeting.
These dedicated mentors will continue to keep in contact with their mentor group students throughout their undergraduate studies and be a resource to them as they consider career paths and advanced degrees.
CDI and these students were very fortunate to have leading toxicologists take this extensive amount of time to share their knowledge and professional development experiences with them.
Toxicological Sciences and Oxford University Press would like to thank the Associate Editors, Editorial Board members, reviewers, and authors for their outstanding contributions. The 2016 Environmental Endocrine Disruptor Gordon Research Conference (EED-GRC) will celebrate its 10th anniversary this summer by focusing on the next generation of questions, chemicals, tools, approaches, challenges, and investigative strategies related to endocrine disruption.
The 56th Annual Meeting of the Teratology Society will be held June 25‒29, 2016, at the Grand Hyatt, San Antonio, Texas. This Society of Toxicology Contemporary Concepts in Toxicology (SOT CCT) conference, Ocular Toxicology, Pharmacology, and Drug Delivery: An Eye on the Future, will provide a forum for communication and interactions between toxicologists, pathologists, clinicians, pharmacologists, basic scientists, and other professionals working in the field of ocular toxicology.
The American College of Toxicology (ACT) is offering an advanced course, Advanced Comprehensive Toxicology, to complement the Toxicology for Pharmaceutical and Regulatory Scientists course. This webinar series will discuss the advances being made with chemical-induced asthma and the role of clinical, toxicological, and epidemiological research in regulatory and hazard characterization approaches. The upcoming Annual Meeting of the Genetic Toxicology Association (GTA) is a 2.5 day event that includes a workshop, keynote address, six symposia, and a poster reception. We invite you to submit a Symposium, Workshop, Roundtable, Continuing Education, or other scientific proposal for the Society of Toxicology 2017 Annual Meeting in Baltimore, Maryland.
The Women in Toxicology Special Interest Group (WIT) is pleased to host a webinar titled Career Development for Female Toxicologists. The Scientific Liaison Coalition (SLC) will hold its next webinar series beginning on Tuesday, May 17, 2016. Strengthening partnerships among scientific, biomedical, and other health-based organizations to increase awareness of the impact of toxicology, diseases, and related subjects on human health. Functioning as a means to enhance cooperation among societies as equals with the goal of accomplishing tasks benefiting human health and disease prevention through joint and shared activities. National Capital Area: The National Capital Area Regional Chapter (NCAC-SOT) will be holding their Spring Symposium on Wednesday, April 20, 2016, at the Georgetown University Conference Center in Washington, DC. Northern California: The Northern California Regional Chapter (NorCal) meeting will be held on Tuesday, April 26, 2016, at SRI International in Menlo Park, California. Allegheny-Erie: The Allegheny-Erie Regional Chapter (AE-SOT) will host their 30th Annual Meeting on May 18-19, 2016, at the Erikson Alumni Center on the West Virginia University Campus in Morgantown, West Virginia.
Ed’s devotion to education, mentoring, and science is now memorialized through the Edward W. Note: May 1 is the next deadline for graduate student applications for Supplemental Training for Education funding.
While CEd-Tox offers some excellent courses to learn about the basics of toxicology risk assessment, including for medical devices, an exclusive course on the safety assessment of food products has yet to be offered. I feel that this course helped me to learn some qualitative and quantitative tools used for the risk assessment of food products. The US Environmental Protection Agency (EPA) invites nominations of scientific experts from a diverse range of disciplines to be considered for appointment to the Clean Air Scientific Advisory Committee (CASAC) and the EPA Science Advisory Board (SAB) and five SAB committees described in this notice. Expertise Sought for the SAB: The chartered SAB provides strategic advice to the EPA Administrator on a variety of EPA science and research programs.
For further information about the chartered SAB membership appointment process and schedule, please contact Mr. The National Organic Standards Board (NOSB) was established to assist in the development of standards for substances to be used in organic production and to advise the Secretary on the implementation of the Organic Foods Production Act of 1990 (OFPA). Thank you for attending the SOT 55th Annual Meeting in New Orleans, Louisiana, March 12‒17, 2016.
We are looking forward to developing an exciting program from the proposals submitted for consideration for the 2017 Annual Meeting. This book, describing the medical aspects of Sir Arthur Conan Doylea€™s life, their expression in his writings, and his personal and professional humanism, is a detailed and comprehensive treatise.
Much of what has been written biographically about Conan Doyle has relatively ignored the deeply ingrained aspects of his medical training and its effect throughout his writings and life.
One cannot exaggerate the detail and comprehensive manner in which Rodin and Key portray each subject; they describe not only Conan Doylea€™s activities, but also present extensive background information, as for example the history of the towns in which Conan Doyle practiced, of the diseases discussed, and the doctors presented, etc.
Along the way Rodin and Key carefully and repeatedly document Conan Doylea€™s thoughtfulness in his dealings with people and social causes. For many years, Conan Doylea€™s attendance and graduation from the University of Edinburgh with the degrees of B.M. He was one of many writers who have started out to make a career in medicine, and under the impulse of a creative spirit abandoned practice for the life of letters.
Conan Doyle has always been overshadowed by Sherlock Holmes, but Rodin and Key clarify how the rigorous and demanding years in medical school, the hours spent day and night with sick people observing their suffering, their joys and their deaths, were the source of many memories and impressions that found expression in Conan Doylea€™s writings. His curiosity about Kocha€™s claims about tuberculosis prompted him to visit Berlin for a firsthand look. It was then, as I surveyed my life, that I saw how foolish I was to waste my literary earnings in keeping up an oculista€™s room in Wimpole Street, and I determined with a wild rush of joy to cut the painter and to trust for ever to my power of writing. After the Boer War, Conan Doyle continued his friendship with medical organizations, giving frequent toasts at various medical societies and a reception for the British Medical Association at his home in 1913. His ophthalmological knowledge benefitted George Edalji, convicted of maiming horses and cattle, with Conan Doylea€™s cogent arguments about Edaljia€™s ophthalmologic problems, in letters to Lancet and the British Medical Journal, contributing to Edaljia€™s release from prison. Unselfishness, fearlessness, humanity, self-effacement, professional honour a€” these are the proud qualities which medicine has ever demanded from her sons.
It was difficult to associate him with the author of Sherlock Holmes: he was a doctor pure and simple, an enthusiastic doctor too. It was a medical recognition of Conan Doyle at the time to be invited to address the opening of St. Rodin and Key list fifty-eight nonfiction and fiction titles by Conan Doyle between 1879 and 1928.


More usually physicians who become serious writers abandon the clinic wholly or visit it only intermittently. The distinguishing feature of Doylea€™s writings was that he knew how to tell a story in an interesting fashion.
Conan Doylea€™s medical fiction ranged from the years 1884 to 1911 with the majority written before 1900. Detective fiction was just emerging in the Victorian era with the stories of Edgar Allan Poe, Emile Gaboriau, Fergus Hume, R. Of equal interest although not as frequent are Conan Doylea€™s accounts of forensic medicine: a test for blood, footprints, fingerprints, changes in the body after death, and deductions based on trauma in various parts of the body. Conan Doyle left a lifetime of diverse activities that almost defy description a€” sports, champion for the unjustly accused, patriotic efforts, war historian, an advocate of the divorce rights of women, and a major player in Spiritualism. Most of this outstanding book resulted from their minute and careful search in newspapers, journals, and books.
Fred Kittle is a notable bookman in addition to his long and distinguished career as a thoracic surgeon.
In Victorian times, becoming a member of the medical profession did not automatically assure prestige and wealth.
3.A  From the Arthur Conan Doyle Archives at Bibliotheque Cantonale et Universitaire Lausanne-Dorigny. Everything (hardware, operating systems, networking, applications, users, corporate goals, org charts, priorities, and budgets) changes over time and with change comes new performance challenges. It will continue to be useful 100 years from now when todaya€™s technology, if it runs at all, will look as quaint as a mechanical cuckoo clock. They help you make sense out of the performance meters you do understand and help keep you from making big mistakes.
It shows you how to use the scientific method to decipher what they mean and how to find patterns in the raw data. This rapidly focuses your companya€™s full and undivided attention on the small part of your computing world (System Z) that is causing the performance problem. Now, the right experts can be consulted and business decisions can be made to fix or work around the problem. I spent about 15 of those years also doing performance work on live systems and critical applications for customers around the world. Ia€™ve had plenty of practice in my standup teaching as well as when working with customers. Back in the 70a€™s he wrote this wonderful little book about repairing literally any bicycle.
It usually includes dealing with immediate performance problems or collecting data that will be used by the other three tools to plan for future peak loads. Without these three things you can only solve the most obvious performance problems and have to rely on tools outside the scientific realm (such as a Ouija Board, or a Magic 8 Ball) to predict the future.
If you have a good sense of what is normal for your situation, then any abnormality will jump right out at you in the same way you notice subtle changes in a loved one that a stranger would miss. Your meters should be running all the time (like bank security cameras) so that when weird things happen you have a multitude of clues to look at. Assuming you know how many guests will show up and have a reasonable understanding of what they will consume, everything you checked should be fine. Almost any day will do, as long as the system load is high enough to clearly differentiate it from the idle system load.
In most situations, people tend to value application stability more than the money they will spend to solve the problem with more hardware.
This gives you a clear picture where the usual daily peaks are and if there are things going on at odd times that you have to factor into any changes you propose. Even if you had perfect metering, doing the math would be a staggering challenge and, even, then youa€™d be gambling the business on reams of calculations. These resources take a little more work and creativity to capacity plan for, but this is completely doable. It can be done in a few days, presented in a few slides and prepared with few additional costs or risks. The overall load starts off low and then increases in stages to the point where you achieved your goal or you fail because some resource has hit a limit and has become a bottleneck. For any test you need to know how much work you are sending into the system, the throughput and response time for the completed work, and how the system resources are responding under that load. If your product is your website then you need to test from where your users are: all the way in and all the way back to where they live. If you only got half way to your goal before you hit a bottleneck, then every measured resource is going to be doing twice the work once you fix the current bottleneck. Imagine your workload is an even mix of Red and Blue transactions, but it is the Blue transactions that really exercise some key component of your computing world. To use a metaphor, running a race tells you about your current aerobic capacity, not the capacity you will have after six more months of training.
To model, you are going to need the data you collected with performance monitoring and maybe some data from load tests. Everyday, in companies all over the world, regular people build simple models that answer important business questions. If circumstances change so much that you lack confidence in that prediction, then try modeling. Either you can directly measure the performance of a live system under load, or you have to guess about a theoretical future situation. It doesna€™t take a genius to understand that your model could be off by a lot and the server would still have plenty of CPU power left. This chapter gives you the keys to understanding all computer performance problems and provides an important foundation for the next four chapters.
With it, and some work on your part, youa€™ll be able to solve performance problems and to walk into the CIOa€™s office with confidence. There are utilization meters that tell you how busy a resource is, there are count meters that count interesting events (some good, some bad), and there are duration meters that tell you how long something took. A useful answer is: accurate enough to answer your question with a reasonable margin of safety. Determine the point at which protagonist must make a decision in order to achieve goal (crisis). Coherent: Distilled image remains True to Life by reproducing the distinctive features of original.
Consistent: Distilled image links the intended meaning from beginning to middle to end creating Unity of Meaning, as in an extended metaphor or exemplification. Allusion requires an understood knowledge base between writer and reader and recognition of a Cultural Memory Tweak by the reader in most cases. Elusion is complex and mysterious and requires not just recognition, but discovery of what is absent. In depicting the motions of the a€?human hearta€™ the durability of the writing depends on the exactitude. Submit line-edit suggestions, marginal comments, and an end comment (summary of your thoughts on the piece) addressed to the writer. Offer an end comment that notes what you believe the work to be about, how you see the work achieving this, and what opportunities you can see for further exploration in this work. My slightly larger hometown of Martin, ten miles north up Highway 45, took its name from tobacco plantation owner Colonel William Martin who donated land for the railroad bed.
Cary had gone on a bike ride with her little brother twenty hours earlier, gotten into a strangera€™s Grand Torino and disappeared. Her stepfather worked in those days on the assembly line at the Goodyear tire plant in Union City, her mother as a nurse at a Jackson hospital, and before moving to Greenfield in the summer of a€?79 the family had lived for a time in Martin.
As the state of Tennessee prepared to execute Coe for the Medlin murder (its first execution in forty years), I began to understand Bean Switch Road as a rutted track in memory which might run between me and many people I loved and respected, separating me from them. Both Medlin and Coe are as dead as they could bea€”Coe for almost five years at this writing, Cary Ann for nearly a quarter century.
He is also the author of Scorekeeping, a collection of coming-of-age essays, and his essays and reviews have appeared widely in American literary magazines, including Missouri Review, Prairie Schooner, American Literary Review, Sycamore Review, Brevity, Sonora Review, Fourth Genre, and Creative Nonfiction. I checked the seams each morning as we stood facing the chalkboard, my hand across a place I called a pocket but she called your heart, and I pledged allegiance to a flag no bigger than my brother's diaper flapping on the line. I fingered my Brownie badge and renewed my oath to help other people at all times, especially those at home. She has also authored four previous books of poetry and two books of writing instruction, including Word Painting: A Guide to Writing More Descriptively. I didna€™t go to the funeral, but those who did said you could see the baby circling around inside of her, like a hand moving under a sheet.
The first one fell with the Twin Towers, and as the clots of blood dripped into the toilet, I said goodbye almost thankfully, glad not to bring a child into such a world.
Something is different, something has changed, and I search my body for signs that my baby is still therea€”check my breasts, my belly, the fluid in the toilet, and back again to the breasts, wondering if the life inside me has died.
Not just any brown, but the kind you make with paint or too many layers of crayon when youa€™re a little kid.
I would have gone to the funeral and made them cut the baby out while it was still alive, instead of after it had died.
Her essay a€?Circling,a€? which first appeared in Brevity, will be anthologized in Online Writing: The Best of the First Ten Years (Snowvigate Press, 2009). As she rifled through the box of pencils, Alejandra must have also been watching my backside as I bent over Todda€™s desk, pondering the thin line of flower-print elastic that clings to my waistline. He has dutifully added the e, but his compositiona€”five sentences describing his homea€”is riddled with errors. Calculating the hours, I am certain the Virginia state legislature steals an hour and a half from me five days a week. Amandaa€™s before and after school care is local to our neighborhood, and my year old baby attends the day care on base.
Calculating the hours, I am certain the Virginia state legislature steals an hour and a half from me every workday. We are working with the Marine Corps program manager to set the timeline and milestones for the new Department of Defense messaging software. She joined the Marine Corps in 1990 and is currently a Master Sergeant servingA with III Marine Expeditionary Force, Okinawa Japan. Those activities included about 200 telephone calls and, getting back to this day at a little after 5 p.m. Having joined for law enforcement training, his first Marine job after a€?recruita€? and a€?studenta€? was as a military policeman. Almost 100 SOT members are employed within the NIEHS, and the institute has been an active participant and sponsor of sessions at the SOT Annual Meeting and other events. The only difference is that we now have a public document acknowledging this beneficial and profound partnership. Moreover, I engaged the students to participate in an activity through which they learned some dos and don’ts of scientific writing, which was liked by everyone and greatly appreciated by those students getting ready to construct their manuscripts for future publication. Moreover, we had to change the venue of this meeting from one auditorium to another hall in the middle to accommodate overwhelming attendance which reflected their enthusiasm. This meeting will offer a forum for sharing basic and applied research in toxicology and is aimed to convene international scientists to present their results related to the exposure to toxic agents, adverse effects, mechanisms of toxicity, preventive alternatives, normativity, and more to strengthen the science-policy interface to foster the progress towards sustainability.
Miller regarding the importance of reproducibility and rigor, "As many of you may be aware, the National Institutes of Health released new guidelines a few months ago regarding rigor and reproducibility, a topic familiar to the readers of Toxicological Sciences. Gehring Diversity Student Travel Award was presented to Lisbeth Perez-Castro by Jorge Naciff, Chair of the Committee on Diversity Initiatives (CDI), during the SOT Annual Meeting at the CDI Reunion. Gehring Diversity Student Award recognizes a student who participated in the SOT Undergraduate Program, is from a group underrepresented in toxicology, and is presenting an abstract at the SOT Annual Meeting. Additionally, over fifty undergraduates joined the travel award recipients for the open Sunday activities. The Committee on Diversity Initiatives (CDI) would like to recognize and give special thanks to these wonderful program volunteers.
Many of this year’s participants have reported back on what a wonderful and affirming experience they had during the Undergraduate Program, and how valuable the experience will be as they look ahead to plan career paths and consider pursuing advanced degrees.
Talks will describe key factors that impact the interpretation of nonclinical discovery and development studies.
This international meeting will bring scientists from around the world to the University of Rochester to discuss emerging knowledge about the AHR and its many ligands. Led by numerous nationally and internationally recognized experts in the field of medical toxicology, this course provides a broad overview of the scope of medical toxicology and a detailed perspective into current clinical and public health toxicological issues. The International Union of Toxicology (IUTOX) organizes the largest and most prestigious International Congress on Toxicology (ICT) every three years, offering the opportunity to learn the latest developments in toxicological science and regulation through general scientific sessions and continuing education courses.
This conference will provide a forum for communication and interactions between toxicologists, pathologists, clinicians, pharmacologists, basic scientists, and other professionals working in the field of ocular toxicology. Career challenges faced by female trainees and professionals will be discussed including negotiating a competitive salary, climbing the career ladder, speaking up without appearing aggressive, and effective networking. To keep you informed and provide you with an opportunity to take action regarding this issue, please refer to an excerpt from the message NABR Executive Vice President Matthew R. Below are a number of upcoming Regional Chapter events that may be of interest to you. The topic of the meeting will be E-cigarettes and medical marijuana and the Keynote Speaker is Dr. The title of the webinar is Current Progress in Immunotoxicology from Medical Devices through Biologics and will explore three therapeutic modalities (small molecule, large molecule, and medical devices) and will emphasize the diversity of immuno-toxicological challenges and approaches for these areas.
Edward Carney was known to many for his outgoing sense of humor, his passion for music, and love of family, but among toxicologists he was known for outstanding leadership in developmental biology and developmental toxicology.
Carney Trainee Award Fund Endowment Fund and how you can support this fund or the many other funds that are part of the family of the SOT Endowment Fund. Through this course, I learned that probability is the language of uncertainty and variability. The SAB Staff Office is especially interested in scientists with expertise and experience in air quality relating to criteria pollutants. Some of the recipients are shown below, who were photographed immediately before the Sunday, March 13 Awards Ceremony held at the SOT 55th Annual Meeting in New Orleans, Louisiana.
At the conclusion of this meeting, several items remained unclaimed in the SOT Headquarters Lost and Found. For this reason, it is good to provide your draft proposals directly to the endorsing groups well in advance of the submission deadline to leave time for their review and feedback and any recommended revision prior to formal submission to SOT (deadline for this is April 30).
Rodin and Key not only tread on fresh ground, they plowed it deeply, and provide a unique look at Conan Doyle. Section One considers Arthur Conan Doyle as medical student and practitioner, and his medical writings. As a result there are few questions left unanswered about Conan Doylea€™s medical life and its relation to his writings and activities.
This viewpoint like the medical events depicts a new aspect of Conan Doyle, since other biographies have devoted themselves more to occurrences themselves rather than his closer, more personal actions.
Rodin and Key show how these experiences, combined with his plethora of interests, provided a full palette for his brush.
Its faculty was renowned, and Conan Doylea€™s years there were filled with talk of a philosophy of rational thinking a€”Darwin, Mendel, and others fueling a new scientific approach that was instilled in the young studentsa€™ minds.
To obtain additional finances for a start in practice, but also because of Conan Doylea€™s natural propensity for adventure, he took yet another sea job after receiving his B.M. Writing produced welcome additional income; he also engaged in sports and other non-medical activities a€” the Portsmouth Literary and Scientific Society, the Masonic Lodge, and the Liberal-Unionists. On this trip a London dermatologist, Malcolm Morris, urged him to leave his small town and come to London.
I remember in my delight taking the handkerchief which lay upon the coverlet in my enfeebled hand, and tossing it up to the ceiling in my exultation. Politically he supported the Daylight Saving Bill of 1908 as likely to increase the general standard of health, particularly for children. In later life, Conan Doyle was to utilize his medical resources in his Spiritualistic activities, by measuring changes in pulse rate in various mediums. For people subjected to emotional trauma in their childhood or teen years, such trauma often remains unresolved. There are 118 doctors mentioned in his short stories and novels, fifty-five in the medical short stories and novels, sixty-three in the nonmedical writings. The total number of medical expressions is quite numerous, more so than with any other author. When he ceased medical practice and became interested in more fields, so did the number of his medical references in writing become less. Watson and the zeal displayed in the magnitude of commentaries about these stories have obfuscated a realistic perception of Doyle and his medical references in the Canon. Sir Henry Littlejohn, one of his professors at Edinburgh, was also the City of Edinburgh Police Surgeon, in the years when forensic pathology was becoming established as a medical specialty and science.
His medical comments described the knowledge of his time but often made surprising predictions about the future of medicine. Two years ago he was honored by a lengthy profile in the monthly periodical of The Caxton Club, Chicagoa€™s century-old bibliophile society.
There are always things to do, things to learn, things to prepare for, and experiments to run. These patterns can tell you useful things about whata€™s going on inside the giant black box that is your computing world.
I had three majors (Wildlife Biology, Botany and Computer Science) but I have no degree as I left college when I ran out of money and got my first job in the computer industry. Mostly Ia€™ve learned from other performance wizards, programmers, system administrators and a few generally smart people Ia€™ve known.
Clarity is essential when explaining to senior management that they need to spend large amounts of money.
There are many other parts that you dona€™t control, cana€™t meter, and have no clue how they do their work. Expected problems are no fun, but they can be foreseen and, depending on the situation, your response might be to endure them, because money is tight or because the fix might introduce too much risk. This could be a simple case of them not caring about doing a good job, but my more charitable assessment is that he had no idea what a€?normala€? was, so everything the register told him had to be taken at face value. This can save your bacon because if you spot the unexpected utilization before the peak occurs, then you have time to find and fix the problem before the system comes under a peak load. You will want to search this data by time (What happened at 10:30?), so be sure to include timestamps. However, even if you miss something, you are still better off having planned for reasonable amounts of the key resources. Ia€™m very sure the CIO looking at all this complex math would feel very uneasy betting his or her job on these calculations. If you need more confidence in your plan, or you need to hold the response time down to a reasonable level, or if the future you are planning for includes significant changes to the transaction mix or vital systems, then you need to do either Load Testing or Modeling. When that happens, throughput stops increasing, response times climb to an unacceptably painful place and things break.
If you (and your boss) only have responsibility for a small subset of the entire transaction path then thata€™s all you really need to test. So take all the peak measurements and double them to get a good idea of what you are likely to run out of as you push the test to the goal load.
Create a load test that sends in all Blue transactions and you can collect the data you need without the interference of the Red transactions. Examples of big changes that preclude simple capacity planning might be things like, large application or middleware changes or a big change in the incoming workload. The closer to the utilization limit (or the projected storm track), the more precise you have to make your model. As the commemorative plate infomercial says: a€?Collect them all!a€?A  Please dona€™t wait for perfection. Scatter descriptive details by breaking large clumps of information into smaller bits and sprinkle throughout the story. More than a century ago now a conductor on a southbound Illinois Central Gulf train offered the town its name, noting the fields of winter wheat still green late in the year. Engineer Casey Jones lived 50 miles south in Jackson, Tennessee at the time of his legendary 1903 wreck, his modest house there now a museum.
By the time they found her tiny body atop a trampled swath of soybean plants just off Bean Switch Road, a notorious Lovera€™s Lane, the corpse had begun to turn in the late summer heat. I was as sad as a nine year-old boy could be about the business I suppose, but Cary had violated that cardinal rule of childhood about talking to strangers, and the Tennessee Bureau of Investigation had Robert Glen Coe in custody just three days later. I sensed with a kind of strange excitement how the photo was an emblem of my childhooda€”the unmistakable heat, those men, something awful hidden just out of sight. We sang of mountains and amber grain, our voices always a beat or two behind the warped '45 spinning on the phonograph beside the globe on Miss Ranney's desk. Later that year, I was in Home Ec tracing my face shape with soap onto a mirror when the intercom crackled the news.
McClanahana€™s work has appeared in The Best American Poetry, The Best American Essays, Kenyon Review, Georgia Review, Gettysburg Review, and numerous other publications. Later I felt bad that I hadna€™t gone to the funeral, but I was never sure if my motivation was guilt or disappointment over missing such a spectacle.
This one is taking its time, and I have nothing more than my intuition to tell me that ita€™s gone.
Ia€™m still not completely sure, so I survey again, trying to find the feeling that was once there, that still comes back in little wisps, but seems mostly gone.
You mix all the colors togethera€”the good colors and the bad colors too, just to see what will happen, and you come up with a muddy, greenish, sickly version of the color brown, a sort of chaos and confusion of life and lifelessness all blended into one, never to be separated into sky blue, tangerine, and sea foam again. I would have taken the dead womana€™s baby for my own, as a guard against the possibility that either of us would ever be alone, as a stone thrown in the face of death, as protection against this circling, this looking for something we both need desperately that is no longer there.
I consider asking him what the correct spelling might be, imagine him looking up at me with big, brown eyes, searching the details of my face for the correct letter, but decide to just tell him what he needs instead. I nod solemnly, mentally adding another dress code violation to my long list of teaching errors. Traffic is finally moving, and this idiot thinks the left lane is for pacing instead of passing.
On the way to work, I listened to the news, but sometimes I turned it off and just listened to the sound of my breathing.


Looking at my watch, I realize that the few minutes that I have been delayed will cost me many more.
With my simple math skills, I conclude that including weekends, they rob me of at least ten hours a week. My thoughts are focused on security, contingency operations, alternate network operations, and the myriad of requirements to overcome the obstacles presented by this occurrence.
She knows something terrible has happened today and I dona€™t know how to explain it to her.
Being a Marine is not something I do; it is who I am, who I have been, and who I will always be. The hands of time are moving again, but now I hear the slow, steady tick tock of each moment. She is also married to a Marine and has two daughters, ages 13 and 8.A She has served in support of Operation Iraqi Freedom, and her husband has served in support of Operation Enduring Freedom.
Once he cut his teeth guarding gates and on patrol, David became a Marine criminal investigator.
I cannot thank the SOT Education Committee enough for giving me this enthralling opportunity to make a strong impact on a group of students and faculty in India.
The needs, obstacles, and questions the students had regarding career and education in the field of toxicology came to light and I did my best to provide answers to those issues. Our journal has been ahead of most in addressing these issues and expanding editorial policies to improve the rigor, reliability, and reproducibility of the science that appears within. The award recipient is selected by the CDI and may be either a graduate student or undergraduate student. The Sunday program is open to any undergraduate student who registered for the Annual Meeting, including the 2016 Pfizer SOT Undergraduate Travel Award Recipients. Featured themes include understanding inter-individual sensitivity, mechanisms of transgenerational inheritance, advances in high throughput screening, and emerging chemicals of concern. Symposia topics include early prenatal diagnosis of birth defects, testicular dysgenesis syndrome, and thrombosis during pregnancy.
The main focus will be two-fold: to improve our understanding of ocular toxicology, pharmacology, and safety assessment and to increase our understanding of the challenges associated with the development of the next generation of ocular drugs and devices. The content of this course will provide information that could be helpful to those seeking certification in toxicology or to those seeking more advanced training in toxicology.
It's an appropriate course for physicians preparing for their board exams as well as any medical professional interested in increasing his or her understanding of the impact of toxicology on human health and local communities.
The webinar series is sponsored by the American Cleaning Institute (ACI), in collaboration with the Toxicology Excellence for Risk Assessment (TERA) Center, University of Cincinnati and endorsed by the Society of Toxicology and Society for Risk Analysis. The goal of this meeting is to communicate recent discoveries and promote discussion of miRNA biomarker research efforts between consortia partners and independent researchers as a critical step toward the streamlined utilization of promising biomarkers for nonclinical and clinical safety assessment.
Visit the Modular Course website for course registration, course content, lodging, and other course information.
Symposia topics include: case studies on current issues within the field of genetic toxicology, exploring the role of DNA damage in epigenetics, recent advances in screening technologies, and the Pig-a gene mutation assay, as well as new techniques for identifying rare genotoxic events.
This series will provide pharmaceutical industry and regulatory perspectives on this topic. The aim of this webinar is to review the use of animal models of disease in the evaluation of exaggerated pharmacology and toxicity to improve the relevance and extrapolation of the assessments to the intended disease population. For additional information about the Regional Chapters, please contact SOT Staff Liaison to the Regional Chapters Ashley Pomper. Ed was President of the Teratology Society, President of the SOT’s Reproductive and Developmental Toxicology Specialty Section, and a distinguished scientist with the Dow Chemical Company.
This fund was seeded with contributions from many colleagues, close friends, and relatives who understood the need to honor Ed and his commitment to toxicology and education. At J&J, I was responsible for the risk assessment of several categories of consumer and personal care products to be launched in North America. Thus, I requested Supplemental Training for Education (STEP) funding to participate in the "Qualitative and Quantitative Risk Assessment Online” course by the Joint Institute for Food Safety and Applied Nutrition (JIFSAN) in order to fill this gap. After this course, I can easily distinguish the discrete data set from the continuous ones and I am now familiar with the most frequently used probability distributions for risk assessment and the Monte Carlo process. Moreover, this class provided me with some basic knowledge and literature that will be very helpful in the near future as I step into the real world of toxicology risk assessment all over again.
For further information about the CASAC membership appointment process and schedule, please contact Mr.
The chartered SAB reviews all SAB committee and panel draft reports and determines whether they are appropriate to send to the EPA Administrator. Award recipients from left to right are Rachel Church, Alison Harrill, Paul Watkins, Karissa Adkins, and Merrie Mosedale.
To have the email Table of Contents (eTOC) alerts delivered to you as well as Advance Access notification of the latest papers and research in Toxicological Sciences as soon as they are accepted and posted to the website, register online.
And unlike most biographies, often written to tell a good story aided by liberal literary license, their account provides extensive, accurate and detailed documentation of the multitude of events they describe.
Other authors have written about medicine a€” the diseases, doctors, treatments, disabilities, etc.
Richardson (Shropshire), Elliot (Shropshire), and Hoare (Ashton Manor), acquiring much background for subsequent stories.[2] Three short stories were published by Conan Doyle while still in medical school, plus a medical letter (a€?Gelseminum as a Poisona€?) in the British Medical Journal in 1879, reporting from observations on himself about the effects of increasing doses of a drug prescribed for neuralgia.
Between graduation in 1881 and the start of his practice in Southsea, four short stories and two articles on photography appeared in print.
Rather abruptly Conan Doyle took this advice, to specialize in ophthalmology after several monthsa€™ training in Vienna.
Turned down for military service because of age, he became a voluntary physician with Langmana€™s Hospital in Bloemfontein, South Africa, arriving in Capetown on March 21, 1900, to begin one of the major episodes of his life, politically and medically. Venereal disease from prostitution gained his attention, and he spoke out forcefully against opponents of the Contagious Disease Act.
In his Spiritualism he remained unconvinced of spirit healing, accepting some cases, but not abandoning his deeply ingrained beliefs in biologic theory and medicine: a€?While in Boston I spent an hour or so in the magnificent temple of the Christian Scientists.
At one point he settled a serious dispute, close to mutiny, between Major Drury and many of the supporting staff. His talk, a€?The Romance of Medicine,a€? reflected many of his experiences as a physician, his philosophy a€” the view that medicine a€?tinges the whole philosophy of life, and furnishes the whole basis of thoughta€? a€” and the effect of disease on historical events. The distortion trauma causes can emerge from the subconscious or unconscious in numerous ways. Their writing carries that special imprint peculiar to those who have felt, smelled and dwelled among fevers, madness, blood and abscesses. His medical scenes portray the basic sciences, clinical information, and doctors of his times. Fifteen of his eighteen medical short stories were published in Round the Red Lamp by 1894, covering a wide range of topics a€” the life of a medical student, starting a medical practice, episodes of practice, the emotional problems of dealing with patients, a love story involving a female physician, several of cuckoldry and the husbanda€™s retaliation, insanity and porphyria, the pain of childbearing, inheritable diseases, and vogues in therapy a€” electrotherapy and hypnotism. Certainly the genesis of this famous couple was based on the people Doyle encountered in his medical school days, particularly Dr.
But the greatest appeal and best characterization belonged to Sherlock Holmes who provided a new configuration, almost forcing the others off-stage.
Rodin and Key show how his excellent medical knowledge, an insatiable curiosity, a vivid imagination, and the artistry of expression combined with his sympathy for humanity to produce a remarkable and memorable author. Dame Jean Conan Doyle, his only living child, aided by her encouragement and personal recollections.
Dame Jean Conan Doyle, his only living child, aided by her encouragement and personalA  recollections. I would arrive knowing almost nothing about their business and their problems and leave having given them a clear path to follow. An engaging style is essential when teaching multi-day classes, especially just after lunch. Furthermore, there are limits placed on you due to politics, time, budget, legal restrictions, and the tools you have available.
Modeling is the only way to project the performance of an application in the design stage where there is no performance data to scale. Start somewhere, collect something and, as you explore and discover, add this to your collection.
After all, something has drawn you here, readera€”you want to know what it is the searchers seek among the soybean plants. Lawrence University, where he teaches courses in nonfiction writing and later American literature, and an adjunct member of the faculty of Ashland Universitya€™s Low-Residency MFA program. Our world was the Weekly Reader, hopscotch and jump rope, the only war the Cold One which America of course was winning. They lived only for my welfare, wrote notes about my progress and pinned them to my shirt, exchanged report card signatures.
McClanahan, who lives in New York, has received the Wood Prize from POETRY, a Pushcart Prize in fiction, and (twice) the Carter prize for the essay from Shenendoah. There is something about the way the breasts suddenly deflate, the way the body stops gurgling and humming, that lets me know I will continue to chase after the symptoms of another life in my body without ever finding what I am looking for.
This brown, this color I am, it sucks in the colors of crocuses, bananas, my husbanda€™s eyes, and it holds them tight, keeping them for its own but never changing, never brightening to a rich mahogany or surrendering to black. As my bitten fingernail zigzags over his sentences, I realize that even my fingers dona€™t match my image of a fourth grade teacher, who should be neat and composed, with a rosy complexion and trimmed, polished nails. He grins back at me, but there is something about his expression, the penetrating, hooded brown eyes, that tells me he knows Ia€™m overlooking his other mistakes.
She is currently working on a travel memoir about her experiences in the United Arab Emirates titled a€?Abu Dhabi Days, Dubai Nights.a€? Her creative work has been published in literary journals such as The Common Review, Brevity, and Fourth River.
Adding lanes in both directions just wouldna€™t have been right a€“ all that grass dividing the highway looks so much better! Most of his career was in military law enforcement minus some out of specialty assignments, including three years on recruiting duty.
A primary goal of this meeting is to feature new investigators, new technology, and new areas of concern, including potential effects on pollinators. There will be numerous career development events designed specifically for students and new and early stage investigators. In particular, the organizing committee has focused on the two challenges that were considered to be of the highest importance in the field.
Topics span organ systems and disease models and will include up-to-date thinking about how the AHR is relevant to the development and function of many organ systems, to numerous diseases, as well as to drug discovery and environmental health. The faculty consists of well-recognized experts in their field of study and most are Board Certified by the American Board of Toxicology (ABT). IUTOX is proud to present this meeting where toxicologists from around the world will share their recent findings with colleagues and other ICTXIV delegates. In particular, the committee has focused on the two challenges that were considered to be of the highest importance in the field. The basic principles of the use of animal models of disease will be reviewed as well as the advantages and disadvantages of these models. The fund proceeds will support travel awards to trainees attending meetings that offer significant educational opportunities in the field of reproductive and developmental toxicology, such as the Annual Meetings of the Society of Toxicology and the Teratology Society.
Kirstin Bircsak, a postdoctoral fellow at the University of Pennsylvania studying the role of placental drug transporters in fetal protection.
Since then, I have always kept myself updated on this fascinating area through the Society of Toxicology (SOT) CEd-Tox courses and contemporary literature.
JIFSAN is jointly administered by the US Food and Drug Administration and the University of Maryland. The Secretary of Agriculture will appoint individuals to serve a five-year term of office beginning January 24, 2017, and ending January 23, 2022. While the Watson and Crick paper gets the most attention, there were two other outstanding papers in that same issue by Wilkins, Stokes, and Wilson and by Franklin and Gosling that provided foundational evidence for the model described by Watson and Crick.
Rodin, a board-certified pathologist, was Professor and Chairman of Postgraduate and Continuing Medicine at Wright State University School of Medicine in Dayton, Ohio; Jack D.
Section Three concerns itself with medical events related to Conan Doyle, Sherlock Holmes, and Dr. His father became progressively more addicted to alcohol, and his mother the prop of the family. Joseph Bell, stood out from the others by his dynamic style of teaching and a diagnostic acumen based on close observation. He found time for an occasional poem such as a€?The Medical Love Song,a€? most likely written to a young lady whom he was seriously considering for marriage. But by the time he left Southsea, eight years later in December 1890, there were about thirty fiction stories, five novels, a medical thesis, and at least fifteen medical and nonmedical magazine articles and letters to newspapers. His experiences there resulted in several accounts: The Great Boer War (1900), an article in the British Medical Journal about enteric fever (1900), and The War in South Africa (1902). He spoke and wrote on behalf of the humanitarian treatment of the Congoa€™s natives, criticizing the a€?civilized nationsa€? who had seen a€?a hapless race, whose safety they have guaranteed, robbed, debauched, mutilated and murdered, without raising a hand or in most cases even a voice to protect them.a€? And he continued to support vivisection, a raging quarrel in Victorian times as at present. Rodin and Key later added to their initial presentation with their commentaries on Conan Doylea€™s Tales of Medical Humanism and Values [4], containing Round the Red Lamp, six other medical short stories, and a€?The Romance of Medicine.a€? It is doubtful if any further significant information about medicine and Conan Doylea€™s writings will be found when the family archives are finally released for scholarly use again.
Conan Doyle, but the other artistically gifted members of that family a€” he also figured in 2002a€™s book Among the Gently Mad: Strategies and Perspectives for the Book-Hunter in the 21st Century by Nicholas A.
I like people and if I couldna€™t make my classes useful, interesting, and relevant, then I would have stopped teaching a long time ago. As the commemorative plate infomercial says: a€?Collect them all!a€? Please dona€™t wait for perfection.
She is not someone who must ask repeatedly for attention and good behavior, whose voice gets muffled in the chatter of children, who anxiously picks at her nails and tears at her cuticles until tiny red bumps appear.
I finally allow myself to smile as I imagine the opportunity to place a full handed slap across the face of the Neanderthal that came up with that brilliant idea. We continue to identify ways to enhance the quality of our science and welcome feedback from our readers to guide us in this process. Rychlik, Allan Somers, and Pamella Tijerina led and inspired the students throughout the entire three-day program. An associated Gordon Research Seminar will be held in conjunction, led and organized by trainees, and featuring work in the area of genes, genetics, and genomics.
For additional information and to register, please visit the Teratology Annual Meeting website. In addition, specific examples of the use of these models in safety assessments will be presented. Michael Holsapple commented “As former colleagues at Dow, Ed was a close personal friend.
In competition with several presidential election primaries the same evening, this antic-filled event drew an enthusiastic and appreciative crowd.
Key was Librarian and Associate Professor of Biomedical Communications at the Mayo Foundation in Rochester, Minnesota. That he practiced medicine for eight years in Southsea was mentioned, along with his brief venture as an ophthalmologist in London. More than any other writer, he deserves credit for introducing the medical genre into literature and to the reading public. Conan Doyle applied and was accepted as a clerk to assist Bell in his out-patient clinics, a most profitable and far-reaching experience. This voyage along the west coast of Africa as shipa€™s surgeon provided further material for stories.
The White Company and Raffles Haw were completed before his departure from Southsea, although not published until 1891 and 1892 respectively. Nevertheless he acquired considerable knowledge about the eye, later displayed in his writings.
Perhaps most important was his understanding of the etiology, epidemiology and prevention of enteric (typhoid) fever, resulting in a marked change in military policy in the crowded and irregular conditions of war.
Statements that there was not a€?an atom of evidencea€? that any lives had been helped by the torture of animals quickly drew a response to the contrary from Conan Doyle.
A strong and kindly personality is as valuable an asset as actual learning in a medical man. There are a great number of medical references in the Sherlock Holmes stories, with thirty-four physicians and two professors, of physiology and of comparative anatomy.
And now these paragraphs lie before you like stands of trees, a deep forest of wonder and darkness whose mystery beckons. Each morning Mother locked my thermos and only Miss Ranney could loosen it, leaning over me in her ivory crepe blouse until the cap sighed once, then was free. The rest of the orbit swirls out from there: King murdered the week of my senior prom, then Bobby in a hotel just miles from my school while I marched to Pomp and Circumstance, not knowing that within a year on a July night in the back seat of a Volkswagen, I would pledge what was left of my heart to a boy leaving for Vietnam while above us the tired moon finally gave in to a tiny man in gravity boots, planting an American flag. Shea€™s probably doodling on the desk, her long, dark lashes cast down as she tries to escape the demands of the classroom and enter into the world of her drawing. She is no longer a manipulative ten year old who pouts when she wants permission to draw hearts on the chalkboard or be excused to the lavatory for the third time in an hour. Focusing on emerging ideas and transformative approaches will be a unifying basis from which participants working on every level from molecule to man can converge and discuss the past, present, and future of the Endocrine Disruptor Chemical (EDC) field. Immunogenicity of these therapeutics is a significant confounding factor and often makes nonclinical risk assessment difficult.
To ensure an interactive meeting, registration is limited, so act soon to guarantee your place.
Abstracts from students and new investigators received by March 4, 2016, will automatically qualify for potential travel awards.
He was always willing to reach out with a scientific insight, with a thought-provoking question, or with just a kind word.
Both had a long interest in medical history and Arthur Conan Doyle authenticated by numerous publications over many years. In London he rented an office near medically fashionable Harley Street, but by his account, no patients came; with no one in the waiting room, he had more than ample time for writing.
He vigorously supported preventive inoculation, something loudly and vigorously disputed by Bernard Shaw. I have known men in the profession who were stuffed with accurate knowledge, and yet were so cold in their bearing, and so unsympathetic in their attitude, assuming the role rather of a judge than a friend, that they left their half-frozen patients all the worse for their contact. Conan Doylea€™s writings are compatible with the last such management of his childhood experiences a€” memories of his familya€™s crowded home and relative poverty in Edinburgh, and his fathera€™s alcoholism perhaps accompanied on occasion by physical abuse. His collection of Doyleana is now at Chicagoa€™s Newberry Library, which in its honor hosts a Conan Doyle symposium on the Saturday morning following each yeara€™s Hounds of the Baskerville (sic) annual dinner in Chicago.
Ia€™m trying to ignore her insubordinationa€”she should be writing a paragraph like the rest of the six students in my after school reading classa€”but clearly another one of my tactics has failed. In a moment, Alejandra has become a young woman learning how to manage the intimate details of our gender. Gehring had a strong interest in encouraging individuals from groups underrepresented in the sciences to enter biomedical sciences and toxicology. Ed helped shape the future of many toxicologists, not just at Dow, but also within the Society of Toxicology. Our environment truly shapes who we are: from our social upbringing, nutritional sustenance, exposures to a variety of exogenous chemical and biological species, to the symbiotic relationship with our planet. Conan Doyle, forty pages of notes of additional information about many of the previous comments, and thirty-five pages of appendices listing the subjecta€™s medical chronology, medical writings, Edinburgha€™s faculty and Conan Doylea€™s medical school grades, the non-Sherlockian doctors, and medical references in the Sherlock Holmes stories.
Both were equally prominent authors, but Conan Doyle brought more scientific and medical understanding to the subject.
Almost all the physicians (save Watson) are peripheral, reinforcing the background, flitting in and out of the stories in various roles, and sharpening the readersa€™ attention.
I turn around, ready to demand she sit back in her seat, prepared to be heard and heeded this time, but she is looking at me, wide eyed. The development of these technologies is complicated by their complex and novel composition, the local cellular response often observed against these systems within the eye, and a lack of clear regulatory guidance in the field. Carney when I applied for this award, I have since come to learn about the significant positive influence he had on the field of reproductive and developmental toxicology both as a scientist and leader. Our field provides the mechanistic basis of the potentially adverse effects of these complex factors that are essential to the understanding of biology. His obituaries in 1930 essentially ignored the medical part of his life, only one giving a reasonable view of his medical activities and their influence on his literary efforts. The physician is taught to be dispassionate in his treatment, but the overpowering dismay and feeling of helplessness when a patienta€™s disease relentlessly progresses to death exceed that of any other profession. The dermatologist Malcolm Morris reportedly drilled and tested Doyle on the value of minute observation and what could be deduced thereby. Rodin and Key illustrate how Conan Doyle adopted many of his own experiences in describing these physicians. For additional information and to register, go to the Ocular Toxicology conference website. His son Adriana€™s The True Conan Doyle gives no attention to his fathera€™s medical activities except to minimize the role of Dr. They separated abruptly in several months, and Conan Doyle went to nearby Southsea, a suburb of Portsmouth: experiences well-portrayed among the short stories of Round the Red Lamp (1894) and in The Stark Munro Letters (1895). Medicine follows rigid methods, and the physician must be methodical, compulsive, even obsessive, in his thoughts and actions. But credit has been given and accepted by Doylea€™s surgical teacher at Edinburgh as Conan Doyle acknowledged: a€?I thought of my old teacher Joe Bell, of his eagle face, of his curious ways, of his eerie trick of spotting details.
Maria Neira, Director, Public Health and Environment Department, World Health Organization; Dr. In the dull interludes of shabby-genteel practice he polished up his talent for writing, and from time to time short stories from his pen would be accepted by editors of magazines. They have learned self-reliance, confidence, and, in a word, have become men of the world while their confreres in England are still magnified school-boys. It fascinated me to watch their cheery doctor carrying the sunshine with him wherever he went, worshipped by all. Whether the patient is rich or poor, pleasant or nasty, calm or angry, responsive or not, the responsibility, accountability, and worry impacts the physician throughout every hour of the day.



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