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Peroxisomes are ubiquitous organelles that are defined as containing at least one hydrogen-peroxide-producing oxidase and catalase to decompose the hydrogen peroxide. Peroxisomes are essential for normal human development and physiology, as shown by the lethality of a group of genetic disorders called the peroxisome biogenesis disorders (PBDs). The yeast vacuole (lysosome) is an attractive organelle for studying the membrane fusion mechanism since it is easily visualized for in vivo studies and simple to isolate in great quantity and purity for in vitro studies.
Natamycin inhibits vacuole fusion at the priming phase via a specific interaction with ergosterol. Cdc42p and Rho1p are sequentially activated and mechanistically linked to vacuole membrane fusion. Cdc42p is activated during vacuole membrane fusion in a sterol-dependent subreaction of priming. Primary granule exocytosis in human neutrophils is regulated by Rac-dependent actin remodeling. The peroxisomal membrane protein Inp2p is the peroxisome-specific receptor for the myosin V motor Myo2p of Saccharomyces cerevisiae.
Fatty acylation is one of many types of post-translational modification of proteins by lipids which also includes modification by isoprenoids, glycosyl phosphatidyl  inositols, and cholesterol. My laboratory studies the role of protein fatty acylation across the full spectrum of signal transduction. Progress in the study of fatty acylation has been hampered by the lack of rapid detection methods. Heart and Stroke Foundation of Alberta, NWT and Nunavut: Mitochondrial palmitoylation and the regulation of gene expression, enzyme activity and metabolism in the metabolic syndrome. Expert tips, local blogger round-ups and unbeatable deals in your area, all in one weekly email. Dani has an MBA in Marketing and works in the Social Media Marketing field for a large media agency. They perform many biochemical functions, including the oxidation of fatty acids and the detoxification of reactive oxygen species.


We therefore developed the fruit fly Drosophila as a valid and tractable multi-cellular, multi-tissue model organism for the PBDs in collaboration with Dr. The peroxin Pex34p functions with the Pex11 family of peroxisomal divisional proteins to regulate the peroxisome population in yeast. Fatty acylation, the covalent attachment of long chain fatty acids to proteins, is a critical cellular control mechanism. Examples include: Src, Ras and Wnt oncogenes are involved in cancer progression while acylated HIV Gag and GP160 are involved in the HIV life cycle and AIDS. Simply put, signal transduction is the movement of a signal from outside to inside the cell. Until very recently, detection of fatty acylated proteins relied on the tedious and hazardous incorporation of radioactive [3H]-fatty acids into proteins followed by lengthy fluorographic exposures (often months). Meyer-Schaller N, Chou YC, Sumara I, Martin DD, Kurz T, Katheder N, Hofmann K, Berthiaume LG, Sicheri F, Peter M. An ancestral role in de novo peroxisome assembly is retained by the divisional peroxin Pex11 in the yeast Yarrowia lipolytica.
Transport and retention mechanisms govern lipid droplet inheritance in Saccharomyces cerevisiae. Dynein light chain interaction with the peroxisomal import docking complex modulates peroxisome biogenesis in yeast. Phosphorylation-dependent activation of peroxisome proliferator protein Pex11 controls peroxisome abundance. Pex3 peroxisome biogenesis proteins function in peroxisome inheritance as class V myosin receptors. Fagarasanu A, Mast FD, Knoblach B, Jin Y, Brunner MJ, Logan MR, Glover JN, Eitzen GA, Aitchison JD, Weisman LS, Rachubinski RA.
Indeed, fatty acylation is a very unique protein modification that impacts on virtually every aspect of cellular life including the regulation of membrane targeting, apoptosis, cell proliferation, protein-protein interaction, protein stability and protein secretion.
In addition, G-protein coupled receptors are involved in a variety of patho-physiological conditions such as hypertension (e.g.


Subsequently, as a post-doctoral fellow, I was part of team that developed the use of [125I]-iodofatty acids as labels, which reduced exposure time significantly but these were also hazardous and not commercially available. We successfully used this method to identify 5 new putative post-translationally myristoylated proteins (29) and 21 palmitoylated rat liver mitochondrial proteins (28,30,34). Fatty acylated proteins are surprisingly abundant and form a large and understudied protein family, which is divided into two groups: myristoylation and palmitoylation. More precisely, we study the role of protein fatty acylation in membrane localization as it pertains to the regulation of apoptosis and cell proliferation.
Recent breakthroughs led to major improvements in detection and identification of fatty acylated proteins: the use of the acyl-biotinyl exchange reaction (ABE) and the use of azido- and alkynyl fatty acid analogues now offer rapid, non-radioactive and sensitive new means of detecting fatty acylated proteins. It is estimated that at least 5% of nuclear encoded proteins are either myristoylated or palmitoylated and yet little is known about the biology of protein fatty acylation. Second, we study the involvement of palmitoylation in the regulation of gene expression and enzymatic activity resulting in the fine-tuning of mitochondrial metabolism. Using this latter method, we can detect the myristoylation of endogenous and exogenous myristoylated proteins as well as the palmitoylation of endogenous or exogenous N- or H-Ras in cells in seconds (33), and, for the very first time, in vivo (33).
Accordingly, all peroxisomal proteins are encoded in the nucleus and synthesized on cytosolic polysomes.
With the exception of N-myristoyl-transferase 1 (NMT1), again, little is also known about the enzymology of the recently identified fatty acyl transferases.
For the first time cancer related deaths exceed deaths from cardiovascular diseases and cancer is now the #1 cause of death.
Also according to StatsCan, ~14,500 new cases of cancer and 5,800 deaths from cancer occurred in Alberta in 2007. Thus, cancer and cardiovascular research is invaluable for the health of Albertans and Canadians.




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