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October 16, 2014 by Paul Cunningham 41 Comments TweetI recently encountered an Exchange 2010 server that was unable to send emails to a small number of domains. Interestingly the domain name was resolving just fine in DNS when queried from the server, including for MX record lookups, and a telnet to port 25 was successful too. There are many reports of this error on forums such as TechNet but no concrete explanations for the causes or how to solve it.
In the end the solution was to enable the option to force the send connector to use the external DNS settings for the transport server. After changing the send connector config and restarting the MSExchangeTransport service the mail delivered successfully to the troublesome domains.
It’s possible this is a bug with the particular combination of Exchange 2010 and Windows Server 2008 R2 that the customer is running, although I could not find anything that specifically confirms this.
TweetSolutions About Paul CunninghamPaul is a Microsoft MVP for Office Servers and Services, specializing in Exchange Server and Office 365, and is the publisher of Exchange Server Pro. I begin experiencing this issue with Exchange immediately after migrating the Domain controllers from Windows 2008 R2 to Windows Server 2012 R2. Same issue with Exchange server 2010 and we’re using EOP as smart host instead of MX records and queues were struck on Retry mode on Hub Transport server.
Resolved the problem by removing individual hosts from CAS NLB manager, restarting Exchange transport server and then re-adding hosts again. I don’t imagine it will cause you a problem with your McAfee service but on the other hand if it does at least you will notice quickly.
I have the same problem on my exchange 2010 SP3 rollup 8, it just happened and did not know what is the cause.

I’m a novice Exchange admin and I originally tried to change the setting on the Edge Transport server and got an error. It’s always troubling to see a fix for a previous version work on a current version and not know exactly why.
I’ve a hunch that if it has issues with DNS Resolution, it may fail the domain, so making the change suggested fixed the issue. I just realized we were having this problem recently, maybe because few weeks ago I decomisioned my old DCs WS2003R2 but it also might be because I installed last rollup 10 to Exchange 2010SP3 on 20150718. When I created a send connector just for that namespace and designated their MX as the smart host IP address delivery was successful.
I saw many references to disabling IPv6 on the server, but also follow up reports that this did not work.
They were simply set to use the DNS settings of the network interface, which worked fine for NSLookup.
It is also not an issue I’ve encountered elsewhere with this combination of server versions, nor can I reproduce it in a test lab.
I have not specifically encountered this issue but now many who do will have a pretty good shot at finding a solution through your blog.
I had a client who has Server 2012 R2 and Exchange 2010 and emails were very delayed and I couldn’t figure out why. I went to the Hubtransport and made the change there and the change sycned to the Edge Transport and all was good after a restart of the MS Exchange Transport service on the Edge server.
I was experiencing similar problems with Exchange 2013 on an Edge transport, but the above suggestion did not fix the problem.

I had 4 MX records for the domain however, one of the A records for the MX Records was unresolvable. But if you do encounter this issue the above solution seems to work fine and is certainly very quick and easy to try.
As Yaun says, no service restart required – I just retried the queue and it flushed through fine. Strangely, my Exchange 2007 Edge transport also has this enabled with a GUID of zeros, but that works and 2013 doesn’t.
They respond with additional Records that MS DNS Server cannot handle in combination with Exchange.
It was tough because we had just changed public IP addresses when this issue showed up so I wrongly thought it was some routing thing with our new IPs. We also routed problem domains out via send connector customization to our Cuda and it sent to our problem domains just fine. If you look into DNS Console in the cached lookups and search for that domain, you may find not just MX and A Records but also RRSIG records.

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