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23.11.2014
Our hunger and appetite are controlled by complex systems within our bodies, which can be profoundly affected by what we eat and drink — including coffee. While people often use caffeinated coffee to control their appetite, new research shows that if you want to reduce your bodyweight, you might be better off sticking to decaf.
Billions of people worldwide drink coffee to get more energy, feel more alert, and improve their athletic performance. Thanks to Famous TV Doctors and media attention to coffee’s health effects, our worries bubble up like a well-formed espresso crema: Should we drink more java?
Coffee’s mixed effects also depend on the type of coffee, the amount you drink, when you drink it, your overall biological makeup, and so on.
Coffee also contains phytochemical compounds called chlorogenic acids, an important group of biologically active and antioxidant dietary phenols. Chlorogenic acids are also found in apples, pears, artichokes, strawberries, pineapple, sunflower and blueberries (1). Chlorogenic acids have recently caught the attention of obesity researchers and dietary supplement manufacturers alike, as they can help decrease hunger. As a side note, an easy trick to remember the difference between these two: ghrelin = stomach GRemlins and GRowling. For more on how leptin and ghrelin work, see Leptin, Ghrelin, Weight Loss: It’s Complicated. Cells of the intestinal mucosa of the ileum and large intestine release the third hormone, peptide YY (PYY). PYY lowers appetite and food intake, perhaps by acting on neurons in the hypothalamus to help people feel full or satisfied.
How do caffeine, caffeinated coffee, and decaffeinated coffee affect people’s feelings of hunger and fullness?
Hypothesis 2: These effects would occur during the 60 minutes after subjects drank the test beverage and during the subsequent 120-minute period following glucose ingestion. This type of design allows researchers to compare the drinks more effectively without being concerned about variation between subjects.
Because there were four test conditions (placebo drink, caffeinated coffee, decaffeinated coffee, caffeine in water) the subjects visited the lab four times for testing, 1-2 weeks apart (so that there would be no potential interaction between drinks). Subjects rested in a chair while a catheter was inserted into a vein for blood sampling throughout the study. An initial blood sample was collected.
Subjects were given a randomly selected beverage: placebo drink, caffeinated coffee, decaffeinated coffee, or caffeine in water, and asked to drink it within ten minutes. More resting for 60 minutes, after which subjects were asked to drink a ten ounce bottle of flavored water containing 75 g glucose.
Meanwhile back at the lab… glucose ingestion was followed by six more blood draws over a two hour period.
The visual analogue scale (VAS) is a well-validated and often-used tool that researchers use for more subjective or nebulous things like pain or fatigue (5).


My mom thinks I am a coffee snob, and I must admit I laughed when I saw that Chock Full O’Nuts Original was the brand that was used in this test. Coffee snob or not, the $200 participation fee would keep me stocked with my favorite organic fair trade coffee beans for at least a month or two. Researchers wanted to maximize the concentration of non-caffeine coffee compounds, yet achieve a brew that wasn’t tar-thick. This amount equals about 16-20 ounces of coffee, which is about what your average coffee drinker consumes these days considering the ginormous mugs we all use.
Results were reported two ways: plotted as a graph of time vs beverage effect, and calculated as area under the curve or AUC. Hunger AUC was not significantly different for caffeine than placebo or for decaffeinated coffee vs. Ratings of satiety (at 180 minutes): While there were no significant beverage effects detected, ratings of satiety produced a similar pattern to those of hunger.
While caffeine has long been used as an appetite suppressant, in this study it was decaffeinated coffee that resulted in significantly lower hunger levels and higher plasma levels of PYY than placebo (plain water) and the other caffeinated beverages.
Another interesting finding was that the decrease in hunger and increase in PYY persisted through and after the glucose ingestion.
We can speculate here that there is something – one or more noncaffeine components (coffee includes hundreds of them) – that can decrease hunger and increase PYY. For rating hunger and fullness, food measurements could be used, and maybe researchers could even measure brain waves. Regardless, this study providing some interesting data that may lead to practical applications for increasing feelings of fullness and decreasing feelings of hunger. Coffee is full of antioxidants and provides numerous health benefits, though not everyone responds to it equally well. In it you’ll learn the best eating, exercise, and lifestyle strategies – unique and personal – for you. Use these free images for your websites, art projects, reports, and Powerpoint presentations! JavaScript seems to be disabled in your browser.You must have JavaScript enabled in your browser to utilize the functionality of this website. Mehmet Oz, if you want to lose weight, then you should skip brewed coffee and take green coffee bean extract instead. Or does every drop float us closer to a well-caffeinated grave? The truth seems as muddy as truck stop joe.
Mouse studies to date have produced mixed results, so I wouldn’t run out and buy green coffee bean extract just yet (2,3).
It’s tricky, as appetite, hunger, and satiety are influenced by dozens of interacting hormones.


Subjects ate the same identical light breakfast before each visit, then nothing else — no lunch and no snacks. Well, they also tested levels of three internal peptides (the term peptide refers to two or more amino acids linked by chemical bonding between their carboxyl group and their amino group): ghrelin, PYY, and leptin. They scanned the literature and found that a brew equal to 6 mg of caffeine per kg of body weight was about right. I can just picture a lab full of jittery, hyper-alert scientists, slapping the invisible bugs off their skin. AUC is a statistical means of summarizing data from a series of measurements on one individual. In other words, ratings of satiety were higher after the decaffeinated coffee than any of the other beverages, just not high enough to reach statistical significance. PYY AUC in the 90-minute period was significantly higher for decaffeinated coffee than for placebo and caffeine. Not only that, but the decrease in hunger lasted for the full 3 hours of the lab visit, even though, after 1.5 hours, levels of PYY decreased. The use of green coffee extract as a weight loss supplement: Review and meta-analysis of randomised clinical trials.
The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass. Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies.
Please note: this image is protected by copyright law and may not be used without buying a license. However, if you aren’t an Oz fan, and prefer to drink your coffee instead of taking it in pill form, could it still help you lose weight? Leptin is a hormone, synthesized primarily in fat cells, that has been shown to decrease food intake and increase energy expenditure. During each of those eight draws, the subjects were asked to rate their levels of hunger and satiety (fullness) on visual analog scales (VAS).
Hunger AUC yielded similar results and was statistically significantly lower following consumption of decaffeinated coffee vs. The difference between hunger after decaffeinated coffee and placebo did not vary significantly over time after glucose ingestion and did not diminish toward the end of the study. However, hunger after caffeinated coffee was not significantly lower than after placebo or caffeine.



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